일개 철강 사업장에서 대사증후군의 위험요인과 γ-GTP와의 관련성

문제혁,이상준,박정덕 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 대사증후군은 심혈관계 질환의 이환과 이로 인한 사망률을 증가시키는 것으로 알려져 있으며, 비만, 고 중성지방혈증, 저 HDL-콜레스테롤혈증, 고혈압, 공복 시 고혈당 등에서 3개 항목 이상을 만족한 경우로 정의된다. 간기능 검사 중 γ-GTP는 간세포 손상에 대한 생체지표로 흔히 사용되는 검사이며, 고혈압, 제 2형 당뇨 및 뇌졸중과도 관련이 있음이 밝혀져 있다. 이번 연구에서는 일개 철강 사업장내 근로자들의 대사증후군의 유병률과 위험요인 및 대사증후군과 γ-GTP와의 관련성을 알아보았다. 방법: 수도권 소재 일개 철강 사업장 남자 근로자 1,604명을 대상으로 대사증후군의 구성요소(체질량지수, 중성지방, HDL-콜레스테롤, 수축기와 이완기 혈압, 공 복 시 혈당)와 γ-GTP, 교대근무 여부, 음주력, 흡연력, 운동 여부 및 가족병력 등을 조사하여 분석하였다. 결과: 일개 철강사업장근로자에 있어서 대사증후군의 유병률은 21.3%, 연령 보정 유병률은 15.5%이었다. 대사증후군에 영향을 미치는 역학적 요인은 연령(OR: 1.063, 95% CI: 1.033-1.094), 음주(OR: 1.657, 95% CI: 1.175. 2.337) 및 흡연(OR: 1.359, 95% CI: 1.017. 1.816) 등 이었고, 교대근무는 고혈압(OR: 1.329, 95% CI: 1.038-1.700)에만 영향을 주었다. 고 γ-GTP 혈증군에서 대사증후군의 구성인자인 비만, 고 중성지방혈증, 고혈압 및 공복시 고혈당의 위험도는 각각 2.625, 3.384, 1.887, 2.406이었고, 대사증후군의 위험도는 3.345이었다. 결론: 이번 연구결과로 볼 때, 철강 사업장에서 대사증후군에 대한 적극적인 관리를 위하여 금주와 금연 등 생활행태 개선을 위한 보건교육이 요구되었고, γ-GTP가 대사증후군의 조기 색출지표로서의 가능성이 제기되었다. Objectives: This study was performed to estimate the prevalence and possible risk factors of the metabolic syndrome in steel-mill workers, and to evaluate the relation between γ-glutamyltransferase (γ-GTP) and the metabolic syndrome. Methods: The study subjects comprised 1,604 male steel-mill workers. The indices of metabolic syndrome, such as BMI, triglyceride, HDL-cholesterol, blood pressure, fasting glucose, and γ-GTP were analyzed in each subject. We collected information about demographic characteristics, behavioral patterns, such as alcohol drinking, smoking, and exercise, and family medical history through a self-administered questionnaire. Statistical analysis was done by using the chi-square test, Mantel-Haenszel trend test and logistic regression model. Results: The crude and age-adjusted prevalences of the metabolic syndrome were 21.3% and 15.5%, respectively, in the steel-mill workers. Age (OR: 1.063, 95% CI: 1.033-1.094), alcohol drinking (OR: 1.657, 95% CI: 1.175-2.337) and smoking (OR: 1.359, 95% CI: 1.017-1.816) were risk factors for the metabolic syndrome. Meanwhile, shift work showed a significant relation with hypertension (OR: 1.329, 95% CI: 1.038-1.700), but not with other metabolic syndrome components. However, tenure, exercise and family medical history were not significant factors for the metabolic syndrome in this study. The risk ratio of the metabolic syndrome (OR: 3.345, 95 % CI: 2.534-4.416) and its components, such as obesity, hypertriglyceridemia, hypertension and hyperglycemia, were higher in the high γ-GTP group (≥63 IU/Ɩ ) than in the controls (<63 IU/Ɩ ). Conclusions: These results confirm the need for health education to control the metabolic syndrome by improving behavioral patterns, such as alcohol drinking and smoking, in factory workers. In addition, it is suggested that γ-GTP might be a useful candidate in screening for the metabolic syndrome.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

Effects of Intensive Neuro Rehabilitation Intervention on the Motor Function Recovery and Balance in Stroke Patients

