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cDNA Cloning and EXpression of a Cytochrome P450 1A(CYP1A) from the Pale Chub, Zacco platypus
( Hyoung Joo Jeon ),( Young Chul Park ),( Wan Ok Lee ),( Jong Ha Lee ),( Jin Hyoung Kim ) 한국하천호수학회(구 한국육수학회) 2011 생태와 환경 Vol.44 No.4
The pale chub (Zacco platypus) is generally found in Asian countries, such as Korea, Japan, and China. Nevertheless, very little information exists about the genes involved in the metabolism of xenobiotics in this species. This species is useful in monitoring the environmental impact on various pollutants in freshwater as a sentinel fish species. We cloned the full-length cUNA sequence of xenobiotic metabolizing cytochrome P450 1A (CYP1A) gene from Z. platypus and characterized it. Tissue distribution and time-dependent induction of CYP1A were studied by real-time RT-PCR. Induction pattern of CYP1A were studied by exposing the fish to an arylhydrocarbon receptor agonist, β-naphthoflavone (BNF). The liver showed the highest level of expression in basal state as well as BNF- treated fish. However, appreciable levels of expression were also recorded in Gill and kidney and the least level of expression was observed in the eye. The results of the time-course study revealed an induction in the liver, brain, and gills after 6 h and 12 h in most of the tissues. This study provides an insight into the xenobiotics metabolizing system of Z. platypus and offers baseline information for further research related to biomarker, stress, and adaptive response of this ecologically important fish species in the freshwater environment.
김주형 ( Joo Hyoung Kim ),전용철 ( Yong Cheol Jeon ),김태엽 ( Tae Yeob Kim ),은창수 ( Chang Soo Eun ),손주현 ( Joo Hyun Sohn ),한동수 ( Dong Soo Han ),장재정 ( Jae Jung Jang ),박용욱 ( Yong Wook Park ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.5
Intestinal tuberculosis is a common disease of extrapulmonary tuberculosis and should be differentiated from the inflammatory bowel diseases and malignancy such as Crohn`s disease, ulcerative colitis, amebic colitis, and colon cancer. Most frequently involved sites (75% of cases) are the terminal ileum and cecum. Other sites of involvement, in order of frequency, are ascending colon, jejunum, appendix, duodenum, stomach, esophagus, sigmoid colon, and rectum. Intestinal tuberculosis simultaneously involving the stomach and colon has been very rarely reported. Recently, we experienced a case of synchronous gastric and colonic ulcers with granulomatous inflammation. Although we did not find acid fast bacilli and the culture test was negative, empirical anti-tuberculosis therapy resulted in dramatic clinical and endoscopic improvement. We report a rare case of multifocal gastrointestinal tuberculosis with a review of literature. (Korean J Gastroenterol 2008;52:320-324)
Cho, Jin-Hyoung,Jeon, Young-Joo,Lee, Ra-Ham,Shim, Jung-Hyun,Chae, Jung-Il 한국유기농업학회 2014 韓國有機農業學會誌 Vol.22 No.1
Korean Panax ginseng C. A. Meyer (P. ginseng) is a well-known and one of the most important tonic herbs used in traditional Korean medicine. The pharmacological effects of P. ginseng have been reported by many researchers. Nevertheless, little is known between the mechanism of action and the active compounds. In this study, we performed a comprehensive proteomic analysis and protein categorization in order to understand the physiological characteristics of the major components in the adventitious roots of P. ginseng. Whole proteins extracted from the cultured adventitious roots of P. ginseng were separated by two-dimensional polyacrylamide gel electrophoresis (2-DE). Among the 1000 spots which were detected by silver staining, 113 spots were labeled and identified by matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF MS). Our results showed that 40 proteins were identified among the 113 spots, with a hit ratio of 35.3%. A number of proteins identified on the 2-DE gels (30%; 16 spots) were involved in energy metabolism. These proteomic data will be helpful to better understand the physiological and pharmacological effects of P. ginseng.
Joo, Yuri,Ahmed, Mohammad Shamsuddin,Han, Hyoung Soon,Jeon, Seungwon Pergamon Press 2017 International journal of hydrogen energy Vol.42 No.34
<P><B>Abstract</B></P> <P>The synthesis and performance of electrochemically reduced graphene oxide-based silver-cobalt (AgCo/ERGO) alloy electrocatalysts for the oxygen reduction reaction (ORR) are discussed in this study. The surface morphology, alloying nature, and chemical changes of the bimetallic precursors within the AgCo/ERGO catalyst has examined in detail. The presence of poly(ethylene glycol) (PEG) and a cobalt precursor during the electroreduction step is a necessary condition for synthesizing a highly active and stable alloy electrocatalyst for the ORR. Morphological analysis demonstrated that the AgCo nanoparticles (NPs) are homogeneously dispersed on the ERGO support with the assistance of PEG, thus resulting in higher electrochemical surface area and mass activity. X-ray analysis also confirmed the successful formation of the AgCo alloy NPs and the electrochemical reduction of graphene. The direct four-electron transfer pathway for ORR with minimal H<SUB>2</SUB>O<SUB>2</SUB> yield has committed at the AgCo/ERGO catalyst over other catalysts. The as-prepared AgCo/ERGO catalyst has shown better electrocatalytic activity, stability, and tolerance to crossover effects compared to the state-of-the-art Pt/C catalyst for ORR.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ERGO-based AgCo alloy catalyst (AgCo/ERGO) was prepared for ORR electrocatalysis. </LI> <LI> The PEG is necessary for synthesizing a highly active and stable alloyed catalyst. </LI> <LI> Direct 4<I>e</I> <SUP>−</SUP> transfer pathway ORR with minimal H<SUB>2</SUB>O<SUB>2</SUB> yield has committed at AgCo/ERGO. </LI> <LI> AgCo/ERGO showed better ORR catalytic activity, stability, selectivity than Pt/C. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
S-80 Clinical outcomes of Lower gastrointestinal bleeding
( Hyoung Il Choi ),( Min Seob Kwak ),( Jae Myung Cha ),( Yong Jae Han ),( Jin Young Yoon ),( Jung Won Jeon ),( Hyun Phil Shin ),( Kwang Ro Joo ),( Joung Il Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Goals:?The aim of this study was to identify the clinical outcomes of lower gastrointestinal bleeding (LGIB) and predictors of poor outcomes in LGIB compared with those of upper gastrointestinal bleeding (UGIB).?Background:?The incidence of LGIB are increasing, however, predictors of outcomes in LGIB are not as well-defined as in UGIB.?Study:?This study was performed in patients with LGIB or UGIB who underwent endoscopic procedures between July 2006 and February 2013. Propensity score matching was used to improve comparability between LGIB and UGIB groups.The clinical outcomes and predictors of 30-day rebleeding and mortality rate were analyzed between two groups.?Results:?In total, 601 patients affected with UGIB (n=500) or LGIB (n=101) were finally eligible, and 202 patients with UGIB and 101 patients with LGIB were analyzed after 2:1 propensity score matching. The 30-day rebleeding and mortality rate were 9.9% and 4.5% for UGIB group and 16.8% and 5.0% for LGIB group, respectively. After logistic regression analysis, Rockall score (p=0.013) and CRP (p=0.047) were significant predictors of 30-day mortality, however, nothing predicted rebleeding in patients with LGIB. Conclusions:?The clinical outcomes of LGIB are not better than those of UGIB. Clinical Rockall score and serum CRP level may be used as a predictor of 30-day mortality in the patients with LGIB.