HBV : Dynamic Change of HBsAg Titer during Anti-Viral Therapy in Treatment-Na?ve Patients with Chronic Hepatitis B

( Han Wook Chung ),( Yu Jin Ko ),( Sang Wook Lee ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background/Aims: Quantitative HBsAg (qHBsAg) titers are emerging as useful tools for measuring viral load and predicting predicting virologic response (VR). This study aimed to determine whether serial monitoring of HBsAg levels could predict virologic response to entecavir(ETV) & clevudine(CLV) therapy in treatment-naive patients with CHB Methods: A total of 157 treatment-naive patients with CHB, who visited Chung-Ang University Hospital between January 2007 and December 2008, were enrolled in this study (100 males). 97 patients(69 males, mean age 48) were treated with ETV for average 53 months, and 60 patients (31 males, mean age 43) were treated with CLV for 26months average. HBsAg levels were measured at baseline, week 12, 24, and 48. All patients were assessed for virological response (HBV DNA<140 copies/mL). Serum HBV DNA was quantified using the real time PCR assay (Artus HBV LC PCR Kit, Roche Diagnostics, lower limit of quantification, 140 copies/mL). Results: In 97 ETV-treated patients, the rates of virological response were 56.7% (55/97) at 48months and 60 CLV-treated patients, 30% (18/60) at 24 months, respectively. Mean reduction of baseline HBV DNA was -5.3, and -4.9 log10 copies/mL. In 55 VR patients treated with ETV, 43(78.1%) patients showed early decline of HBsAg titer and 31(56.3%) patients had lower baseline HBsAg levels (< 3.7 log IU/mL). In 18 VR patients treated with CLV, 9(50%) patients showed early decline of HBsAg titer and 11(61.1%) patients had also lower baseline HBsAg levels (< 3.7 log IU/mL) . Conclusions: Early decline of HBsAg was useful for predicting VR, and baseline HBsAg could be indicative as well in CHB patients treated with ETV than patients treated with CLV.

1인승 운송체계로서의 스쿠터 디자인에 관한 연구

정주현,이욱영 홍익대학교 산업디자인 연구소 2004 미술디자인 논문집 Vol.- No.9

오늘날 지구촌을 도심어디로 가더라도 날로 증가하는 차량으로 인해 극심한 교통전쟁을 치르고, 베기가스에 의한 환경오염은 심각한 수위에 와있다. 도시 생화자들에게 차량이용의 주목적이 출퇴근용이라는 것을 감안한다면 나 홀로 차량이 시내 운행의 대부분을 차지한다고 해도 과언이 아닐것이다. 나라마다 나름의 해결책으로 차량의 시내 진입을 억제하기 위해 대중교통의 활성화 또는 시내 진입 시 활증료의 부과 등 정책적인 방법으로 도시 운전자들에게 가하는 압박은 수위를 높여가고 있다. 본 연구는 이와 같이 시내를 중행하는 대부분의 차량이 1명만 탑승한다는 점과 항상 주차가 고민이라는 점을 해결하기 위한 새로운 방향을 모색하였다. 이에 최근 다시금 주목 받고 있는 스쿠터의 효율성을 인식하고 향후 1인승 운송기기로서의 새로운 가능성을 토대로 본 연구를 지행하였다. 스쿠터는 많은 모터사이클과 달리 경제적인 가격대와 실용성(수납박스, 쉬운 조작성, 저연비) 등 다른 모터사이클에서 느낄 수 없는 장점이 있다. 최근 이러한 실용성을 극대화한 BMW C1과 같은 새로운 형태의 스쿠터들이 많이 연구되고 있다. 이와 같은 스쿠터들은 기존의 실용성뿐만 아니라 운전자의 안전성을 극대화해주며, 또한 자동차와 같은 운전환경을 제공하고 있다. 본 연구는 기존의 실용성뿐만 아니라 운전자의 안전과 새로운 라이프 스타일에 부합하며 새로운 교통문화를 창출할 수 있는 스쿠터 디자인을 사례를 통해 제안하였다. Today, our world suffers severe traffic war since car is increasing day by day in every corner of the world and environmental pollution due to waste gas threatens to be aggravated. In view of present situation that main reason for using vehicles for citizen is going for work, it is not too much to say that most of running vehicles in city area should be driver only vehicles. Therefore, each countries intensify their pressure on drivers in city through employment of policies such as recommendation to use public transportation and imposition of premium charge for entering city area to restraint vehicles' entering to city. In this study, we had searched new direction to solve the problems that lack of parking lots and most of vehicles driving in city are single occupant's vehicles. Moreover, we could recognized that the effectiveness of Scooter that noticed again recently and had been studying based on new possibility of Scooter as a future single riding transportation tool. Scooter has many merits like economical price and practicalities such as container box, convenient control and high efficiency of gasoline that couldn't be felt from other motorcycles. Recently, new types of Scooter such as "BMW C1" that maximized practicality has been studied. These kind of Scooters not only maximize existing practicality but also safety of drivers, moreover, can provide driving circumstances as vehicles. This study proposed new design of Scooter that not only corresponds practicality and safety as well as new life style but also can create new traffic culture.

煉炭灰魚汁 吸着飼料開發에 關한 硏究

鄭鉉丞,金哲旭 진주산업대학교 1986 論文集 Vol.24 No.-

본 試驗은 煙炭灰 魚汁 吸着飼料 開發을 爲하여 1次에 成分分析과 2次로서 ??飼育에 添加 飼養詩에 나타나는 效果를 究明하고져 本 大學에서 生産한 Landrace(♀)×Berkshire(♂)=F_1 同腹 離乳仔??10頭를 配合飼料 單飼區인 對照區에 5頭, 煙??灰 魚汁吸着 飼料給與區인 試驗區에 5頭를 供試하여 1986年 1月 8日부터 4月 3日(84日間)에 걸쳐 育成期에는 煙炭灰 魚汁吸着飼料를 5% 添加하고 肥育期는 10%添加하여 飼養 試驗한 結果 및 煙炭灰魚汁吸着飼料의 成分分析 內容은 다음과 같다. 1. 煙炭灰魚汁吸着 飼料의 一般成分, 鑛物質成分, Amino酸成分 含量은 濃縮魚汁吸着 水準에 比例하여 높게 나타났다(組蛋白質 : 10%→3.42, 100%→22.16). 2. 日當 增體量은 試驗區(780g)가 對照區(650g)보다 높게 나타났다. 3. 飼料 攝取量은 試驗區(927kg)가 對照區(817kg)보다 높게 나타났으며 4. 飼料效率은 試驗區(2.82)가 對照區(3.05)보다 有意的으로 높게 나타났다. 5. 煙炭灰魚汁 吸着飼料 添加 飼養으로서 1kg 增體當 飼料費가 48원이 節減되었다. 9. 90kg 到達日令은 試驗區(155日)가 對照區(169日)보다 14日이 短縮되었다. 以上의 結果를 보아 廢棄物인煙炭灰와 廢水處理되는 魚汁을 混合 飼料資源化하므로써 飼料費 節減, 飼料效率改善, 營養素利用 增進, 環境汚染防止, 公害處理, 混合加工 飼料 生産으로 導入飼料 節減效果를 期待할 수 있고 國內 配合 飼料 原料 및 實需要 養畜農家 供給 活用이 可能할 것으로 飼料된다. A series of experiment was carried out to studdy the effect of brequette ash addition absorbed concentrated fish soluble in pig formula feed with the first crossbred progeny of the same litter weaned (Landrace ♀× Berkshire ♂), and analyzed the chemical composition, mineral content and amino acid content of brequette ash absorbed concentrated fish soluble. The results obtained are summarized as follow : With increasing absorbed rate of concentrated fish soluble to brequette ash, chemical composition, mineral content and amino acid content were higher. Average daily weight gain was heavier with 780g in the treatment than in the control(650g) Though total feed intake was higher in the treatment(927kg) than in the control(817kg), feed efficiency was superior with 2.82 in the treatment and feed cost per 1kg weight gain was cut down by more 48 won in the treatment than in the control. Average days of age at 90kg was shortened by 14 days in the treatment(155days) than in the control(169days). It was suggested from the results obtained as above that there seem to contribute to curtailment of feed cost, reformation of feed efficiency, body weight effect and shortening of days of age at 90kg by feeding brequette ash addition absorbed concentrated fish soluble in pig formula feed.

