Effect of Developmental Lead Exposure on the Expression of Hippocampal NMDA Receptor Subunit mRNA

Kim, Tae-Wan,Chung, In-Sung,Bae, Jae-Hoon,Shin, Dong-Hoon,Lee, Mi-Young,Kim, Joon-Sik 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

목적: in vivo 및 vitro에서 해마 신경세포의 발생단계별 NMDA 수용체 아단위 mRNA 발현에 대한 연 폭로 영향을 알아보고자 하였다. 방법: 흰쥐 해마 신경세포의 발생단계별 NMDA 수용체 NR2A, NR2B 아단위 mRNA 발현에 대한 연의 영향은 정상군과 연 폭로군의 출생 후 7일, 14일, 22일 흰쥐의 해마에서 in situ hybridization으로 mRNA 발현 정도를 densitometer로 측정하여 비교하였고, 연과 NMDA 의 세포독성은 해마 신경세포 일차배양 후 도립현미경을 이용한 형태학적인 관찰과 LDH 활성도를 이용하여 측정하였다. 결과: 연 과 NMDA 에 의한 세포독성에 대한 in vitro 실험에서 형태학적 소견과 LDH 활성도에서 해마 미성숙 신경세포와 성숙 신경세포사이의 차이가 있었으므로, 연과 NMDA 독성효과는 해마 신경세포의 발달 단계에 따라 차이가 있다. 정상군의 해마에서의 NR2A mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나, NR2B mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나 NR2B mRNA 발현은 연령의 증가에 따른 변화가 없었다. 연 폭로에 희한 NR2A mRNA 발현은 유의하게 감소하였으나(p<0.05), NR2B mRNA 발현은 변화가 나타나지 않았다. 만성적 연 폭로는 NR2A를 포함하는 NMDA 수용체를 감소시킬 수 있음을 알 수 있다. 결론: 연은 해마신경세포의 발생단계에서 NMDA 수용체 아단위 특히 NR2A mRNA 발현의 변화를 야기하여 시냅스 신호 전달에 영향을 나타냄을 알 수 있었다. Hippocampus

Erratum to: Occurrence and surgical treatment of massive Morel-Lavallée lesion after large-volume liposuction: A rare clinical case

Byeong Jun Kim,Chul Hoon Chung,이승준 대한미용성형외과학회 2020 Archives of Aesthetic Plastic Surgery Vol.26 No.1

We have noticed an error in our published paper above. In the title, the order of “Byeong Jun Kim, Chul Hoon Chung, Seung Jun Lee” should be “Byeong Jun Kim, Seung Jun Lee, Chul Hoon Chung.” We sincerely apologize for the inconvenience that this may have caused.

沙上地域 産業體 勞動者의 職場體育 參與擴大 方案

安永弼,鄭琮勳,鄭三鉉,金海禮,趙在基,朴俊東,金垠利,張禎允,金福善,孔庚鎬 東亞大學校附設스포츠科學硏究所 1989 스포츠科學硏究論文集 Vol.7 No.-

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

위그너 분포함수를 이용한 이중장벽 공명 투과다이오드의 전류-전압특성에 관한 연구

金裕承,金正勳,徐柾河,沈載勳 弘益大學校 科學技術硏究所 1996 科學技術硏究論文集 Vol.7 No.2

By means of the self consistent calculation of the related Poisson's equation and the Wigner distribution function, the quantum transport of electrons in a double barrier tunneling diode(DBRTD) has been studied. The computer simulation has been accomplished by assuming the contacts/terminals of a DBRTD are open with regard to the surrounding. The eigenvalues of the Liouville superoperator of the equation of motion were also calculated. The derived Ⅰ-Ⅴcharacteristic of a DBRTD shows a similar trend with the results obtained by the conventional tunneling models.

집속이온빔을 이용한 3차원 마이크로스케일 몰드 제작 및 폴리머 복제

김충수,안성훈,장동영 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

Focused ion beam (FIB) sputtering was used to fabricate a low microscale mold having a circular curved structure, as well as variable sizes. Experimentally, in this work, a continuous slicing method, which was modified from two-dimensional slice-by-slice approach developed by Fu, was tested with the aim of excluding the material redeposition phenomena by repeating the discrete slicing process with a combination of spiral scans as part of an overall vector scan. Three types of fabrication strategies, including scan strategy, ion beam condition, and processing parameter, were defined and the mould was fabricated as a function of ion dose for specific dwell times. Through replication technique from fabricated moulds, polymeric microstructures were replicated from polydimethy-lsiloxane (PDMS) and polyurethane acrylate (PUA) and compared with the mould dimension. Furthermore, micro-lens arrays was also fabricated and replicated.

