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- 저자 : ( Jian Lin Li ) (검색결과 180 건)
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Ooi, Poh Choon,Lin, Jian,Kim, Tae Whan,Li, Fushan Elsevier 2016 ORGANIC ELECTRONICS Vol.32 No.-
<P><B>Abstract</B></P> <P>Indium-tin-oxide (ITO) free, nonvolatile memory (NVM) devices based on graphene quantum dots (GQDs) sandwiched between polymethylsilsesquioxane (PMSSQ) layers were fabricated directly on polyethylene terephthalate (PET) substrates by using a solution process technique. Current-voltage (<I>I-V</I>) curves for the silver nanowire/PMSSQ/GQD/PMSSQ/poly(3,4-ethylenethiophene):poly(styrene sulfonate)/PET devices at 300 K showed a current bistability. The ON/OFF ratio of the current bistability for the NVM devices was as large as 1 × 10<SUP>4</SUP>, and the cycling endurance time of the ON/OFF switching for the NVM devices was above 1 × 10<SUP>4</SUP> s. The Schottky emission, Poole-Frenkel emission, trapped-charge limited-current, and space-charge-limited current were dominantly attributed to the conduction mechanisms for the fabricated NVM devices based on the obtained <I>I-V</I> characteristics, and energy band diagrams illustrating the “writing” and the “erasing” processes of the devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ITO-free, two-terminal, MIM, NVM devices containing GQDs sandwiched between PMSSQ layers were fabricated by using a simple solution process. </LI> <LI> <I>I-V</I> curves for the Ag NW/PMSSQ/GQD/PMSSQ/PEDOT:PSS/PET devices at 300 K showed a current bistability. </LI> <LI> ON/OFF ratio of the current bistability for the NVM devices was as large as 1 × 10<SUP>4</SUP>. </LI> <LI> Cycling endurance time of the ON/OFF switching for the NVM devices was above 1 × 10<SUP>4</SUP> s. </LI> <LI> Schottky and PF emissions, TCLC, and SCLC were the dominant carrier transport mechanisms for the MIM, NVM device. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Jian Li(Jian Li),Seung-Lin Hong(Seung-Lin Hong) The International Academy of Global Business and T 2023 The International Academy of Global Business and T Vol.19 No.1
Purpose - This study expounds that logistics enterprises should make use of an information-sharing mechanism, benefit distribution mechanism, and government guarantee mechanism to optimize and balance resource allocation with cooperative participants. Design/Methodology/Approach - This study developed a theoretical research model with interface management analysis, interface resource allocation, and interface management measures as independent variables; an interface connection mechanism and collaborative innovation capability as intermediary variables; and the low-carbon performance of enterprises as a dependent variable based on the structural equation model (SEM) and the empirical test, by selecting a certain number of logistics enterprises nationwide as research objects. Findings - This study discloses that elements such as interface management analysis, interface resource allocation, interface management measures, interface connection mechanism, and collaborative innovation capability contribute proportionally to the low-carbon performance of logistics enterprises. Meanwhile, the interface connection mechanism plays an intermediary role in the impact of interface management analysis and interface management measures on the low-carbon performance of enterprises. Research Implications - This study proposes that the collaborative innovation capability of enterprises should be improved through various interface management measures, and that R&D and the application of low-carbon technology and equipment must be accelerated, thus promoting the improvement of the low-carbon performance of enterprises, and enabling a low-carbon transformation in logistics enterprises, and even the whole logistics industry, so as to help achieve the carbon peak and move toward carbon neutrality as soon as possible.
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Lin, Jian-Ying,Wang, Ming-Sheng,Dong, Liang-Peng,Xu, Da-Wei,Wang, Ying,Li, Xue-Liang,Li, Xiu-Min Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
The aim of this study was to investigate QoL (quality of life) of patients with esophageal cancer in northern Henan province, China, and to accurate evaluate and reflect the relationship between patient characteristics and QoL. In the high risk area of esophageal cancer in the north of Henan province, 735 patients with esophageal cancer were investigated. The Eysenck personality questionnaire (EPQ) and QoL were analyzed by using the questionnaire of general situation, EPQ, QLQ-C30 and QLQ-OES18. The effects of personal character on the QoL of esophageal carcinoma patients were analyzed by SPSS 11.0 software. The QoL of esophageal cancer patients in Northern Henan region was significantly affected by character. The difference between choleric and type of melancholic temperament types was significant (P<0.01), also in OESEAT, OESTA, OESCO and OESSP (P<0.05). Differences in personal character can thus influence the quality of esophageal cancer patient lives.
