약물처방 개선을 위한 선진국의 노력

배종면 대한의사협회 2004 대한의사협회지 Vol.47 No.2

Annual Report of the Korea Central Cancer Registry Program 2000: Based on Registered Data from 131 Hospitals

Jong-Myon Bae,Young-Joo Won,Kyu-Won Jung,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.2

Purpose: The Korea Central Cancer Registry (KCCR)program completed a nationwide hospital-based cancerregistry to provide basic statistical data on cancer incidence.Materials and Methods: In 2000, 131 hospitals participatedin the KCCR program. All cancer registry data,which were submitted by the participating hospitalsduring the year, were reviewed and analyzed by thecommittee members.Results: Of the 94,474 cases that were registered, 7,735(8.2%) duplication cases were excluded. Of the remaining86,739 cases, 2,893 cases (3.3%) of carcinoma in situ(morphology code/2) were excluded, leaving a final totalof 83,846 cases for analysis, 48,005 (57.3%) male and35,841 (42.7%) female. The leading age group was 60∼64years (15.1%). The six leading primary cancer sites in theorder of their relative frequency were the stomach (20.8%),lung (12.2%), liver (12.2%), colorectum (10.3%), breast(6.5%), and uterine cervix (4.5%). In males, the threeleading primary cancer sites were the stomach (24.5%),liver (16.3%), and lung (16.3%). In females, the stomach(15.8%), breast (15.1%), and uterine cervix (10.6%). Amongthe 1,126 cases of childhood malignancies, leukemia(32.7%) was the most common cancer type.Conclusion: We report our analysis of the KCCR datafrom 131 nationwide hospitals during 2000. (Cancer Res Treat. 2002;34:77-83)

Cigarette Smoking and Risk of Lung Cancer in Korean Men: The Seoul Male Cancer Cohort Study

Bae, Jong-Myon,Lee, Moo-Song,Shin, Myung-Hee,Kim, Dong-Hyun,Li, Zhong-Min,Ahn, Yoon-Ok KOREAN ACADEMY OF MEDICAL SCIENCE 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22 No.3

<P>Lung cancer is the leading cause of cancer deaths in Korea. The aim of this study was to estimate lung cancer risk of cigarette smoking in Korean men by a 10-yr follow-up prospective cohort study using the primary databases. The number of subjects was 14,272 men, who had full information of smoking habits among participants in the Seoul Male Cancer Cohort Study (SMCC). Total 125,053 person-years were calculated by determining the number of days from the start of follow-up, January 1, 1993, until the date of lung cancer diagnosis, death from another cause, or the end of follow-up, December 31, 2002, followed by converting the number of days to years. The information of outcome was obtained by the database of Korea Central Cancer Registry, Seoul Regional Cancer Registry, and Korea Statistical Office. The relative risk (RR) and its 95% confidence interval (CI) values of smoking were calculated using Cox proportional hazards regression stratified on potential confounders. During the follow-up periods, 78 cases of lung cancer occurred. The cigarette smoking is the major risk factor and increases the 4.18-fold risk of lung cancer in Korean men. In order to control lung cancer, intervention of quitting smoking is needed.</P>

Rates of Change to a Positive Result in Subsequent Screening Mammography in Korean Women: A Retrospective Observational Study

Jong-Myon Bae,Sang Yop Shin,Eun Hee Kim,Yoon-Nam Kim,남정모 대한예방의학회 2015 Journal of Preventive Medicine and Public Health Vol.48 No.1

Objectives: This retrospective cohort study aimed at calculating some parameters of changes in the findings of the subsequent screening mammography (SSM) in female Korean volunteers. Methods: The study included screenees aged 30 to 79 years who underwent SSM voluntarily after testing negative in the baseline screenings performed between January 2007 and December 2011. A change to a positive result was defined as category 4 or 5 by usingthe American College of Radiology Breast Imaging Reporting and Data System. The proportion of results that had changed to positive(CP, %) was calculated by dividing the number of cases with results that were positive in the SSM by the total number of study participants. The rate of results that had changed to positive (CR, cases per 100 000 screenee-months) was calculated by dividing the number of cases with results that were positive in the SSM by the total number of months of the follow-up period. Results: The overall CP and CR in all age groups (n=77 908) were 2.26% and 93.94 cases per 100 000 screenee-months, respectively. The median CP interval in the subjects who had positive SSM results was 30 to 36 months, while that in the age group of 30 to 39 years was shorter. Conclusions: Different screening intervals should be considered among women aged between 30 and 59 years. In addition, a strategy for a screening program should be developed for the age group of 30 to 39 years, in particular.

Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen

Bae, Jong-Myon The Korean Society for Preventive Medicine 2018 Journal of Preventive Medicine and Public Health Vol.51 No.4

In recent years, a number of studies have been reported on the various types of cancer arising from epigenetic alterations, including reports that these epigenetic alterations occur as a result of radiation exposure or infection. Thyroid cancer and breast cancer, in particular, have high cancer burden, and it has been confirmed that radiation exposure or onco-viral infection are linked to increased risk of development of these two types of cancer, respectively. Thus, the environment-epigenetic alteration-cancer occurrence (EEC) hypothesis has been suggested. This paper reviews the trends in research supporting this hypothesis for radiation exposure and onco-viral infection. If more evidences accumulate for the EEC hypothesis from future research, those findings may greatly aid in the prevention, early diagnosis, treatment, and prognosis of the thyroid cancer and breast cancer.

