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혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement
임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1
Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.
생물학적 소양의 함양을 위한 BSCS 통합 권고안과 6, 7차 교육과정 비교
구수정,김영신,김병석,이성조,정완호 한국교원대학교 과학교육연구소 2000 청람과학교육연구논총 Vol.10 No.1
본 연구에서는 BSCS 위원회가 생물학적 소양의 함양을 위하여 제시한 중등 생물 교육과정 개발 지침과 우리 나라 제6차, 제7차 교육과정을 개념 제시 형태, 하위 개념들의 내용 일치도, 개념 수의 측면에서 비교 분석하였다. 연구 결과 우리 나라 교육과정의 내용 체계에서의 상의 수준으로서의 지식 영역과 하위수준으로서의 내용 요소 부분에 제시되어 있는 개념들이 포괄성의 차이 없이 단순히 개념 나열적으로 제시되어 있는 상태라서 개념 수준간 등급화가 충분하지 못한 것으로 나타났다. 그리고 우리 나라 생물 교육과정에는 생태계, 유전과 생식, 물질대사 부분에 너무 많은 개념들이 들어 있는 것으로 나타났는데 이로부터 BSCS가 학문중심 교육 과정기에 제시했던 많은 개념들에 대해서 현 시대 흐름에 비추어 학생들의 생물학적 소양의 함양을 위해 재조정하도록 권고하면서 제시한 6개의 통합 원리들을 편중되지 않게 고르게 포하하기 위해서는 우리 나라에서도 생물교육과정에 대한 재구성 노력이 필요한 것을 알 수 있었다. 한편 생물 Ⅰ보다 생물 Ⅱ에 생물학적 소양의 함양을 위한 필수 개념들이 더 많이 제시되어 있는 것으로 분석되었는데 이는 우리 나라 제7차 교육과정의 과학 10에서 과학적 소양이, 그리고 생물 Ⅰ에서 생물학에 대한 기초 소양이 강조되고 있고, 생물 Ⅱ에서는 생물학 관련 전공 과목 이수 준비를 강조하고 있는 과목별 성격과 목표에 부합되지 않는 것이며 따라서 우리나라 교육과정에서도 각 과목별 특성을 분명히 제시 및 반영하려는 노력이 필요함을 알 수 있었다. 이상과 같은 연구 결과로부터 현재 우리 나라 과학 및 생물 교육의 중요한 목적의 하나로 설정되어 있는 학생들의 생물학적 소양의 함양을 위해서 제7차 교육과정에 의한 생물 교과서의 교수 자료 개발 및 장차 제8차 교육과정 개발에 사용할 수 있는 실제적인 지침을 마련하기 위한 구체적인 논의가 있어야 함을 시사받았다. In this study, the concept presentation form, the content coherence of sub-dimensional concepts and the number of concepts of the 6th and the 7th Korean curriculum were analyzed comparing the guide to developing the secondary biology curricula to develop biological literacy with BSCS. According to the result, the discrimination between concept levels in the frame of contents of the Korean curricula is insufficient, because each of concepts presented in the knowledge domain as upper level and sub-dimensional concept elements as lower level are simply arrayed. Considering too much concepts of ecosystem, genetics, reproduction and metabolism, there should be an effort to reform the biological curriculum to include concepts evenly, not in the biased state, to reflect all the 6 unifying principles by BSCS for developing students' biological literacy. Finally there should be an effort to reflect the characteristics of each subjects concretely among Science 10, Biology Ⅰ and Biology Ⅱ in the 7th curriculum considering the result that essential concepts to develop biological literacy are presented more in some principles of Biology Ⅱ than Biology Ⅰ. Thinking the results of the present study, concrete discussions should be made to set up the standard reference about biological literacy and to present essential concepts for teaching and learning to develop it in the process of biology textbook development for meeting the 7th Korean curriculum and in the development of 8th Korean curriculum in advance.
