嶺南地方 全業養豚場의 돼지 繁殖實態 調査

河成珍,金鳳煥 COLLEGE OF AGRICULTURE KYUNGPOOK NATIONAL UNIVERSI 1984 慶北大農學誌 Vol.2 No.-

A partial and preliminary report of the reproductive performance of swine in the south eastern part of Korea (Youngnam province) during 1983 was given. For the 871 farrowings recorded, the mean litter size at birth was 8.9 and 0.61 piglet per litter was stillborn. Of the total number of piglets born alived, some 15.4 percent never reached the age of weaning, the vast majority succumbing within 3 days of birth. The major factor of piglet death from birth to weaning were diarrhoea (34.6%), crushing(17.4), weak pigs (15.8%), starvation(11.8%) and pneumonia (6.7%).

브로모크립틴 복용후 발생한 산후뇌혈관병증

하상욱,강성진,김민정,김종국,유봉구,김광수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

Postpartum cerebral angiopathy(PCA) is a rare entity with severe initial features, which usually leads to a good outcome. The mechanism of PCA remains uncertain. It is clear that in the puerperium there is an increased susceptibility to arterial vasospasm and factors related to the hormonal events occurring during pregnancy and puerperium are involved. Vasoconstrictive drug, such as bromocriptine, may also be associated with PCA. We report a patient of PCA following bromocriptine medication, who had previous migraine history.

유전자 재조합 사람 IFN-beta인 제네베타와 베네세린의 생물학적 활성의 비교

하종천,이협준,박봉환,김진숙,유대근,남상윤 전주대학교 자연과학종합연구소 2003 전주대학교 자연과학연구소 학술논문집 Vol.15 No.1

Background: Recombinant IFN-beta products have been approved for the treatment of several diseases. Recently, Inbionet, Co. has successfully developed rhIFN-beta product, Genebeta. This study was performed in a purpose of confirming the biological activity of Genebeta by comparison with another recombinant IFN-beta, Beneserin which was already approved. Methods: In vitro antiporliferative activity, regulation of MHC class I expression, antiviral activity, regulation of natural killer cell cytotoxicity were studied for functional comparison of these two rhIFN-beta products. Results: Proliferation assay data showed that two recombinant IFN-beta inhibited T cell and Daudi cell proliferation to a similar extent. When antiviral activity was compared, there was no significant difference between them. The treatment of these two rhIFN-beta also resulted in a similar level of upregulation of class I expression on the surface of A549 cells. Cytotoxicity experiment against tumor cells revealed that both of rhIFN-beta could enhance NK cell cytotoxicity to comparable level. Conclusion: All comparison data indicated that rhIFN-beta products, Genebeta and Beneserin have comparable potentials as a biological response modifier.

궤양성대장염의 관장치료

김진성,류봉하,박동원,류기원 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.1

늘어나는 추세에 있는 궤양성 대장염의 국소요법으로서 관장치료의 효용성에 대하여 알아보고자 본 고찰를 시행하였다. 1995-96년 사이에 간행된 최근의 중국저널에 실려있는 "保留灌腸" 이란 궤양성 대장엽의 국소요법에 대한 내용과 서양의학의 관장요법에 대한 내용을 함께 분석하였다. 관장치료는 기존의 내과적 치료에 반응을 보이지 않는 원위부의 궤양성 대장염에 대하여 지속적인 임상적 효능을 나타내며 안전하며,특히 직장내 출혈의 경우에 즉시형의 효과를 나타낸다. 保留灌腸은 주로 淸熱, 利濕, 解毒, 澁腸, 止血 등의 효과가 있는 한약 전탕액을 항문내로 주입하여 직장내에 국한된 병소에 직접적으로 약물을 투여하는 방법으로서 직장내 주입량은 100-150㎖ 정도이며 15-20일을 기본 치료기간으로 한다. 관장액의 구성 약물로는 주로 淸熱利濕, 澁腸止血의 효능이 있는 白頭翁, 地楡, 白급, 苦蔘, 敗ㅁ草, 五倍子 등이 사용되었다. Ulcerative colitis is an inflammatory disorder of the mucosa of the rectum and colon. The rectum is virtually always involved, and if any portion of the remaining colon is involved, it is in a continuous manner extending proximally from the rectum. Patients with ulcerative colitis typically complain of bloody stool, diarrhea and lower abdominal pain. 5-ASA enemas are safe and effective in maintaining remission in patients with distal ulcerative colitis. Specially, the efficacy is shown by a reduction in rectal bleeding. Retention enema(保留灌腸) is local therapy that the manufactured herbs are administered into the rectum of patients with distal ulcerative colitis, Thp. administered volume is 100-150㎖, and treatment period is 15-20days. The enema-fluid consist of Pulsatillae Radix(白頭翁), Sanguisorbae Radix(地楡), Bletillae Tuber(白급), Sophorae Radix(苦蔘), Patriniae Radix(敗醬草), Chinensis Galla(五倍子) that have effects of clearing away pathogenic heat and dampness(淸熱利濕), astringing intestine to correct diarrhea(澁腸), arresting bleeding(止血). This retention enema is effective, but it needs to be compared with efficacy of 5-ASA enemas. Also, we should investigate about the safety and toxicity of the herbal medicines.

