우관상정맥동에서 기시하는 단일 관상동맥 1예

정현광,김태우,조윤성,김강민,장재훈,이재우,정준훈 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Coronary artery anomalies are found incidentally in approximately 1% of all patients undergoing routine coronary angiography. Of these, an isolated single coronary artery anomaly is the rarest one. Patients with an isolated single coronary anomaly may present with symptoms such as angina pectoris, myocardial infarction, arrhythmias, syncope, sudden death, and congestive heart failure. We report a case of single coronary artery anomaly with the left anterior descending and left circumflex coronary artery originating from the right coronary artery.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

사과나무 腐爛病 防除에 關한 硏究 : 腐爛病源菌의 生育抑制에 미치는 化學藥劑, 抗生劑 및 生藥抽出物의 效果 The effects of Chemical Compounds, Antibiotics and Extracts of Herbal Plants on the Growth Inhibition of Valsa ceratosperma Strains

정재훈,양덕춘 경희대학교 부설 식량자원개발연구소 1990 硏究論文集 Vol.11 No.-

These studies were conducted to control of apple cankers caused by Valsa ceratosperma strains by treatment of chemical compounds, antibiotics, extracts of herbal plants and compounds produced from mutant of Streptomyces melanosporofaciens. Effects of chemical control for apple canker were evaluated by grwoth inhibition of Valsa ceratosperma on the PDA media and the most effective chemical was found to be berberine followed by neoasogin, branchi Q, in general. Inhibitory concentration of Valsa ceratosperma was 500mg/ℓ in berberine, and l0,000mg/ℓ in neoasogin. The antifungal antibiotic, cycloheximide, was effective for growth inhibition of Valsa ceratosperma; all strains were inhibited on the media with l00㎍/㎖ of cycloheximide and M26 strain was inhibited by lower concentration of 10㎍/㎖. Effects of extract of herbal plants for growth inhibition of Valsa ceratosperma were excellent with Phellodendron amurense and Coptis japonica, and especially in Coptis japonica, low concentration of l,000mg/ℓ was effective. Compounds produced from mutant of S. melanosporofaciens for growth inhibition of Valsa ceratosperma were more effective than other compounds, i.e., chemical compounds, antibiotics and extracts of herbal plants. Minimum inhibitory concentration of compound C-1 for IF03025 and M1099 was 31.25㎍/㎖.

기관지석으로 발현한 기관지성 방선균증 1예

정숙인,천정학,홍종락,고영민,정만표,권오정,이종헌,백경란,송재훈 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

기관지성 방선균증은 매우 예외적이고 드물며 임상양상이 다양하여 폐암과의 감별이 어렵기도 하지만 기관지내시경 검사를 통해 진단할 수 있고 항생제 투여로 완치될 수 있는 질환이다. 저자들은 기관지석과 함께 발현한 기관지성 방선균증을 장기간의 경구 항생제 요법으로 완치한 1례를 경험하였기에 보고하는 바이다. Endobronchial actmomycosis is considered as an exceptional event. We report a case of a 49-year-old woman who presented with cough and exertional dyspnea for 20 months. Her chest X-ray showed calcified lymph nodes in the right lower paratracheal and subcarinal area and consolidation in the right middle lobe. Bronchoscopic examination demonstrated whitish broncholithiasis with mucosal nodularity in the bronchus intermedius obstructing the lumen near-completely. The biopsy specimen revealed sulfur granules and calcified material which were consistent with actmomycosis. Prolonged oral antibiotic treatment resulted in complete recovery, without need for surgical resection.

사과나무 腐爛病 防除에 關한 硏究 : 腐爛病源菌의 生育抑制에 미치는 化學藥劑, 抗生劑 및 生藥抽出物의 效果 The Effects of Chemical Compounds, Antibiotics and Extracts of Herbal Plants on the Growth Inhibition of Valsa ceratosperma Strains

정재훈,양덕춘 경희대학교 유전공학연구소 1990 遺傳工學論文集 Vol.2 No.-

These studies were conducted to control of apple cankers caused by Valsa ceratosperma strains by treatment of chemical compounds, antibiotics, extracts of herbal plants and compounds produced from mutant of Streptomyces melanosporofaciens. Effects of chemical control for apple canker were evaluated by growth inhibition of Valsa ceratosperma on the PDA media and the most effective chemical was found to be berberine followed by neoasogin, branchi Q, in general. Inhibitory concentration of Valsa ceratosperma was 500㎎/ℓ in berberine, and 10,000㎎/ℓin neoasogin. The antifungal antibiotic, cycloheximide, was effective for growth inhibition of Valsa ceratosperma; all strains were inhibited on the media with 100㎍/㎖ of cycloheximide and M26 strain was inhibited by lower concentration of 10㎍/㎖. Effects of extract of herbal plants for growth inhibition of Valsa ceratosperma were excellent with Phellodendron amurense and Coptis japonica, and especially in Coptisjaponica, low concentration of 1,000㎎/ℓ was effective Compounds produced from mutant of S melanosporofaciens for growth inhibition of Valsa ceratosperma were more effective than other compounds, i.e., chemical compounds, antibiotics and extracts of herbal plants. Minimum inhibitory concentration of compound C-1 for IF03025 and M1099 was 3125㎍/㎖.

