항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

철도교통안전진단제도 발전방향 제시

정연욱(Yeun Wook Jung),이주영(Ju Young Lee),김영선(Young Sun Kim),노남진(Nam Jin Noh),이승열(Seung Yeoul Lee),송병호(Byung Ho Song) 한국철도학회 2015 한국철도학회 학술발표대회논문집 Vol.2015 No.10

철도실시설계단계에서 이용자 중심의 안전성을 강화하고자 교통안전법 및 교통안전진단 지침이 개정됨으로써 14 년 10 월 13 일 철도교통안전진단제도가 시행되었다. 이후 중앙선, 하남선 등 15 개 철도건설사업 실시설계에 대하여 철도교통안전진단이 시행되었고, 그 결과 이용자 및 열차운행측면에서의 안전위험요인이 도출 및 개선되었다. 본 연구에서는 철도교통안전진단제도가 보다 더 실효성 있게 시행될 수 있도록 진단대상 · 진단시기 등을 명확화 하였고, 진단항목 고도화를 위하여 기존 진단항목 보완 및 신규진단항목을 개발하였다. 이와 함께, 철도교통안전진단에 대한 평가제도 도입의 필요성 및 시행방안을 제시하였다. To enforce safety of passenger at enforcement design stage of rail, Railroad Traffic Safety Diagnosis is introduced at Oct 13, 2014 by revising Traffic Safety Act and Traffic Safety Diagnosis. Railroad Traffic Safety Diagnosis is implemented about enforcement design which is for 15 railroad construction like Jung-Ang Line and Ha-Nam Line, therefore, danger factors about safety are deducted and improved in respect of passenger and train operation. In this study, diagnosis object, diagnosis time and other article are clarified for effectiveness of the Safety Diagnosis and diagnosis articles are supplemented and developed for enhancement. In addition, necessity and execution plan of evaluation system are proposed.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

청소년 문화축제참여가 자아정체성과 사회공존지수에 미치는 영향

정명수,송은미,이강욱,정진영 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-

This study aims to examine the influence of the participation in the festivals on the development of the self identity and the influence of the emotional outlooks based on the participation in the festivals and the emotional outlooks produced by the interaction with others on the development of the self identity with the young people who participated in the 2004 Yeosu International Youth Festival as the subjects. Putting these findings together, it is shown that the participation of the adolescents in cultural festivals has a positive influence on the development of their self-identity, and, in particular, it is also shown that the emotional outlooks produced by the participation in cultural festivals and the emotional outlooks obtained through the interaction with others have a positive influence on the self-identity of the adolescents. Accordingly, it is necessary to study those programs producing no oppositions and the methods of participation for the development of the self-identity of the adolescents, and it is also necessary to develop natural programs and incentives to smooth the complex and diverse interactions among the participants.

결핵균 동정을 위한 microplate colorimetric assay의 개발

정진욱,황승용 한양대학교 이학기술연구소 2003 이학기술연구지 Vol.6 No.-

Polystyrene(PS) microplate는 DNA hybridization 방법을 이용하여 미생물의여러 특정 염기서열들을 동시에 간단하게 검색할 수 ㅣㅇㅆ기 때문에 임상에서 많이 사용되고 있다. 본 연구에서는 결핵균 유전자에 같은 염기서열로 반복되는 direct repeat(DR) sequence region 사이에 위치한 서로 다른 염기서열들을 PS plate microplate를 사용하여 손쉽게 검색할 수 있는 방법을 개발하였다. 이들 DR sequence 사이의 유전자들은 서로 다른 염기배열로 이루어져 있으며 배열이 안정하기 때문에 이것을 이용한 결핵균의 동정이 가능하다. DR regiion을 통한 결핵균 동정을 위하여 DR region 사이에 존재하는 43종류의 염기서열들을 phosphorylated oligonucleotide로 제작하여 1-ethyl-3-(3-dimethyl-aminopropyl)carbodiimide)와 1-methylimidazole을 매개체로 microplate와 공유결합시켰다. 결핵균의DR region을 이용하여 이들 사이의 유전자들을 PCR로 증폭한 수, 이 증폭산물들과 microplate에 결합되어 있는 oligonucleotide probe들과 hybridizaton하였다. PCR primer에는 biotin이 붙어있기 때문에 alkaline phosphatase가 붙어있는 streptavidin 을 발색반응 매개체로 사용하였다. 마지막으로alkaline phosphatase와 substrate의 발색반응을 이용하여 M.tuberculosis H37Rv 와 M. bovis BCG를 동정할 수 있다는 것을 확인하였다. Developing a fast method for detecting mutations is very important in diagnosis. Some mutations cause genetic disorders and often cause drug resistance in mycobacterium. Many different detection methods have been used to find mutations such as RFLP, sequencing and oligonucleotide dot blotting. However, most of them are not easy to detect many different mutaions simultaneously and are not easy to use. In order to overcome these problems, we have developed a simple micro well hybridization method for detecting mutations. This method has three main steps including oligonucleotide coating on to microwells as probes, PCR amplification of target DNA and colorimetirc detection after hybridization. In order to test this assay system, we have amplified direct sequence (DR) region of bacterium bovis BCG strain using biotinylated primer. Modified oligonucleotides which are complement to DR region were covalently immobilized onto microwells by 1-ethyl-3-(3-dimethylaminoprophyl) -carbodiimide and 1-methyl-imidazeole. Each set of oligonucleotides contains a normal oligonucleotide as a control and also has mutated oligonucleotides which have substitution, deletion and insertion. We have found that this microwell detection system is very reliable and fast method to detect multiple mutations. All of the mutated oligonucleotides did not hybridize to target DNA. As a matter of fact, this method can be made as a cheap and fast detection kit for multiple mutations .

