米麥混食이 白鼠體內 脂質代謝에 미치는 影響

洪進敎,柳總根 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.3

The comparative study was conducted on the effect of rice diet and rice mixed with barley(10%, 30%, 60%) diet on accumulation of adipose tissue and levels of triglyceride(TG), phospholipid(PL), total cholesterol(TC), and high density lipoprotein(HDL)-cholesterol in serum of albino rats(Wistar). 1. Adipose tissue accumulation and levels of TG, PL, TC serum in were lower in rice mixed with barley diet group than in rice diet group to the extent that the more barley was mixed with rice, the lower the levels of the above parameters. 2. HDL-cholesterol level was lower in the group where more barley was mixed with rice at 2 weeks after feeding. Rice diet group showed the highest level. 3. TC-HDL cholesterol level was lower in rice mixed with barley diet group than in rice diet group. 4. HDL-cholesterol level decreased in all the diet groups as the feeding period went, in contrast that TC-HDL cholesterol level increased gradually during the same period. 5. The average contents of NDF, ADF and lignin in barley(38% polished Convered barley) were 5.25g%, 2.078% and 1.11g%, respectivity. Based on the above observations it can be deduced that rice mixed with barley diet has the effect to suppress the adipose tissue accumulation and serum elevation of lipid level mainly by dietary fibers contained in barley to the extent that the more barley contained in diet, the more inhbitory effect it shows.

Duchenne형 進行性 筋異養症 保因者 檢出에 Restriction Fragment Length Polymorphism 이용에 관한 硏究

李美正,朴吉洪,朴善華,柳總根 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.3

We performed genetic analysis for detection of carrier state of Duchenne's muscular dystrophy (DMD). As genetic markers of the disorder, We used DNA-sequence polymorphisms detected with 6 different DNA probes derived from the vicinity of the DMD locus at genetic distance less than 15 cmo or from within the gene. on the short arm of X chromosome. In the family we studied. a consultand was a 29 years old woman whose maternal grandfather was a DMD patient who was unavailable. Therefore, all of her maternal aunts were DMD carriers whose next generations were requested for DNA studies. On the basis of linkage analysis. a proband and her niece were deemed to be unaffected with an accuracy of more than 99%, and we anticipated another two femals and one malt to be unaffected with 98% probability (normal serum creatine kinase level) where crossover events between intragenic(pERT 87.30) and flanking probes(pXUT23) were detected. but carrire risk of a female with the same haplotype was elevated to 41% taking account of an increased serum creatine kinase level. Two other females were predicted to be affected with 99.9 and 97.1% probabilities each. However. a genetic interpretation was impossible for one male in which a crossover breakpoint could not be determinied because of his mother's homozygosity of the alleles between crossovered alleles where hitherto pessibility of intragenic crossover could not be ruled out Our experience suggests that genetic diagnosis based on recombinant deoxyribonucleic acid techniques are assuming increasing importance. and provide a highly accurate method for carrier detection and prenatal diagnosis of DMD. By the way, despite the large number of intragenic and flanking DNA polymorhpisms available, uncertainties often remain in the genetic diagnosis of DMD. Pitfalls are presented by the large size of the region in which Duchenne's mutations can occur. Crossover events in this region. especially intragenic ones, which result in an exchange of DNA between two X chromosomes, can,rener DNA-marker studies inaccurate.

종격동 종괴를 의심케한 우대동맥궁 1례

김만우,백학연,정춘해,장경식,홍순표,조건국,김종진 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1

Developmental anomalies of the aortic arch, commonly known as vascular rings, are relatively rare congenital vascular anomalies which can compress the trachea and esophagus. One routine chest film of a patient who was checked and hepatoma-diagnosed in Internal Medicine, Chosun University Hospital left the room for doubt of mediastinal mass. But no subjective symptoms for the mass was told by the patient. This is to report our experience of a patient having right side aortic arch with aberrant left subclavian artery, as proved by diagnosis, but none of congenital heart disease. This right side aortic arch with aberrant left subclavian artery is the most frequent type among right aortic arch, the anomaly of which is usually detected from the incidental suspicion for mediastinal mass at routine chest film; because no symptoms are accompanied therewith.