( Je-hyeok Lee ),( Jong-duk Choi ) 대한물리의학회 2016 대한물리의학회지 Vol.11 No.4

PURPOSE: The purpose of this study was to investigate the effects of differences in exercise time arrangement on the functional recovery of the lower limbs and balance of stroke patients. METHODS: The subjects of this study were 100 patients who were hospitalized in two hospitals located in Gyeonggi-do. Before the experiment, 60 of these patients who met the inclusion criteria and did not meet the exclusion criteria were randomly divided into an experimental group (n = 30), whose exercise time was concentrated, and a control group (n = 30), whose exercise time was diffuse. The two groups underwent six weeks of physical and occupational therapy four times a day for five days a week. One session of therapy took 30 minutes, including three sets of physical therapy and one set of occupational therapy. The rest time between the sessions was different for each group. The experimental group had five minutes of rest between each therapy session, and the control group had two hours of rest time between each session. The Fugl-Meyer assessment (FMA), an assessment of each patient`s limit of stability (LOS), and a timed up and go test (TUG) were used as test tools. RESULTS: Both groups showed statistically significant increases in their FMA results, LOS measurements, and TUG results. The FMA results of the experimental group were significantly higher than those of the control group. CONCLUSION: Thus, concentrated exercise time was more effective than diffuse exercise time for the recovery of motor function.

Effect of exercise program using mirrors for stroke patients

Je-Hyeok Lee,Hyun-Joo Kim 한국콘텐츠학회 2013 International Journal of Contents Vol.9 No.1

This study was performed for two of specific reasons, one is for exercise development for improving stroke patients muscle power, balance and gait and, after verifying the effect of the exercise, the other is for showing that the appling this exercise was more effective on hemi-plegic stroke patients into the clinical trial. The subjects of this study were hemi-plegic patients by stroke, 51 patients were picked up, who were agreed with this research. Close kinetic chain leg exercise using mirrors was applied to study groupⅠ, Close kinetic chain leg exercise without mirrors was applied to study groupⅡ and general physical therapy was applied to comparison group. The results of this study are as follows. The difference of the groups, study groupⅠ showed more effective than study groupⅡ on checking rectus femoris, vastus lateralis, biceps femoris, Korean version of Berg Balance Scale, Center of pressure, Functional gait assessment. In this study, Close kinetic chain leg exercise showed more effective and significant on improving for muscle power, balance and gait on stroke patients. Especially, doing exercise using mirrors is considered as more effective method than without mirrors.

Effect of exercise program using mirrors for stroke patients

Lee, Je-Hyeok,Kim, Hyun-Joo The Korea Contents Association 2013 International Journal of Contents Vol.9 No.1

This study was performed for two of specific reasons, one is for exercise development for improving stroke patient's muscle power, balance and gait and, after verifying the effect of the exercise, the other is for showing that the appling this exercise was more effective on hemi-plegic stroke patients into the clinical trial. The subjects of this study were hemi-plegic patients by stroke, 51 patients were picked up, who were agreed with this research. Close kinetic chain leg exercise using mirrors was applied to study group I, Close kinetic chain leg exercise without mirrors was applied to study group II and general physical therapy was applied to comparison group. The results of this study are as follows. The difference of the groups, study group I showed more effective than study group II on checking rectus femoris, vastus lateralis, biceps femoris, Korean version of Berg Balance Scale, Center of pressure, Functional gait assessment. In this study, Close kinetic chain leg exercise showed more effective and significant on improving for muscle power, balance and gait on stroke patients. Especially, doing exercise using mirrors is considered as more effective method than without mirrors.

Hierarchical Pore Structures Fabricated by Electron Irradiation of Silicone Grease and their Applications to Superhydrophobic and Superhydrophilic Films

Lee, Eun Je,Lee, Hyeok Moo,Li, Yue,Hong, Lan Young,Kim, Dong Pyo,Cho, Sung Oh WILEY-VCH Verlag 2007 Macromolecular Rapid Communications Vol.28 No.3