煉炭灰 魚汁吸着飼料 開發에 關한 硏究

鄭鉉丞,李乙熙,金哲旭,宋瑛敏,吳錫斗 진주산업대학교 농업기술연구소 1990 農業技術硏究所報 Vol.3 No.-

우리나라에서 年間 50萬M/T 生産廢水處理되는 魚汁中의 蛋白質, U.G.F., Ca等과 991萬M/T 生産廢棄되는 煉炭灰中의 Fe, Zn等의 微量鑛物質을 混合한 煉炭灰 魚汁吸着飼料(FBF:Fish-soluble-abosorbed briquette ash feed)를 開發하기 爲하여 一次로 1981年부터 1984年까지 煉炭灰의 成分分析과 煉炭灰 添加給與試驗을 哺乳中仔豚과 育成-肥育豚에 實施하였고 哺乳中 仔豚에 實施하고 있는 1, 2次 鐵分注射代用 給與試驗을 거쳐 添加給與飼料化 可能性 確認後 1985年부터 1989年까지 煉炭灰 魚汁吸着飼料를 製造하여 5∼10% 添加 給與試驗結果 優秀한 成績이 나타났으므로 3%, 5%, 10% 水準을 代替配給한 飼料를 製造하여 哺乳仔豚의 鐵分注射代用으로서의 效果, 育成期, 肥育期, 育性-肥育期의 飼養試驗, 試驗飼料의 製造,貯藏性, 消化率 및 經濟性, 豚의 背脂肪層,屠體率, 血液像 等으로 調査한 바 다음과 같다. 1. 煉炭灰와 煉炭의 一般成分 및 鑛物質 分析結果 煉炭灰의 成分含量은 수분(0.15%), 조단백질(0.52%), 조지방(0%), 조섬유(4.13%), NFE(0%), 조회분(95.35%), Ca(0.807%), P(0.074%), K(0.138%), Na(0.025%), Mg(0.183%), Fe(3,769mg/kg), Mn(98mg/kg), Zn(139mg/kg) 및 Cu(21.0mg/kg)이였고 煉炭은 NFE(10.96%), 조회분(71.35%), Ca(0.224%), P(0.043%), K(0.158%), Na(0.039%), Mg(0.191%), Fe(7,385mg/kg), Mn(116mg/kg), Zn(306mg/kg) 및 Cu(17.5mg/kg)이었다. 2. 煉炭灰 魚汁吸着飼料成分 分析 煉炭灰 500g에 濃縮魚汁量을 50g에서 250g 및 1,250g 乾物換算(1:1) 水準까지 混合시킨 煉炭灰 魚汁吸着飼料의 成分含量은 濃縮魚汁量이 50g일때는 各各 11.69% 및 31.31%와 2.61% 및 10.6%로 增加하였고 粗纖維와 粗灰分은 各各 5.51% 및 3.86%와 62.82% 및 50.42%로 감소하였다. 아미노酸 成分에서 lysine의 境遇 濃縮魚汁量이 50g일 때 0.19%로 나타났으나 濃縮魚汁量 增加에 比例하여 250g일 때 0.75%로 나타났다. 기타의 아미노酸들도 濃縮 魚汁量이 增加할수록 아미노산 含量이 높게 나타나는 傾向을 보였다. 鑛物質成分은 Ca, Fe, Zn, Mg, Mn 및 Co등은 濃縮魚汁量인 높을수록 높게 나타났다. 3. 哺乳中의 成長期와 離乳後 育成-肥育期에 微量鑛物質 供給濟로서 煉炭灰를 自由 採食시켰을 때 (1) 增體量은 配合飼料 單飼區보다 配合飼料 + 煉炭灰 給與區가 多少 높았으나 有意性은 認定되지 않았다(p>0.05). (2) 飼料效率은 配合飼料單飼區(4.71)보다 煉炭灰 給與 育成肥育區(4.84)가 약간 낮게 나타났다. (3) 仔豚育成區에서는 飼料效率이 3.0이었으며 萎縮豚에 效果가 좋은 것으로 나타났다. (4) 經濟性 分析結果 1kg增體當 飼料肥로 換算하면 配合飼料單飼區(829원)에서 比해 配合飼料 + 煉炭灰區(852원)가 23원이 增加하였다. (5) 仔豚育成區에서는 1kg 增體當 528원이 소요되었다. (6) 煉炭灰의 嗜好性은 좋은 편이었고 건강상태도 양호했다. 4. 哺乳仔豚에 鐵分注射代用으로서 效果 및 離乳仔豚의 育成期에 微量鑛物質 供給源으로서 煉炭灰를 3, 5, 7% 水準으로 添加 給與하였을 때 (1) 哺乳中 鐵分注射 代用으로 煉炭灰를 自由採食 시켜도 仔豚의 發育成績과 健康狀態는 異狀이 없었고 比較的 良好한 便이었다. (2) 增體量은 煉炭灰를 3% 添加 給與하였을 때 가장 좋게 나타났다(P>0.05). (3) 飼料要求量은 對照區와 處理區間에는 큰 差異가 없었다(p>0.05). (4) 1kg增體에 所要된 飼料費는 T1(3% 첨가구), T2(5% 첨가), C 및 T3(7% 첨가구)에서 636.40, 646.72, 672.52 및 684.56원이었다. (5) 對照區에 比해 處理區에서의 血色素 含量은 암·수 供히 良好하였다. 5. 母豚과 哺乳仔豚에 煉炭灰를 自由 採食시켰을때의 乳汁을 通한 鐵分이 哺乳仔豚에 미치는 影響과 哺乳仔豚이 直接 採食하므로서 哺乳中 實施하는 鐵分注射代用으로서의 效果는 (1) 生後 3週間의 體重은 本 大學(5.27kg)이 原種豚(5.00kg)보다 다소 높게 나타났다. (2) 育成數 및 育成率은 本 大學(8.0頭, 86.0%)이 原種豚(8.3頭, 88.3%)보다 낮게 나타났다. (3) 離乳時 體重은 本 大學(17.8kg)이 原種豚(17.4kg) 보다 多少 높게 나타났다. (4) 分娩時期와 哺乳仔豚數가 같은 區에서 鐵分注射區와 煉炭灰給與區間의 比較成績은 煉炭灰給與區가 多少 좋게 나타났으나 有意差는 없었다(p>0.05). (5) 哺乳中 鐵分注射代用으로 煉炭灰를 自由採食시켜도 仔豚의 發育成績과 健康狀態는 異狀이 없었고 比較的 良好한 便이었다. 5. 哺乳仔豚에 2回 實施하고 있는 鐵分注射를 1回로 줄이고 哺乳母豚과 仔豚에 煉炭灰를 自由 採食시켰을 때 (1) 哺乳中 21日齡의 體重은 鐵分注射 1回 煉炭灰給與區(4.48kg)가 鐵分注射 2回區(4.43kg)보다 苦干 좋게 나타났다. (2) 離乳時體重은 鐵分注射 1回 煉炭灰給與區(16.8kg)가 鐵分注射 2回區(17.4kg) 보다 낮게 나타났다. (3) 15週齡의 體重은 鐵分注射 1回 煉炭灰給與區(48.85kg)가 鐵分注射 2回區(46.0kg) 보다 좋게 나타났다. (4) 終了時 體重은 鐵分注射 1回 煉炭灰給與區(78.3kg)가 鐵分注射 2回區(71.6kg) 보다 좋게 나타났다. (5) 日當 增體量은 鐵分注射 1回 煉炭灰給與區(0.589kg)가 鐵分注射 2回區(0.537kg) 보다 좋게 나타났다. (6) 飼料效率은 鐵分注射 1回 煉炭灰給與區(2.32)가 鐵分注射 2回區(2.34)보다 낮게 나타났다. (7) 鐵分注射 1回 煉炭灰給與區의 健康狀態는 正常이었다. 以上의 結果로 生後 3週齡까지의 鐵分注射 1回代替로서 煉炭灰 給與가 可能하고 育成-肥育 前期까지 微量鑛物質 供給源으로 煉炭灰 給與效果가 있는 것으로 나타났다. 7. 1981年부터 1984年까지 4年間 돼지에 煉炭灰를 급여하였을 때 鐵分注射代用 및 微量鑛物質 供給源으로서 效果를 究明하기 위하여 본 대학 부속목장에서 실시한 결과를 綜合的으로 考察해 본 것이다. 대체적으로 姙娠中 암돼지에 煉炭灰給與區와 대조구간에 나타난 仔豚의 生時體重, 21日齡 體重, 56日齡 體重은 有意的인 差異가 없었다. 育成率은 煉炭灰給與區가 優秀하였다. 離乳後 계속 煉炭灰를 給與한 育成豚은 대조구보다 15週齡 체중, 일당증체량 및 사료효율이 유의적으로 높았다. 이상의 결과를 綜合 考察할 때 平素에 煉炭灰를 먹이면 仔豚에 鐵分注射를 아니해도 이상이 없고 育成豚은 微量鑛物質 不足으로 발생하는 여러 가지 疾病이 발생하지 아니하였으므로 煉炭灰를 먹였을 때 돼지의 성장 및 飼料費 節減에 效果가 있는 것으로 나타났다. 8. 煉炭灰 魚汁吸着飼料를 育成期에 5%, 肥育期에는 10%를 添加하여 飼養試驗하였을 때 (1) 日當 增體量은 試驗區(784.52g)가 對照區(645.24g)보다 높게 나타났다. (2) 飼料攝取量은 試驗區(185.53kg)가 對照區(165.46kg)보다 높게 나타났으며, (3) 飼料效率은 試驗區(2.82)가 對照區(3.05)보다 有意的으로 높게 나타났다. (4) 煉炭灰 魚汁吸着飼料 添加 飼養으로서 1kg 增體當 飼料費가 49.45원이 節減되었다. (5) 90kg 到達日齡은 試驗區(155日)가 對照區(169日)보다 14日이 短縮되었다. 9. 煉炭灰 魚汁吸着飼料의 代替水準(0%, 3%, 5%, 10%)別 飼養試驗成績은 (1) 育成期 煉炭灰 魚汁吸着飼料를 C(0%), T1(3%), T2(5%), T3(10%) 水準別로 代替 配合한 飼料로 飼育하였을 때 ① 日當增體量은 試驗區가 T1:658g, T2:686g, T3:683g으로 對照區의 618g 보다 높게 나타났으며, ② 1일 飼料攝取量은 T3:1.61kg>T2:1.59kg>T1:1.55kg>C:1.54kg의 順으로 魚汁吸着飼料量이 增加함에 따라 증가하였다. ③ 增體量은 T2(38.47kg)>T3(38.20kg)>T1(36.83kg)>對照區(34.59kg)의 順으로 T2區가 가장 높게 나타났고, 飼料要求率도 T2(2.32), T1(2.36), T3(2.37)區의 순으로 좋게 나타났으며 全般的으로 處理區가 對照區(2.49)에 比하여 좋은 성적을 나타내었다. ④ 1kg 增體當 飼料單價는 T2區가 291.24원으로 가장 낮게 나타났고 對照區에 比해 1kg 增體當 24.62원의 節減效果가 나타났다. ⑤ 育成期飼料의 消化率은 對照區의 處理區間에 有意적인 差異가 없었고 貯藏期間에는 成分의 變化없이 安定한 것으로 나타났다. (2) 肥育期 煉炭灰 魚汁吸着飼料를 配合飼料에 0%(C), 3%(T1), 5%(T2) 및 10%(T3) 水準으로 代替 配合하여 飼育하였을 때 ① 日當增體量은 T3(779.33g)와 T2(752g)에서 對照區(674g) 보다 높았고 (p<0.01) 