Implementation of Quaternary Prevention in the Korean Healthcare System: Lessons From the 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea

Bae, Jong-Myon The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.6

Quaternary prevention should be implemented to minimize harm to patients because the ultimate goal of medicine is to prevent disease and promote health. Primary care physicians have a major responsibility in quaternary prevention, and the establishment of clinical epidemiology as a distinct field of study would create a role charged with minimizing patient harm arising from over-medicalization.

Survival of Korean Cancer Patients Diagnosed in 1995

Jong-Myon Bae,Young-Joo Won,Kyu-Won Jung,Kyung-Ae Suh,Young-Ho Yun,Myung-Hee Shin,Yoon-Ok Ahn,Duk-Hee Lee,Hai-Rim Shin,Don-Hee Ahn,Dae-Kyu Oh,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5

Purpose: To produce the nationwide 5-year survivalrates of Korean cancer patients by primary cancer site.Materials and Methods: The study subjects were cancerpatients diagnosed in 1995, as documented by the KoreaCentral Cancer Registry (KCCR) Program. This data wascollected in 120 (93%) of 129 nationwide intern- andresident-training hospitals and 75 (94%) of the 80 Koreanuniversity hospitals. Follow-up was performed by obtaininginformation upon vital status (i.e., whether living ordead) from the government administered whole populationfiles. Cumulative observed survival rate (OSR) wascalculated by using the life table method and the relativesurvival rate (RSR) was computed using the life-time tablefor the years 1995, 1997, and 1999.Results: Of the 55,042 study subjects, the OSR for allKorean cancer patients was 61.4% at 1 year and 38.1%at 5 years. The RSR for all cancers was 62.5% at 1 yearand 41.4% at 5 years, and the 5-year RSRs for all cancersin men and women were 32.6% and 53.2%, respectively.Conclusion: This is the first nationwide report upon5-year cancer survival by primary site in Korea. Menshowed a lower survival rate than women in most malignancies.Pancreatic and thyroid cancer had the lowestand highest 5-year survival rates, respectively. (Cancer Res Treat. 2002;34:319-325)

Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review

Bae, Jong-Myon,Kim, Eun Hee The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.5

Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women. Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models. Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556). Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.

Mean Sojourn Time of Preclinical Gastric Cancer in Korean Men: A Retrospective Observational Study

Bae, Jong-Myon,Shin, Sang Yop,Kim, Eun Hee The Korean Society for Preventive Medicine 2014 Journal of Preventive Medicine and Public Health Vol.47 No.4

Objectives: This retrospective cohort study aimed to estimate the mean sojourn time (MST) of preclinical gastric cancer in Korean men. Methods: The subjects consisted of voluntary male screenees aged 40 to 69 years who underwent subsequent screening gastroscopies after testing negative at a baseline screening performed between January 2007 and December 2011. A new case was defined if gastric cancer cells were present in the biopsy specimens obtained from gastroscopy. The follow-up period was calculated as the number of person-years between the date of baseline screening gastroscopy and positive findings at a subsequent screening. The MST was calculated using transition rates of gastric cancer to determine the best screening interval. Results: Of the 171 979 voluntary male screenees, 61 688 (36%) underwent subsequent screening gastroscopies between January 2007 and December 2011. A total of 91 incident cases were found during 19 598 598 person-years of follow-up. The MST of gastric cancer was 2.37 years (95% confidence intervals, 1.92 to 2.96), and those aged 40 to 49 years had a shorter MST than those 50 to 69 years did. Conclusions: These findings support the 2-year interval of screening recommended by the nationwide gastric cancer screening program in Korea. Further studies for the age-specific MST among women are needed.

Rates of Change to a Positive Result in Subsequent Screening Mammography in Korean Women: A Retrospective Observational Study

Bae, Jong-Myon,Shin, Sang Yop,Kim, Eun Hee,Kim, Yoon-Nam,Nam, Chung Mo The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.1

Objectives: This retrospective cohort study aimed at calculating some parameters of changes in the findings of the subsequent screening mammography (SSM) in female Korean volunteers. Methods: The study included screenees aged 30 to 79 years who underwent SSM voluntarily after testing negative in the baseline screenings performed between January 2007 and December 2011. A change to a positive result was defined as category 4 or 5 by using the American College of Radiology Breast Imaging Reporting and Data System. The proportion of results that had changed to positive (CP, %) was calculated by dividing the number of cases with results that were positive in the SSM by the total number of study participants. The rate of results that had changed to positive (CR, cases per 100 000 screenee-months) was calculated by dividing the number of cases with results that were positive in the SSM by the total number of months of the follow-up period. Results: The overall CP and CR in all age groups (n=77 908) were 2.26% and 93.94 cases per 100 000 screenee-months, respectively. The median CP interval in the subjects who had positive SSM results was 30 to 36 months, while that in the age group of 30 to 39 years was shorter. Conclusions: Different screening intervals should be considered among women aged between 30 and 59 years. In addition, a strategy for a screening program should be developed for the age group of 30 to 39 years, in particular.