수종 한약제의 위암세포에 대한 항암작용 효능 검색 및 약리작용에 관한 분자생물학적 연구

김진성,이지향,류봉하,박재훈,지성길,유진화 대한한방종양학회 1999 대한한방종양학회지 Vol.5 No.1

Traditional oriental medicines have ken used for tmament of various kinds of human cancers for long times and some of mem proven to k effective clinical-. However, the pItarmacologica1 actions ad mechanisms related to cancer treatment are generally unknown. In an effort to clarify the action mechanisms of several oriental medicines used for cancer treatments. we planned this experimental praedura. We selected Cadyceps sinensis (동충하초), Punellae Herba (夏柱草), Rehmanniae Radix (熟地黃), Paeoniae Radix (白均案), Oldedamar Herba (白花批告草), Partulaceae Herba (馬首算), Scdopendrasubspinipes mudans (蜈松), Mylabris Phalerara (班藝), Phellinus igniarius(蔡黃), Ganodermae Lignum(靈芝) for evaluation, which have ken used for patients of gastric cancers. The twenty grams of medicines were boiled in 100㎖ of water for 1 hour and filtered with O.2㎛ pore-sized filter unit to remove insoluble particles. Initially we evaluated the effects oriental medicines on growth inhibition in stomach cancer cells. The gastric cancer cell line, AGS, was cultured in RPMI l640 supplemented with lO% heat-inactivated fetal bovine serum and Heated with lO㎕ oriental medicines per l㎖ of medium up to 48 hours. The specimens were subjected to MTT assay for evaluation of growth inhibition. We found mat Mylabris piulema (班 察) markedly supmessed the growth of cancer cells as shown in results. Next, we checked the effects of orielntl medicines on cancer on cell cycles and apMonsis. Mylabrls phalerata (반모) inhibited cell cycle progression of Canea cells a compared with connol cells and cells treated with other medicines. In addition, Mylabri phalerata (반모) induced apptosis in 30-40% of stomch cancer cells within 24 hours. Other oriental medicines used for this experiments did not show apoptosis-inducing effects on cancer cells. Finally, we determined the expmSSion levels of genes associated with cell cycle Md apoptosis. The expressions of bcl-2 and bcl-XL were downregulated by the treamerm of Mylabris phalerata (반모). However, the expression levels of genes related to cell cycles were not altered significantly. In conclusion, we found that Mylams phalerata (반모) has in vivo gowth-inhibiting ad apptosis- inducing effects on stomach cancer cells. However, we think that at least animal experiments are necessay for evduations.

건강질단 질병 유소견자들의 순천향구미병원 외래이용에 영향을 미치는 요인

김진석,우극현,함정오,유재영,최태성,하봉구,윤성용 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background ; The purpose of routine health screening of employee is not only to detect worker's disease at early stage but also to provide early appropriate health service. But, majority of patients who diagnosed by routine health screening haven't underwent health service utilization. Soonchunhyang Kumi Hospital had been provide total occupational health service in kumi industrial estate including health screening, worker interview at workplace by occupational nurses and doctors. Object ; We want to know how much proportion of patient who are diagnosed by routine health screening had visited Soonchunhyang Kumi hospital out-patient clinic and factors influencing such health care service utilization. Method ; Initial study subject were 189 workers who had proved to have hypertension, diabetes mellitus, hyperlipidemia in routine health screening which performed during year of 2000. Among those, 160 workers who had finished questionnaire were selected for final study subject. We investigate whether they had visited health services or not, if they had, what kind of health care facility they visited, and other factors which influencing their health service utilization. Result ; Among 160 workers, 59(36.9%) had visited Soonchunhyang Kumi hospital, 47(29.4%) had visited other health care facility, and 54(33.8%) had not went to any health care facility. Factors which influencing Soonchunhyang Kumi hospital utilization is sex, job, staff's support to hospital visit during worktime, history of medical consultation about health screening result.

