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Aryun Kim(Aryun Kim),Jeonghwan Lee(Jeonghwan Lee),Hansol Moon(Hansol Moon),Chulhan Kim(Chulhan Kim),Min Young Yoo(Min Young Yoo),Woo Yoon Park(Woo Yoon Park),Won Dong Kim(Won Dong Kim),Young-Seok Seo( 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: We aimed to determine whether low-dose radiotherapy (LDRT) is effective in patients with Alzheimer disease (AD). Materials and Methods: We included patients according to the following criteria: probable Alzheimer's dementia according to the New Diagnostic Criteria for Alzheimer’s Disease; confirmation of amyloid plaque deposits on baseline amyloid positron emission tomography (PET); a Korean Mini-Mental State Examination 2nd edition (K-MMSE-2) score of 13–26; and a Global Clinical Dementia Rating (CDR) score of 0.5–2 points. LDRT was performed six times at 0.5 Gy each. Post-treatment cognitive function tests and PET-CT examinations were performed to evaluate efficacy. The medication for AD treatment was maintained throughout the study period. Results: At 6 months after LDRT, neurological improvement was seen in 20% of patients. Patient #2 showed improvement in all domains of the Seoul Neuropsychological Screening Battery II (SNSB-II). Moreover, the K-MMSE-2 and Geriatric Depression Score-Short Form scores improved from 20 to 23 and from 8 to 2, respectively. For patient #3, the CDR score (sum of box score) improved from 1 (4.0) to 1 (3.5) at 3 months follow-up. Moreover, the Z scores for language and related functions, memory, and frontal executive function improved to -2.56, -1.86, and -1.32, respectively at the 6-month follow-up. Two patients complained of mild nausea and mild hair loss during LDRT, which improved after treatment. Conclusion: One of the five patients with AD treated with LDRT experienced a temporary improvement in SNSB-II. LDRT is tolerable in patients with AD. We are currently under follow-up and will conduct cognitive function tests after 12 months after LDRT. A large-scale randomized controlled trial with a longer follow-up period is warranted to determine the effect of LDRT on patients with AD.
( Jeonghwan Lee ),( Yong Chul Kim ),( Soie Kwon ),( Lilin Li ),( Sohee Oh ),( Do Hyoung Kim ),( Jung Nam An ),( Jang-hee Cho ),( Dong Ki Kim ),( Yong-lim Kim ),( Yun Kyu Oh ),( Chun Soo Lim ),( Yon Su 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.4
Background: The effect of each health-related quality of life (HRQOL) component on hemodialysis prognosis has not been well studied. We aimed to investigate the clinical factors associated with HRQOL and the effect of HRQOL after dialysis initiation on long-term survival in an Asian population. Methods: A total of 568 hemodialysis patients were included from a nationwide prospective cohort study. HRQOL was evaluated using the Kidney Disease Quality of Life (KDQOL) Short FormTM 1.3 at 3 months after dialysis initiation. The effect of each KDQOL item score on mortality was analyzed. Multivariable Cox analysis was performed after adjusting for age, sex, modified Charlson comorbidity index, and causes of primary kidney disease. Results: Old age, diabetes mellitus, high comorbidities, and low serum albumin levels were associated with poor physical health status. Decreased urine output was associated with both poor physical and mental health status. The scores of 3 indices in the kidney disease domain (effect of kidney disease, social support, and dialysis staff encouragement) showed significant associations with mortality, as did the 3 indices (physical function, physical role limitation, and body pain) in the physical health domain. Neither the 4 indices in the mental health domain nor the mental composite score showed a significant association with mortality. However, a high physical composite score was associated with decreased overall patient mortality (P = 0.003). The effect of physical composite score on survival was prominent among young or middle-aged groups. Conclusion: Poor physical health status 3 months after hemodialysis start correlates significantly with overall mortality.