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Li, Qing-Qing,Lu, Zhi-Hao,Yang, Li,Lu, Ming,Zhang, Xiao-Tian,Li, Jian,Zhou, Jun,Wang, Xi-Cheng,Gong, Ji-Fang,Gao, Jing,Li, Jie,Li, Yan,Shen, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR, GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.
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Jian Lin,Wen-Hai Huang,Shu-Hua Lei,Chang-Cheng Liu,Qi Bian,Li-Na Ma,Dong-Wei Li 한양대학교 세라믹연구소 2008 Journal of Ceramic Processing Research Vol.9 No.4
Nano-crystals embedded in glass always have interesting quantum effects, while nano-crystal patterns may have wide potential applications in preparing PIC, OEIC and other types of electronic and optoelectronic devices. A direct current electric field, accompanied by heat treatment, was applied on tellurite or silicate glass sheets. The silver ions in a diffused film were introduced into the glass matrix under a high-voltage electric field, instead of supplied during glass melting. The direct diffusion of metal ions, the nucleation and crystallization of nano-crystals in the glass were well controlled by the electric field accompanied by heat treatment. It was found that silver nano-crystal patterns can be transfer printed into tellurite and silicate glass sheets with both patterned diffusion and patterned crystallization. Nano-crystals embedded in glass always have interesting quantum effects, while nano-crystal patterns may have wide potential applications in preparing PIC, OEIC and other types of electronic and optoelectronic devices. A direct current electric field, accompanied by heat treatment, was applied on tellurite or silicate glass sheets. The silver ions in a diffused film were introduced into the glass matrix under a high-voltage electric field, instead of supplied during glass melting. The direct diffusion of metal ions, the nucleation and crystallization of nano-crystals in the glass were well controlled by the electric field accompanied by heat treatment. It was found that silver nano-crystal patterns can be transfer printed into tellurite and silicate glass sheets with both patterned diffusion and patterned crystallization.
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Lin-Li Li,Xian-Cheng Zhan,Jian-Lin Tao 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
The influence of both moisture and heat on the stability of aspirin was investigated by a single pair of experiments, one with programmed humidity control and the other non-isothermal, rather than many standard isothermal studies, each at constant relative humidity. In experiments, we adopted the acid-base back titration method to measure the content of aspirin in the presence of its degradation products. It was found that the degradation of aspirin could be expressed as ln[(c0-c)/c]=kt+D, where D was a lag time item not related to humidity and temperature. The relationship between the degradation rate constant k and humidity Hr and temperature T could be described as Arrhenius equation multiplied by an exponential item of relative humidity: k = A · exp(mHr) · exp(-(Ea/RT)), where A, Ea and m were the pre-exponential factor, observed activation energy, and a parameter related to humidity, respectively. The results obtained from the programmed humidifying and non-isothermal experiments, A=(1.09±2.04)×1012 h-1, Ea=(93.5±2.2) kJ ·mol-1 and m=1.18±0.19, were comparable to those from isothermal studies at constant humidity, A=(1.71±0.35)×1012 h-1, Ea=(94.9±0.7) kJ ·mol-1 and m=1.20±0.02. Since the programmed humidifying and non-isothermal experiments save time, labor and materials, it is suggested that the new experimental method can be used to investigate the stability of drugs unstable to both moisture and heat, instead of many classical isothermal experiments at constant humidity.