정신종양학의 역사와 현황

함봉진,심은정,김하경,김종흔 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Cancer statistics shows a high risk and increasing incidence of cancer among Koreans. Considerable burdens related to cancer and its treatment causes significant psychosocial distress among cancer patients and their family. Due to early detection and progress in cancer treatments, cancer is becoming a chronic illness and the quality of life and long-term impact of cancer is receiving increasing attention. Psycho-oncology is a subspecialty of oncology that addresses a psychosocial dimension of cancer throughout 'the continuum of cancer care', viz. from prevention and early detection to palliative and end-of-life care. This paper reviews the development of psycho-oncology and its current status in international and national context so as to promote efforts toward an integrative cancer care in Korea.

흰쥐에서 반복적 스트레스가 신경활성 스테로이드의 GABAA 수용체 조절작용에 미치는 영향

장봉석,이종범,박형배,하정희,송창진 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연 구 : 신경활성 스테로이드는 대뇌피질 세포막의 GABAA 수용체 복합체에서 GABAA 수용체 효현제 양상으로 작용하여 [³H]flunitrazepam이 GABAA 수용체에 결합하는 항진 작용이 관찰되었으나, 반복적으로 신경활성 스테로이드를 처치한 세포에서는 이러한 신경활성 스테로이드의 [³H]flunitrazepam 결합 항진효과가 소실되었다는 보고가 있었다. 이에 본 연구에서는 반복적인 스트레스에 부하된 흰쥐를 사용하여 신경활성 스테로이드의 GABAA 수용체에 대한 배위자(ligand)의 결합반응 양상을 정상 실험동물과 비교, 관찰하여 보고자 하였다. 방 법 : 본 연구에서, 벤조다이아제핀 수용체 결합반응(receptor binding assay)을 위한 [3H]flunitrazepam 결합반응을 위해서는 GF/B 여과지(Whatman) 상에서 Brandel M-24R을 사용하여 측정했고, GABAA 수용체 결합반응 (receptor binding assay)을 위한 [3H]muscimol 결합반응에서는 각 시험관 당 100㎕의 대뇌피질 조직(약 0.32mg 단백에 해당)을 사용하였으며, 상기 벤조다이아제핀 수용체 결합반응과 동일한 실험방법을 실시하였다. 결 과 : 신경활성 스테로이드인 pregnanolone은 대뇌피질 세포막의GABAA수용체 복합체에 대한 [³H]flunitrazepam 결합반응을 항진시켜 GABAA 수용체 효현제 양상으로 작용하는 것으로 관찰되었다. 또 pregnanolone이 GABAA 수용체 복합체상의 GABA 결합부위에 대한 결합력을 알아보기 위하여 GABAA 수용체 효현제인 [³H]muscimol 결합반응을 실시하였을 때 pregnanolone은 50%정도의 억제율을 보여주는 GABA와는 그 결과가 다르게 [³H]muscimol 결합반응을 억제하지 않음으로써. muscimol과 경쟁적으로 같은 결합부위에 작용하지 않는다는 것을 보여주었다. 또 반복적인 부동화 스트레스에 부하된 흰쥐의 대뇌 피질조직을 사용하여 pregnanolone의 [³H]flunitrazepam 결합반응을 관찰하였을 때, 대조군에 비하여 pregnanolone의 [³H]flunitrazepam 결합 항진작용이 감약되는 것을 관찰하였다. 결 론 : 이상의 결과로부터 반복적인 스트레스에 부하된 흰쥐의 대뇌피질조직에서는 정상 흰쥐에 비하여, pregnanolone이 GABA성 신경전달에 미치는 항진작용이 감약되었으며, 이는 반복적인 스트레스와 연관된 불안장애의 정신생리 규명에 중요한 정보라고 사료된다. Objectives : Pregnanolone is a potent positive modulator of the γ-aminobutyric acid(GABA) response that enhances the binding of [³H]flunitrazepam to the GABAA receptor. Recently, it was reported that chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. The present study was designed to assess the effect of repeated stress on the modulation of neuroactive steroids on the GABAA receptor. Methods : The effect of steroids on the ligands binding to GABAA receptor was investigated using cerebral cortices of unstressed and repeatedly immobilized rats. Male Sprague-Dawley rats, weighing 200-250g were forced to suffer an immobilization stress for 2 hours. Results : Pregnanolone enhanced the binding of [³H]flunitrazepam to GABAA receptor in both of unstressed and repeatedly stressed rats. However, repeatedly stressed rats showed significantly higher values in EC50 and lower values in Emax of enhancement binding of [³H]flunitrazepam than those of unstressed rats. Conclusions : From these findings, it can be concluded that repeated stress reduced the positive modulation of neuroactive steroid no the GABAA-receptor complex.