Kim, Jeonghwan,Ramasamy, Thiruganesh,Choi, Ju Yeon,Kim, Ssang Tae,Youn, Yu Seok,Choi, Han-Gon,Yong, Chul Soon,Kim, Jong Oh Elsevier 2017 Colloids and surfaces Biointerfaces Vol.150 No.-
<P><B>Abstract</B></P> <P>In this study, a core-shell type polypeptide-based lipid nanocapsule was developed to enhance anticancer efficacy of erlotinib in non-small cell lung cancers. Mean particle size of PEGylated polypeptide-lipid nanocapsules (PLN) for erlotinib (ERL) delivery was ∼200nm with an effective surface charge of −20mV. Protective PEGylated polypeptide layer acted as a molecular fence and effectively controlled the diffusion of erlotinib from the lipid nanocapsule core, whereas pH-responsiveness of poly(L-aspartic acid) accelerated the release of erlotinib in acidic conditions. Blank lipid nanocapsules showed excellent biocompatibility. ERL-loaded PLN (ERL-PLN) showed dose-dependent cytotoxicity in NCI-H358 and HCC-827 lung cancer cells. ERL-PLN treatment resulted in a superior tumor regression profile in a xenograft tumor model, compared to free ERL and control, suggesting high therapeutic efficacy. ERL-PLN-treated mice showed 5- and 2-fold smaller tumor volume compared to control and free ERL groups, respectively. Based on these results, PLN provide a promising drug delivery approach for lung cancer therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Erlotinib-loaded lipid nanocapsule consists of inner lipid core and outer polymeric shell. </LI> <LI> Protective PEGylated polypeptide layer effectively controlled the release of anticancer drug. </LI> <LI> It showed marked effect on NCI-H358 and HCC-827 lung cancer cells. </LI> <LI> Core-shell type polypeptide-based lipid nanocapsules enhanced the antitumor efficacy of erlotinib. </LI> <LI> PEGylated polypeptide-based nanocapsules offers a promising approach in lung cancer therapy. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
유사 경유가 연료공급시스템의 내구성에 미치는 영향에 관한 연구
김정환(Jeonghwan Kim),박종배(Jongbae Park),김성우(Seongwoo Kim),김재권(Jaigeoun Kim),김동길(Dongkil Kim) 한국트라이볼로지학회 2008 한국트라이볼로지학회 학술대회 Vol.2008 No.11
Recently, due to the high price of diesel fuel the usage of illegal diesel fuel is increasing steadily. Illegal diesel fuel does not satisfy the standard quality measurements such as lubricity ,density, sulfur contents and so on. Common rail diesel fuel injection systems are becoming widely used by vehicle manufacturers due to their microprocessor control, enabling a more flexible approach to how much and when fuel is injected into the engine cylinder. In order to avoid any contamination of the fuel, the high pressure pump is lubricated solely by the fuel. This means that it is vulnerable to variations in the quality of the fuel and, in particular, the lubricity performance of the fuel. Common rail fuel supply pump(high pressure) wear tests and injector wear tests were conducted on a legal diesel fuel and an illegal-diesel fuel using a 1000-hour test method developed for this study. After each fuel system component durability test, fuel supply pumps and common rail injectors were disassembled to check wears which arose from a lack of lubricity.
Off-cycle에서 Euro 6a, 6b 및 6d 규제 만족 디젤 자동차의 NOx 배출 특성
김정환 ( Kim Jeonghwan ),김성우 ( Kim Sungwoo ),김기호 ( Kim Kiho ) 한국액체미립화학회 2018 한국액체미립화학회지 Vol.23 No.3
Major countries have tighten their NOx regulation of diesel passenger cars. In the case of the EU, the regulation has been toughen up to 6.25 times since 2000. Despite the regulation the NOx concentration of the ambient has not been reduced proportionally. As these issues, to reduce NOx emission practically, Korea and the EU introduced the real-world driving emission (RDE) regulation and the test method that will be applied after 2017. In this paper, for the regulation to make a soft landing in Korea, 6 diesel passenger cars which met Euro 6a~6d regulation and were equipped with LNT/SCR were tested at a chassis dynamometer with environmental chamber applying the off-cycles (FTP, US06, SC03, HWFET and CADC) and several ambient conditions (-7 and 14℃) as well as certification modes (NEDC, WLTC@ 23℃). The result of the test showed that the ambient temp. and the engine load as a test mode impacted the NOx emission of the cars while the vehicles with SCR emitted NOx lower than with LNT. Additionally, to propose an effective RDE test method, the above result was compared with the results of the other papers which tested RDE using the same cars.
자동차용 경유의 윤활성(HFRR)이 커먼레일 고압펌프에 미치는 영향에 관한 연구
김정환(Jeonghwan Kim),박종배(Jongbae Park),송호영(Hoyoung Song),김재권(Jaigeoun Kim),김동길(Dongkil Kim) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
Recently, Common rail diesel fuel injection systems are becoming widely used by vehicle manufacturers due to their microprocessor control, enabling a more flexible approach to how much and when fuel is injected into the engine cylinder. In order to avoid any contamination of the fuel, the high pressure pump is lubricated solely by the fuel. This means that it is vulnerable to variations in the quality of the fuel and, in particular, the lubricity performance of the fuel. Common rail fuel supply pump(high pressure) wear tests and injector wear tests were conducted on two fuels which have a different lubricity property using a 1000-hour test method developed for this study. After each fuel system component durability test, fuel supply pumps and common rail injectors were disassembled to check wears which arose from a lack of lubricity.
FT-IR을 이용한 정상휘발유와 유사휘발유의 엔진 성능 및 배기가스 특성에 관한 연구
김정환(Jeonghwan Kim),이민호(Minho Lee),김기호(Giho Kim),김재권(Jaigueon Kim),신성철(Seoungchul Shin) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
As the interest on the air pollution is gradually rising up at home and abroad, automotive and fuel researchers have been working on the exhaust emission reduction from vehicles through a lot of approaches, which consist of new engine design, innovative after-treatment systems, using clean fuels and fuel quality improvement. However, a study that the fuel quality affect on exhaust emission from vehicle. FT-IR spectroscopy, useful technology for simultaneous and continuous measurement of the various components of the automotive exhaust gas, is utilized to a few unregulated exhaust emissions measurement of the irregular gasoline fuel including the regulated exhaust emissions. This research shows that the irregular gasoline fuel had some problem that cause of ambient pollution, power decreasing, fallen to safety and trouble of engine. Also, based on these problem, this paper discusses the influence of gasoline quality on automotive exhaust emissions.