飼料效率 및 90kg 到達日齡도 試驗區에서 良好한 成績을 나타내었다. ② 肥育飼料의 消化率은 多少 向上되는 傾向이나 有意的인 差異는 없었다. ③ 煉炭灰魚汁吸着飼料를 配合한 試驗區에서는 貯藏初期 7日間에 成分含量이 낮아졌으나 以後 21日까지는 安定的인 狀態를 나타내었다. ④ 背脂肪層 두께는 T3(10%)區가 1.51cm로 對照區 1.56cm보다 얇게 나타났다 (p<0.01). ⑤ 屠體率은 對照區(61.99%)에 比하여 試驗區(63.67∼64.65%)가 높게 나타났다 (p<0.01). ⑥ 1kg 增體에 所要된 飼料費는 對照區(386.81원), T1(374.19원), T2(347.79원) 및 T3(33699원)로써 試驗區의 飼料費가 절감되었다. (3) 育成-肥育期 煉炭灰 魚汁吸着飼料를 配合飼料에 0%(C), 3%(T1), 5%(T2) 및 10%(T3) 水準으로 代替 配合하여 飼育하였을 때 ① 增體量, 日當增體量, 飼料效率 및 90kg 到達日齡 等에서 對照區에 比하여 FBF를 5%(T2), 10%(T3) 代替 配合하여 飼育하였을 때 良好하게 나타났다 (p>0.01). ② 育成期 및 肥育期飼料의 消化率은 多少 向上되는 傾向이었으나 有意性은 없었다. ③ 煉炭灰魚汁吸着飼料를 代替 配合한 試驗區에서는 貯藏初期 7日間에 成分含量이 낮아졌으나 以後 21日까지는 安定的 狀態를 나타내었다. ④ 背脂肪層은 T3(10%)區가 1.51cm로 對照區 1.56cm 보다 얇게 나타났다 (p<0.01). ⑤ 屠體率은 對照區(61.99%)에 比하여 試驗區(63.67∼64.65%)가 높게 나타났다 (p<0.01). ⑥ 1kg當 增體에 所要된 飼料費는 對照區(350.77원), T1(336.32원), T2(320.89원), T3區(316.11원)의 순으로써 煉炭灰魚汁吸着飼料 添加時 飼料費가 節減되었다. 10. 煉炭灰 魚汁吸着飼料와 濃縮魚汁을 配合飼料에 各各 10%씩 代替 給與하였을 때 (1) 終了時體重과 日當增體量은 對照區(94.05kg, 678g)에 比하여 煉炭灰魚汁吸着飼料 代替區(98.65kg, 752g) 및 濃縮魚汁代替區(95.40kg, 709g)順으로 나타났다. (2) 飼料效率은 對照區에 (3.65) 比하여 煉炭灰魚汁吸着代替區(3.24) 및 濃縮魚汁 代替區(3.40)에서 良好하게 나타났다. (3) 1kg增體當 所要飼料費는 煉炭灰 魚汁代替區(369.33), 濃縮魚汁代替區(388.15), 對照區(413.56)의 順으로 나타났다. (4) 90kg到達日齡은 煉炭灰魚汁 代替區(162.1), 濃縮魚汁 代替區(163.7) 및 對照區(166.9)의 順으로 短縮되었다. 11. 煉炭灰 魚汁吸着飼料給與 飼養時의 血液狀은 赤血球, 血色素量, 赤血球容積 및 白血球數는 無處理區에서 높은 편이고, 平均赤血球容積, 平均血球血色素量, 平均赤血球血色素濃度는 煉炭灰魚汁吸着飼料 添加區에서 약간 높았으나, 白血球 鑑別計劃數를 包含한 이들 血液像은 正常値 範圍內였다. 12. 哺乳仔豚에 鐵分注射代用으로서 煉炭灰 魚汁吸着飼料를 給與하였을 때 (1) 日當 飼料攝取量은 對照區 408g 보다 處理區가 418g으로 10g이 더 높았다 (p<0.01). (2) 平均 日當增體量은 對照區 222.94g 보다 處理區가 296.89g이 더 높았다(p<0.01). (3) 飼料效率은 對照區 1.83 보다 處理區가 1.41로 改善되었다. (4) 哺乳仔豚에 鐵分注射代用으로 煉炭灰魚汁吸着飼料를 自由採食 시켰을 때 仔豚의 健康狀態의 發育成績은 比較的 良好하였다. 13. 煉炭灰 魚汁吸着飼料 代替 水準別 配合飼料製造費用은 1kg當 單價로서 育成期 配合飼料는 代替水準 0%가 125.34원, 3%가 125.56원, 5%가 126.03원 및 10%가 125.43원으로 나타났고, 肥育期飼料는 0% 113.31원, 3% 113.52, 5% 113.68, 10% 114.10원으로 나타났다 (煉炭灰 魚汁吸着飼料 1kg當 生産費 100원 基準). 以上의 結果를 보아 廢棄物인 煉炭灰와 廢水處理되는 魚汁을 混合하여 飼料資源化하므로써 飼料費節減, 飼料效率改善, 營養素利用 增進, 環境汚染防止, 公害處理, 煉炭灰魚汁吸着飼料 開發 活用으로써 導入飼料外貨 節減效果와 養畜農家의 所得增大에 이바지할 것으로 生覺된다. In Korea, 500,000M/T of fish soluble and 9,910,000M/T of briquette-ash are yearly produced and discarded as waste materials. A series of experiments was performed to develop fish soluble-absorbed briquette ash feed(FBF) in order to utilize the protein, UGF, Ca contained in the abandoned fish soluble and Fe, Zn, and other microminerals in the discarded briquette-ash. From the year 1981 to 1984 the chemical composition of briquette-ash was analyzed and its feeding effects on sucking, growing and fattening pigs were studied. Also the effects of briquette-ash addition for substituting Fe injection in pigs at sucking were examined. After the potential of briquette-ash feed was proved, from the year 1985 to 1989 fish soluble-absorbed briquette ash feed(FBF) was made and previously fed from 5 to 10%, subsequently, 3, 5, and 10% of pig ration was substituted by FBF and its effects on sucking pig as substitution for Fe injection, its feeding effects on growing, fattening and growing-fattening pigs, changes during storage, digestibility, economics, backfat thickness and hematological values were examined and gave results as follows. 1. Analysis of proximate composition and mineral contents of briquette and briquette-ash. Briquette-ash contained moisture(0.15%), C·protein (0.52%), C·fat (0%), C·fiber (4.13%), NFE (0%), C·ash (95.35%), Ca (0.807%), P (0.074%), K (0.138%), Na (0.025%), Mg (0.025%), Mg (0.183%), Fe (3,769mg/kg), Mn (98mg/kg), Zn (139mg/kg), Cu (21.0mg/kg). And in the briquette contained NFE (10.96%), C·ash (71.35%), Ca (0.224%), P (0.043%), K (0.158%), Na (0.039%), Mg (0.19%), Fe (7,385mg/kg), Mn (116mg/kg), Zn (306mg/kg), Cu (17.5mg/kg). 2. Analysis of Fish soluble-absorbed Briquette ash Feed (FBF). To study the effects of feeding Fish soluble-absorbed Briquette ash Feed (FBF) in pigs, firstly the chemical composition, mineral contents and amino acids contents of briquette ash absorbed concentrated fish solubles were analyzed. Increasing absorbed rate of concentrated fish soluble to briquette ash, chemical composition, mineral contents and amino acids contents resulted higher. 