Brain Topological Correlates of Motor Performance Changes After Repetitive Transcranial Magnetic Stimulation

Park, Chang-hyun,Chang, Won Hyuk,Yoo, Woo-Kyoung,Shin, Yong-Il,Kim, Sung Tae,Kim, Yun-Hee Mary Ann Liebert 2014 Brain connectivity Vol.4 No.4

<P>Repetitive transcranial magnetic stimulation (rTMS) influences the brain temporally beyond the stimulation period and spatially beyond the stimulation site. Application of rTMS over the primary motor cortex (M1) has been shown to lead to plastic changes in interregional connectivity over the motor system as well as alterations in motor performance. With a sequential combination of rTMS over the M1 and functional magnetic resonance imaging (fMRI), we sought changes in the topology of brain networks and specifically the association of brain topological changes with motor performance changes. In a sham-controlled parallel group experimental design, real or sham rTMS was administered to each of the 15 healthy subjects without prior motor-related dysfunctions, over the right M1 at a high frequency of 10 Hz. Before and after the intervention, fMRI data were acquired during a sequential finger motor task using the left, nondominant hand. Changes in the topology of brain networks were assessed in terms of global and local efficiency, which measures the efficiency in transporting information at global and local scales, respectively, provided by graph-theoretical analysis. Greater motor performance changes toward improvements after real rTMS were shown in individuals who exhibited more increases in global efficiency and more decreases in local efficiency. The enhancement of motor performance after rTMS is supposed to be associated with brain topological changes, such that global information exchange is facilitated, while local information exchange is restricted.</P>

Acute and Subacute Oral Toxicity Evaluation of Crude Antifungal Compounds Produced by Lactobacillus plantarum HD1 in Rats

Hee-Kyoung Son,Hae-Choon Chang,Jae-Joon Lee 한국식품영양과학회 2015 Preventive Nutrition and Food Science Vol.20 No.3

The aim of this study was to investigate the acute and subacute oral toxicity of crude antifungal compounds produced by Lactobacillus plantarum HD1 in Sprague-Dawley rats. In the acute toxicity study, the crude antifungal compounds (0.625, 1.25, 2.5, and 5.0 g/kg) did not produce mortality, significant changes in general behavior, or changes in the gross appearance of the organs. In the subacute toxicity study, the crude antifungal compounds were administered orally to rats at doses of 0, 0.5, 1.0, and 2.0 g/kg daily for 28 days. There were no test article-related deaths, abnormal clinical signs, or body weight changes. The study also showed no significant differences between the control and treated groups in hematological and serum biochemical parameters, histopathological examination, or any other findings. These results suggest that acute or subacute oral administration of crude antifungal compounds from L. plantarum HD1 is not toxic in rats.

Acute and Subacute Oral Toxicity Evaluation of Crude Antifungal Compounds Produced by Lactobacillus plantarum HD1 in Rats

Son, Hee-Kyoung,Chang, Hae-Choon,Lee, Jae-Joon The Korean Society of Food Science and Nutrition 2015 Preventive Nutrition and Food Science Vol.20 No.3

The aim of this study was to investigate the acute and subacute oral toxicity of crude antifungal compounds produced by Lactobacillus plantarum HD1 in Sprague-Dawley rats. In the acute toxicity study, the crude antifungal compounds (0.625, 1.25, 2.5, and 5.0 g/kg) did not produce mortality, significant changes in general behavior, or changes in the gross appearance of the organs. In the subacute toxicity study, the crude antifungal compounds were administered orally to rats at doses of 0, 0.5, 1.0, and 2.0 g/kg daily for 28 days. There were no test article-related deaths, abnormal clinical signs, or body weight changes. The study also showed no significant differences between the control and treated groups in hematological and serum biochemical parameters, histopathological examination, or any other findings. These results suggest that acute or subacute oral administration of crude antifungal compounds from L. plantarum HD1 is not toxic in rats.

