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Fabrication of Poly (ethylene oxide) Hydrogels for Wound Dressing Applicationg Using E-Beam
( Haryanto ),( Seongcheol Kim ),( Jeong Hwan Kim ),( Jong Oh Kim ),( Saekwang Ku ),( Hyunkug Cho ),( Do Hung Han ),( Pilho Huh ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Cross-linked poly(ethylene oxide) (PEO) hydrogel was developed for application to wound dressings. Todetermine the optimum conditions for wound dressing materials, PEO with different molecular weights and variousPEO/poly(ethylene glycol) diacrylate (PEGDA) compositions were irradiated in order to obtain cross-linked hydrogelsusing an electron beam with various beam intensities. The contents of the PEGDA influenced the gel fraction,swelling ratio, mechanical properties, and water vapor transmission rate. To evaluate the healing effect of PEO/PEGDA cross-linked hydrogel for wound dressing, wounds on the backs of mice were covered with PEO/PEGDAhydrogel films. Healing under the wet environment of the hydrogel dressing was faster than with a gauze controland a commercial reference. The results demonstrate the possibility of the facile production of mechanically robustand transparent wound dressing materials with improved wound healing characteristics.