3. When the briquette-ash was fed ad libitum to sucking and growing-fattening pigs as micromineral supplements; (1) Body weight gain was little higher in the briquette-ash supplied group than control(p>0.05). (2) In the growing-fattening pig, feed efficiency was better in the control group (4.71) than the briquette-ash supplied group (4.84). (3) In the weaning pig the feed efficiency was 3.0 and suplemental effects of briquette-ash were outstanding in atrophic pigs. (4) Making economical analysis by term of feed cost per kg weight gain, in the briquette-ash supplemented group, the feed cost was increased to 852 won where it was 829 won in the control group. (5) In the weaning pig group, 528 won was used per kg weight gain. (6) The palatability of briquette-ash was good and healty conditions were normal, too. 4. When the briquette-ash was supplemented in 3%(T1), 5%(T2) and 10%(T3) to the sucking, weaning and growing pigs; (1) When the briquette-ash was fed as substitution for Fe injection for sucking pigs, the growing state and health conditions were good enough. (2) Body weight gain was best when 3% of briquette-ash was supplemented(p>0.05). (3) There was no significant difference in feed efficiency(p>0.05). (4) Feed costs required per kg weight gain for T1, T2 and T3 were 636.40, 672.52 and 684.56 won respectively. (5) Hematological values of treatment group were in normal range. 5. Effects of briquette-ash addition as substitution for Fe injection when breeding and sucking pigs are fed with briquette-ash. (1) The pig of this college (5.27kg) had slightly heavier average weight at the age fo 3 wks. than the purebred of National Livestock Breeding Station(5.00kg). (2) The purebred (8.3pigs. 88.3%) had higher litter size and survival rate at weaning than the pig of this college. (3) The pig of this college (17.8kg) had slightly heavier average weight at weaning than the purebred of National Livestock Breeding Station (17.4kg). (4) In the group equal to farrowing season and litter size at sucking, there were nonsignificant defferences for the reproductive traits between briquette-ash addition and Fe injection group. (5) When fed liberally, briquette-ash as the substitute for Fe injection in sucking pig, there is relatively superior tendency to the growth and health conditions in pigs. 6. When the Fe injection was reduced to once and briquette-ash was supplied liberally; (1) Pig weight at 21 days was heavier in the pigs feeding briquette-ash after injected Fe once than in those injected Fe twice. (2) Pig weight at weaning(16.8kg) was lower in the pigs feeding briquette-ash after injected Fe once than in those injected Fe twice (17.4kg). (3) Pig weight at 15 wks. was heavier in the pigs feeding briquette-ash after injecte Fe once (48.85kg) than in those injected Fe twice (46.0kg). (4) Final body weight was heavier in the pigs feeding briquette-ash after injected Fe once (78.3kg) than in those injected Fe twice (71.6kg). (5) Feed efficiency was better in the pigs feeding briquette-ash after injected Fe once (2.32) than in those injected Fe twice (2.34) (6) The health conditions of the pigs feeding briquette-ash injected Fe once were normal. (7) The results obtainced in this study suggest that briquette-ash feeding can substitute Fe injection effectively supplementing sufficient microminerals from growing to fattening. 7. The results of feeding briquette-ash to pigs during 4 years from 1981 to 1984 in substitution for Fe injection and as micromineral supplements are reviewed. Generally, when sows are fed briquette-ash ad libitum, there were no significant differences in birth weight, weight at 21 days and weight at 56 days. The survival rate was better in the briquette-ash supplemented group. However when the briquette-ash was supplied continuously after weaning, there were significant differences in weight at 15 days, weight gain and feed efficiency. In conclusion, it might be suggested that the pigs farrowed from sows fed ad libitum briquette-ash could grow without Fe injection and when fed briquette-ash ad libitum, it can prevent micromineral deficiency and gain body weight more rapidly. 8. When FBF was added by 5% in the growing pig ration and 10% in the fattening pig ration; (1) Daily body weight gain was higher in the treatment group (784.52g) than the control group (645.24g). (2) Feed intake was higher in the treatment group (185.53kg) than the control group (165.46kg). (3) Feed efficiency was significantly higher in the treatment group (2.82) than the control group (3.05). (4) Adding FBF in ration, 49.45 won was saved per kg body weight gain. (5) Ages at 90kg were shortened by 14 days in the treatment group (155d) than the control group (169d). 9. Effects of levels 0%(C), 3%(T1), 5%(T2), and 10%(T3) of substitution of FBF (1) Growing period 1) Daily body weight gain was higher in the treatment group (T1:658g, T2:686g, T3:683g) than the control group (618g). 