초광역경제권(MegaloPolis)으로 본 한국-일본간 경제협력에 관한 연구 -부산-후쿠오카현 초광역경제권 형성을 중심으로-

이창현 ( Chang Hyun Lee ),김경희 ( Kyoung Hee Kim ) 한국통상정보학회 2009 통상정보연구 Vol.11 No.1

I wish to examine plan about megalopolis formation with Japan and Busan, possess location condition that can be injured to center hub of North-east Asia. First for this, through competitive analysis of Korea and Japan in industrial structure, I will search competition relation. Second, examine what exports and specialization industry of two area are, through industrial structure of Busan and Kyushu area of Japan. Third, to form megalopolis, wish to present what business belt that can bind two area. Fourth, I wish to present preview point about this study in the conclusion. Examine from 2004 to 2007 through exports, degree of trade join(combination), index of trade specialization degree, index of Revealed comparative advantage, and etc, for analysis of this study how in changed industry competitive between two countries or two area have changed.

한국흑염소에서의 실험적 신증의 임상병리학적 연구

최희인,성재기,남치주,이창우,이경갑,Choi Hee-In,Sung Jai-Ki,Nam Tchi-Chou,Lee Chang-Woo,Lee Kyoung-Kap 한국임상수의학회 1989 한국임상수의학회지 Vol.6 No.2

In order to study the effects of administration of neomycin on the kidney of Korean black goats, 4.5(group A), 9(group B) or 14(group C) mg/kg, body weight of neomycin was injected intramuscularly turice a day for 84 days. On day 31, unilateral nephreotomy was performed in one animal of each group. The results were as follows: Serum neomycin concentrations were 8.7, 13.8, and 20.2 ${\mu}$g/ml 12 hours after injection. Serum BUN and creatinine concentration in nephreotomized goats, regardless of dosage, rapidly increased and came to peak on 3 days after, and then began to decrease to normal range, gradually, In non-nephrectomized goats, regardless of dosage, there was no notable change. In nephreotomized goats, PSP Tl/2 was delayed to the utmost 1 day after nephrectomy, regard-less of dosage, and then began to decrease to normal range, gradually in non-nephrectomized goats, there was not notable change in PSP T$\frac{1}{2}$. The intact kidney was markedly enlarged compared with the kidney of non-nephrectomized goats, but there was no microscopic change. It is concluded that administration of neomycin up to 14mg/kg body weight twice a day for 84 days was not nephrotoxic to the Korean black goats.

배내측 시상핵 손상이 학습에 미치는 영향

장현갑,임호찬,장경희 한국심리학회 1989 한국심리학회지 생물 및 생리 Vol.1 No.1

본 연구는 흰쥐에 있어서 배내측 시상핵의 손상이 인지적 학습과제인 미로학습과 정서적 학습과제인 조건회피 학습의 수행에 어떤 영향을 미치는 가를 검토하였다. 본 연구의 결과를 요약하면 다음과 같다. 첫째, Hebb-Williams미로학습과제에서 배내측 시상핵 손상군은 통제군에 비해 유의미하게 많은 오류수를 보여주었고, 둘째, 일방 조건회피학습에서도 손상군은 통제군에 비해 학습수행력이 유의미하게 감소하였다. 세째, 미로학습에서 손상동물은 학습 제1일째에 비해 제2일째에 오류수가 유의미하게 감소하였지만 조건회피학습에서는 제1일째와 제2일째 사이에 별다른 변화가 없었다. 이러한 결과는 배내측 시상핵이 이 인지적 학습과제의 수행에 영향을 미칠 뿐만 아니라 정서성이 요구되는 학습과제의 수행에도 영향을 미친다는 사실을 시사한다. The purpose of this study was to investigate the effects of dorsomedial thalamic nuclei lesions on cognitive learning task(eq. maze learning) and emotional learning task(eq. conditional avoidance learning) in the rat. The results of this study were as follows. First, experimental group showed significantly more errors than control group in the Hebb-Williams maze task, Second, experimental group showed significantly lower learning ability than control group in the one-way conditional avoidance learning. Third, in the maze learning, experimental group showed reduced errors in the second day learning compared to the first day learning score. But, in the conditional avoidance learning, does not showed any difference between two days learning score. These results suggested that dorsomedial thalamic nuclei might be related to emotional learning task, as well as cognitive learning task.