과학 성취도에 영향을 미치는 전두엽 연합령의 기능에 대한 종단적 연구
김영신,권용주,박윤복,구수정,정완호 한국교원대학교 과학교육연구소 2000 청람과학교육연구논총 Vol.10 No.1
The purpose of this study was to longitudinally analyze influences of functional prefrontal lobe on science achievement in middle school students. In this longitudinal study, 47 students(male 19, female 27) were sampled in local area. The students were administered test of GALT(group assessment of logical thinking), CTST(classroom test of scientific test), FIT(figural intersection test), GEFT(group embedded figural intersection test), TOL(tower of London), WCST(Wisconsin card sorting test) at December 1997 and 1999. It is substitute science achievement for science grade each year. The resulted that prefrontal lobe was influenced upon science achievement. Science achievement statistically significant correlated with functional prefrontal lobe, specially logical thinking level, scientific reasoning, perseveration error. And, the development of functional prefrontal lobe functions did not only linear, but also each function has differ with development speed and period. School science classroom was suited high level students. Who has been grade C and D in first-grade, they did not improved. A first-grade achievement effect on science achievement. And also scientific reasoning ability effect on science achievement.
企業 附設 硏究所 活動實態에 관한 硏究 : 釜山·慶南地域을 中心으로
河正鎭,黃圭完,申大赫,兪炳哲 동아대학교 공과대학 부설 한국자원개발연구소 1990 硏究報告 Vol.14 No.2
The research institute of an enterprise attaches have been enlarged in korea. This study grasps the status and the research activity in the research institute of an enterprise attached in the Pusan and Kyungnam. So, we find the important role in the research institute of a enterprise attached.
「에너지·환경 탐구대회」 초등팀 탐구 활동 소개 및 보고서에 환경 가치 분석
구수정,김영신,정완호 한국교원대학교 과학교육연구소 2000 청람과학교육연구논총 Vol.10 No.1
The purpose of this study is to analyze the content of environmental inquiry activities and values of elementary school students written in their reports of the EnergyㆍEnvironment Inquiry Activity Contest which is a unit contest of the Youth Science Festival held annually in Korea and get some ideas for the valuable way of Korean environmental education. 10 teams' reports were gathered and the locality, class study area, inquiry theme, inquiry method and values were analyzed and introduced as case studies to get some insights to teach elementary school students environmental values through inquiry activities of science subject approach. Each teams set various inquiry themes in the content domain of energy resources and earth environment conservation focusing on each team's geographical characteristics and occurring environmental problems in their local areas. There were 16 sentences representing technocentrism and 12 sentences representing ecocentrism. 5 of 10 teams showed both of technocentrism and ecocentrism in their reports. But their was only scientific knowledge without any environmental values in one team's report. Inquiry activity is a good teachingㆍlearning method to develop environmental literacy. There should be environmental values involved as far as it is the environmental inquiry activities using environmental subject matter. The result of this study proposes that environmental educators should actively intervene for inquirers to set a stage in the whole process to search for an alternative to solve environmental problems involved in their project activities. The reason is because the environmental education in the elementary school is established to operate by the infusion way into various subjects already existed in the Korean curriculum.