기능성 소화불량증 환자에 대한 반하사심탕 엑기스제의 임상효과

윤상협,류봉하,류기원,김진성 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : We evaluated the therapeutic effect of Banwhasasimtang dry extract powder on gastrointestinal symptoms and its side effects in patients with functional dyspepsia. Methods : Patients with functional dyspepsia, defined as discomfort in the epigastrium. A total 45 patients participated participated in this study. Dyspeptic symptoms ratio was obtained by patients, total point of symptom score / total 21 points x 100(%). On each of symptom after 4 weeks administration of Banwhasashim-tang was made by variation of symptom score: If symptoms score of posttreatment is lower than that of pretreatment, It is improved ; Otherwise aggravated, and if there is no change between them, unchangeable. When a full health condition of normal control is assumed 100%, relative health condition of dyspeptic patient could be calculated from 'full health condition- dyspeptic symptoms ratio. Therefore a whole satisfaction rate on symptom improvement was presented with variation of a relative health condition to dyspepsia between pretreatment and post. Results : Banwhasashimtang significantly unproved symptoms in patients. The significance was shown in both all seven items(p< 0.01, respectively) and 19.2% (p<0.01) of increase of a whole symptom improvement. There is no remarkable side-effect in all laboratory test, excepting 1 case abdominal pain another one case of recurred pain of chronic prostatitis. Conclusion : Banwhasashimtang extract provides symptomatic relief in functional dyspepsia and is no remarkable side-effect drug.

아동기 가정 내 스트레스가 공동의존성에 미치는 영향 및 공동의존성과 정신병리와의 관련성

곽운환,손지욱,한규희,박철수,김장락,김붕년,김봉조,강여화,하형래 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.1

연구목적: 본 연구는 공동의존성에 영향을 미치는 아동기 가정내 스트레스 요인과 공동의존성과 다른 병리와의 연관성을 규명하고자 하였다. 더불어 특정한 질환에서의 공동의존성의 평가가 가지는 의의를 탐색해 보고자 하였다. 방 법: 연구 대상은 정상 일반인 남성집단 88명과 알코올리즘 남성 집단 76명으로 구성되어 있다. 평가도구는 본 저자가 직접 작성한 '아동기 가정내 스트레스 요인 측정용 설문'과 공동의존 척도(RPS), 간이증상 진단검사(SCL-90-R)를 사용하였다. 통계적 분석은 Mann-Whitmey test, Kruskall- Wallis test, Multiple linear regression analysis, Spearman correlation analysis를 이용하였다. 결 과: 1) 정상 일반인 군과 알코올리즘 군의 공동의존성 평균값은 각각 49.12점(표준편차=15.41)과 88.31점(표준편차=17.48)이었다. 2) 정상 일반인 군에서는 '아동기 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01)의 3가지 요인에서, 알코올리즘 군에서는 '어린시절 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01) '부도의 도박'(p<0.01) '사회 병질자 부모의 존재'(p<0.05)의 5가지 요인에서 스트레스 유무에 따라 공동의존성에 유의한 차이를 보였다. 3) 두 집단 동시에 SCR-90-R의 8개 소척도 중 '대인관계 예민성'이 공동의존성과 가장 높은 연관성(rs>0.06, p<0.01)을 보였다. 이외에도 '우울증' '불안증'등이 두 집단 모두에서 통계적으로 유의한 연관성을 보였다. 결 론: 본 연구는 부모의 알코올리즘뿐만 아니라 여러 가정 내 스트레스 요인이 공동의존성의 발생에 영향을 미칠 수 있음과 공동의존성이 높은 집단이 다른 정신과 질환을 동반할 가능성이 높음을 증명한다고 할 수 있다. Objectives : The aim of this study was to examine the relationships of codependency with family stressors in childhood and psychopathology. Methods : Subjects were a group of 88 normal adult males and a group of 76 alcoholic males. The degree of codependency was assessed with the Korean version of Recovery Potential Survey(RPS). All subjects filled out questionnaires regarding demographic information and family stressors. The psychopathology was measured by self-administred questionnaires using Symptom Check List-90-Revision(SCL-90-R). Results : 1) There were no significant differences in codependency levels by sociodemographic characteristics in two groups, but obvious difference in mean of codependency scores(normal group : 49.12±15.41, alcoholism group : 88.31±17.48). 2) There were significant differences in codependency levels between the presence and absence of parental physical abuse, parental death, and parental alcoholism(p<0.01) in both groups. 3) Among family stressors, parental physical abuse had the largest contribution to codependency level in multiple linear regression. 4) There were significant correlations between the codependency levels and the scores of SCL-90-R's subscales of interpersonal sensitivity, depression, and anxiety in both groups. Conclusion : The codependency levels were related to some family stressors such as parental physical abuse, parental death, and parental alcoholism and the high-level codependency was correlated with higher level of psychopathology in both normal and alcoholism group. These results suggested that various family stressors, as well as parental alcoholism may be predictors of codependency, and codependency also may be a predictor of other psychiatric disorders.