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RISS 인기검색어
- 검색키워드
- 저자 : ( Fang Taishi ) (검색결과 2 건)
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PE-133: Fate of Potential Living Donors for Liver Transplantation
( Taishi Fang ),( Ok-kyung Kim ),( Sanghee Song ),( Ok Soo Kim ),( Curi Ahn ),( Hyeyoung Kim ),( Suk Kyun Hong ),( Kyung Chul Yoon ),( Hyo-sin Kim ),( Hyeyoung Kim ),( Youngrok Choi ),( Hae Won Lee ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: In this study, we aimed to elucidate the fate of potential live liver donors. Methods: From July of 2011 to June of 2013, 372 potential donors were evaluated for 302 matched recipients. Data was prospectively collected. Results: Among 302 recipients, 209 patients received LDLT finally. Among 302 recipients, 53 recipients (17.5%) had more than 1 potential donor. 64.8% of donors was male and 53.5% was children of the recipients. Among 372 potential donors, 209 donors (56.2%) finally received donor hepatectomy for living donation. 159 cases (42.7%) were excluded for various reasons. Among 159 excluded cases, 87 cases were excluded due to donor reasons. The other 72 cases could not donate due to recipient reasons e.g. death, infection or Deceased donor LT. Donor reasons for exclusion consisted of withdrawal of consents (n=25, 28.7%), medical problems (n=24, 27.6%), small remnant volume (n=17, 19.5%), and others (n=21, 24.1%). The main reasons for donor exclusion were medical problem and withdrawal of consent. Therefore, thorough medical clearing and careful examination for donor voluntarism are important in donor evaluation process. Conclusions: The main reasons for donor exclusion were medical problem and withdrawal of consent. Therefore, thorough medical clearing and careful examination for donor voluntarism are important in donor evaluation process.
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( Fang Taishi ),( Hong Suk Kyun ),( Lee Kwang-woong ),( Yoon Kyung Chul ),( Kim Hyo-sin ),( Nugroho Adianto ),( Murokawa Takahiro ),( Kim Hyeyoung ),( Yi Nam-joon ),( Suh Kyung-suk ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Mycophenolate mofetil is the most common auxiliary immunosuppressant after liver transplantation to relieve calcineurin inhibitor related complications. There is one type of Cellcept<sup>®</sup> available, but Myrept<sup>®</sup> produced by Chong Kun Dang Company in Korea is available as 500 mg tablet as well as 250 mg capsule. However, there has been no clinical study to assess the feasibility of this generic product. Therefore, we aimed to evaluate the feasibility, cost-effectiveness, and convenience of Myrept<sup>®</sup> 500 mg tablet in recipients after liver transplantation. Methods: A 24 week, phase 4, single center, open-label, non-comparative study was employed. A total of 50 patients were recruited. Acute rejection, changes in blood chemistry, white blood cell count, renal function, adverse drug reaction and other characteristics of the patients were recorded for 24 weeks Results: All enrolled patients and their grafts were survived within 24 weeks. Mean GFR was 119.61 ± 76.52 ml/min at beginning of the study and reached 85.20 ± 23.70 ml/min after 24 weeks and showed a significant decrease overall (p < 0.001).Nine patients (18.75%) had adverse drug reactions which had been commonly reported in other Mycophenolate mofetil generic products, and there was no serious one. These adverse reactions included gastrointestinal problems (nausea, vomiting, and abdominal discomfort), laboratory abnormality (mild increase of aspartate or alanine aminotransferase). The size of Myrept<sup>®</sup> 500 mg tablet is smaller than Myrept<sup>®</sup> 250 mg capsule (17.1 x 7.1 x 6.5 mm vs. 19.18 x 7.23 x 6.40 mm). When comparing the same dose, the cost is less expensive (1,344 Korean won vs. 1,792 Korean won for 500 mg). Conclusions: In conclusion, Myrept<sup>®</sup> 500 mg tablet is feasible, cost-effective, and convenient in recipients after liver transplantation.
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