Cutaneous Plasmacytosis Showing a Neuronal Involvement in a 35-Year-Old Female

( Joong-heon Suh ),( Ho-young Kim ),( Jae Ho Lee ),( Soo-kyung Lee ),( Un-ha Lee ),( Myoung-shin Kim ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.2

A case of malignant chondroid syringoma on nose

( Joong Heon Suh ),( Jae Ho Lee ),( Ho Young Kim ),( Soo Kyung Lee ),( Un Ha Lee ),( Myoung Shin Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Malignant chondroid syringoma, also known as malignant mixed tumor of the skin, is an extremely rare tumor, with only approximately 50 cases reported in the literature to date. It is known to have a predilection for males and is commonly located on the extremities and the trunk. Due to its indistinctive clinical appearance and rare incidence, it is not easy for clinicians to make impression when they encounter in their clinics. A 54-year-old male presented with 0.9 x 0.6 cm sized skin colored to bluish papule on the nose. The history was that of a painless, slow growing papule over a 1.5-year time period. Clinically the patient was suspected to have a basal cell carcinoma. Biopsy showed chondroid and mucinous mesenchymal stroma in the dermis. The tumor cell nuclei ranged from being monomorphic to pleomorphic. Some areas showed apocrine glandular differentiation forming multiple tiny cystic cavities within the stroma. The tumor cells were even infiltrated to the deepest part of the dermis that specimen showed. On the basis of these findings, we established the diagnosis of malignant chondroid syringoma with apocrine differentiation. We recommended the wide local excision with further imaging study but patient refused to receive any of these. This case suggests that malignant chondroid syringoma can occur in the region of face mimicking other cutaneous tumors. Surgical excision is necessary and close follow up is essential.

A case of pigmented intradermal spitz nevus

( Joong Heon Suh ),( Jae Ho Lee ),( Ho Young Kim ),( Soo Kyung Lee ),( Myoung Shin Kim ),( Un Ha Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Spitz nevus is a benign tumor, which histologically resembles malignant melanoma (MM) and may be misdiagnosed as MM. Accurate diagnosis is vital in that the misdiagnosis between Spitz nevus and MM may cause overtreatment or life-threatening result. In histology, Spitz nevus is classically considered to be poor in pigmentation resulting in pink or reddish-brown colored clinical appearance. Twenty one year old woman presented with a 1 year history of 0.7 cm sized black colored dome shaped papule on her lower leg. Biopsy showed symmetrical intradermal deposition of melanocytes with nest formation and maturation. Characteristic pigmentation of the melanocytes and dermal melanophages was remarkable in the papillary dermis. The melanocytes in dermis were positive for Melan-A stain. On the basis of findings above, we established the diagnosis of pigmented intradermal Spitz nevus, which is a rare variant of Spitz nevi.

Facial herpes zoster: a 15-year retrospective singlecenter study

( Joong Heon Suh ),( Joong Ho Kim ),( Jae Ho Lee ),( Ho Young Kim ),( Soo Kyung Lee ),( Un Ha Lee ),( Myoung Shin Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Few studies have reported about facial herpes zoster and its complications in the Korean dermatologic literature. Objectives: The purpose of this study was to investigate epidemiology, clinical features, and complications of facial herpes zoster. Methods: We analyzed 977 patients who visited Sanggye Paik Hospital between January 2002 and December 2017. We categorized them into 8 groups based on dermatomes. We investigated the correlations between clinical features, prognosis, and complications. Results: The most common site of involvement of facial herpes zoster was the ophthalmic branch (59.2%). Herpes zoster involving the ophthalmic and maxillary branches showed a significantly higher incidence rate of herpes zoster ophthalmicus than that involving only the ophthalmic branch (odds ratio 7.373). Age and periorbital swelling were significantly correlated with herpes zoster ophthalmicus (p<0.001). Facial palsy was significantly correlated with otalgia and cutaneous ear involvement (p <0.001). Patients who received antiviral treatment within 3 days showed lower rates of postherpetic neuralgia (35.8%) than patients who received treatment after 4 days (45.4%) (p=0.002). Conclusion: Facial herpes zoster is associated with several complications. Age, periorbital swelling, otalgia, and cutaneous ear involvement are useful predictors of complications and prognosis. Early institution of antiviral treatment is required for better outcomes.