2) Daily feed intake was in order of T3:1.61kg>T2:1.59kg>T1:1.55kg>C:1.54kg. it increased according to the level of fish soluble. 3) Body weight gain was in order of T2:38.47kg>T3:38.20kg>T1:36.83kg>C:34.59kg. Feed efficiency was in order of T2:2.32>T3:2.37>T1:2.36>C:2.49. Generally the treatment group was better than the control group. 4) Feed cost per kg weight gain was lowest in T2(291.24won) and it saved 24.62won per kg weight gain compared to the control group. 5) There was no significant difference in the digestibility of growing diets and it was stable during the storage period. (2) Fattening period 1) Daily weight gain was higher in T3 (779.33g) and T2 (752.0g) than control (674.0g) significantly (p<0.01). Feed efficiency and ages at 90kg were also better in the treatment group. 2) Digestibility was improved in the treatment group by not signivicantly. 3) Until the 7th day of storaging period, the chemical composition of FBF added ration decreased but it did not show any change until the 27th day. 4) Backfat thickness was significantly (p>0.01) thinner in T3 (1.51cm) than control (1.56cm). 5) Dressing percentage was significantly (p>0.01) higher in the treatment group (63.67∼64.65%) than in the control group (61.99%). 6) Feed costs required per 1kg weight gain were 386.81 won in control, 374.91won in T1, 347.79 in T2 and 336.99won in T3. As result feed costs were saved adding FBF in the ration. (3) Growing-fattening period 1) Weight gain, feed efficiency and ages at 9kg were significantly higher in FBF added T2(5%) and T3(10%) group. 2) Digestibility of growing and fattening diet was improved in the treatment group but not significantly. 3) The chemical composition of FBF added ration decreassed slightly till the day 7 of storaging period. But after 7th day it did not show and change untill the dat 27. 4) Backfat thickness was significantly (p<0.01) thinner in T3 (1.51cm) than control (1.56cm). 5) Dressing percentage was significantly (p<0.01) higher in the treatment group (63.67∼64.65%) than in the control group (61.99%). 6) Feed costs required per 1kg weight gain were 350.71won in control, 336.32 won in T1, 320.89won in T2 and 316.11won in T3. As result feed costs were saved when FBF was added in the ration. 10. When the ration was substituted by FBF and fish soluble by 10% respectively; (1) Final weight and daily weight gain were 94.05kg, 678g in control group whereas 98.65kg, 752g in FBF substituted ration and 95.40kg, 709g in fish soluble substituted ration. (2) Feed efficiency was 3.65 in control group whereas 3.24 in FBF substituted ration and 3.40 in fish soluble substituted ration giving better resuluts. (3) Feed cost required per kg weight gain was in order of FBF substituted ration (369.33 won), fish soluble substituted ration(388.15 won) and control group (413.56 won). (4) Ages at 90kg were in order of FBF substituted ration (162.1), fish soluble substituted ration (163.7) and control group (166.9). 11. Hematological values of FBF fed pigs RBC, hemoglobin, hematocrit and WBC were higher in the non-treated group, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration were a little higher in the treated group. And all the above hematological values including differential count were within the normal range. 12. Effects of FBF addition as substitution for Fe injection for sucking pigs. (1) Daily feed consumption was larger by 10g in the treatment group (418g) than in the control group(408g). (2) Average daily weight gain was larger by 73.95g in the treatment group (296.98g) than in the control group (222.94g). (3) Feed efficiency was higher in the treatment group (1.41) than in the control group (1.83). (4) When the sucking pigs were fed liberally FBF as the substitute for Fe injection, there was relatively superior tendency to their growth and health conditions. 13. Production cost of FBF per kg (when the production cost of 1kg of FBF is fixed as 100 won) (1) Growing 0% ; 125.34 won, 3% ; 125.56 won, 5% ; 126.03 won and 10% ; 125.43 won (2) Fattening 0% ; 113.31 won, 3% ; 113.52 won, 5% ; 113.68 won and 10% ; 114.10 won As conclusion, making FBF with the abandoned briquette-ash and fish soluble results in lowering feed cost, increasing feed efficiency, increasing nutrient availability, decreasing pollution, saving the foreign currency used to import feed ingredients and increasing farmers income.

