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( Young Joo Park ),( Hyun Young Woo ),( Jeong Heo ),( Sang Gyu Park ),( Young Mi Hong ),( Ki Tae Yoon ),( Dong Uk Kim ),( Gwang Ha Kim ),( Hyung Hoi Kim ),( Geun Am Song ),( Mong Cho ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Glecaprevir/pibrentasvir (G/P) is a pangenotypic direct-acting combination of antiviral agents used to treat chronic hepatitis C virus (HCV) infections. There are limited real-life data on G/P for Korean patients. We evaluated the real-life effectiveness and safety of G/P at single institution in Korea. Methods: This was a retrospective, observational, cohort study. The primary effectiveness endpoint was sustained virologic response at 12 weeks after treatment completion (SVR12). Safety and tolerability were also assessed. Results: Of 267 patients with chronic HCV infections who received G/P, females were 148 (55.4%) and the median age was 63.0 years (range: 25-87 years). Eighty-three (31.1%) had HCV genotype-1 and 182 (68.2%) had HCV-2. A total of 212 (79.4%) were HCV treatment-naive, 200 (74.9%) received the 8-week treatment, 13 (4.9%) received prior treatment for hepatocellular carcinoma, 37 (13.7%) had chronic kidney disease stage 3 or more, and 10 (3.7%) were receiving dialysis. Intention-to-treat (ITT) analysis indicated that 256 (95.9%) achieved SVR12. A modified ITT analysis indicated the SVR12 was 97.7% (256/262). Six patients failed therapy because of post-treatment relapse. The SVR12 was significantly lower in those who received prior sofosbuvir treatment (P=0.002) and those with detectable HCV RNA at week 4 (P=0.027). Seventy (26.2%) patients experienced at least one adverse event, most of which were mild. Conclusions: These real-life data indicated that G/P treatment of patients with HCV infections had high effectiveness and was well-tolerated, regardless of viral genotype and the presence of comorbidities.
( Young Joo Park ),( Hyun Young Woo ),( Jeong Heo ),( Sang Gyu Park ),( Young Mi Hong ),( Ki Tae Yoon ),( Dong Uk Kim ),( Gwang Ha Kim ),( Hyung Hoi Kim ),( Geun Am Song ),( Mong Cho ) 대한간학회 2021 Gut and Liver Vol.15 No.3
Background/Aims: Glecaprevir/pibrentasvir (G/P) is a combination of direct-acting antiviral agents that is an approved treatment for chronic infections by all six hepatitis C virus (HCV) genotypes. However, there are limited data on the effect of G/P in Korean patients in actual real-world settings. We evaluated the real-life effectiveness and safety of G/P at a single institution in Korea. Methods: This retrospective, observational, cohort study used sustained virologic response at 12 weeks after treatment completion (SVR12) as the primary effectiveness endpoint. Safety and tolerability were also determined. Results: We examined 267 individuals who received G/P for chronic HCV infections. There were 148 females (55.4%), and the overall median age was 63.0 years (range, 25 to 87 years). Eightythree patients (31.1%) had HCV genotype-1 and 182 (68.2%) had HCV-2. A total of 212 patients (79.4%) were HCV treatment-naïve, 200 (74.9%) received the 8-week treatment, 13 (4.9%) had received prior treatment for hepatocellular carcinoma, 37 (13.7%) had chronic kidney disease stage 3 or higher, and 10 (3.7%) were receiving dialysis. Intention to treat (ITT) analysis indicated that 256 (95.9%) achieved SVR12. A modified ITT analysis indicated that SVR12 was 97.7% (256/262). Six patients failed therapy because of posttreatment relapse. SVR12 was significantly lower in those who received prior sofosbuvir treatment (p=0.002) and those with detectable HCV RNA at week 4 (p=0.027). Seventy patients (26.2%) experienced one or more adverse events, and most of them were mild. Conclusions: These real-life data indicated that G/P treatment was highly effective and well tolerated, regardless of viral genotype or patient comorbidities. (Gut Liver 2021;15:440-450)