골격성 Ⅲ급 부정교합자의 전치부 수직피개도에 영향을 미치는 요소 - 개교군과 피개군간의 비교

정정화,남형진,강상욱,손우성 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

경남 일부지역 농민들의 수면습관

정근화,손진욱 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

In order to investigate the sleep habits of farmers in a rural area, we studied 270 subjects(farmers) in a rural area from August 14, 1995 to August 19, 1995. Sleep habits were analyzed according to age groups(3 groups of 18-30, 31-50, over 51 years) and sex. The results were as follows : 1) The mean sleep length was 6.7±1.5 hours, and was longer in female than in male. In the above 51-year-old age group, sleep length was significantly shorter than those in the other two age groups. 2) The mean sleep latency was 21.6±21.5 minutes, and was longer in female than in male. There were no significant differences in sleep latency among age groups. 3) The sleep onset time was later in the 18-30-year-old age group than in the other two age groups. The awakening time was earlier in the over 51-year-old age group than in the other two age groups. 4) One hundred and four subjects(38.5%) complained difficulty falling asleep, 196 subjects(72.6%) complained fragmented sleep, and 86 subjects(31.9%) complained early morning awakening during the past two weeks. Difficulty falling asleep and fragmented sleep were more common in females than in male. 5) One hundred and seventeen subjects(43.3%) had napped during the past two weeks and there were no significant differences among age groups. 6) One hundred and sixty five subjects(61.1%) experienced daytime drowsiness during the past two weeks and there were no significant differences among age groups. 7) Ninety-one subjects(33.7%) reported nightmares, 32 subjects(11.9%) reported sleeptalking 3 subjects(1.1%) reported sleepwalking, and 15 subjects(5.6%) reported bruxism during past two weeks.