원발성 연수 출혈증 1예

하현욱,한정호,이정석,송은향,김우정,김두응,최진영 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Pure primary medullary hemorrhage is a rare condition, which is characterized by ipsilateral hypoglossal nerve palsy and contralateral hemiparesis. The hemorrhage usually extended to medial and ventral medulla, these two characteristic signs distinguished from the classical presentation of Wallenberg's lateral medullary syndrome. A 53-years-old man was admitted with sudden onset left sides weakness and vertigo. Neurologic examination showed dysarthria, mild dysphagia, Horner syndrome of right side, spontaneous horizontal jerking nystagmus to left side and right deviation of tongue at protrusion. Pain and temperature sensation of left trunk, left extremity and right face were decreased. Brain CT scan and brain MRI revealed focal hemorrhage in the right medulla. We report a case of pure primary medullary hemorrhage with undetermined etiology.

가교화 쌀 전분의 이화학적 특성

최현욱,정구민,김정호,문태화,박천석,백무열 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

돼지의 仔豚體重間의 相關에 관한 硏究

金哲旭,鄭鉉丞 진주산업대학교 1985 論文集 Vol.23 No.-

本 硏究는 慶尙南道 種畜場에서 1982年부터 1983年까지 2年間 分娩한 Landrace, Berkshire 및 Yorkshire種의 仔豚 總 2,498頭에 대한 仔豚體重成績을 근거로 SPSS Package Program을 이용하여 品種, 産次, 分娩季節, 姙娠期間 및 性別에 따라 仔豚體重間의 相關係數를 推定하였던 바 그 結果를 要約하면 다음과 같다. 品種別 仔豚體重間의 相關에 있어서는 Birkshire種에 있어서 生時體重과 21日齡體重間의 相關係數가 Yorkshire種의 것보다 有意的으로(p<.05)높아 Birkshire種의 仔豚은 生時體重이 무거울수록 21日齡體重이 增加될 수 있는 것 같다. 21日齡體重과 56日齡體重間의 相關係數는 品種間에는 아무런 差異가 없었지만 生時體重보다는 21日齡體重이 56日齡體重과 더 큰 相關이 있었다. 産次別 仔豚體重間의 相關에 있어서는 生時體重과 21日齡體重間의 相關係數는 7産次와 1·4·5·8産次間에는 有意的인(p<.05) 差異가 있었고, 특히 7産次에 있어서 相關係數가 .5118로 生時體重과 21日齡體重間에는 밀접한 相關이 있었다. 21日齡體重과 56日齡體重間의 相關係數는 1産次를 除外한 나머지 産次群에서 모두 높게 나타나 21日齡體重이 무거울수록 56日齡體重이 增加될 수 있는 것 같다. 分娩季節別 生時體重과 21日齡體重·56日齡體重間의 相關係數는 季節間에 아무런 差異가 없었지만 21日齡體重과 56日齡體重間의 相關係數가 가을과 겨울群이 봄과 여름群에서 보다 有意的(p<.05)으로 높았다. 姙娠期間別 仔豚體重間의 相關에 있어서는 生時體重과 21日齡體重間의 相關係數가 110日과 111日群間에서 有意的(p<.05)으로 差異가 있었고 나머지 群에서는 差異가 없었다. 生時體重과 56日齡體重間의 相關係數는 111日과 119日群에서 각각 .6840과 .5935로 다른 群보다 有意的으로 높았고 21日齡體重과 56日齡體重間의 相關係數에서는 112日과 110日群에서 有意的인 差異가 있었고 112日群에서 相關係數가 .7275로서 가장 높았다. 性別에 있어서 生時體重과 21日齡體重, 56日齡體重間의 相關係數가 암컷보다 수컷에서 有意的으로 높게 나타났다. 이상과 같은 結果를 종합적으로 검토해 보면 生時體重은 56日齡體重보다 21日齡體重과 더 相關이 높고 21日齡體重과 56日齡體重間의 더 높은 相關이 있기 때문에 21日齡體重이 무거우면 무거울수록 56日齡體重이 增加되어지는 것으로 생각할 수 있다. This study was conducted to estimate the correlation coefficient between pig weights by breed, parity, farrowing season, duration of pregnancy and sex on the basis of the data obtained from total 2,498 pigs of Landrace, Birkshire and Yorkshire born from 1982 to 1983 at the livestock station, Gyeongsang Nam-do. The data were analyzed by the SPSS package program(Nie, 1975) and Miller's method(1983) and the results obtained were as follows: In correlation coefficients between pig weights by breed, the correlation coefficients between pig weights at birth(PWB) and pig weight at 21 days(PW21) in Birkshire were significantly(p<.05) higher than that in Yorkshire and PW21 in Birkshire seemed to increase more as PWB was heavier. Though the correlation coefficient between PW21 and Pig weight 56days(PW56) was nonsignificant differences(p>.05) between breeds, PW21 was more correlated with PW56 than PWB. In correlation coefficients between pig weights by parity, the correlation coefficient between PWB and PW21 was significant differences(p<.05) between 7th parity and 1, 4, 5 and 8th parity groups, specially the correlation coefficient between PWB and PW21 in the 7th parity group was .5118, and there was the high correlation between PWB and PW21. The correlation coefficient between PW21 and PW56 was high in the other groups except the first parity and PW56 in parity seemed to increase more as PW21 was heavier. In correlation coefficients between pig weights by farrowing season, though the correlation coefficients between PWB and PW21 and PW56 were nonsignificant differences(p>.05), the correlation coefficient between PW21 and PW 56 was significantly(p<.05) higher in the fall and winter-born groups than in the spring and summer born groups. In correlation coefficients between pig weights by duration of pregnancy, the correlation coefficient between PWB and PW21 was significant differences(p<.05) between the 110 days group and the 111 days group and nonsignificant(p>.05) between the other groups. The correlation coefficient between PWB and PW56 was significantly(p<.05) higher with .6840 and .5935 in the 11 days and 119 days groups than in the other groups, and the correlation coefficient between PW21 and PW56 was significant differences(p<.05) between the 112 days group and the 110 days groups. The correlation coefficient in the 112 days group was the highest with .7275. In correlation coefficients between pig weights by sex, the correlation coefficients between PWB and PW21 and PW56 were significantly(p<.05) higher in the male group than in the female group. Specially, PW 21 was more correlated with PW56 than PWB. From the results summarized as above, it could be inferred that PWB be more correlated with PW21 than PW56, and PW56 seem to increase more as PW21 was heavier because there was the more correlation between PW21 and PW56.