A case of clear cell squamous cell carcinoma in situ

( Joong Heon Suh ),( Jae Ho Lee ),( Ho Young Kim ),( Soo Kyung Lee ),( Un Ha Lee ),( Myoung Shin Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Cutaneous clear cell squamous cell carcinoma in situ (SCCIS), known as clear cell Bowen disease, is a rare variant of squamous cell carcinoma (SCC). The clear cell change of keratinocytes is regarded as a result of hydropic cytoplasmic swelling and accumulation of lipid vacuoles. Ultraviolet radiation has been suggested as possible etiology. A 72-year-old woman presented with a 1-year history of localized non-healing erythematous scaly patches on her elbow. In histology, atypical, pale and vacuolated keratinocytes were spread throughout the epidermis. There was no neoplastic cell change or infiltration below the dermal-epidermal junction. Mild perivascular lymphocytic infiltration was also observed in upper dermis. The lesion was positive for p63 stain. On the basis of the clinical findings and microscopic results, it was diagnosed as clear cell variant Bowen disease.

안면부 대상포진에 대한 15년간의 후향적 연구: 단일 기관에서의 경험

서중헌 ( Joong Heon Suh ),이수경 ( Soo Kyung Lee ),이운하 ( Un Ha Lee ),김명신 ( Myoung Shin Kim ) 대한피부과학회 2019 大韓皮膚科學會誌 Vol.57 No.5

Background: Many studies about herpes zoster exist in the Korean dermatologic literature. However, few studies have reported about facial herpes zoster and its complications. Objective: The purpose of this study was to investigate the epidemiology, clinical features, and complications of facial herpes zoster. Methods: We analyzed the medical records of 977 patients who visited Sanggye Paik Hospital between January 2002 and December 2017. We categorized patients into 8 groups based on the dermatomal distribution of herpetic lesions. We investigated the correlations between clinical features, prognosis, and complications. Results: The most common site of involvement of facial herpes zoster was the ophthalmic branch of the trigeminal nerve (59.2%). Herpes zoster involving the ophthalmic and the maxillary branches of the trigeminal nerves showed a significantly higher incidence rate of herpes zoster ophthalmicus than that observed with herpes zoster involving only the ophthalmic branch (odds ratio 7.373). Age and periorbital swelling were significantly correlated with herpes zoster ophthalmicus (p<0.001). Facial palsy was significantly correlated with otalgia and cutaneous ear involvement (p<0.001). Postherpetic neuralgia (PHN) occurred in 41% of patients with facial herpes zoster. Patients who received antiviral treatment within 3 days showed lower rates of PHN (35.8%) than patients who received treatment after 4 days (45.4%) (p=0.002). Conclusion: Facial herpes zoster is associated with several neurological complications. Variables including age, periorbital swelling, otalgia, and cutaneous ear involvement are useful predictors of complications and prognosis. Early institution of antiviral treatment and appropriate interdepartmental consultations are required for better treatment outcomes. (Korean J Dermatol 2019;57(5):235∼242)

영아에서 발생한 파종성 구진 양상의 B세포 가성림프종 1예

서중헌 ( Joong Heon Suh ),김호영 ( Ho Young Kim ),이재호 ( Jae Ho Lee ),김중호 ( Joong Ho Kim ),이수경 ( Soo Kyung Lee ),이운하 ( Un Ha Lee ),김명신 ( Myoung Shin Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.6

