Biofilter modeling integrated with Lim’s adsorption model

Eun Ju LEE,Wui Sook JEON,Hye Min YOON,Hye Jin SONG,Byeung Soo KIM,Hee Jeong KIM,Eun Jeong OH,Kwang-Hee LIM 한국생물공학회 2011 한국생물공학회 학술대회 Vol.2011 No.10

일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성

주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-

Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.

2003년 5월의 연무 관측시 에어로졸의 기상·물리·화학 특성

임주연,전영신,조경미,이상삼,신혜정 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.5

Severe haze, mist, and fog phenomena occurred in the central part of Korea during 15~25 May 2003 resulted in poor visibility and air quality. When these phenomena occurred, Korean peninsula was under the effects of anticyclone. The atmosphere was stable, and wind speed was so weak. Under this meteorological conditions, air quality was worse and worse. The characteristics of aerosol in Seoul, Incheon, and Gosan (Jeju) during this period are investigated from the PM_(10). TSP concentrations and aerosol number concentrations. Concentrations of PM_(10) and TSP measured at KMA increased upto 176 and 230㎍/㎥ on 22 May 2003, respectively. Aerosol number concentrations of size range from 0.82 to 6.06 ㎛ increased in Seoul on 17, 19, and 21~24 May 2003, and the concentrations of NO₂ and SO₂had maximum value of 0.165 ppm at Gwanak Mt. and 0.036 ppm at Guro-dong on 23 May 2003, respectively. Result from analysis on heavy metal elements showed high concentrations of Zn, Pb, Cr, Ni, Cu, and Cd during 20~24 May 2003. This event is examined by comprehensive analyses of synoptic weather conditions, satellite images, concentrations of suspended particles and air pollutants, and heavy metal elements.

급성 복통을 주소로 진단된 자발성 양측 부신 출혈에 의한 부신피질부전

조아름,홍주영,김동호,박민지,권미혜,박근용,원희관,임동미 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.S

Thomas Addison은 1855년 발표된 그의 논문에 일차성 부신피질부전에 의하여 발생한 근력 약화, 피로, 식욕부진, 복통, 체중감소, 색소침착 등에 대하여 처음으로 기술하였다[1,2]. 부신피질부전은 부신피질의 파괴에 의해 발생하는 당질 코르티코이드 결핍과 관련된 일차성과 뇌하수체에서 혈청 부신피질자극 호르몬(adrenocorticotropic hormone, ACTH)의 분비장애에 의해 발생하는 이차성으로 구분할 수 있다. 일차성과 이차성의 중요한 차이는 무기질 코르티코이드의 결핍이 일차성에는 있고 이차성에 는 없다는 점이다. 일차성 부신피질부전의 원인으로 이전에는 결핵에 의한 양측 부신 파괴가 가장 흔한 원인이었으나, 결핵 진단율 및 치료약제 보급률이 좋아진 20세기 후반부터는 감소 추세를 보이고 있으며, 선진국에서는 자가면역성 부신염에 의한 일차성 부신피질 부전이 80~90%로 가장 흔한 것으로 보고되었다[3]. 이외에 다른 감염성 질환, 전이성 암, 림프종, 부신출혈 또는 경색, 약물 등의 원인을 들 수 있다. 일차성 부신피질부전의 임상 증상과 징후로는 전신무력감, 식욕부진, 피로감, 체중감소, 과다한 색소침착, 오심, 복통, 기립성 저혈압, 저혈당, 전해질 장애 등이 올 수 있고, 심하면 탈수, 저혈압, 의식장애 및 쇼크가 동반될 수 있다. 일차성 부신피질부전은 본 증례와 같이 드물게 양측 부신 출혈성 경색으로 인해 발생되는 경우가 보고되었는데, 위험인자로는 항응고제 또는 헤파린 투여, 혈전성 질환, 항인지질 증후군과 같은 과응고 상태, 물리적 외상, 감염, 심한 스트레스와 관련되어 발생할 수 있으며 드물게 임신, 부신 종양, 쇼크 등이 원인이 되고 있다[4,5]. 그러나 본 증례와 같이 원인 없이 발생한 자발성 출혈에 의한 부신피질부전의 보고는 매우 드물다. 양측 부신 출혈의 임상 증상과 징후로는 저혈압, 쇼크, 복부, 등, 옆구리, 흉부의 통증, 발열, 의식저하, 복부 강직, 반발 압통 등이 있다[6]. 적절한 치료를 시행하지 않으면 쇼크가 진행하여 혼수와 사망에 이를 수 있어 정확하고 빠른 진단과 치료가 필요하다. 환자가 생존한다면 부신 기능은 드물게 수개월 후 정상으로 회복될 수 있다[7]. 저자들은 상복부 통증을 주소로 내원한 환자에서 매우 드물게 원인 없이 발생한 자발성 양측 부신 출혈에 의한 급성 부신피질부전 1예를 경험하였기에 보고하는 바이다.