개구리(Rana nigromaculata)胃 粘液質의 組織化學的 硏究

趙顯旭,朴重錫,河在淸 慶尙大學校 1985 論文集 Vol.24 No.2

개구리 위 점막내에 존재하는 점액질의 성분을 변태 시기에 따라서 조직화학적으로 관찰하였다. 원주세포 내 점액질은 변태 XVI와 XXIV 시기에는 바황화점액질로 된 산성점액질에 비해서 중성점액질이 주를 이루었고 변태 XX 시기에서는 산성 및 중성점액질이 혼재하였다. 점액선 세포내 점액질은 관찰된 변태 세 시기에서는 주로 중성점액질로 되어 있었다 This study was-performed histochemically to observe the responses of mucus secreting cells in the gastric mucosa of frog, Rana nigromaculata during metamorphosis. The obtained results were as follows: 1. Columnar cells contained a small amount of acidic mucosubstances including nonsulfated. mucin and a large amount of neutral mucosubstances at XVI and XXIV stages of metamorphosis. At XX stage, columnar cells contained acidic and neutral mucosubstances. 2. Mucous glands contained mainly neutral mucosubstances at XVI, XX and XXIV stages.

접착제와 와동형성의 차이에 따른 5급 복합레진 수복의 전향적 임상연구

이경욱,정세준,한영철,손호현,엄정문,오명환,조병훈 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.4

본 연구의 목적은 복합레진을 이용한 비우식성 치경부 5급 병소 수복에 있어서, 3가지 다른 접착제를, 유지구를 부여한 치아와 부여하지 않은 치아에 적용하였을 때의 임상적인 효능의 차이를 비교하기 위함이다. 총 150개의 치아를 각각 25개씩 6개의 군으로 나누었다. A군 Scotchbond Multi-Purpose (SBMP, 3M ESPE, St, Paul, MN, USA, 4세대 접착제)를 사용하고 유지구를 부여하지 않음. B군: SBMP를 사용하고 유지구를 부여. C군: BC Plus (Vericom Co., Anyang, Gyeonggido, Korea, 5세대 접착제)를 사용하고 유지구를 부여하지 않음. D군: BC Plus를 사용하고 유지구를 부여. E군: Adper Prompt (3M ESPE, Seefeld, Germany, 6세대 접착제)를 사용하고 유지구를 부여하지 않음. F군: Adper Prompt를 사용하고 유지구를 부여. 모든 치아는 복합레진인 Denfil(Vericom Co., Anyang. Gyonggido. Korea)을 이용하여 충전하였다. 수복 직후와, 수복 6개월 후에 modified USPHS (United States Public Health Service) criteria에 따라 수복물을 임상적으로 평가하였다. 추가적으로 임상사진을 촬영하였으며, 에폭시 레진을 이용하여 복제한 후 주사전자현미경을 이용하여 이를 관찰하였다. 6개월 후 관찰 결과. alpha rating의 수가 각 실험군마다 동일하지는 않았지만, 통계적으로는 3가지의 접착제간에 유의할만한 차이는 없었고, 기계적인 유지구를 부여한 군과 부여하지 않은 군 간에도 유의할만한 차이는 없었다 (p > 0.05). 그러나 6개월의 관찰 기간은 일반적으로 기대되는 레진의 수명보다 짧기 때문에, 각 실험군 간의 차이를 알아보기 위해서는 추후 더 오랜 기간의 관찰이 요구된다. The purpose of this study is to evaluate prospectively the effect of different bonding systems and retention grooves on the clinical performance of resin restorations in non-carious cervical lesions (NCCLs). Thirty nine healthy adults who had at least 2 NCCLs in their promolar areas were included in this study. One hundred and fifty teeth were equally assigned to six groups; (A) Scotchbond Multi-Purpose (SBMP, 3M ESPE, St, Paul, MN, USA, 4th generation bonding system) without retention grooves; (B) SBMP with retention grooves: (C) BC Plus (Vericom Co., Anyang, Gyeonggido, Korea, 5th generation bonding system) without retention grooves; (D) BC Plus with retention grooves; (E) Adper Prompt (3M ESPE, Seefeld, Germany, 6th generation bonding system) without retention grooves: (F) Adper Prompt with retention grooves. All cavities were filled with a hybrid composite resin, Denfil (Vericom Co., Anyang, Gyeonggido, korea) by one operator. Restorations were evaluated at baseline and at 6-month recall, according to the modified USPHS (United states Public Health Service) criteria, Additionally, clinical photographs were taken and epoxy resin replicas were made for SEM evaluation. At 6-month recall, there were some differences in the number of alpha ratings among the experimental groups. But, despite the differences in the number of alpah ratings, there was no significant difference among the 3 adhesive systems (p > 0.05). There was also no significant difference between the groups with or without mechanical retention (p > 0.05). Follow-ups for longer periods than 6 months are needed to verify the clinical performance of different bonding systems and retention grooves. 〔J Kor Acad Cons Dent 31(4):300-311, 2006〕

당뇨병 환자에서 혈장 Thrombin-Antithrombin Ⅲ 및 Plasmin-α_2-Plasmin Inhibitor 복합체의 임상적 의의

김경욱,김은숙,정상수,윤수지,박우일,이준희,남수연,안철우,문병수,김경래,차봉수,송영득,임승길,이현철,허갑범 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.5

