Case Reports : A Case of Uterine Cervical Cancer Presenting with Granulocytosis

Heui June Ahn,Yeon Hee Park,Yoon Hwan Chang,Sun Hoo Park,Min Suk Kim,Baek Yeol Ryoo,Sung Hyun Yang 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.3

Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of product

The clinicopathologic analysis in mucosal malignant melanoma of head and neck

( Heui June Ahn ),( Im Il Na ),( Hye Jin Kang ),( Yeon Hee Park ),( Baek Yeol Ryoo ),( Sung Hyun Yang ) 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10

Poster Session : PS 1446 ; Hemato-Oncology(Oncology) : Brain Metastasis in Elderly Small Cell Lung Cancer Patients without Prophylactic Cranial Irradiation

( Moon Ho Kim ),( Heui June Ahn ),( Hyun Joong Kim ),( So Young Park ),( Su Jung Jung ),( Yongchel Ahn ),( Ho Suk Oh ),( Heui June Ahn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Prophylactic cranial irradiation (PCI) is an essential treatment in limited- stage small cell lung cancer (SCLC) for reducing the incidence of brain metastasis (BM) and improving overall survival rates. In extensive stages, PCI is also recommended for those who show good performance. However, PCI is optional for elderly patients with SCLC due to its toxicity, and there is no specific upper age limit for the use of PCI. In this study, we performed an observational study in elderly SCLC patients above the age of 60 who were not receiving PCI. Methods: In total, 156 elderly patients (aged 60 or above) were diagnosed with SCLC between 2001 and 2009 from GangNeung Asan Medical Center. Of them, 104 were included and investigated retrospectively. Forty-Seven were lost to follow-up, two had BM at the time of initial diagnosis, and three had PCI. The median age of the patients at the time of diagnosis was 70.01 years. Of the patients, 91 (87.5%) were male and 13 (12.5%) were female. Results: Symptomatic BM was detected in 14 out of the 104 (13.5%). When analyzed by age group at diagnosis, the incidence of BM in the age ranges 60-64, 65-69, 70-74, and 75 and older were 23.8% (five out of 21), 17.6% (Six out of 34), 8.0% (Two out of 25), and 4.2% (One out of 24), respectively. Conclusions: This study shows that the incidence of BM in SCLC patients aged 60 and above was 13.5%, which is lower than among the whole SCLC population compared to previous studies. This study implies that there is a lesser incidence of BM as age increases. Therefore, when performing PCI, practitioners should be more concerned with elderly SCLC patients.

이공계와 의약계 진로 희망 초등학생의 진로 선택 이유, 과학과목과 수학과목 선호도, 과학에 대한 흥미, 과학적 포부 비교

김은숙 ( Eun Sook Kim ),안유민 ( Yu Min Ahn ),정원영 ( Won Young Jung ),계영희 ( Young Hee Kye ),김희백 ( Heui Baik Kim ),노태희 ( Tae Hee Noh ),유준희 ( June Hee Yoo ),이경우 ( Kyung Woo Yi ),최승언 ( Seung Urn Choe ),김찬종 ( Ch 한국과학교육학회 2014 한국과학교육학회지 Vol.34 No.8