矮性사과나무 樹體生長 果實의 收量과 品質에 對한 몇가지 다른 剪定方法間의 比較 硏究

鄭載薰 公州大學校 資源科學硏究所 1993 資源科學硏究論文集 Vol.1 No.-

A series of experiment was carried out to contribute in establishing a model of pruning through investigating in relation to the tree form, tree vigour, yield and fruit quality in 4-examplary orchards practising unique pruning methods. The major results can be summarized as follows. 1. Sizes for height of trees were in the order of steady, thinning-out only("T" pruning)<steady, short, heading-back only("H" pruning)< steady, long heading-back with thinning-out only("H+T" pruning)=three years short heading-back only then thinning-out only("3HT" pruning). 2. The number of flower buds per 10a of branch was in the of three years short, heading-back only then thinning-out only> steady, thinning-out only> steady, short, heading-back only> steady, long heading-back with thinning-out only. Also, the size of flower bud for 6-year old 'Fuji' apple tree was in the order of steady, thinning-out only> three years short, heading-back only then thinning-out then thinning-out only> steady, short, heading-back only = steady, long heading-back with thinning-out only. 3. The carbohydrate/nitrogen(C/N) ratio in bark of one-year-old shoot was high in steady, thinning-out only and was low on the other three pruning treatments. 4. In accumulated yield for 8 years of cropping, the fruit number per 10a was in the order of steady, thinning-out only=steady, short, heading-back only>three years' short, heading-back only then thinning-out only. Also the yield per 10a was in the order of steady, thinning-out only > steady, short, heading-back > steady, long heading-back with thinning-out only = three years' short, heading-back 5. The percentage of incident light intensity, relative to the outer canopy, into the innermost part of the canopy belonging 1.0m-1.5m abvoe the ground and within the radius of 0.5m around the main stem, was in the order of steady, thinning-out only > three years' short, heading-back only then thinning-out only > steady, short, heading-back only = steady, long heading-back with thinning-out only. 6. The distribution percentages of fruits coloured with 60% and over were in the order of steady, thinning-out only > three years' short, heading-back only then thinning-out then only = steady, long heading-back with thinning-out only > steady, short, heading-back only. While the distribution percentages of fruits weighting over 300g each were in the order of steady, long heading-back with thinning-out only = steady, thinning-out only;> three years' short, heading-back only then thinning-out only = steady, long heading-back with thinning-out only. 7. The content of chlorophyll b in fruit skin from steady, thinning-out only pruning treatment was less while the content of anthocyanin in fruit skin from steady, thinning-out only pruning treatment was compared with the other three pruning teatment, respectively. 8. The soluble solid contents of fruits were in the order of steady, thinning-out only > three years' short, heading-back only then thinning-out only> steady, long heading-back with thinning-out only. While the titratable acidity content was higher in steady, thinning-out pruning then the other three pruning treatments.

矮性사과나무의 剪定程度 및 誘引方向에 關한 比較硏究

鄭載薰 公州大學校 資源科學硏究所 1995 資源科學硏究論文集 Vol.3 No.-

切斷剪定의 程度와 가지誘引의 方向이 矮性사과나무에서 營養生長과 生殖生長間의 關係에 미치는 影響을 알아보기 위한 一連의 試驗이 1994년 3월부터 10월까지 실시하였다. 切斷剪定의 程度에 관한 試驗에서는, 新梢와 側枝의 發達은 切斷剪定의 程度가 증가함에 따라 촉진되었으며, 剪定處理를 한 가지의 生長部位에 發生한 葉數, 葉面積, 그리고 生體重은 中 切斷剪定 處理區에서 가장 많았다. 花芽와 果實의 發育은 切斷剪定을 一切하지 않은 對照區에서 가장 높은 結果를 보여주었다. 사과나무에 대한 誘引方向의 影響을 알아보기 위한 試驗에서는 東쪽과 西쪽으로 誘引된 가지에서 新梢와 側枝의 生長이 효과적으로 抑制되었다. 東쪽으로 誘引된 가지는 가장 良好한 花芽發達 狀態를 보여준 반면, 東쪽과 南쪽으로 誘引된 가지는 結實된 果實의 수와 무게에서 가장 良好한 着果狀態를 보여주었다. 本 試驗은 剪定의 程度가 증가함에 따라 新梢의 生長은 촉진되지만 花芽의 發達과 着果抑制된다는 것과 經濟性을 고려한 사과나무의 가장 효과적인 誘引 方向은 東쪽과 남쪽임을 언급한다. A series of experiments was carried out to investigate the effects of pruning severity and training directions on the relationship between vegetative and reproductive growth in dwarf apple trees('Fuji'/M.26/Malus prunifolia seedlings) from March to October 1994, in Yesan area. In the experiment of pruning severity, terminal and lateral shoot development were stimulated as pruning severity was increased, and leaf number, total leaf area and fresh weight of leaf were the most in moderate pruned shoots. The number and weight of flower bud and fruit were the most in no heading-back pruned shoot(control). In another experiment to know the most direction for apple tree, terminal and lateral shoot growth was effectively restricted in the shoot directed to the east and the west. Although the shoot directed to the east showed the best result in flower bud development, the shoots directed to the east and south kept the best result in fruit number and weight. This experiment suggest that as the pruning severity was increased, the shoot growth was stimulated, but flower bud development and fruiting was restricted, and that the more effective directions in apple trees considered with commercial purpose were the east and the south.