Cutaneous pseudolymphoma is a heterogeneous group of benign reactive T- or B-cell lymphoproliferative diseases of the skin that simulate cutaneous lymphomas histologically and, sometimes, clinically. Thus far, only a few cases of pseudolymphomas showing atypical clinical manifestations have been reported. A 10-month-old boy presented with multiple flesh-colored, yellowish erythematous disseminated papules on the face, abdomen, and arms. The cutaneous lesions morphologically resembled molluscum contagiosum, Langerhans cell histiocytosis, or juvenile xanthogranuloma. Punch biopsy and immunohistochemistry studies were performed, and the lesion was identified as a cutaneous B-cell pseudolymphoma. Most of the lesions were cleared within a month with systemic corticosteroids and oral antihistamine administration. In this report, we present an interesting rare case of infantile cutaneous B-cell pseudolymphoma mimicking many other dermatological diseases in addition to a cutaneous lymphoma. (Korean J Dermatol 2020;58(6):406∼410)

등에 발생한 유방외 Paget’s 병 1예

서중헌 ( Joong Heon Suh ),이수경 ( Soo Kyung Lee ),이운하 ( Un Ha Lee ),김명신 ( Myoung Shin Kim ) 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.6

Ectopic extramammary Paget’s disease (EMPD) is a rare variant of EMPD that develops in non-apocrine regions. We present a 70-year-old man in whom ectopic EMPD affected the lower back. Initially, erythematous scaly plaques with several papules on the back were suggestive of Bowen’s disease. However, the biopsy specimen and immunohistochemical study results were consistent with EMPD features. The lesion was resected with a 1-cm safety margin and covered with a full thickness local skin graft. Ectopic EMPD is so rare that only few cases of EMPD in a non-apocrine region have been reported. We considered this case of EMPD on the back to be interesting since there has been no previous case reported in this location in Korea. (Korean J Dermatol 2018;56(6):380∼384)

장기적 트립토판 결여식이 생쥐의 유해감각예민도에 미치는 영향

서영대,박제민,김명정,전명호,양구범,장세헌,강철중,김정태,김용식 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

The depressive patients can be divided into two subgroups by presence and absence of pain symptoms. Those without pain symptoms have blunted pain sensitivity whereas those with pain have normal range of pain sensitivity, and are clinically characterized by anxiety and irritability. The aim of the study is to test if these clinical profiles of the depressives with pain symptoms are related with reduced level of brain serotonin(5-HT). Forty four mice were randomly divided into two groups : one group to be bred with tryptophan free diet and the other with normal control diet, each for 4 weeks. Before the beginning of the breeding period, measured were locomotor activity by open field test, anxiety by elevated plus maze and nociceptive sensitivity by tail flick test, before and after forced swimming(FS). During each FS, duration of immobilization was also measured. The sable sets of measurements were repeated at the end of the breeding period. The brain 5-HT and 5-hydroxyindoleacetic acid(5-HIAA) were measured by high performance liquid chromatography. The results were as follows 1.Four weeks of tryptophan free diet reduced significantly body weight, brain weight, and levels of 5-HT and 5-HIAA in the whole brain. 2.Tryptophan depletion did not influence basal nociceptive sensitivity as measured by tail flick latency before FS. The normal blunting of the pain sensitivity induced by forced swimming was preserved in the tryptophan depleted group. 3.Tryptophan depletion did not influence general locomotor activity in open field. 4.Tryptophan depletion increased significantly time spent on the open arms at the elevated plus maze test done before FS. This anxiolytic-like effect was reduced by FS. 5.Tryptophan depletion did not influence duration of immobilization during FS. From these results, it is suggested that the genesis of the depression with pain symptoms is not medicated by quantitative reduction of brain serotonin

라운드 형태 건물의 모델링 방법론에 관한 연구

김헌중(Kim Heon-Joong),이현근(Lee Hyun-Geun),최원기(Choi Won-Ki),서승직(Suh Seung-Jik) 한국태양에너지학회 2006 한국태양에너지학회 학술대회논문집 Vol.- No.-

This study is for introducing a method by which we could gain proper results from the simulation tools economically, specially in modelling the rounded shape of building. For calculating the effect of the method, we assumed a model of half-round shape, then defined a reference model divided in 10°, a central angle, for evaluating the relative thermal performance. As results, it is necessary to divide the central angle at least as 20° for accuracy, but in case of horizontal division of the round body it is necessary to divide the area into more than 3 sections. Consequently, we could model the building for simulation more easily and economically by dividing the shape body of model as horizontal division, with accuracy as well.