이공계 또는 의약계 직업을 희망하는 초등학생의 진로선택이유, 과학/수학 과목 선호도, 과학에 대한 흥미, 과학적 포부를 조사하여. 과학 관련 진로지도에 시사점을 얻고자 하였다. 이공계 희망 여학생의 비율은 낮지만 학년 차이가 크지 않은 반면, 이공계 희망 남학생의 비율은 6학년이 3학년의 절반에 가까웠다. 의약계 희망 학생 비율은 남녀 학생 모두 6학년이 3학년보다 1.4배 많았다. 이러한 차이로 인해 3학년에서 이공계 희망 학생 비율은 의약계 학생의 두 배였지만 6학년에서는 두 계열이 거의 같았다. 진로 선택 이유에서 희망 직업이 이공계인 경우 하고 싶다는 이유가 가장 중요했고, 사회에 필요한 일이라는 점이 그 다음이었다. 의약계의 경우는 다른 사람을 도울 수 있다는 점과 하고 싶은 일이라는 점이거의 비슷했고 부모의 권유나 소득보다 두세 배 중요해서 이전 연구와 다른 결과를 보였다. 돕기는 여학생들이 중요하게 생각한 진로 선택 이유이기도 하다. 이는 과학관련 진로 지도에서 그 직업을 통해 사람들을 도울 수 있다는 점이 비중 있게 고려되어야 함을 시사한다. 과학과목 선호도는 이공계가 가장 높고, 의약계, 기타 진로의 순서이다. 수학과목 선호도는 과학 과목 선호도 보다 낮으며, 이공계와 의약계가 비슷하고, 기타가 그 보다 낮다. 학년이 올라갈수록 수학의 비중이 커지는 점을 고려할 때 초등학생의 이공계와 의약계 진로 희망이 지속되려면 과학과목과 더불어 수학을 좋아하고 잘하도록 지도할 필요가 있다. 과학에 대한 흥미와 과학적 포부는 3학년이 6학년보다, 남학생이 여학생보다 높으며, 이공계가 가장 높고, 의약계, 기타의 순으로 값이 낮아지는 분포를 보이고 있다. 그런데 이공계 집단만 포부 값이 흥미값보다 높고 학년별, 성별, 진로별로 나누어진 다른 모든 집단에서 포부값이 흥미값보다 낮다. 이는 과학에 대한 흥미보다 과학적 포부가 이공계 진로 결정에서 보다 결정적인 요인이 될 수 있는 가능성을 보여준다. on the reasons for jobs, science/math preferences, interests in science, and science aspirations. For 3rd grade boys, twice more students picked Sci/Eng than Med choices. However, for 6th grade boys, the numbers of Sci/Eng and Med became close. The ratios of girls with Sci/Eng in 3rd and 6th grade did not differ much. The 6th graders chosing Med was 1.4 times bigger than 3rd graders for both boys and girls. For students with Sci/Eng, the most important reason for a job was that he/she liked it. For Med, helping others was as much important as doing what he/she liked. Science preference were the highest in the Sci/Eng group. The Med group came next with the non-science group being last. Math preferences were lower than the science preferences. Therefore, children need to be guided to increase the preferences for math as well as for science to keep the Sci/Eng and Med career choices. The interests in science and the science aspirations show similar patterns. The 3rd graders showed higher value than the 6th graders, the boys higher than girls, and the Sci/Eng group highest, the Med the second and non-science group the last. Science aspirations were higher than the interests only for the Sci/Eng group, while it was lower than the interests in all other groups. This implies that science aspirations might have bigger influence on getting a career in Sci/Eng than interest does.

마우스 사육에 있어서 깔집의 종류에 따른 기호도 및 재료성질 분석에 관한 연구

Jun-Sung Lim,Hyun-Suk Kim,Jae-Bum Ahn,Dae-Hun Park,Jong-Sung Park,Heui-Jin Kim,Jong-Sung Kim,Jin-Soo Han,Mi-Sook Lee,Ja-June Jang,Myng-Sang Kwon,Min-Jae Lee(이민재) 한국실험동물학회 2004 한국실험동물학회 학술발표대회 논문집 Vol.2004 No.-

Detection of <i>Plasmodium vivax</i> infection in the Republic of Korea by loop-mediated isothermal amplification (LAMP)

Chen, Jun-Hu,Lu, Feng,Lim, Chae Seung,Kim, Jung-Yeon,Ahn, Heui-June,Suh, In-Bum,Takeo, Satoru,Tsuboi, Takafumi,Sattabongkot, Jetsumon,Han, Eun-Taek Elsevier 2010 Acta tropica Vol.113 No.1

<P><B>Abstract</B></P><P>Loop-mediated isothermal amplification (LAMP) is a novel technique that rapidly amplifies target DNA in isothermal conditions. In a previous study, the sensitivities and specificities of LAMP, microscopy, and nested PCR were compared in the context of rapid malaria detection. In the present study, LAMP detected vivax malaria parasites in 115 of 117 microscopically positive samples (sensitivity, 98.3%; 95% CI, 97.4–100%), which agreed well with the nested PCR results (sensitivity, 99.1%; 95% CI: 96.0–100%). No positive cases of malaria were detected by LAMP or nested PCR in 50 consecutive feverish patients other than malaria from malaria endemic areas. LAMP performed on DNA extracted from heat-treated blood had a sensitivity of 93.3% (28/30, 95% CI: 84.4–100%) and specificity of 100% (30/30, 95% CI: 100%). The present study shows that LAMP based assays have high sensitivity, specificity, and amplification efficiencies for <I>Plasmodium vivax</I> detection. The authors recommend that LAMP can be considered as a rapid nucleic acid amplification assay for the molecular diagnosis of <I>P. vivax</I> in both clinical laboratories and malaria clinics in areas where vivax malaria is endemic.</P>