급성 백혈병 환자에서 수두양 피부병변을 보인 파종성 Fusarium 감염 1예와 국내 파종성 Fusarium 감염증에 대한 고찰
오수진,정희선,김준성,김태석,조병식,최수미,김명신,이연수,이석,신완식 대한감염학회 2007 감염과 화학요법 Vol.39 No.5
최근 면역저하환자의 증가와 함에 국내에서도 점차 침습성, 파종성 Fusarium 감염증 보고가 증가하고 있다. Fusarium 감염은 아스페르길루스 감염과 유사한 임상양상을 보이지만 특징적인 피부병변을 동반하고 혈액배양에서 균이 분리되는 경우가 더 많다. 저자들은 급성 림프구성 백혈병으로 진단받고 치료중인 30세 남자 환자에서 중증의 호중구 감소 상태에서 비특이적인 피부병변을 동반한 파종성 Fusarium 혈류감염을 경험하였기에 국내 증례 고찰과 함께 보고하는 바이다. 환자의 초기 피부병변은 구진에서 시작하여 주로 소포성 병변과 일부 통증을 동반한 결절 등 여러 형태로 나타났고, Tzank 도말검사 양성으로 비정형 수두로 오인되었다. 이후 피부병변은 농포로 변하였고, 혈액배양 및 피부 조직검사에서 파종성 Fusarium 감염으로 진단받았다. 환자는 liposomal amphotericin B, voriconazole 병합요법과 G-CSF 투여, 과립구 수혈을 받았으나, 호중구 감소증에서 회복하지 못하고 급성 호흡곤란증후군과 다장기 기능부전으로 사망하였다. 본 증례는 파종성 Fusarium 감염의 경우에도 수두양 병변으로 비특이적인 양상으로 나타날 수 있으므로, 감별진단을 위해 적극적으로 혈액배양과 피부조직검사를 시행해야 함을 보여준다. Recently, we experienced a case of disseminated fusarial blood stream infection with varicelloid skin eruptions, who had suffered from persistent neutropenic fever after salvage chemotherapy for relapsed acute lymphocytic leukemia (ALL). Neutropenia continued in spite of G-CSF and granulocyte transfusion, and he failed to respond to conventional amphotericin B initially, and then liposomal amphotericin B and voriconazole combination therapy. Disseminated fusariosis can be diagnosed by blood cultures in 50% of patients and present skin lesions in more than 80% of patients. So, typical skin lesions are important clue to diagnose of the disseminated fusariosis. However, many skin lesions in immunocompromised hosts are due to various infectious and non-infectious causes. So, this case shows that it is important to obtain biopsy specimens of skin lesions for histopathologic examination, culture and staining. Here, we present our case with the review of the literatures reported in our country, so far.
김윤정,전은경,조병식,최수미,이석,민창기,신완식 대한감염학회 2008 감염과 화학요법 Vol.40 No.5
Hematopoietic stem cell transplantation (HSCT) can cause various complications involving lung, liver intestine and other organs, Chemotherapy, radiation therapy, and graft-versus-host disease (GVHD) may injure the cells in the intestinal mucosa of HSCT recipients. Pneumatosis cystoides intestinalis (PI) is a condition that presence of air in the bowel wall is demonstrated by radiologic or pathologic tests, It is one of the infrequent complications after HSCT and is associated with several medical and surgical conditions. However its pathogenesis and definite etiologic factors are still unknown. Here, we present a case of PI in a HSCT recipient, who was diagnosed of bronchiolitis obliterance accompanied with chronic GVHD and pulmonary disease caused by Mycobacterium abscessus.
초·중·고 학생들의 과학 정의적 특성 추이 분석을 위한 종단적 연구
김효남,정완호,정진우,양일호,김영신 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1
이 연구는 우리 나라 학생들의 과학의 정의적 특성의 성취 수준을 종단적으로 분석하여 국가 수준에서 과학교육 성과를 가늠해 봄으로써, 과학교육의 질을 향상시킬 수 있는 과학교육 정책의 기초자료를 제공하는데 그 목적이 있다. 이를 위하여 1997년 2월에 초중고학생 3603명, 1999년 3월에 초중고학생 4737명을 대상으로 과학의 정의적 특성을 조사하였다. 본 연구의 결과는 학교급별 과학의 정의적 특성의 성취 수준이 초등학교에서 중학교까지 통계적으로 유의미하게(p<.05) 하락 한 후 고등학교에서 상승하는 것으로 나타났다. 또한, 남학생이 여학생보다 통계적으로 유의미하게 높게 나타났다(p<.05). 남녀간의 성취수준의 차이는 학년이 올라갈수록 감소하는 것으로 나타났다. 지역별로는 소도시보다 대도시가 높게 나타났으며, 시간이 지날수록 그 차이가 커지는 것으로 나타났다. 1997년과 1999년의 성취 수준을 비교해보면 1999년의 성취수준이 통계적으로 유의미하게 낮게 나타났다. 또한, 국가수준의 과학에 대한 성취도를 분석할 수 있는 모니터 과정이 계속적으로 이루어지길 기대한다. The purpose of this study was to longitudinally analyze Korean students' trend on science-related affective characteristics and provide descriptive data for improving the quality of Korean science education. In this longitudinal study, 3603 students and 4737 students were sampled in elementary and secondary schools, respectively in January 1997 and March 1998. The result showed that students' affective characteristics were decreased with statistical significance(p<0.05) during elementary and junior high school periods, but students' affective characteristics were increased during high school period. Affective characteristics of male were significantly higher than those of females' (p<0.05). Difference on affective characteristics between female and male students was being decreased by increasing grades. Students' affective characteristics in metropolitan areas were significantly higher than those in regional areas and difference between them was increased in 1999 comparing to 1997. The students' affective characteristics in 1999 were lower than those in 1997 totally.