참외 흰가루병에 대한 살균제의 예방 및 치료효과 검정

장태현,류연주,임혜정,임수진,최미영,정병룡,김철웅,이용세 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.

관절염으로 발현한 재발성 다발성 연골염 1례

엄민식,박원우,서승철,이진호,조주연,최혜영,이찬희,임소덕 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Relapsing polychondritis is an uncommon multisystemic disease which is characterized by recurrent episodes of inflammation and progressive destruction of cartilaginous tissue. The cause of relapsing polychondritis is unclear and suspected to be autoimmune pathophysiology. It involves cartilage of nose, vertebra, trachea, peripheral joint as well as structures of eye, heart, blood vessels or inner ear. Auricular chondritis is present in almost all patients, and multiple arthritis, nasal chondritis, saddle nose, eye involvement, laryngotracheal involvement and skin manifestations are also present. We report a case of relapsing polychondritis presented a arthritis with review of literatures.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

Decrease of Both Cofilin and LIM Kinase Phosphorylation in the Skeletal Muscles of Immobilization-induced Atrophy Rats

Kim, Mee-Young,Kim, Ju-Hyun,Lee, Jeong-Uk,Lee, Lim-Kyu,Yang, Seung-Min,Jeon, Hye-Joo,Lee, Won-Deok,Noh, Ji-Woong,Lee, Tae-Hyun,Kwak, Taek-Yong,Kim, Bokyung,Kim, Junghwan The Society of Physical Therapy Science 2014 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.26 No.3

<P> [Purpose] Immobilization-induced atrophy is a general phenomenon caused by prolonged muscle disuse associated with orthopaedic conditions. However, changes in the phosphorylation of atrophy-related cofilin and LIM kinases are still poorly understood. In this study, we examined whether or not phosphorylation of cofilin and LIM kinases is altered in the skeletal muscles of rats after 3, 7, 14, and 21 days of cast immobilization. [Methods] We used two-dimensional gel electrophoresis, mass spectrometry, and western blotting to examine protein expression and phosphorylation in atrophied rat gastrocnemius muscles. [Results] The expression of the cofilin was detected in gastrocnemius muscle strips using proteomic analysis. Cast immobilization after 3, 7, 14, and 21 days significantly diminished the phosphorylation of cofilin and LIM kinases. [Conclusion] The present results suggest that cast immobilization-induced atrophy may be in part related to changes in the phosphorylation of cofilin and LIM kinases in rat skeletal muscles.</P>

HCV : PE-100 ; Development of various double transgenic liver cancer models by hydrodynamic transfection

( Hye Lim Ju ),( Kwang Hyub Han ),( Weonsang S. Ro ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background/Aims: Liver cancer is a major health concern worldwide. Liver cancer is known to develop through complicated interactions of oncogenes and tumor suppressor genes. However, its pathogenesis and underlying mechanisms are incompletely understood. In this study, various double transgenic liver cancer mouse models have been developed using a hydrodynamic injection method and the Sleeping Beauty transposon system. The strategy allows a double transgenic mouse to be developed efficiently reducing time and resources significantly. Using the double transgenic liver cancer models, we could detect tumors noninvasively in vivo and reveal genetic influences on the development of liver cancer. Methods: Transposon vectors each encoding an oncogene or down-regulating a tumor suppressor gene (SmoM2, HrasG12V, Ctnnb1S33Y and shp53) were constructed. To induce liver cancer, total 50 μg of the three plasmids - encoding the Sleeping Beauty transposase and two transposons - were diluted in 2.5 ml of 0.9% saline and then injected into the lateral tail veins of 6- to8-week-old C57BL/6 mice. Tumors were observed via bioluminescence imaging. Results: Liver cancer was induced by the stable expression of the transposed oncogenes into the mouse chromosome. Tumor growths were observed via repeated bioluminescence imaging of mice over time. Whereas control mice that stably expressed only luciferase showed no significant changes in the luciferase signal intensities over time, the mice expressing oncogenes in the liver exhibited continuous tumor growth over months, based on the luciferase signal intensities. Conclusion: Established double transgenic mouse models could be an efficient alternative to traditional transgenic mouse models for liver cancer with significantly reduced time and cost.