A New Cold Tolerant, High Forage and Grain Yielding Winter Oat Cultivar “Samhan”
Hwa-Young Heo,Hyong-Ho Park,Maing-Jung Kim,Sun-Woo Choi,Kwang-Geun Park,Jung-Hyun Nam,Jung-Gon Kim,Choon-Ki Lee,Young-Up Kwon 한국육종학회 2003 한국육종학회지 Vol.35 No.4
Samhan (Avena sativa L.), a winter forage oat was released by the National Crop Experiment Station (NCES) in2001. Samhan was selected from the cross Early 80/CI 7518. CI 7518 is a winter oat line that was obtained from UnitedStates Department of Agriculture (USDA). Subsequent generations followed by the cross were handled in bulk and pedigree selec-Suwon, and was designated as a line name of Gwiri 37. Samhan was subsequently evaluated for winter hardiness and forageyield in Suwon, Unbong and Iksan from 2000 to 2001. Over 2 years, the average forage yield of Samhan harvested at May 10was 7.1 ton ha1, compared with 2.76 ton ha1 for Ol and 2.96 ton ha1 for Swan. Samhan is about 6 days later than Olfor heading date. Samhan is adapted primarily for winter planting for forage use in the central regions of Republic of Korea.
A New Waxy Wheat Cultivar "Shinmichall" with Stress Tolerance
Hwa Young Heo,Chul Soo Park,Moon Suk Kang,Hyung Ho Park,Chun Kee Lee,Hong Sik Kim,Bon Chul Goo,Jong Chul Park,Kwang Geun Park,Young Keun Cheong,Jung Gon Kim 한국육종학회 2007 한국육종학회지 Vol.39 No.3
“Shinmichal1”, a waxy red winter wheat (Triticum aestivum L.) cultivar was developed by the National Institute of Crop Science, RDA. It was derived from the cross “Alchan”/“Chal2”during 1997. “Alchan” is a soft red winter wheat with high yield and good noodle quality. “Chal2” is a waxy wheat line crossed by “Kanto107” (Wx-A1b and Wx-B1b) and “BaiHuo” (Wx-D1b). “Shinmichal1” was evaluated as “Suwon306” in Advanced Yield Trial Test in 2002. It was tested in the regional yield trial test between 2003 and 2006. “Shinmichal1” is an awned, semi dwarf and soft red winter wheat, similar to “Uri” (check cultivar). The Heading and maturing date of “Shinmichal1” were similar to “Uri”. Culm and spike length of “Shinmichal1“ were 79 cm and 7.8 cm. “Shinmichal1“ had greater test weight (802 g) and lower 1,000-grain weight (31.8 g) than “Uri” (782 g and 35.2 g, respectively). It has resistance to winter hardiness, wet-soil tolerance, lodging tolerance and moderate post-harvest sprouting damage. “Shinmichal1” had higher flour yield (66.2%), ash (0.73%), protein (10.9%) and SDS sedimentation volume (40.7 ml) than “Uri” (64.7%, 0.53%, 9.3%, and 32.5 ml, respectively) and similar flour color to “Uri”. “Shinmichal1” had higher dough extensibility and lower dough strength than “Uri”. It is 5.2% of amylose content and had typical waxy starch pasting properties. Average yield of “Shnmichal1” in the regional adaptation yield trial was 5.24 MT ha-1 in upland and 5.58 MT ha-1 in paddy field, which was 3% and 8% lower than those of “Uri” (5.39 MT ha-1 and 6.09 MT ha-1, respectively). “Shinmichal1” would be suitable for the area above the daily minimum temperature of -10℃ in January in Korean peninsula.