<P>Unique hierarchical pore structures were fabricated by simply irradiating an electron beam onto silicone grease films. The hierarchical pore structures consisted of micrometer-sized pores and macroporous walls. Due to the high surface roughness, the hierarchical pore structures exhibited both superhydrophobicity with a water contact angle (CA) of 170° and superhydrophilicity with an extremely low water CA of 3° after the chemical treatment of the surfaces. In addition to the hierarchical pore structures, sponge-like pore structures were also fabricated by the electron irradiation of silicone grease films.</P><P> <img src='wiley_img/10221336-2007-28-3-MARC200600746-gra001.gif' alt='wiley_img/10221336-2007-28-3-MARC200600746-gra001'> </P>

딸기 설향의 질산암모늄농도와 온도에 따른 ‘팁번’ 생리장애

유제혁(Je Hyeok Yoo),김현숙(Hyun Sook Kim),남명현(Myeong Hyeon Nam),이인하(Inha Lee),이희철(Hee Chul Lee),이병주(Byeong Joo Lee) 한국원예학회 2020 한국원예학회 학술발표요지 Vol.2020 No.11

딸기 ‘하이베리’의 수확기 EC 농도에 따른 생육과 과실수량 및 품질특성

유제혁(Je Hyeok Yoo),김현숙(Hyun Sook Kim),남명현(Myeong Hyeon Nam),이인하(In Ha Lee),이희철(Hee Chul Lee),이병주(Byung Joo Lee) 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10

딸기‘하이베리’는 2018년 충남농업기술원 딸기연구소에서 육성된 신품종으로 경도가 높고 고온기에도 과실의 품질이 유지되는 장점을 가진 품종이다. 본 연구는 신품종 ‘하이베리’의 안정적인 농가 정착을 위하여 수확기 양액의 적정 EC농도를 설정하고자 수행하였다. 2020년 9월 10일 딸기 ‘하이베리’ 품종을 비닐하우스 안 딸기전용상토를 채워 넣은 고설배드에 정식 하였으며 관수방법 및 관주량은 누적일사량 100J/㎠ 도달 시 40~70mL가 자동관주 되게 설정하였다. 양액의 조성은 N:P:K:Ca:Mg = 15:5:7:6:2(me/L)였으며 시험구는 EC 0.7, 1.2, 1.7dS·m<SUP>-1</SUP>로 완전임의배치 3반복을 이용하여 배치 후 시험을 진행하였다. 1화방 및 2화방 개화 직후 실시된 2회의 생육조사에서 통계적으로 유의미한 차이는 보이지 않았으나 모두 EC 1.2dS·m<SUP>-1</SUP>에서 초장, 엽병장, 엽장, 엽폭, 화경장이 높게 측정되는 경향을 보였다. 공급 EC농도에 따른 과실의 수량을 6월까지 조사한 결과 EC 1.2dS·m<SUP>-1</SUP>에서 4,712kg/10a 로 가장 높게 조사되었으며, 이를 시기별로 분석한 결과 수확 초중기까지는 처리에 따른 차이가 크지 않았으나 후기인 4월부터 EC 1.7dS·m<SUP>-1</SUP>에서 수량이 서서히 줄어드는 결과를 나타내어 최종적으로 가장 낮은 수량을 나타내었다. 이어 과실의 품질도 시기별로 조사한 결과, 수확 후기인 6월에 EC1.7dS·m<SUP>-1</SUP>에서 과실품질 중 경도와 당도가 급격히 하락하는 것으로 조사되었으며, 산도의 경우 수확기 전반에 걸쳐 EC농도가 높을수록 낮아지는 결과를 나타내었다. 생육 및 과실의 수량, 품질을 비교하여 본 결과 신품종 ‘하이베리’의 수확기 적정 EC 농도는 1.2dS·m-1로 판단되며, 이 농도를 기준으로 추후 ‘하이베리’품종의 시기별 EC농도 설정시험을 수행할 예정이다.

딸기 육묘기 파밤나방(Spodoptera exigua) 발생시기 예측을 위한 온도발육 모형 비교

유제혁(Je Hyeok Yoo),김현숙(Hyun Sook Kim),남명현(Myeong Hyeon Nam),이인하(Inha Lee),이희철(Hee Chul Lee),한다솜(Dasom Han),이두희(Doo Hee Yi) 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.11

결빙 다중 익형의 공력 및 소음 특성에 대한 수치적 연구

이혁진(Hyeok-Jin Lee),강민제(Min-Je Kang),김시진(Sijin Kim),명노신(Rho-Shin Myong),이학진(Hakjin Lee) 한국항공우주학회 2023 韓國航空宇宙學會誌 Vol.51 No.6