Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells

Kim, Il-Kyu,Kim, Byung-Seok,Koh, Choong-Hyun,Seok, Jae-Won,Park, Jun-Seok,Shin, Kwang-Soo,Bae, Eun-Ah,Lee, Ga-Eun,Jeon, Hyewon,Cho, Jaebeom,Jung, Yujin,Han, Daehee,Kwon, Byoung S,Lee, Ho-Young,Chung, Nature Publishing Group, a division of Macmillan P 2015 Nature medicine Vol.21 No.9

<P>T cell stimulation via glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related protein (GITR) elicits antitumor activity in various tumor models; however, the underlying mechanism of action remains unclear. Here we demonstrate a crucial role for interleukin (IL)-9 in antitumor immunity generated by the GITR agonistic antibody DTA-1. IL-4 receptor knockout (Il4ra(-/-)) mice, which have reduced expression of IL-9, were resistant to tumor growth inhibition by DTA-1. Notably, neutralization of IL-9 considerably impaired tumor rejection induced by DTA-1. In particular, DTA-1-induced IL-9 promoted tumor-specific cytotoxic T lymphocyte (CTL) responses by enhancing the function of dendritic cells in vivo. Furthermore, GITR signaling enhanced the differentiation of IL-9-producing CD4(+) T-helper (T(H)9) cells in a TNFR-associated factor 6 (TRAF6)- and NF-kappa B-dependent manner and inhibited the generation of induced regulatory T cells in vitro. Our findings demonstrate that GITR co-stimulation mediates antitumor immunity by promoting T(H)9 cell differentiation and enhancing CTL responses and thus provide a mechanism of action for GITR agonist-mediated cancer immunotherapies.</P>

저인신염혈증 골연화증 치료중 발생한 삼차성 부갑상선 기능항진증 1예

신원식,임수,조영민,김태용,문민경,박도준,박경수,김성연,조보연,이홍규,윤여규,오승근 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

Design of a compact rectangular mono-cone antenna for UWB applications

Choi, Il H.,Choi, Sang S.,Park, Jong K.,Song, Hyo W.,An, Hee S. JOHN WILEY & SONS LTD 2007 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.49 No.6

<P>In this articel, we have designed, fabricated, and measured a compact rectangular mono-cone antenna for UWB applications. The measured bandwidth is 8.2 GHz from 2.8 GHz to 11 GHz for S<SUB>11</SUB> < −10 dB. The path loss S<SUB>11</SUB> and phase were measured and discussed. The radiation patterns and antenna gain across the frequency bands are also presented. From the measured results, the proposed antenna shows a good characteristic (almost linear phase, omni-directional pattern, and very low gain variation). © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 1320–1323, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22430</P>

Q-BOM(Quality-BOM) 기반의 품질보증 효율화 방안 연구

이창희 ( Chang Hee Lee ),양경우 ( Kyung Woo Yang ),박두일 ( Doo Il Park ),김상부 ( S Kim ) 한국품질경영학회 2013 품질경영학회지 Vol.41 No.3

Purpose: For effective quality assurance activities, BOM-based quality assurance method is presented. This study introduces various BOM conversions such as Q-BOM. T-BOM, and S-BOM based on M-BOM structure. Methods: Product quality control via Q-BOM manages inspection/audit information. overall supply-chain of product. part requirements. and inventory status, T-BOM manages part traceability, and S-BOM enables statistical control over key process and parts at various hierarchy levels. Results: Quality plan template was developed based on the study results of BOM system including Q~BOM. T-BOM, and S-BOM. Conclusion: Through BOM(Q-BOM. T-BOM, and S-BOM) study and development of quality plan template, more systematic and comprehensive quality management plan is achieved.

Effect of Electroacupuncture on the Mechanical Allodynia in Rat Model of Neuropathic Pain

Hwang, Byung-Gil,Min, Byung-Il,Kim, J.H.,Na, H.S.,Park, D.S. 경희대학교 2001 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.2001 No.1

The analgesic effects of acupuncture on mechanical allodynia have not been studied so far. The aim of the present study is first, to determine if electroacupuncture(EA) effects to the mechanical allodynia using the rat model of neuropathic pain, and secondly, to examine if these effects may be mediated by endogenous opioid . To produce neuropathic pain, under sodium pentobarbital anesthesia, the right superior caudal trunk was resected between the S3 and S4 spinal nerves. After the surgery, the mechanical allodynia was assessed by stimulating the tail with von Frey hair (2.0g) for 21 days. Twenty one to 35 days after the surgery, low frequency stimulation (2Hz, 0.3ms, 0.07mA) was delivered for 30 minutes, to Houxi (SI3), which is located on the forelimb of a rat. Houxi electroacupuncture(H￡≠EA) relieved the behavioral signs of mechanical allodynia. These relieving effects were prevented by pretreatment with naloxone(2mg/kg, i.p.). The results suggest that low frequency (2Hz) EA can control the mechanical allodynia of neuropathic pain through the activation of endogenous opioid systems.