칼만증후군(Kallmann's Syndrome) 1례

김용성,백승훈,유경훈,구기선,형근영,김경년,조정구 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

Kallmann's syndrome is the most common form of isolated gonadotropin deficiency, characterized by hypogonadotropic hypogonadism due to GnRH deficiency, delayed puberty and smelling difficulty. It occurs sporadic or familial pattern, and the mode of inheritence has not been fully documented. The defect in patient of Kallmann's syndrome occurs at suprapituitary level involving mechanism that regulate GnRH synthesis or release, so this syndrome classified as a secondary hypogonadotropic hypogonadism. The gonadotropin or pulsatile GnRH administration enable successful stimulation of spermatogenesis and fertility. We have experienced 1 patient with Kallmann's syndrome and presented with the review of the literature.

유아체육'의 인터넷 검색 구조 분석

김기영,이충훈 한국유아체육학회 2003 한국유아체육학회지 Vol.4 No.-

본 연구는 현대인의 정보전달과 공유에 있어서 그 영향력이 대단히 큰 인터넷상의 '유아체육' 에 대한 검색결과를 조사·분석하여 나타난 문제점을 도출하고 향후 '유아체육'에 대한 보다 신속하고 정확한 정보검색의 방향을 논의하고 제시하는데 그 목적이 있다. 연구의 목적에 따라 국내 5대 검색 엔진의 사이트를 대상으로 하였으며, 최상위 카테고리(Category)에서 최하위 카테고리(Category)까지 조사하되, 최상위의 카테고리(Category) 또는 디렉토리를 분석한 결과 다음과 같은 결론을 얻었다. 1. '유아체육' 카테고리(Category) 형성의 미흡으로 정보검색 방향이 난해함. 2. 제2수준에서의 카테고리(Category) 형성 분류의 명확성이 결여됨. 3. 사이트 등록에 있어서의 '유아체육'에 대한 학문적 인식이 부족함. 상기와 같은 결과를 통해서 볼 때 '유아체육'검색 카테고리(Category) 형성의 방향성을 제시하자면, 첫째는 '유아체육' 웹사이트 제작자가 인터넷 검색 기능의 효율성을 제대로 인식해야 되겠으며, 둘째로는 검색 카테고리(Category) 분류에 있어서의 신중성과 세분화를 고려해야한다고 본다. 셋째는 '유아체육'웹사이트 개발자의 검색 등록시 유아체육 비 관련자에게의 위탁을 지양해야 한다는 것이고, 넷째는 '유아체육'의 학문적 위상 정립을 위한 끊임없는 연구 활동이 계속되어야 할 것이다. Internet have a effect on information-sharing and transmission of the modems. This research aims at deduction of a point at issue on checking and analyzing retrieval and then presenting more quick, exact information-retrieval about the infant physics of the future. According to the purpose of the research, five best search engines of domestic here in Korea are selected, from the investigated highest category to the investigated lowest, we draw the following conclusion of the best category or directory. 1. Because the form of infant physics category is insufficient, we have the difficulty in finding the direction of information search. 2. The clarity of category forming classification lacks from 2nd level. 3. There to be to site registration, the study recognition about an infant physics is insufficient. Through the above conclusion we can suggest the direction of infant physics search category from like that. First the infant physics web site manufacturer can recognize the efficiency of internet search function. Second they may consider the foresight and in search category classification departmentalization. Third when we register the manufacturer's infant physics. Web site, we should stop the consign to the non-relatived persons in infant physics. Forth we should continuously study to put the position of the infant physics highly.

선천성 골형성부전 1예

김정혜,이경일,전정식,조성훈 최신의학사 1985 最新醫學 Vol.28 No.10

혈행화된 두개골 피판을 이용한 안와저 및 안와하연의 재건술 치험례

정윤규,이훈범,김석원,봉정표,김균태,김주봉 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.5

A number of methods have been introduced for support the orbital floor following a maxillectomy without orbital exenteration or severe facial trauma. These methods including skin graft and muscular sling provided the unsatisfactory results, like as diplopia, orbital ptosis, enophthalmos and severe facial deformity. Therefore the bone and soft tissue reconstructions using microvascular free flaps were performed recently by many surgeons, but long time operation, donor site morbidity, postoperative large scar, and ptosis of the flap were pointed out as disadvantages of free flap reconstruction. Vascularized calvarial bone flap, a modified method of free calvarial bone graft, was adequate for reconstruction of the orbital floor and the infraorbital rim as a horizontal buttress, especially in case of poor vascular bed and postradiated state. The authors introduced the vascularized calvarial bone flap for the orbital floor and the infraorbital rim reconstruction in 3 cases of maxillectomy, and could be obtained satisfactory results aesthetically and functionally.