S-528 : The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

체조경기시 국ㆍ내외 우수선수의 종목별 가점내용에 관한 비교 분석 : With a Focus on Long Horse, Parallel Bars, and Horizontal Bar 조마, 평행봉, 철봉을 중심으로

조성동,한충식,안애정 한국체육대학교 부속체육연구소 1995 체육연구소논문집 Vol.13 No.-

As a result of making a comparative analysis of the scored content by event for the participation athletes in three games in the 1993 World Championship Competition and Korean representative athletes in the 1995 World Championship Competition, the following conclusion was drawn; 1. Long Horse Exercise The scored content of performance exercised by the participation athletes in both competitions was shown only in cuervo sikill. 2. Parallel Bars The scored content of performance exercised by the participation athletes in both competition was shown to by highest in Morisue and Diamidor skills in terms of the degree of difficulty. 3. Horizontal Bars The scored content of performance exercised by the participation in both competitions was shown to be highest in free stoop(strad) and circlefwd skills and the continuance of release part interms of both the degree of difficulty and the coupling skill.

혈장 중 Cefprozil의 이성체인 cis-Cefprozil과 trans-Cefprozil의 동시분석법

조애리,문희경,이성창 德成女子大學校 藥學硏究所 2004 藥學論文誌 Vol.15 No.1

Cefprozil is a broad-spectrum oral beta-lactam cephalosporin consisting of cis-- and trans-isomers in and approximately 90:10 ratio. To establish an assay condition for a Bioequvalence study of cefprozil, a column liquid chromatographic (HPLC) method using UV detection for the determination of the cis- and trans-isomers of cefprozil in blood has been developed. The HPLC apparatus used in this study was Waters 2695 Separation Module (Alliance) system. Samples were analyzed with dual absorbance detector (280㎚). C8 (150×4.6㎜, Luna 5㎛, Phenomenex) column with column inlet filter (3㎜×O.5㎛), provided a good resolution, The mobile phase was composed of acetonitrile : glacial acetic acid : water: (5:2:93 as v/v/v, pH 2.7). The flow rate was 1.0㎖/min. Typical retention times with Luna column were 10.8, 14.8 and 20.5min for cis-cefprozil, trans-cefprozil and cepharolidine (internal standard), respectively. For the data manipulation, Waters Millennium program was employed. Calibration curves for the determination of cis-cefprozil and trans isomers of cefprozil in plasma showed a good linearity at a concentration range from 0.05 to 15㎍/㎖ (r²=0.999) and 0.01-1.5㎍/㎖ (r²=0.998). The lower detection limits for cis- and trans-cefprozil were 0.05 and 0.01㎍/㎖, respectively.

아세메타신 및 인도메타신의 혈장 중 동시분석법

조애리,문희경 德成女子大學校 藥學硏究所 2003 藥學論文誌 Vol.14 No.1

Acemetacin is a new potent non-steroidal anti-inflammatory compound which is used for the treatment of arthritis and rheumatic diseases. To establish an assay condition for a Bioequivalence study of acemetacin, a column liquid chromatographic (HPLC) method using UV detection for the determination of acemetacin and its metabolites indometacin in blood has been developed. The HPLC apparatus used in this study was a Waters 2695 Separation Module (Alliance) system. Samples were analyzed with Dual-λ-Absorbance Detector (UV254 nm). C_(18) (250×4.6mm, Luna 5μm, Phenomenex) column which maintained at 40℃, provided a good resolution. The mobile phase was composed of 0.02M 인산용액 (pH 4.5):MeOH=45:55. The flow rate was 1.4ml/min. Typical retention times with Luna column were 23, 31 and 34 min for flubiprofen (internal standard), acemetacin and indometacin, respectively. For the data manipulation, Waters Millennium program was employed. Calibration curves for the determination of acemetacin and indometacin in plasma showed a good linearity at a concentration range from 100ng/ml to 4000ng/ml(r²=0.999). The lower detection limits for both compounds were 100ng/ml.

경피흡수 약물송달 시스템에 적용되는 의료용 점착제의 평가

조애리,임현주 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1

TDD systems must provide good, reliable skin contact for a specified period of time in order to provide consistent drug delivery, then should be easy to remove when desired, without causing trauma to the skin. To meet these goals, proper evaluation of the adhesives is important. Prior to the development of polyurethane adhesives, the adhesive property of seven commercially available TDD systems have been quantitatively compared by performing the Probe tack test and Peel adhesion test. The tack strength of adhesives have been measured by the Probe test method. Effect of dwell time (0.1, 0.4, 1 and 50 sec) on tack strength was measured. The tested adhesives showed progressive increase in tack strength as dwell time increased. Each adhesive system showed a different tack temperature relationship. Among seven, three PSA showed no decrease in tack in 1 st, 2 nd, 3 rd tack test which simulate the reapplication of TDD system for repositioning of the device. For twice a day patches, tack strength range 0.34-0.39 kgf and once a day patches show 0.53-0.79 kgf and 72-96 hr application patches range 0.8 kgf (dwell time Isec at 25℃, 1 st tack strength). Also the 180˚degree peel adhesion test has been performed according to PSTC test no.1. From the peel adhesion test, the forces required to detach the adhesives from the stainless steel have been evaluated. For once a day patches, the average peel strength ranges 0.9-1.4 (kgf/25㎜) and for twice a day patches, they ranges 0.2-0.35 (kgf/25㎜) when peel-off speed was 100 ㎜/min. In conclusion, required tack and peel adhesion property to maintain proper adhesives for twice a day, once a day and 72-96 hr application patches have been evaluated.