GATA-3 is a Key Factor for Th1/Th2 Balance Regulation by Myristicin in a Murine Model of Asthma

이규,이창민,정인덕,정영일,천성학,박희주,최일환,안순철,신용규,이상율,염석란,김종석,박영민,Lee, Kyu,Lee, Chang-Min,Jung, In-Duk,Jeong, Young-Il,Chun, Sung-Hak,Park, Hee-Ju,Choi, Il-Whan,Ahn, Soon-Cheol,Shin, Yong-Kyoo,Lee, Sang-Yull,Yeom, S Korean Society of Life Science 2007 생명과학회지 Vol.17 No.8

Myristicin은 육두구에서 발견되는 고농축 정유 중 하나인 물질이다. 하지만 Th1/Th2 면역반응에서 육두구의 항알레르기 효과는 아직 밝혀지지 않았다. 최근에 Th1/Th2 전사인자로서 T-bet, GATA-3가 밝혀졌는데 이번 실험에서 myristicin이 ovalbumin(OVA)으로 유도한 천식(asthma) 생쥐모델에서 Th1,Th2 싸이토카인과 유전자 발현을 조절할 수 있는가에 대하여 알아보았다. 또한 기관지 폐포 세척액을 회수하여 백혈구의 수적 변화, 제2형 협조T세포(Th2 cell)가 생산하는 IL-4, IL-5의 생산에 미치는 영향과 폐조직에서 matrix metalloproteinase (MMP)-9 활성을 측정하였다. 그 결과 기관지 폐포 세척액에서 OVA로 감작하여 천식을 유도한 실험군에서는 호산구의 현저한 증가, Th2 형 싸이토카인(IL-4, IL-5)의 증가가 관찰되었다. 그러나 myristicin을 투여한 그룹에서는 OVA의 감작에 의하여 증가한 각종 염증성 지표들이 감소하거나 정상화 되었다. 또한 OVA에 의하여 증가된 기도저항성이 myristicin 투여에 의하여 감소하였으며 폐조직의 염증성 소견도 뚜렷하게 감소되었다. 이와 같은 연구 결과는 myristicin이 천식의 치료에 유용하게 쓰일 수 있음을 시사해준다. Myristicin, l-allyl-3,4-methylenedioxy-5-methoxybenzene, was one of the major essential oils of nutmeg. However, its anti-allergic effect in the Th1/Th2 immune response was poorly understood. Recently, it was shown that T-bet and GATA-3 was master Th1 and Th2 regulatory transcription factors. In this study, we have attempted to determine whether myristicin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in ovalbumin (OVA)-induced asthma model mice. Myristicin reduced levels of IL-4, Th2 cytokine production in OVA-sensitized and challenged mice. In the other side, it increased $IFN-{\gamma}$, Th1 cytokine production in myristicin administrated mice. We also examined to ascertain whether myristicin could influence eosinophil peroxidase (EPO) activity. After being sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions. These reactions included an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration into the lung tissue around blood vessels and airways, and the development of airway hyper-responsiveness (AHR). The administration of myristicin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, these findings provide new insight into the immunopharmacological role of myristicin in terms of its effects in a murine model of asthma.

제품의 리스크 분석 기법에 관한 연구 : HuBRA 기법 개발 Development of HuBRA (Human Behavior Risk Analysis)

박경수,조일행,김운회 한국안전학회 2003 한국안전학회지 Vol.18 No.3

Since the introduction of The Product Liability Law, effective since July 2002, more and more companies and end-users have been giving their attention to the safety of products. A number of existing risk analysis techniques are being implemented to manufacturing sites. However, they have certain restrictions such as incurring different techniques that are to be implemented at each stage of the product development. This is due to their domain of the analysis differing from one to another. Moreover, the results of these analyses are not specific enough, and are subject to further revision. This study proceeds to look at various examinations undertaken on the existing risk analysis techniques. Through implementing them on certain products, investigations on the strengths and weaknesses were ascertained. This has allowed improvements on the existing techniques to be achieved as well as the development of a new risk analysis technique, 'HuBRA (Human Behavior Risk Analysis).' Finally the new technique was implemented on products to confirm its effectiveness.

Molybdenum - benzoinoxime complex 로부터 molybdenum 의 분리

김연구,정원명,박경배,박진호,황두성,이규일,박소진 한국공업화학회 1999 응용화학 Vol.3 No.2

Generally, a sodium hydroxide solution containing hydrogen peroxide is used to dissolve molybdenum-benzoinoxime complex in the α-benzoinoxime precipitation method. However, the existence of residual hydrogen peroxide in the solution will interfere with the adsorption of ^(99)Mo by alumina. The separation of molybdenum with only sodium hydroxide solution was carried out in this work. A simulated solution consisted of 50 ppm molybdenum and 1 M nitric acid was used. Adding benzoinoxime with the 20-weight ratio of benzoinoxime to molybdenum produced molybdenum-benzoinoxime complex. Molybdenum was separated from molybdenum-benzoinoxime complex by reaction during 5 minutes using distillated water,0.1 N,0.4 N sodium hydroxide solution, and sodium hydroxide solution containing 1 wt% hydrogen peroxide. As results, molybdenum was separated over 97 %, and the separation efficiency was not different with the case of solution containing hydrogen peroxide. It is estimated that hydrogen peroxide acts to accelerate dissolution rate of benzoinoxime and does not affect to separate molybdenum from molybdenum-benzoinoxime complex.