S-460 : Male breast adenoid cystic carcinoma: Case Report

( Dong Seok Lee ),( Ho Suk Oh ),( Yong Chel Ahn ),( Heui June Ahn ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Adenoid cystic carcinoma (ACC) of the breast is a rare subtype of breast cancer, and even rarer are the male cases. The 41-year-old healthy male patient was consulted due to cervical back pain for two months. Cervical spine CT scan showed osteolytic change with bony fragmentations in C3-C6 transverse process and vertebral body. It seems to be pathologic fracture related with tumorous conditions rather than trauma related. In bone scan, osteolytic bone lesion like multiple myeloma was found. But in serum and urine protein electrophoresis and immune fixation, there was no evidence of monoclonal gammopathy. In the bone marrow examination, hematopoietic cells almost replaced by neoplastic cells was showed. PET-CT scan showed hypermetabolic lesion in axial skeleton, lung and left axillary lymph nodes. The result of core biopsy in left level I axillar area was adenoid cystic carcinoma. After revieing the image study and whole body physical examination, movable small nodular lesions were found in periareolar of left breast. In breast US, irregularly shaped solid lesion was observed in the left sub-areolar area. Pathologic result was the Adenoid cystic carcinoma same as auxiliary lymph node biopsy. Finally ACC of breast with multiple lung, bone metastases and bone marrow involvement was diagnosed. Male breast ACC could be neglected by patient himself and difficulty to diagnosis, it can be an aggressive metastasis for long time until diagnosis. This case showed extraordinary pattern of bone metastasis finding compare to other solid tumor.

S-458 : Prognostic implication of primary tumor resection in elderly stage IVB colorectal cancer

( Dong Seok Lee ),( Ho Suk Oh ),( Yong Chel Ahn ),( So Young Park ),( Heui June Ahn ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background: The aim of this study was to identify prognostic factors in elderly stage IVB colorectal cancers, especially focused on the influence of treatment modalities including palliative chemotherapy and primary tumor resection. Patients and Methods: We selected and analyzed 64 stage IVB patients with over 65 year-old at the Gangneung Asan Hospital from July 1, 2001 through December 31, 2009. Demographics, tumor location, tumor grade, performance status, levels of CEA, level of aspartate aminotransferase (AST), and distant metastatic site at diagnosis were analyzed. In according to treatment history, palliative chemotherapy and surgical resection of primary tumor were analyzed retrospectively. Kaplan-Meier analyses were used to compare the overall survival and Cox` proportional hazards model was employed for multivariate analysis of prognostic factors. Results: A total of 64 patients participated in this analysis. The total group consisted of 30 men (46.9%) and 34 women (53.1%). The median age for the cohort was 76.5 years. Primary tumor resection was done in 28 (43.8%) of patients and 30 patients (46.9%) received palliative chemotherapy. According to the primary tumor resection or not, the median survival time was 12.43 months in resection group, 3.58 months in non-resection group (p<0.001). In addition, gender, level of CEA, level of AST, ECOG performance status, tumor location and presence of liver metastasis also showed significant differences in overall survival. On multivariate analysis using Cox` proportional hazards model, male gender, higher level of CEA, higher AST level and no primary tumor resection were independent poor prognostic factors. Especially no primary tumor resection was most potential risk factor in this elderly patients study group (p=0.001, 95% C.I. 2.33 to 21.99, H.R; 7.16). Conclusion: In elderly stage IVB colorectal cancer patients, resection of the primary lesion may enhance the survival.