설파디아진은의 피부세포 증식 및 화상모델에 있어서의 상처치유과정에 미치는 영향

조애리 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1

Cyto-toxic effect of silver sulfadiazine (Ag-SD) on kerationcytes and its implication of wound healing process were investigated in 2^nd degree burn hairless mouse model. As a dermal model, HaCat (immortalized Keratinocytes) monolayer culture in DMEM with 10% FBS was used. Cyto-toxicity of Ag-SD was estimated by measuring the cell viability using neutral red assay after adding the drug. The 2^nd degree burn was prepared on hairless mouse back skin (1 cm diameter)and dressings with Ag-SD were applied for 96 hr. The process of re-epithelialization and the presence of inflammatory cells were investigated and histology with Hematoxylin-Eosin staining was performed. Ag-SD displayed highly cyto-toxic effect on cultured HaCat cells in a concentration dependent manner (1-100 ㎍/mL). Topical applicantion of Ag-SD(2%) could control the infection: no inflammatory cells were obsevered in histology. However the cyto-toxic effect of Ag-SD on skin cells induced the impairment in epidermal regeneration.

설파디아진은의 피부세포 증식 및 화상모델에 있어서의 상처치유과정에 미치는 영향

조애리 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.2

Cyto-toxic effect of silver sulfadiazine (Ag-SD) on keratinocytes and its implication on wound healing process were investigated in 2^nd degree burn hairless mouse model. As a dermal model, HaCat (immortalized keratinocytes) monolayer culture in DMEM with 10% FBS was used. Cyto-toxicity of Ag-SD was estimated by measuring the cell viability using neutral red assay after adding the drug. The 2^nd degree burn was prepared on hairless mouse back skin (1 cm diameter) and dressings with Ag-SD were applied for 96 hr. The process of re-epithelialization and the presence of inflammatory cells were investigated and histology with Hematoxylin-Eosin staining was performed. Ag-SD displayed highly cyto-toxic effect on cultured HaCat cells in a concentration dependent manner (1-100 ㎍/mL). Topical application of Ag-SD (2%) could control the infection: no inflammatory cells were observed in histology. However the cyto-toxic effect of Ag-SD on skin cells induced the impairment in epidermal regeneration.

두경부 전산화 단층촬영시의 주요 장기선량, 유효선량 및 위험도

김애지,나경수,조봉혜 大韓口腔顎顔面 放射線學會 1995 Imaging Science in Dentistry Vol.25 No.1

The organ or tissue doses were determined with head and neck phantom measurement for multiple axial scans (36 slices), multiple coronal scans (13 slices), 3 types of single axial scans(orbit, maxillary sinus and mandibular canal) and single coronal scan(maxillary sinus). For each scan sequence 30 TLDs were placed in selected sites(16 internal site and 14 external sites) in a tissue-equivalent phantom. The exposure was made at 120kVp, 500mAs with 5 mm slice width. The results were as follows: 1. In multiple axial scans, the greatest effective dose recorded was that delivered to the thyroid glands(2.77 mSv) and the least was that received by the skin(0.05 mSv). From these data, stochastic effects were ?? and ??, respectively. 2. In multiple coronal scans, the greatest effective dose recorded was that delivered to the salivary glands(0.58 mSv) and the least was that received by the skin(0.01 mSv). From these data, stochastic effects were ?? and ??, repectively. 3. Among single axial scans, the greatest effective dose recorded was that delivered to the salivary gland(0.38 mSv) in maxillary sinus scan. From this data, stochastic effect was ??. 4. In single coronal scan, the greatest effective dose recorded was that delivered to the salivary gland(0.01 mSv). From this data, stochastic effect was ??. 5. The equivalent dose measured that delivered to the lens of the eyes was 69.64 mSv in multiple axial scan, 39.32 mSv in multiple coronal scan and 36.77 mSv in single axial scan(orbit).

감자 튀김 조리시 Silicone Oil 효과에 관한 연구

염초애,윤숙자 淑明女子大學校 生活科學硏究所 1988 論文集 Vol.2 No.1

In this study, for the prevention of deterioration of soybean oil, 0.5ppm, 1ppm, 2ppm, 5ppm of silicone oil were used for the cooking of fried potatoes. In proportion to the increased of cooking time, Acid Value (AV), Carbonyl value (COV), Thiobarbituric acid value (TBA), Color density, composition of fatty acid were determined. The addition of silicone oil into cooking oil inhibited the deterioration of lipid during frying. Especially, the amount of addition of silicone oil was differented in the inhibition of deterioration of lipid. When 2ppm of silicone oil was added, AV and color density showed that inhibition effect of oxidation was increased. When 1ppm of silicone oil was added, TBA, POV showed that inhibition effect of oxidation was increased. On The basis of these results, addition of 1∼2ppm silicone oil into cooking oil inhibited the deterioration of lipid during frying.