한국인 3차원 인체형상모델을 이용한 고리뼈의 성별판별 검증

홍종근(Chong-Kun Hong),정재광(Jae-Kwang Chung),이우영(U-Young Lee),김덕수(Duk-Soo Kim),박대균(Dae-Kyoon Park),박경호(Kyung-Ho Park) 대한체질인류학회 2014 해부·생물인류학 (Anat Biol Anthropol) Vol.27 No.4

사망 당시의 정보를 알고 있는 마른뼈들을 통계학적으로 분석한 연구가 있다면 마른뼈를 법의인류학적으로 분석하여 개인식별항목(biological profile)을 추정하는 것이 가능하다. 한국인의 경우 개인식별항목을 추정하는 데 필요한 뼈표본이 거의 없기 때문에 개인식별항목을 추정하기 위한 통계학적 자료가 부족하다. 그러므로 뼈대에 붙어 있는 물렁조직을 모두 제거하여 뼈표본을 제작하는 방법의 대안으로 방사선으로 촬영된 진단영상을 활용하여 뼈대를 3차원으로 재구성하는 연구가 제안되고 있다. 이 연구는 해부용 시신을 컴퓨터단층촬영(computed tomography)하여 구축한 3차원 인체형상모델에서 뼈대 정보를 재구성하여 계측하였고, 통계학적 분석을 통해 성별을 추정하는 데 도움이 되는지를 조사하였다. 가톨릭대학교 가톨릭응용해부연구소에서 관리하고 있는 디지털 코리언(Digital Korean) 데이터베이스에서 고리뼈 (atlas) 100개 (남성 51개, 여성 49개)를 계측하였다. 3차원 컴퓨터 프로그램인 미믹스 (Mimics, Simulation module, Version 13.0, Materialise NV, Belgium)를 이용하여 계측항목들을 계측하였고, IBM® SPSS® (version 20.0, Armonk, New York)를 이용하여 통계학적 분석을 하였다. 계측 결과를 실제 마른뼈의 연구에서 얻은 판별함수를 적용하였을 때 정확도가 떨어졌기 때문에 새롭게 판별함수를 구하였고, 19개 계측항목들 중에서 고리뼈너비(Width of Atlas)가 성별을 추정하는 데 가장 유용한 계측 항목이었다. 본 연구 결과 고리뼈너비가 76.7mm보다 큰 값일 경우 남성으로 판별할 수 있었다. 뼈표본이 부족한 현실에서 한국인 뼈대의 체질인류학적 특징을 연구하는 것은 한계가 있다. 그러므로 방사선 진단영상에서 3차원으로 재구성한 뼈대를 활용하여 형태학적 특징을 규명하려고 시도된 이번 연구의 결과는 디지털 코리언 데이터베이스를 활용하여 체질인류학적 연구를 할 수 있는 가능성을 보여주었다고 생각되고 현장에서도 계측값을 통해 성별을 추정하는 데 도움이 될 것으로 판단된다. Estimation of biological profile for skeletal remains by forensic anthropological examination would be possible based on physical anthropological studies which were statistically analyzed. However, physical anthropological studies for Korean population are not enough to establish biological profile for Korean because there is lack of documented osteological specimens in Korea. Recent study suggested that physical anthropological examination could be possible on the three dimensional data which were reconstructed from computed tomography, instead of preparing skeletal specimen by defleshing bone. One of the aim of this study is to evaluate Digital Korean database which were composed of computed tomographic images of 100 cadavers. The other is to perform statistical analysis on morphometrics for segmented atlas whether the results could be helpful to estimate sex in Korean. We measured 100 segmentation atlases (male 51, female 49) from the Digital Korean database which were under the control of Catholic Institute for Applied Anatomy, The Catholic University of Korea. Measurements of segmented atlas were carried out by using Mimics software (Simulation module, Version 13.0, Materialise NV, Belgium), and values of measurement were performed statistical analysis by IBM® SPSS® (version 20.0, Armonk, New York). Among 19 measurements, the width of atlas showed most crucial element for estimating sex, which was consistent with the result using dried bones of atlas and hit ratio of discriminant functions was 88.0%. 76.7 was the cut-off score of discriminant functions. This results showed that morphometrics for segmented atlas could be helpful in estimating sex using the Digital Korean database. In the future, we expect that the other researchers could more actively use the Digital Korean database as a good specimen for physical and forensic anthropological study.