A New Early-Heading and High-Yielding Forage Rye Cultivar "Okjeon"
Hwa Young Heo,Hyoung Ho Park,Kwang Geun Park,Maing Jung Kim,Jong Jin Hwang,Choon Ki Lee,Jung Hyun Nam,Jung Gon Kim,Young Up Kwon 한국육종학회 2003 한국육종학회지 Vol.35 No.4
‘Okjeon’ rye (Secale cereale L.) was developed by the National Crop Experiment Station (NCES). It was released in 2001 because of its excellent earliness and yield potential. ‘Okjeon’ was developed from an open pollination with 20 rye lines in 1984. Subse
허재영(Jae-Young Heo),이성태(Seong-Tae Lee),김민근(Min-Geun Kim),홍광표(Kang-Pyo Hong),송원두(Won-Doo Song),노치웅(Chi-Woong Rho),조주식(Ju-Sik Cho),이영한(Young-Han Lee) 한국토양비료학회 2010 한국토양비료학회지 Vol.43 No.5
석회고토 및 패화석비료를 대체할 수 있는 토양개량제로 활용가치가 높은 굴껍질을 사과 ‘감홍’ 재배 과수원에 시용하여 고두병 발생에 미치는 효과를 검토하였다. 석회고토와 굴껍질을 처리한구는 무처리구에 비해 표토와 심토의 토양 pH와 치환성 칼슘 함량이 증가된 반면, 치환성 나트륨 함량은 차이가 없었다. 사과의 고두병 발생 비율은 무처리구가 10.4%로 가장 높았고 굴껍질 4 Mg ha<SUP>-1</SUP> 이상 처리할 경우 3.7% 이하로 유의적인 감소를 보였으며 석회고토 처리구는 8.9%로 무처리구와 비슷한 수준이었다. 굴껍질 시용량과 수확기 표토 및 심토의 pH와 치환성 칼슘 함량은 고두병 발병비율과 고도로 유의적인 부의상관을 보였다. 고두병 발병비율을 경감시킬 수 있는 굴껍질 시용량은 4 Mg ha<SUP>-1 </SUP>이지만 시험 후 토양의 치환성 칼슘 함량, pH 및 과실중량, 수량 등을 감안할 때 최적의 굴껍질 시용량은 2 Mg ha<SUP>-1</SUP>로서 석회소 요량과 같았다. For enhancement of apple productivity, the calcium fertilizers to increase the calcium content of fruit, and reduce the incidence of bitter pit in apples are applied. Crushed oyster shell contains a plenty of calcium carbonate, and a very small amount of boron, ferrous, and manganese. A field study was conducted to determine the optimum level of crushed oyster shell for soil nutrient management, and its effect on the induction of bitter pit in cultivar ‘Gamhong’ apple. The application of crushed oyster shell increased organic matter, available phosphate, and exchangeable cation concentration in soil. We found a significant positive correlation between soil pH, and application level of crushed oyster shell in both top, and subsoils. The incidence of bitter pit in apple fruit at the harvest stage was significantly higher in non treatment and calciummagnesium carbonate treatment than on over applications 4 Mg ha<SUP>-1</SUP> for crushed oyster shell. However, the optimum level of crushed oyster shell was 2 Mg ha<SUP>-1</SUP>, especially considering the soil Ca content, soil pH, fruits weight, and yield. Our results show that the crushed oyster shell can be effective in restoring the soil nutrient balance, and inducing the bitter pit in apple fruit.
Stress and Vibration Analysis of Motor Back Plate in HDD
Heo, Geun Sub,Kang, Oh Hyun,Park, Cheol Woo,Lee, Sang Ryong,Lee, Choon Young Trans Tech Publications, Ltd. 2011 Advanced materials research Vol.275 No.-
<P>In the present study, we have simulated stress characteristics and vibration modes in the back plate of head-stack driving motor of 2.5 inch small sized hard disk drives (HDDs). The magnets in head-stack driving motor have large magnetic fields, and therefore, the resulting large force may induce fracture and deformation in the back plate of the motor. Since the high-speed motion of head-stack motor generates high frequency vibration, we analyzed the vibration mode to avoid resonant frequency. ANSYS software was used in this study to check the deformation of back plate with the following design parameters: thickness of plate, the number of support beams, and the width of support beams. From the vibration mode analysis, we obtained a stable plate shape whose operating frequency is off the resonant frequency.</P>