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사회교육 무용 프로그램이 정신건강에 미치는 영향에 대한 연구
권의준,윤현정 목원대학교 자연과학연구소 2000 自然科學 硏究論文集 Vol.9 No.1
본 연구는 구청 문화원에서 주관하는 사회교육 프로그램 중 중년 여성들이 무용 프로그램에 참가후 신체적 정신적 건강 측면에서 효과를 검증하고자 하였다. 본 연구의 목적을 달성하기 위해서 서울특별시 소재 3개 구청의 문화원과 경기도 고양시 관내 3개의 문화원의 프로그램 참가자 138명이 본 연구에 참여 하였으며 이들이 정신건강차원에서 여러 발생 요인들을 공변량 분석을 통해 분석한 결과 프로그램 참여자가 비참여자에 비해 정신적 건강에 대한 치료효과가 있음을 입증하고 있다.
윤상구,김민환,정은숙,한금현,곽이경,조종래,엄태현,김의석 대한감염학회 2007 감염과 화학요법 Vol.39 No.4
삼일열 말라리아는 일반적으로 경미한 임상경과를 거치며, 열대열 말라리아와 달리 뇌형말라리아, 폐부종, 신부전등의 치명적인 합병증을 일으키지 않는 것으로 알려져 있다. 저자들은 특이한 과거력이 없던 건강하던 성인이 국내에서 삼일열 말라리아에 걸린 후 발작과 쇼크가 발생하여, 항말라리아 약제와 대증치료로 치료된 증례를 경험하였다. Vivax malaria reemerged in the Republic of Korea in 1993. Vivax malaria is generally a benign disease with few severe complications. Even in the worldwide literature, there is only a small number of case reports on severe complications in vivax malaria. We report a unique case of P. vivax infection complicated by seizure and shock. A 58 year-old male showed generalized tonic-clonic seizure and shock after P. vivax infection. The species of malarial parasite was identified using peripheral blood film examination and polymerase chain reaction (PCR). He successfully recovered after treatment with hydroxychloroquine.
( Eu Hyun Jung ),( Seung Il Cho ),( Sang Jin Oh ),( Kyung O Kim ),( Young Lip Park ),( Kyu Uang Whang ),( Sung Yul Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Various Q-switched (QS) lasers, such as the ruby, alexandrite or neodymium:YAG (Nd:YAG) lasers are used to remove cosmetic tattoo procedure. Unfortunately there has been no indication or a guideline for the optimal time of tattoo removal using lasers. Objectives: To set a guideline for the optimal time for the tattoo removal via 1064nm QSND, we compared the degree of removal and histopathologic changes according to the time of irradiation. Methods: We made 6 artificial tattoos on the rat`s skin with black color semi-permanent makeup ink and machine. We irradiated the 1064nm QSND to the artificial tattoos on rat on the same day of semi-permanent makeup, 3 days, 1 week, 2 weeks and 3 weeks after. We checked the pigment level of irradiated site using Mexameter® and biopsied the irradiated site paired with non-irradiated site on each day. Results: There was no significant difference in the level of pigment removal between on the day of semi-permanent makeup, 3 days, 1 week, 2 weeks and 3 weeks after. As time goes on, the tattoo pigments seemed to go into from epidermis to deep dermis as well. However, the deep dermis pigments were not reflected. Conclusion: It would be appropriate to do the laser therapy on the day of tattooing only in the aspect of pigment removal. But, histopathologically, it is recommended to remove the tattoo when the crusts are peeled off (about a week after the tattooing), since it is the time when the wound repair process is almost completed.
FC 1-12 : Elevated aurora kinase a protein expression in diabetic skin tissue
( Eu Hyun Jung ),( Ji Hoon Sim ),( Hong Ki Cho ),( Kyung O Kim ),( You In Bae ),( Jong Suk Lee ),( Moon Kyun Cho ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Aurora kinase A (Aurora-A) plays an important role in regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods: Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results: Increased expression of Aurora-A protein was detected in all diabetic skin tissues both in western blot analysis and immunohistochemical staining. However, in normal skin tissues, there were no bands of Aurora-A protein in western blotting and also negative in immunohistochemical staining. Conclusion: There have been no studies on the expression of Aurora-A in diabetic skin tissues so far. We thought that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved in human diabetic skin tissue.
Structure and Orientation of a Voltage-Sensor Toxin in Lipid Membranes
Jung, Hyun Ho,Jung, Hoi Jong,Milescu, Mirela,Lee, Chul Won,Lee, Seungkyu,Lee, Ju Yeon,Eu, Young-Jae,Kim, Ha Hyung,Swartz, Kenton J.,Kim, Jae Il Elsevier 2010 Biophysical journal Vol.99 No.2
<P><B>Abstract</B></P><P>Amphipathic protein toxins from tarantula venom inhibit voltage-activated potassium (Kv) channels by binding to a critical helix-turn-helix motif termed the voltage sensor paddle. Although these toxins partition into membranes to bind the paddle motif, their structure and orientation within the membrane are unknown. We investigated the interaction of a tarantula toxin named SGTx with membranes using both fluorescence and NMR spectroscopy. Depth-dependent fluorescence-quenching experiments with brominated lipids suggest that Trp<SUP>30</SUP> in SGTx is positioned ∼9 Å from the center of the bilayer. NMR spectra reveal that the inhibitor cystine knot structure of the toxin does not radically change upon membrane partitioning. Transferred cross-saturation NMR experiments indicate that the toxin's hydrophobic protrusion contacts the hydrophobic core of the membrane, whereas most surrounding polar residues remain at interfacial regions of the bilayer. The inferred orientation of the toxin reveals a twofold symmetry in the arrangement of basic and hydrophobic residues, a feature that is conserved among tarantula toxins. These results have important implications for regions of the toxin involved in recognizing membranes and voltage-sensor paddles, and for the mechanisms by which tarantula toxins alter the activity of different types of ion channels.</P>
Hwang, Eu Chang,Yu, Seong Hyeon,Jo, Yang Hyun,Jung, Seung Il,Kang, Taek Won,Kwon, Dong Deuk,Choi, Chan,Heo, Suk Hee,Hwang, Jun Eul,Jung, Sung-Hoon,Jung, Tae-Young Medknow PublicationsMedia Pvt Ltd 2016 ASIAN JOURNAL OF ANDROLOGY Vol.18 No.1
<P>Several studies have revealed that the preoperative serum testosterone and percent tumor volume (PTV) predict extra-prostatic extension (EPE) and biochemical recurrence (BCR) after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy (LRP). We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen (PSA) >0.2 ng ml<SUP>−1</SUP>. The threshold for serum total testosterone was 3.0 ng ml<SUP>−1</SUP>. Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone (<3.0 ng ml<SUP>−1</SUP>) was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone (<3.0 ng ml<SUP>−1</SUP>, adjusted OR, 8.52; 95% CI, 5.04–14.4, <I>P</I> = 0.001) predicted EPE and PTV (adjusted OR, 1.02; 95% CI, 1.01–1.05, <I>P</I> = 0.046) predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP.</P>