Helicobacter pylori의 생육과 각종 유기산의 식품 보존료로서의 효과
송재철,조은경,박현정,신완철,최석영 울산대학교 2002 생활과학논문집 Vol.3 No.2
Helicobacter pylori의 생육과 각종 유기산의 식품보존료로서의 효과를 검토하였다. 우선 보존료로 현재 식품첨가물로 사용되고 있는 소르빈산(sorbic acid), 프로피온산(propionic), 안식향산(benzoic acid) 등의 H. pylori에 대한 항균능력을 검토한 결과 소르빈산, 프로피온산, 안식향산의 H. pylori에 대한 항균효과가 관찰되었으며 안식향산은 소르빈산이나 프로피온산과 비교했을 때는 별로 큰 효과를 나타내지 못하였다. 보존료의 조합에 대한 H. pylori의 생육억제효과는 0.5% 소르빈산과 0.5% 프로피온산을 조합하는 경우 나타났으며 다른 조합군과 비교할 때 큰 차이를 나타내지 못하였다. 유기산과 H. pylori의 생육관계에서는 단독 첨가시에는 항균력이 크게 나타나지 않고 조합하는 경우에만 좋은 항균력을 나타내었다. 유기산, 보존료와 H. pylori 생육관계는 유기산류는 어떤 보존료와 혼합하여도 항균력에 상승효과가 있는 것으로 나타났다. 특히 구연산의 경우 소르빈산과 조합한 경우에는 H. pylori생육이 많이 억제되었으며 그 다음이 구연산+안식향산, 구연산+프로피온산 순으로 균에 대한 항균력이 감소되었다. 또 사과산과 숙실산은 구연산과 비슷한 경향을 나타내었다. The purpose of this study was to examine the effect of various organic acids as food preservatives on the growth of Helicobacter pylori(H.pylor). The antimicrobial effects of sorbic acid, propionic acid and benzoic acid currently used as food preservatives were examined in light of the growth of Helicobacter pylori. Each of them was observed to have positive antimicrobial effect on Helicobacter pylori. However, benzoic acid wasn't higher than sorbic acid and propionic acid in antimicrobial effect. As for the combination of preservatives, antimicrobial activity of H. pylori was shown in the combination of sorbic acid(0.5%) and propionic acid(0.5%). However, its effect was not significantly different in comparison with other combinations. In the relationship of organic acids and H. pylori's growth, organic acid had no effect on antimicrobial activity when it was used alone, whereas antimicrobial effect was shown to be better in case of combination. If intermix of organic acids and preservatives and addition to the medium for suppression of H. pylori growth were achieved, organic acid exhibited synergistic effect on suppression of H. pylori's growth, even in combination of any other preservatives. In particular, in combination of citric acid and sorbic acid, the growth of H. pylori was shown to be remarkable suppression. And the effectiveness on suppression of H. pylori's growth was lowered in order of citric acid + bezoic acid and citric acid + propionic. acid. It was also found that the antimicrobial effects of malic acid and succinic acid were similar to those of citric acid.