증례 : 면역 기능이 정상인 성인에서의 패혈증으로 발현한 살모넬라 척추 골수염

김정민 ( Jung Min Kim ),박연희 ( Yeon Hee Park ),김동호 ( Dong Ho Kim ),박명준 ( Myung Joon Park ),안희준 ( Heui June Ahn ),류백렬 ( Baek Yeol Ryoo ),양성현 ( Sung Hyun Yang ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-

살모넬라는 골수염의 원인으로 흔하지 않은 병원체로서 1% 미만의 발생률을 가진다고 알려져 있다. 살모넬라 골수염은 면역기능저하 환자, 겸상적혈구 빈혈, 림프종, 만성 간 질환 등의 선행 요인이 있는 경우 발생하는 것으로 보고되어왔으나, 저자들은 선행 요인이 없고, 비교적 건강한 환자에서의 흉추와 요추의 살모넬라 척추 골수염이 패혈증으로 발전한 예를 경험하였기에 보고하는 바이다. 57세 남환으로 약 15일 전부터 시작된 요통과 호흡곤란 주소로 근처 병원에서 경호전 없어 본원 방문하였다. 장티푸스를 앓은 과거력이나 위장관계 증상은 없었다. 혈액 검사상 백혈구와 혈소판의 감소, 간 아미노전이효소 수치의 증가 외에 이상소견은 없었으며, 사람면역결핍바이러스 음성, 간염 바이러스 표지자 음성이었다. 내원 후 발열, 호흡부전, 패혈증, 파종혈관내응고, 간염이 있었으며 추가 검사상 흉추와 요추 골수염, 경막외 농양, 요근 농양, 둔부 농양 발견되어 항생제 투여하였다. 혈액, 소변, 골흡인 배양에서 D군 살모넬라가 동정되었다. 항생제 치료 후 활력징후 안정되어 수술적 배농 시행하여 성공적으로 치료되었고 혈액 검사도 정상화되었으며 현재 완전히 회복되어 외래에서 추적관찰 중이다. Salmonella rarely causes osteomyelitis and the incidence is less than 1 percent. Immuno-compromised state, sickle cell anemia and lymphoma are known as the predisposing factor of salmonella osteomyelitis. We report a case of the salmonella osteomyelitis patient who have no predisposing factors and previously is healthy. Fifty seven years old man visited our hospital with the complaints for the back pain and respiratory distress. He had neither medical history of typhoid fever nor gastrointestinal symptoms. He had fever, respiratory failure, sepsis, DIC and hepatitis. We could detect the osteomyelitis in thoracic and lumbar vertebras and the abscess of epidura, right buttock and psoas muscle by L-spine and abdomen scan. So, the patient was given intravenous antibiotics. Salmonella group D was grown in the culture of blood, urine and bone marrow aspiration. After the patient was stabilized, we had successfully treatment with surgical drainage. (Korean J Med 69:S1003-S1008, 2005)

Advanced Gastric Cancer Associated with Disseminated Intravascular Coagulation Successfully Treated with 5-fluorouracil and Oxaliplatin

Lee, Dong Seok,Yoo, Seung Jin,Oh, Ho Suk,Kim, Eun Jung,Oh, Kwang Hoon,Lee, Sang Jin,Park, Jong Kyu,Ahn, Yong Chel,Eom, Dae-Woon,Ahn, Heui June The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.2

Gastric cancer patients with acute disseminated intravascular coagulation experiences a rare but severe complication resulting in a dismal prognosis. We report a case of advanced gastric cancer complicated with disseminated intravascular coagulation with intractable tumor bleeding which was successfully treated with chemotherapy consisting of 5-fluorouracil and oxaliplatin. The patient was a 63-yearold man who complained of abdominal pain, melena, and dyspnea on 24 November 2010. We diagnosed stage IV gastric cancer complicated by disseminated intravascular coagulation. Gastric tumor bleeding was not controlled after procedures were repeated three times using gastrofiberscopy. With the patient's consent, we selected the 5-fluorouracil and oxaliplatin combination chemotherapy for treatment. After one cycle of 5-fluorouracil and oxaliplatin therapy, symptoms of bleeding improved and the disseminated intravascular coagulation process was successfully controlled. The primary tumor and multiple metastatic bone lesions were remarkably shrunken and metabolically remitted after eight cycles of chemotherapy. In spite of progression, systemic chemotherapy is effective in disease control; further, the patient gained the longest survival time among cases of gastric cancer with disseminated intravascular coagulation.