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RISS 인기검색어
- 검색키워드
- 저자 : ( Gang Hoon Kim ) (검색결과 236 건)
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이경훈,문병석,김강석,남길정 대한상하수도학회 2003 상하수도학회지 Vol.17 No.5
This study. which chose Sum-Jin river dam and Ju-Amdam of Sum-Jin river water system for objection region, forecasted inflow of dam to manage a multipurpose dam during flood period, using neural network model, executed HEC-5 to be inputted the foresaw and measured inflow data and investigated the result data. HEC-5 is dam imitative operating program. When no damaging channel capacity was 100% or 70%, this study investigated the flood control storage probability so that we understand concerning with no damaging channel capacity and the flood control storage capacity of reservoir. As a result that forecasted dam inflow through neural network model, we got excellent forecasting outcome that the coefficient of determination is over 0.9. and find to be able to apply HEC-5 because. as a result that ￡ was applied to HCE-5 forecasting outcome and surveyed inflow data. the forecasting outcome were more superior managing result than real outflow one at the phases of peak flow control rate, reservoir outflow rate, and reswyoir storage rate. finally this study investigated abut application of HEC5 model at the best suited dam management and regulation of no damaging channel capacity. as deciding the best suited outflow by adjusting no damaging channel capacity.
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Risperidone이 백서의 억제된 자발적 교대행동에 미치는 영향
이기철,이정호,김진규,정홍경,천강훈,류정환,최영민,전성일 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2
Objectives : Recently, some case reports have shown that risperidone is effective to refractory obsessive-compulsive disorder. Possible explanations for efficacy of risperidone in refractory obsessive-compulsive disorder maybe due to that it is both serolonin and dopamine receptor antagonist. On the basis of serotonin-dopamine interaction hypothesis, a biological etiology of obsessive-compulsive disorder, the effect of risperidone was evaluated to the suppressed spontaneous alternation behaviour of animal model of obsessive-compulsive disorder in rats. Methods : The apparatus for spontaneous alternation behaviour was a black plexiglas T-maze with distinctive black and white goal boxes. Black gullotine doors separated the start box and the goal boxes from the main body of the T-maze Small cups were placed in the corners of both goal boxes(all arms measured 50×10cm) 24 hours prior to experiment, rats(Spraque-Dawley) were food-deprived. The food-deprived rats were put into T-maze, in which both goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for checked. After baseline of the number of choices of spontaneous alternation behaviour was stabilized, the pontaneous alternation disrupted by nonselective 5-HT agonist, 5-MeODMT (1.25mg/kg/IP). The experimental animals were stratified into 5 groups, fluoxetine(10mg/kg/IP), risperidone(0.1mg/Kg/IP), haloperidol(0.1㎎/Kg/IP), fluoxetine(10mg/Kg) with haloperidol(0.1 mg/Kg), and saline(0.5cc/IP) control group. Each drugs were injected for 21 days as a chronic treatment. The protective effects were evaluated on the nest day of discontinuation of the each drugs among 5 groups. Results : 1) After 21 days of the drug treatment, the risperidone group and the fluoxetine group showed significant difference from the haloperidol group and the saline control group on the protection of the 5-MeODMT induced suppression of spontaneous alternation behaviour. 2) The fluoxetine group and fluoxetine with haloperidol group showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. The risperidone group also showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour, but the protective effect of risperidone was superior to fluoxetine. Conclusion : These findings suggest that both risperidone and fluoxetine have a favorable effect in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. We think that risperidone can be possible alternatives to SSRIs in the treatment of refractory obsessive-compulsive disorder in clinical situation.
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Kim, Min Su,Roy, Shrawan,Lee, Jubok,Kim, Byung Gu,Kim, Hyun,Park, Ji-Hoon,Yun, Seok Joon,Han, Gang Hee,Leem, Jae-Young,Kim, Jeongyong American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.42
<P>Monolayer transition-metal dichalcogenides (1L-TMDs) are atomically thin direct band gap semiconductors, from which the emission of light is determined by optical transitions of exciton complexes such as neutral excitons and trions. While the quantum yields of 1L-TMDs are quite low, the ability to control the populations of exciton complexes in 1L-TMDs through various doping processes is an interesting advantage, and provides ample possibilities for engineering the optical properties of these semiconductor monolayers. Here we demonstrate a simple method of controlling the populations of excitons and trions to enhance the light emission of 1L-TMDs by having them form heterostructures with ZnO thin films (TFs). 1Ls of MoS2 or MoSe2 showed up to 17-fold increases in photoluminescence (PL) when they were placed on similar to 50 nm thick ZnO TFs. This enhancement of the PL was due to charge exchanges occurring through the 1L-TMD/ZnO interface. The PL enhancements and changes in the PL spectra of the 1L-TMDs were greater when the 1L-TMD/ZnO heterostructures were subjected to 355 nm wavelength laser excitation than when they were excited with a 514 nm wavelength laser, which we attributed to the onset of energy transfer by photoexcited excitons and/or the additional p-doping by photoexcited holes in ZnO. The p-doping phenomenon and the enhanced light emission of 1L-TMD/ZnO heterostructures were unambiguously visualized in spatially resolved PL and Raman spectral maps. Our approach using the 1L-TMD/ZnO TF heterostructure suggests that a rich variety of options for engineering the optical properties of 1L-TMDs may be made available by carrying out simple and intuitive manipulations of exciton complexes, and these endeavors may yield practical applications for 1L-TMDs in nanophotonic devices.</P>