부분 무치악 환자에서 마그네슘 이온주입 임플란트의 성공률에 대한 전향적 임상연구

최수정,유정호,이규복,김진욱 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: This study examined the clinical success rate of Mg titanate implants (M Implant system, Shinhung, Korea), which employ a Mg coating method, by evaluating the marginal bone loss and implant stability using radiographs and Osstell, over a 1 year. Materials and methods: The locations of the implants placement were divided into 4 areas; the maxillary and mandibular premolars and molars. In the maxilla, 8 and 9 implants were inserted in the premolar and molar areas, respectively. In the mandible, 11 and 51 implants were inserted in the premolar and molar areas. Marginal bone loss and ISQ of all implants (79) were measured after insertion, mounting the prosthetic appliance, and 1, 3, 6, and 12 months after loading. The marginal bone loss was measured from the radiograph using XCP bite, which was customized, and the implant stability measured using Osstell. Fisher's exact test (α=.05) was used to compare the success rates of each region. Results: The mean marginal bone loss for the upper and lower jaws were 1.537 mm and 1.172 mm. The mobility showed a non-significant reduction or increase according with time. The success rates were accounted for 94.12% and 98.39% in the upper and lower jaws; the premolars and molars were accounted for 100% and 96.67%. The two cases of early failure resulted from failure of primary stability during implant insertion. The late failures were not observed for 1 year after adding a loading to the implants. Conclusion: The Mg titanate implant showed good primary stability and good clinical results in both healing and function. 연구 목적: 부분 무치악 환자에서 Mg titanate implant (M Implant system, Shinhung, Korea)의 보철후 1년간의 방사선사진을 이용한 변연골 흡수량과 Osstell을 이용한 임플란트 안정성 평가 결과를 분석하여 임상적인 성공률에 대해 알아보고자 한다. 연구 재료 및 방법: 38명의 환자에 79개의 임플란트를 식립하여 보철 후 1년 동안 변연골 흡수량, 임플란트의 동요도, 임플란트 식립 위치에 따른 분포 및 성공률, 보철 전후에 따른 성공률을 분석했다. 결과: 변연골의 흡수량은 보철물 장착 후 1년간의 평가에서 상악에서는 평균 1.537 mm, 하악에서는 평균 1.172 mm의 변연골 흡수가 관찰되었으며, 전체적인 상하악의 평균 변연골 흡수량은 1.255 mm로 관찰되었다. 수술 후 시간이 경과함에 따라 ISQ값은 미약하게 감소하였다가 증가하는 경향을 보였으나, 상악과 하악 모두에서 식립 당일 이후 예비 인상일, 최종 보철물의 장착일과 주기적인 평가 기간 동안 ISQ값의 큰 증가나 감소를 나타내지는 않았다. 성공률은 상악에서의 94.12%였고, 하악에서의 98.39%였다. 결론: 본 실험의 결과로 미루어 Mg titanate implant는 임상적으로 양호한 결과를 보여주었다.

Silorane-based 복합레진의 색안정성에 관한 연구

손유진,현홍근,김영재,김정욱,이상훈,김종철,한세현,장기택 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구의 목적은 silorane-based 복합레진의 색안정성을 기존의 methacrylate-based 복합레진과 비교하여 평가하는 것이다. Silorane-based 복합레진인 P90(3M ESPE, USA), methacrylate-based 복합레진인 Tetric Ceram(Ivoclar Vivadent, Liechtenstein), Z250, Z350(3M ESPE, USA)을 이용하여 시편을 제작하고, 증류수, 커피, 레드 와인, 카레 용액에 담가 1일, 3일, 7일, 14일, 21일, 28일 후 색 변화를 분광광도계로 측정하고 실험 전후의 색상차이(ΔE*_(ab))값을 산출하여 다음과 같은 결과를 얻었다. 1. 카레 용액 > 레드 와인 > 커피 > 증류수의 순으로 레진 시편의 변색이 크게 나타났다. 2. 네 가지 종류의 레진을 비교하였을 때, Z350 > Z250 > Tetric Ceram > P90의 순으로 변색이 크게 나타났다. 3. 카레 용액의 경우 네 종류의 레진 모두에서 침지 1일 이후 수용도 역치 이상(ΔE*_(a)b>3.3)의 변색이 나타났다. 4. 레드 와인의 경우 Z350, Z250, Tetric Ceram에서 침지 1일 이후, P90에서는 침지 28일 이후에 수용도 역치 이상의 변색이 나타났다. 5. 커피의 경우 Z350에서 침지 1일 이후, Z250에서 침지 3일 이후, Tetric Ceram에서 침지 7일 이후에 수용도 역치 이상의 변색이 나타났으나 P90에서는 침지 28일 이후에도 수용도 역치 이상의 변색이 나타나지 않았다. The objective of this study was to evaluate the color stability of new silorane-based composite resin compared with methacrylate-based composite resins after immersion in 3 staining solutions. One silorane-based composite(Filtek P90) and 3 methacrylate -based composites(Filtek Z250, Filtek Z350, Tetric Ceram) were evaluated. Twenty disk-shaped specimens(10×2mm) of each of 4 composite resins were prepared. The specimens were then divided into 4 groups of 5 specimens each and immersed in 3 staining solutions( coffee, red wine, curry solution) or distilled water(control) for 28-day test period. Color of the specimens was measured with a spectrophotometer(Color Eye 7000A) using CIE L*a*b* color space relative to CIE standard illuminant D65 at baseline, 1day, 3days, 7days, 14days, 21days and 28days after staining. The color differences( ΔE*_(ab)) were calculated. The results were obtained as follows ; 1. The mean color changes(ΔE*_(ab)) of the composites were greatest in curry solution, then red wine, coffee and distilled water, in decreasing order. 2. The mean color changes(ΔE*_(ab)) of the composites were greatest in Z350, Z250, Tetric Ceram and P90, in decreasing order.