Capsaicin으로 유도된 신경성 염증반응에 미치는 상백피의 영향

윤창용,신동환,홍충만,이원규,장동덕,채옥희,강경진,이무삼 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

알루미늄 튜브 하이드로포밍에서의 예비 굽힘 공정의 효과에 관한 연구

임희택,박경창,김형종,김헌영 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

Recently social demands of fuel economy and environmental regulations require the development of lightweight components and new manufacturing technologies. The aluminum tube hydroforming is a manufacturing process which can provide lightweight components as automotive parts. In this paper, the hydroformability of aluminium tube in different condition of bending process is presented. An investigation has been conducted on how to control the deformed shape and its effect on thinning distribution after hydroforming by using finite element simulation. Finite element simulation of tube hydroforming for automotive trailing arm is carried out to explore the effect of 2-dimensional and 3-dimensional bending.

폐탄광 배수에 의한 주변 화천 오염 실태 조사

조경숙,장용근,류희욱 崇實大學校 生産技術硏究所 1996 論文集 Vol.26 No.1

The survey was carried out to investigated the contamination of streams by the acid mine drainage originates from abandoned coal mines and coal refuse piles. The physico-chemical characteristics such as pH, sulfate and elements concentrations of waters and sediments in streams were analyzed, and the microbial activities in the sediments were evaluated by measuring dehydrogenase activities. In sites contaminated by the acid mine dranage, the pH of waters adn sediments declined to acid from neutral due to the accumulation of sulfate. Dehyfrogenase activities ranged from 12 to 170 ㎍-TPF·g-dry soil-¹·24h-¹in the contaminated sites, whereas teh uncontaminated sites had activities of 1,176-4,259 ㎍-TPF·g-dry soil-¹·24h-¹. Dehydrogenase activities were significantly affected by low pH of sediments, indicating that high strength of sulfate inhibited microbial activities. The concentrations of heavy matals such as Pb and Fe in contaminated sediment (37-46 ppm Pb; 46,000 ppm Fe) were much higher than those in the uncontamnated sediments. concentration of Al in the contaminated water acidfied by the abandoned coal drainage was in range of 11 to 42 ppm. compared with those in the uncontaminated sediments, the concentrations of Mn, Mg and Ca in contaminated sediments were low because of the leaching of them from soil to water by acidfied stream water.

대구지역 일부 중학생의 건강증진행위와 관련요인

김경희,한창현,권진희,이성국 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.2

The propose of this study is to find out how well the middle school students are practicing the health Promotion behaviors and the factors relating their health promotion bahavior. Questionnaire survey on 922 middle school students attending 6 middle schools (three middle schools for each sex) located in Taegu City from the 7th through 19th of Feb. 2000 were conducted. The following were as follows; 1.The perceived health status is higher in male students than in female students(p<0.01). And the ratio of the students' feeling that they are healthy becomes also high in proportion to their economic status, and their mothers' educational level, and their parents' interest in health(p<0.01). The perceived importance of health is high in proportion to the student's economic status, and their parent's interest in health. 2.In case of the Health Locus of Control in Personality, the students with both parents have higher trend of inner control than the students with single mother or single father. The perceived self efficacy is significantly higher in male students than in female students(p<0.01). And it becomes significantly high in proportion to the students' economic status and their parents' educational level and interest in health(p<0.01). It is also higher in the students who had no diseases. 3.In case of the perceived benefit of the health promotion behavior, the ratio of the students responding that it is high is higher in male students than in female students(p<0.01). It also becomes high in proportion to the students' economic status, and their parent's educational level and interest in health(p<0.01). The barriers of the health promotion behavior was found to have no variables that are related to itself. 4.According to the data from Multiple Regression of Analysis which has the health promotion behavior practice as a subordinate variable, in male students' case the degree of health promotion behavior practice becomes high in promotion to their parents' interest in health, and the perceived health status. Their degree of health promotion behavior practice is also in proportion to their perceived self efficacy and the perceived benefit of the health promotion behavior practice. But in case of the barriers of the health promotion behavior practice, the result is the opposite. As to the female students, their health behavior practice becomes high in proportion to their parents' interest in health. It also becomes high in proportion to the perceived health status, the understanding of the importance of the health, the perceived self efficacy and the perceived benefit of the health promotion behavior. But in case of the barriers of the health promotion behavior, it was the same as the male students' case.