主枝의 誘引角度가 樹體生長, 花芽形成 및 結實에 미치는 影響

鄭載薰 公州大學校 資源科學硏究所 1994 資源科學硏究論文集 Vol.2 No.-

主枝의 誘引角度가 新消仲長量에 미치는 影響은 15°=75°>90°>105°=165°의 順으로 仲長量을 크게 하였다. 分枝角度의 크기와 지지內 C/N 率은 負의 相關關係를 보였으며 또한 分枝角度의 크기와 형성층 부위에 點滴시킨 basic fuchin용액의 轉流距離도 負의 相關關係를 보였다. 그러나 新消 껍질내의 室素의 含量은 分枝角度가 커지는데 정비례하게 높아지는 것을 알 수 있었다. 分枝角度가 점차 넓어짐에 따라 ?C-labelled carbohydrate의 轉流量이 正의 相關으로 증가 하였다. 가장 바람직한 分枝角度로서 본 硏究에서 얻어진 결과는 主枝에 대하여 75°였다. The effect of the acropetal branching angle trained toward the main stem on the elongation length of the terminal shoot was in the order of 15°=75°>90°>105°=165°, respectively. There was a negative correlation between the size of acroptal branching angle trained toward the main stem and the content of C/N ratio in the bark of a branch. There was also a negative correlation between the translocation distance of basic fuchsin solution dropped into the cambium layers of the branch and the size of acropetal branching angle trained toward the main stem. Along with the gradual increase of acropetal branching algle of 15°, 45°, 75°, 90°, 135°,165° trained toward the respective main stem, there was a positive correlation betwen the size of branching angles and translocation distance of basic fuchin solution dropped onto the cambium layers of the trained branches. The acropetal branching angle trained toward the main stem with the greatest number of flower buds and with the biggest individual fruit size was 75°.

스코폴라민의 흰쥐 피부투과에 대한 투과촉진제들의 영향

정재영,감성훈,김건남,지상철,박은석 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

The transdermal therapeutic system (TTS) of scopolamine has various advantages over its oral dosage forms. The ideal scopolamine TTS requires high skin permeation rate in short time after it is applied on the skin. In order to increase the initial skin permeation rate of scopolamine from TTS, various permeation enhancers were employed. Enhancers employed were fatty acids(oleic and linolenic acids), cyclic monoterpenes(menthol, camphor, cineole and limonene) and others(isopropyl myristate, sodium lauryl sulfate and glyceryl monostearate). The concentration of enhancers in the base were fixed to 5% (w/w). While fatty acids had little enhancing effect on the skin permeation of scopolamine, cyclic monoterpenes, isopropyl myristate and sodium lauryl sulfate resulted in 1.5∼2.36-fold higher skin permeation rate of the drug compared to the control. However, lag time was not affected by enhancers studied.

만성두통환자에 대한 침치료가 심박변이도에 미치는 영향

정인태,이상훈,김수영,차남현,김건식,이두익,이재동,임사비나,이윤호,최도영 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The purpose of this study was to assess the effect of acupuncture treatment for chronic headache patients using power spectrum analysis of the heart rate variability(HRV). Methods : 15 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as Chronic Headache patients. Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of acupuncture treatment were analyzed using power spectrum analysis of the HRV, HRV was recorded before and after acupuncture treatment. Results : HRV before and after treatment was compared after 8 weeks of acupuncture treatment. Increase in mean values of SDNN and RMSSD were observed but the increases were not statistically significants. Increase in mean values of TP, LF and HF were observed but, the increase was significant(p<0.05) only in TP. Conclusions : The results suggest that acupuncture treatment on chronic headache patients can increase the activity of autonomic nervous system. Further use of HRV for quantitative analysis of acupuncture treatment on autonomic nervous system related symptoms is suggested.