High-performance supercapacitors using flexible and freestanding MnO_x/carbamide carbon nanofibers

Samuel, Edmund,Jo, Hong Seok,Joshi, Bhavana,Park, Hyun Goo,Kim, Yong Il,An, Seongpil,Swihart, Mark T.,Yun, Je Moon,Kim, Kwang Ho,Yoon, Sam S. Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.423 No.-

<P><B>Abstract</B></P> <P>We demonstrate the fabrication of a MnO<I> <SUB>x</SUB> </I>/carbamide carbon nanofiber (CCNF) composite consisting of MnO particles embedded in CCNFs as a highly flexible and freestanding electrode material for supercapacitors. A sacrificial polymer component, polymethylmethacrylate, included in the precursor solution, pyrolyzes during heating, resulting in pores in the fibers, some of which are filled by the MnO nanocrystals. Carbamide is added to control the size of the MnO<I> <SUB>x</SUB> </I> particles as well as to increase the carbon content of the composite and hence its conductivity. The X-ray diffraction and Raman spectra of the composite show that the MnO particles formed have low crystallinity. Transmission electron microscopy confirms that the MnO particles are distributed very uniformly over the CCNFs. Symmetric supercapacitors constructed using electrodes of this composite exhibit specific capacitances of 498F∙g<SUP>−1</SUP> at a scan rate of 10mV∙s<SUP>−1</SUP> and 271F∙g<SUP>−1</SUP> at a current density of 1A∙g<SUP>−1</SUP>. They also exhibit excellent long-term cycling performance, retaining 93% of their initial capacity after 5000 cycles of galvanostatic charging/discharging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We successfully fabricated a novel flexible MnO/CCNF composite. </LI> <LI> Flexible MnO/CCNF showed excellent retention (93%) after 5000 cycles at 1Ag<SUP>−1</SUP>. </LI> <LI> MnO/CCNF composite demonstrated specific capacitance of 498Fg<SUP>−1</SUP> at a scan rate of 10mVs<SUP>−1</SUP>. </LI> <LI> Dynamic MnO particle formation controlled by using carbamide. </LI> </UL> </P>

The influence of climate regime shifts on the marine environment and ecosystems in the East Asian Marginal Seas and their mechanisms

Kun Jung, H.,Rahman, S.M.,Kang, C.K.,Park, S.Y.,Heon Lee, S.,Je Park, H.,Kim, H.W.,Il Lee, C. Pergamon Press 2017 Deep-sea research. Part II, Topical studies in oce Vol.143 No.-

Step changes to seawater temperature (SWT) in the East Asian marginal seas (EAMS) are associated with three recent climate regime shifts (CRS) occurring in the mid-1970s, late 1980s, and late 1990s, but the responses of the ocean conditions and marine ecosystems had regional differences. A step change in SWT in the East China Sea (ECS) was detected after the CRS of the 1970s as were step changes in the North Pacific Index (NPI), Pacific Decadal Oscillation Index (PDOI), and East Asian Winter Monsoon Index (EAWMI). SWT in the ECS decreased with decreasing warm water volume transport into the EAMS and a strong monsoon, but step changes in SWT in other regions were not detected as clearly. After the CRS of the 1980s, SWT in all EAMS increased rapidly with step changes detected in all five climate indices examined. These changes were associated with a weak winter monsoon, increasing surface air temperature (SAT), and increasing warm water volume transport into the EAMS. However, after the CRS of the 1990s, a decrease in SWT around the EAMS was detected in the northern part of East China Sea (NECS), and the ECS with step changes also in the EAWMI and the Arctic Oscillation Index (AOI). In contrast, SWT in the East Sea/Sea of Japan (EJS) and the Yellow Sea (YS) continuously increased during this time. Long-term changes in zooplankton biomass were affected by regional differences in the responses of atmospheric and oceanic variability to CRSs. Specifically, long-term changes in the timing of peaks in zooplankton abundances exhibited differences. During warm periods (e.g. after the 1980s CRS) in the EJS, the amount of zooplankton biomass in October increased, while in February it decreased. On the contrary, in the YS and the NECS, the peaks of October and June in zooplankton biomass occurred during cold periods (after the 1970s and 1990s CRS). Major fisheries resources also responded to the three CRSs, although warm and cold water species responded differently to changes in oceanographic conditions in regional spawning grounds.