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Lin, Mei-Gui,Liu, Li-Ping,Li, Chen-Yin,Zhang, Meng,Chen, Yuling,Qin, Jian,Gu, Yue-Yu,Li, Zhi,Wu, Xin-Lin,Mo, Sui-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background and Aims: Scutellaria is one of the most popular traditional Chinese herbal remedies against various human diseases, including cancer. In this study, we examined the active effects of Scutellaria extract and its main flavonoid constituents on the proportion of side population cells within human multiple myeloma cell line RPMI8226 in vitro and explored the potential molecular mechanisms involved. Materials and Methods: The contents of flavonoids in ethanolic extract of Scutellaria baicalensis Georgi were determined using high performance liquid chromatography. The antiproliferative effect of the ethanolic extract on RPMI-8226 was determined by CCK assay. Apoptosis was measured by annexin combining with propidium iodide in a flow cytometer. Cell cycle analysis was performed by propidium iodide staining in combination with flow cytometry analysis. Hoechst 33342 exclusion assay was used for the identification of side population within RPMI8226 cells. The expression of ABCG2 protein was assessed by Western blotting assay. Results: The content of major flavonoids constitutents of Scutellaria extract was baicalin (10.2%), wogonoside (2.50%), baicalein (2.29%), and wogonin (0.99%), respectively. The crude Scutellaria extract did not show significant anti-proliferative effect, apoptosis induction and cell cycle arrest in RPMI-8226 within the concentrations of $1-75{\mu}g/mL$. However, the ethanolic extract, baicalein, wogonin and baicalin reduced the side population cells in RPMI-8226, and data showed that baicalein and wogonin had stronger inhibitory effects. Correspondingly, they also exhibited significant effects on decreasing the expression level of ABCG2 protein in RPMI-8226 in vitro. Conclusions: Our results for the first time demonstrated a novel mechanism of action for Scutellaria extract and its main active flavonoids, namely targeting SP cells by modulating the expression of ABCG2 protein. This study provides an insight for new therapeutic strategies targeting cancer stem cells of multiple myeloma.
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A New Antioxidant from the Marine Sponge-derived Fungus Aspergillus versicolor
Jian Lin Li,이윤미,홍종기,배경숙,최재수,Jee H. Jung 한국생약학회 2011 Natural Product Sciences Vol.17 No.1
A chemical investigation of the marine-derived fungi Aspergillus versicolor led to the isolation of a new aromatic polyketide (1), The structure was elucidated by spectroscopic analysis, and its radical-scavenging activity, reducing power, and inhibitory activity to lipid oxidation were investigated. Those activities of compound 1 were compared with standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tertiarybutylhydroquinone (TBHQ), and ascorbic acid (VC). Compound 1 showed antioxidant activity comparable to that of BHA, and siginificantly higher than that of BHT.
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Anti-inflammatory Amino Acid Derivatives from the Ascidian <i>Herdmania momus</i>
Li, Jian Lin,Han, Sang Chul,Yoo, Eun Sook,Shin, Sook,Hong, Jongki,Cui, Zheng,Li, Huayue,Jung, Jee H. American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.8
<P>Four new amino acid derivatives, herdmanines A–D (<B>1</B>–<B>4</B>), were isolated from the marine ascidian <I>Herdmania momus</I>. Herdmanines A–C contain the unusual <SMALL>d</SMALL>-form of arginine. Compounds <B>3</B> and <B>4</B> had a moderate suppressive effect on the production of NO, with IC<SUB>50</SUB> values of 96 and 9 μM, respectively. These compounds were found to inhibit the mRNA expression of <I>iNOS</I>. The inhibitory activities on the production and mRNA expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 were evaluated.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-8/np200397g/production/images/medium/np-2011-00397g_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np200397g'>ACS Electronic Supporting Info</A></P>
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Oxygenated Hexylitaconates from a Marine Sponge-Derived Fungus <i>Penicillium</i> sp.
Li, Jian Lin,Zhang, Ping,Lee, Yoon Mi,Hong, Jongki,Yoo, Eun Sook,Bae, Kyung Sook,Jung, Jee H. The Pharmaceutical Society of Japan 2011 Chemical & pharmaceutical bulletin Vol.59 No.1
<P>In the course of our search for bioactive metabolites from marine organisms, new hexylitaconic acid derivatives (<B>1</B>—<B>4</B>), along with (3<I>S</I>)-hexylitaconic acid (<B>5</B>), were isolated from a sponge-derived fungus <I>Penicillium</I> sp. Based on the NMR and MS data, the structures of compounds <B>1</B>—<B>4</B> were defined as α,β-dicarboxylic acid derivatives, such as hexylitaconic acid and tensyuic acids which were previously reported as metabolite of <I>Aspergillus niger</I>, <I>Penicillium striatisporum</I>, or <I>Apiospora montagnei</I>. The isolated compounds were evaluated for cytotoxicity against a panel of five human solid tumor cell lines, and for anti-inflammatory activity gauged by their inhibitory effects on the production of major pro-inflammatory mediators (nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β) in murine macrophage cells. Compounds <B>1</B> and <B>4</B> showed weak inhibition of IL-1β production at the concentration of 200 μ<SMALL>M</SMALL>.</P>
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