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Kim, Min Su,Seo, Changwon,Kim, Hyun,Lee, Jubok,Luong, Dinh Hoa,Park, Ji-Hoon,Han, Gang Hee,Kim, Jeongyong American Chemical Society 2016 ACS NANO Vol.10 No.6
<P>Heterostacking of layered transition-metal dichalcogenide (LTMD) monolayers (1Ls) offers a convenient way of designing two-dimensional exciton systems. Here we demonstrate the simultaneous hosting of positive trions and negative trions in heterobilayers made by vertically stacking 1L MoSe2 and 1L MoS2. The charge transfer occurring between the 1Ls of MoSe2 and MoS2 converted the polarity of trions in 1L MoSe2 from negative to positive, resulting in the presence of positive trions in the 1L MoSe2 and negative trions in the 1L MoS2 of the same heterostacked bilayer. Significantly enhanced MoSe2 photoluminescence (PL) in the heterostacked bilayers compared to the PL of 1L MoSe2 alone suggests that, unlike other previously reported heterostacked bilayers, direct band transition of 1L MoSe2 in heterobilayer was enhanced after the vertical heterostacking. Moreover, by inserting hexagonal BN monolayers between 1L MoSe2 and 1L MoS2 we were able to adjust the charge transfer to maximize the MoSe2 PL of the heteromultilayers and have achieved a 9-fold increase of the PL emission. The enhanced optical properties of our heterostacked LTMDs suggest the exciting possibility of designing LTMD structures that exploit the superior optical properties of 1L LTMDs.</P>
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Kim, Don-Kyu,Gang, Gil-Tae,Ryu, Dongryeol,Koh, Minseob,Kim, Yo-Na,Kim, Su Sung,Park, Jinyoung,Kim, Yong-Hoon,Sim, Taebo,Lee, In-Kyu,Choi, Cheol Soo,Park, Seung Bum,Lee, Chul-Ho,Koo, Seung-Hoi,Choi, Hu American Diabetes Association 2013 Diabetes Vol.62 No.9
<P>Type 2 diabetes mellitus (T2DM) is a progressive metabolic disorder with diverse pathological manifestations and is often associated with abnormal regulation of hepatic glucose production. Many nuclear receptors known to control the hepatic gluconeogenic program are potential targets for the treatment of T2DM and its complications. Nevertheless, the therapeutic potential of the estrogen-related receptor γ (ERRγ) in T2DM remains unknown. In this study, we show that the nuclear receptor ERRγ is a major contributor to hyperglycemia under diabetic conditions by controlling hepatic glucose production. Hepatic ERRγ expression induced by fasting and diabetic conditions resulted in elevated levels of gluconeogenic gene expression and blood glucose in wild-type mice. Conversely, ablation of hepatic ERRγ gene expression reduced the expression of gluconeogenic genes and normalized blood glucose levels in mouse models of T2DM: <I>db</I>/<I>db</I> and diet-induced obesity (DIO) mice. In addition, a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in <I>db</I>/<I>db</I> and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production. Our findings suggest that the ability of GSK5182 to control hepatic glucose production can be used as a novel therapeutic approach for the treatment of T2DM.</P>
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김현철,신동훈,김병엽,김철우,김도형,한승혜,오명돈,이재용,이민영,김상억,김학찬,오인균,이병두,최강원 대한내과학회 2002 대한내과학회지 Vol.62 No.2
Non-Hodgkin's lymphoma (NHL) is the secondary most common tumor in HIV-infected individuals. The AIDS-related lymphomas are a late manifestation of HIV infection and may increase in frequency as patients live longer with highly active antiretroviral therapy and effective prophylaxis of opportunistic infections. Histologically AIDS-related NHL are either high (2/3) or intermediate (1/3) grade lymphoma. We report a case of gastric Non-Hodgkin's lymphoma in AIDS patient. Two years ago, she was diagnosed as HIV-infected individual in public hospital. She presented with epigastric pain and mass-like sensation. Under the impression of gastric cancer, subtotal gastrectomy was done. But, she diagnosed as diffuse large B cell lymphoma by histologic finding, immunohistochemical study. This is the first report of gastric Non-Hodgkin's lymphoma from AIDS patients in Korea(Korean J Med 62:223-229, 2002)
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Kim, Hyun,Han, Gang Hee,Yun, Seok Joon,Zhao, Jiong,Keum, Dong Hoon,Jeong, Hye Yun,Ly, Thuc Hue,Jin, Youngjo,Park, Ji-Hoon,Moon, Byoung Hee,Kim, Sung-Wng,Lee, Young Hee IOP 2017 Nanotechnology Vol.28 No.36
<P>Synthesis of monolayer transition metal dichalcogenides (TMDs) via chemical vapor deposition relies on several factors such as precursor, promoter, substrate, and surface treatment of substrate. Among them, the use of promoter is crucial for obtaining uniform and large-area monolayer TMDs. Although promoters have been speculated to enhance adhesion of precursors to the substrate, their precise role in the growth mechanism has rarely been discussed. Here, we report the role of alkali metal promoter in growing monolayer TMDs. The growth occurred via the formation of sodium metal oxides which prevent the evaporation of metal precursor. Furthermore, the silicon oxide substrate helped to decrease the Gibbs free energy by forming sodium silicon oxide compounds. The resulting sodium metal oxide was anchored within such concavities created by corrosion of silicon oxide. Consequently, the wettability of the precursors to silicon oxide was improved, leading to enhance lateral growth of monolayer TMDs.</P>
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