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Eun Sook Nam,Duck Hwan Kim,Gi-Taek Jang,Hae Rim Park,Jeong Rye Kim,Hyung Sik Shin 대한암학회 2002 Cancer Research and Treatment Vol.34 No.1
Purpose: There are increasing evidences that angiogenesisenhances tumor growth and biological aggressivenessin gastric carcinoma. Mast cells have beenimplicated in the angiogenic process, by secretingangiogenic factors including vascular endothelial growthfactor (VEGF), or enzymes that degrade extracellularmatrices. However, the exact nature of mast cells inrelation to cancer is contradictory so we conductedretrospective studies, to find the significance of mast celldensities, and microvessel counts in each clinicopathologicfactors, including VEGF expression, in propermuscle (PM) gastric carcinoma.Materials and Methods: 52 specimens, obtained frompatients with PM gastric carcinoma, were studied usingthe immunohistochemical methods, monoclonal antibodiesfor mast cell tryptase, factor VIII-related antigenand VEGF.Results: Mast cell densities were significantly increasedin diffuse histologic type (p=0.042), infiltratingmargins (p〈0.0001) and VEGF positive (p=0.010) tumors.Microvessel counts were significantly higher in patientsover 55 years old (p=0.024), with tumor sizes larger than〉3 cm (p=0.015), diffuse histologic type (p=0.038) andlymph node metastasis (p=0.001). Similarly there were significantlyincreased densities in VEGF positive tumors (p〈0.0001). Pearson's correlation analysis revealed asignificant relationship between mast cell densities andmicrovessel counts (r=0.614, p〈0.01), indicating a highvascular grade with increased number of mast cells.Conclusion: We demonstrated a close relationshipbetween mast cell densities, microvessel counts andVEGF expression. These results suggest that mast cellsand VEGF are important regulators of tumor angiogenesisand cooperatively induce the formation of vascular stromain PM gastric carcinomas. (Cancer Res Treat. 2002;34:41-45)