일개 응급센터에서 급속가압수액주입기의 사용경험

홍종근 ( Chong Kun Hong ),송형곤 ( Hyoung Gon Song ) 대한외상학회 2006 大韓外傷學會誌 Vol.19 No.1

Purpose: Hypovolemia is not uncommon among trauma patients in the emergency department (ED). Successful resuscitation of a hypovolemic patient often requires rapid intravenous administration of massive amounts of fluid. A rapid fluid infuser is used in the ED for this purpose, there have been no studies of their clinical uses and effectiveness. We studied clinical experience with a rapid fluid infuser at an urban university hospital in Seoul, Korea. Methods: We reviewed the medical records of 38 patients admitted to the ED with a history of application of a rapid fluid infuser from January 2004 to July 2005. Adult trauma patients older than 15 years of age were included in this study. Clinical data on the patients and the volume of fluid used to achieve a stable blood pressure were extracted from their medical records. Results: The total number of adult trauma patients with a history of application of a rapid fluid infuser from January 2004 to July 2005 in the ED was 16. The mean systolic blood pressure for deciding to apply the rapid fluid infuser was 74.9±12.7 mmHg. The mean time and volume used to achieve a stable blood pressure were 40.4 min and 2947.3±1339.2 ml, respectively. In all patients, the amount of fluid infused before using the rapid fluid infuser was between 500 ml and 10,000 ml, compared to 1,000 ml and 6,200 ml with the rapid fluid infuser. The mean amount of fluid per min. via the rapid fluid infuser was 85.5 ml. Vital signs were stabilized in 11 patients, 6 of the 11 were discharged alive. Conclusion: The mean amount of fluid delivered per min. via the rapid fluid infuser was much less than expected; thus, there should be clinical guidelines on volume resuscitation with a rapid fluid infuser in the ED. In the future, prospective, multicenter, clinical-data collection is needed for a more sophisticated study. (K Korean Soc Traumatol 2006;19:41-46)

해안 하구역의 이용계획과 문제점

홍길표,편종근 한국해안해양공학회 1991 학술강연회 발표논문초록집 Vol.1 No.1

식육판매장의 HACCP system 운용 개선을 위한 제언

홍종해 ( Chong-hae Hong ),강천근 ( Cheon Kun Kang ) 한국동물위생학회 2012 韓國家畜衛生學會誌 Vol.35 No.4

Hazard Analysis Critical Control Point (HACCP) system application is expanded to food chain from farm to table to supply safe livestock products with consumers in Korea. The objectives of this study were to analyze the HACCP operating conditions in butcher shops and to suggest for better HACCP implementation. We analyzed the HACCP inspection reports for butcher shops implemented by the Korea Livestock Products HACCP Accreditation Service from 2007 to 2009 and from 2010 to 2012 to compare the rate of HACCP non-compliances. The overall rate of non-compliances was higher in 2010∼2012 than 2007∼2009. The current inadequate HACCP operating level was directly related with the business size. Ninety-nine percent of the butcher shops were very small business with under 10 em-ployees in Korea, and these small-sized businesses usually had great difficulties in implementing HACCP due to lack of technical expertise and financial resources. To overcome the obstacles and to facilitate more effective HACCP application and operation in butcher shops, government should play a leading role in developing flexible and simplified HACCP-based system which merges both the pre-requisite and HACCP principles.

광고 메시지 프레이밍 및 지식 유형에 따른 기억정보처리 과정 연구

진홍근(Hong Kun Chin),김민정(Min Jung Kim),이종민(Chong Min Lee) 한국광고홍보학회 2011 한국광고홍보학보 Vol.13 No.3

본 연구의 목적은 광고 메시지 프레이밍 유형(긍정 vs. 부정) 및 지식 유형(주관적 vs. 객관적)에 따라 기억정보처리 과정에 어떠한 차이가 존재하는지 살펴보는 데 있다. 이를 위해 본 연구는 소비자의 광고 기억정보 유형을 4가지로 구분하였으며, 각 조건에서 어떤 유형의 기억 정보가 구매결정에 더 중요한 역할을 하는지 살펴보았다. 분석 결과에 따르면 긍정 메시지 프레이밍 조건에서는 종합적인 기억 정보가 더 중요한 역할을 수행하는 반면에, 부정 메시지 프레이밍 조건에서는 개별적인 기억 정보가 더 중요한 역할을 수행하는 것으로 나타났다. 한편 지식의 유형에 따라서도 차이가 나타났다. 주관적 지식이 높은 소비자는 종합적인 기억 정보를 더 많이 활용하는 반면에, 객관적 지식이 높은 소비자는 개별적인 기억 정보를 더 많이 활용하는 것으로 나타났다. The purpose of this study is to investigate the difference of advertising memory information processing by types of message framing(positive vs. negative) and consumer knowledge(subjective vs. objective). For this, this study classified advertising memory information into four types and then examined what type of advertising memory information plays a more significant role in determining purchase judgement in each condition. According to the findings, the type of global memory information plays a more significant role in the positive message framing condition while the discrete one plays a more significant role in the negative message framing condition. The difference was also found according to types of consumer knowledge. Consumers who were in high level of subjective knowledge tend to use the type of global memory information more significantly in determining purchase judgement while those who were in high level of objective knowledge were likely to utilize the discrete one more significantly.

조류역에서의 지형변동에 관한 사례연구(Ⅰ)

편종근,홍길표,최병호 한국해안해양공학회 1990 학술강연회 발표논문초록집 Vol.1 No.1

골노출을 동반한 피부결손에 대한 근이전술

박홍근(Hong Kun Park),유총일(Chong Ill Yoo) 대한정형외과학회 1979 대한정형외과학회지 Vol.14 No.3