연구배경:당뇨병 환자에서 혈액응고 및 섬유소용해 체계의 이상경향이 있어 그 결과로 여러 혈관합병증의 발생위험이 높다는 사실은 널리 알려져 있다. 그 기전은 아직 확실히 밝혀지지 않았으나, 고혈당으로 인한 혈장 단백질들의 비효소성 당화작용이나 산화성 스트레스로 인한 유리 라티칼 작용으로 응고항진이나 섬유소용해 활성의 저하를 유발하는 것으로 생각되고 있다. 최근 응고 및 용해인자와 그 억제자의 복합체들의 증가가 이 상태를 비교적 예민하게 반영한다고 알려져 있다. 방법:본 연구에서는 당뇨병 환자 101명과 정상 대조군 20명에서 혈장내 thrombin­antithrombin complex(TAT)와 plasmin­α₂­plasmin inhibitor complex(PIC)를 측정하여 비교하고, 당뇨병 환자에서 미세혈관 합병증과 대혈관합병증의 유무에 따른 차이와, 이미 혈관 질환의 위험인자로 알려져 있는 인자들간의 상관성을 알아보고자 하였다. 결과:1. 환자의 분포를 살펴보면 혈관합병증이 있는 군은 85명, 혈관합병증이 없는 군은 16명이었고, 평균연령은 각각 57.9±14.1세, 49.9±16.6세로 혈관 합병증이 있는 군에서 더 나이가 많았고, 체질량지수는 23.2±3.4㎏/㎡, 24.1±3.4㎏/㎡로 두 군간 유의한 차이는 없었다. 또 두 군간의 혈압 및 HbA1c, 공복혈당 및 인슐린과 C­peptide, 총 콜레스테롤, 중성지방, HDL­콜레스테롤, Lp⒜는 유의한 차이가 없었고, 미세혈관합병증이 있는 군에서 당뇨병의 유병기간이 길었다. 2. TAT 및 PIC의 농도는 정상 대조군에서는 2.8±1.2 ng/mL, 240.4±69.7 ng/mL이었고, 당뇨병 환자군에서는 9.5±22.6 ng/mL, 472.2±258.7 ng/mL이었다. TAT와 PIC 모두 당뇨병 환자군에서 정상 대조군에 비해 유의하게 증가되어 있었고(p<0.001), TAT/PIC ratio는 두 군간 차이가 없었다. 3. 당뇨병 환자의 혈관합병증에 따른 TAT 및 PIC, fibrinogen 농도는 합병증이 없는 군은 각각 4.1±2.4ng/mL, 362.2±272.0ng/mL, 322.7±102.4mg/mL으로 PIC와 fibrinogen의 증가를 보였으나, 연령을 보정한 후에는 통계학적 유의성은 없었다. 또 대혈관 합병증군에서는 각각 6.0±4.9 ng/mL, 507.4±321.6 ng/mL, 427.1±194.7 mg/dL이었으며 미세·대혈관 합병증군에서는 10.4±6.4 ng/mL, 484.8±269.7 ng/mL, 388.4±132.4 mg/dL으로 TAT의 증가를 보였으나 역시 연령을 보정한 후에는 통계학적 유의성은 없었다. 4. 미세혈관합병증군에서 HbA1c(>8%)가 높은 군의 PIC 농도가 유의하게 높았고(p=0.049), 대혈관합병증군에서 HbA1c(>8%)가 높은 군의 총 콜레스테롤 농도가 유의하게 높았다(p=0.042). 5. 총 당뇨병 환자군에서 PIC는 fibrinogen과 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며(r=0.47, 0.31,-0.25), 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다(r=0.67). 결론:이상의 결과에서 혈장 TAT 및 PIC 농도는 당뇨병 환자에서 정상 대조군에 비해 의미있게 증가되어 있었고, 당뇨병 환자군에서는 연령의 증가와 유병기간이 혈액응고항진 및 용해의 장애에 큰 역할을 함을 알 수 있었으며, 총 당뇨병 환자군에 PIC와 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다. 따라서 당뇨병 환자에서 혈액응고 및 용해의 장애가 동반되어 있다고 볼 수 있으며, 혈장 TAT 및 PIC는 혈관합병증으로의 진행을 예측하는 지표로서 유용하리라 생각된다. 또 혈당조절정도와 상관성이 있으므로 혈당조절후에 추적검사를 시행하여 합병증의 예방이 가능한지 추후 연구가 필요하리라 생각된다. Background : Abnormality of coagulation and fibrinolystic system is known as a predisposing factor of vascular complication in diabetes. Although the pathogenesis is not well known, non-enzymatic glycation reaction and the increase in production of free radicals due to an increased oxidative stress may be linked to the hypercoagulibility and hypofibrinolytic activity. As indices of abnormality in coagulation and firinolysis in peripheral blood, plasma thrombin-antithrombin Ⅲ complex (TAT) and plasmin-α_2-plasmin inhibitor complex (PIC) were measured. The purpose of this study was to clarify whether hypercoagulability exists in diabetic patients with or without vascular complication. Methods : In our study, we measured plasma thrombin-antithrombin Ⅲ compelx (TAT) and plasmin-α_2-plasmin inhibit or complex (PIC) in 101 diabetic subjects and 20 controls. Comparing TAT and PIC levels in diabetic microvascular complication group, diabetic macrovascular complication group and controls, we examined correlation between risk factors associated with diabetic vascular complication. Results : 1. The group with diabetic vascular complication was older than group without complication. There was no significant difference in BMI, blood pressure, HbA_ic, blood sugar level, insulin, C-peptide, serum creatinine, total cholesterol, triglyceride, HDL-cholesterol, Lp (a) between two groups. The group with diabetic microvascular complication had longer duration of diabetes. 2. Concentration of TAT and PIC were 2.8±1.2 ng/ mL, 240.4±69.7 ng/ mL in controls and 9.5±22.6 ng/ mL, 472.2±258.7 ng/ mL in diabetic patients, respectively. TAT and PIC were significantly higher in diabetic patients than in control (p<0.001). But TAT/PIC ratio was no significant difference between two groups. 3. In diabetic patients, concentration of TAT and PIC and fibrinogen were respectively 4.1±2.4 ng/ mL, 362.2±272.0 ng/ mL, 322.7±102.4 mg/ dL in group without vascular complication and 5.3±4.1 ng/ mL, 529.5±258.7 ng/ mL, 374.9±106.2 mg/ dL in group with microvascular complication, which group had increase in PIC and Fibrinogen but no significance after correction of age. Concentration of TAT and PIC and Fibrinogen were 60.±4.9 ng/ mL, 507.4±321.6 ng/ mL, 427.1±194.7 mg/ dL in macrovascular complication, and 10.4±6.7 mg/ mL, 484.8±269.7 ng/ mL, 388.4±132.4 mg/ dL in combined vascular complication which group showed increase of TAT but also had no significant increase after correction of age. 4. In diabetic microvascular complication patients, group of high HbA_1c (>8%) (p=0.049) had significant high PIC concentration. In diabetic macrovascular complication patients, group of high HbA_1c (>8%) (p=0.042) had significant high total cholesterol concentration. 5. In all diabetic patients, PIC was positively correlated with fibrinogen and HbA_1c and negatively correlated BMI (r=0.47, 0.31, -0.25). Only in daibetic patients without angiopathy, TAT was positively correlated with HbA_1c (r=0.67). Conclusion : In this study, plasma TAT and PIC concentration significantly increased in diabetic patients compared with controls, and PIC was increased in group with microvascular complication, TAT were increased in group with combined micro macrovascular complication. However, there was no significance relationship existed when correctinf for age. PIC was correlated with HbA_1c. TAT was correlated with HbA_1c only in the group without angiopathy. Abnormality of coagulation and fibrinolysis were combined in diabetes, plasma TAT and PIC can be used as an index of vascular complication. Also we found the correlation with the degree of the blood glucose control. Therefore we need follow up study for the possibility of prevention of vascular complication after controlling the blood glucose to age-matched patients (J Kor Diaabetes Asso 25:354~363, 2001).