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이원철,최병철,오민화,박정일,김현욱,구정완 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives: In order to establish prevalence and characteristics of tinnitus and hearing thresholes according to tinnitus, this study was carried out. Methods: Nine hundred and thirty two subjects, undergone human dock or general health check-up and been in college, were surveyed to the questionnaire on the general characteristics, past medical histories, life styles, subjective symptoms about hearing, taking ototoxic drugs and were conducted on the hearing thresholds by pure tone audiometry. Results: Of the total population, 98 reported tinnitus, giving an overall prevalence of 10.5%, prevalence of tinnitus in the subjects with the factors influencing hearing thresholds were 17.4%, prevalence without the factors influencing hearing thresholds were 7.5%. Frequency of tinnitus of the total population was the highest in 'once per several months' (39.6%) and followed by 'once per several days'(29.7%), 'all day long' (16.5%) and 'several times per day' (14.3%). Complaint site of tinnitus was 41.8% in left ear or right ear, 39.6% in both ear and 18.7% in head. The 13.6% of the total subjects complained sleep disturbance. Hearing thresholds in the subjects without the factors influencing hearing thresholds tended to increase or decrease in 20 and 30 years old according to tinnitus, but those with tinnitus tended to increase more than those without tinnitus in 40 and 50 years old. Conclusions: Results also provide evidence that reports of tinnitus at the time of annual audiometric testing may be useful in identifying workers at greater risk for developing significant shifts in hearing thresholds. Awareness of the possible occurrence of tinnitus may encourage workers to cooperate more actively in a company hearing conservation programme.
( Byung Geun Kim ),( Myung Hwan Noh ),( Choong Heon Ryu ),( Hwa Seong Nam ),( Su Mi Woo ),( Seung Hee Ryu ),( Jin Seok Jang ),( Jong Hun Lee ),( Seok Ryeol Choi ),( Byeong Ho Park2 ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.3
Background/Aims: The bedside index of severity in acute pancreatitis (BISAP) is a new, convenient, prognostic multifactorial scoring system. As more data are needed before clinical application, we compared BISAP, the serum procalcitonin PCT), and other multifactorial scoring systems simultaneously. Methods: Fifty consecutive acute pancreatitis patients were enrolled prospectively. Blood samples were obtained at admission and after 48 hours and imaging studies were performed within 48 hours of admission. The BISAP score was compared with the serum PCT, Ranson`s score, and the acute physiology and chronic health examination (APACHE)-II, Glasgow, and Balthazar computed tomography severity index (BCTSI) scores. Acute pancreatitis was graded using the Atlanta criteria. The predictive accuracy of the scoring systems was measured using the area under the receiver-operating curve (AUC). Results: The accuracy of BISAP (≥ 2) at predicting severe acute pancreatitis was 84% and was superior to the serum PCT (≥ 3.29 ng/mL, 76%) which was similar to the APACHE-II score. The best cutoff value of BISAP was 2 (AUC, 0.873; 95% con- fidence interval, 0.770 to 0.976; p < 0.001). In logistic regression analysis, BISAP had greater statistical significance than serum PCT. Conclusions: BISAP is more accurate for predicting the severity of acute pancreatitis than the serum PCT, APACHE-II, Glasgow, and BCTSI scores.
Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향
김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.
Park, Sang Kyu,Cho, Illhun,Gierschner, Johannes,Kim, Jin Hong,Kim, Jong H.,Kwon, Ji Eon,Kwon, Oh Kyu,Whang, Dong Ryeol,Park, Jung‐,Hwa,An, Byeong‐,Kwan,Park, Soo Young WILEY‐VCH Verlag 2016 Angewandte Chemie Vol.55 No.1
<P><B>Abstract</B></P><P>We report on a molecularly tailored 1:1 donor–acceptor (D‐A) charge‐transfer (CT) cocrystal that manifests strongly red‐shifted CT luminescence characteristics, as well as noteworthy reconfigurable self‐assembling behaviors. A loosely packed molecular organization is obtained as a consequence of the noncentrosymmetric chemical structure of molecule <B>A1</B>, which gives rise to considerable free volume and weak intermolecular interactions. The stacking features of the CT complex result in an external stimuli‐responsive molecular stacking reorganization between the mixed and demixed phases of the D‐A pair. Accordingly, high‐contrast fluorescence switching (red↔blue) is realized on the basis of the strong alternation of the electronic properties between the mixed and demixed phases. A combination of structural, spectroscopic, and computational studies reveal the underlying mechanism of this stimuli‐responsive behavior.</P>
위선종에서 mitotic spindle checkpoint 조절유전자인 hsMAD2의 돌연변이
박병규 ( Park Byeong Gyu ),박경화 ( Park Gyeong Hwa ),김한수 ( Kim Han Su ),송시영 ( Song Si Yeong ),홍성필 ( Hong Seong Pil ),박승우 ( Park Seung U ),정재복 ( Jeong Jae Bog ),강진경 ( Kang Jin Gyeong ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> Mitosis 과정에서 염색체 분리는 spindle checkpoint에 의해 조절을 받으며, spindle checkpoint에 결함이 있을시에 aneuploidy가 발생하여 발암과정과 연관된다고 알려져 있다. hsMAD2는 spindle checkpoint를 조절하는 중요한 유전자로 본 연자등은 위암에서 빈번한 돌연변이 및 hot spot을 보고한 바 있으며, hsMAD2돌연변이에 의한 염색체 불안정성과 위암 발생과의 연관성을 제시한 바 있
박소담(Sodam Park),홍종섭(Jongsup Hong),정재용(Jaeyoung Jeong),박경일(Kyoung il Park),박병철(Byeong cheol Park),김동원(Dong won Kim),이규화(Kyu hwa Lee),이은도(Uendo Lee) 한국열환경공학회 2020 한국열환경공학회 학술대회지 Vol.2020 No.춘계
본 연구에서는 연소와 가스화를 위한 복수의 유동층 반응기로 구성된 가압 순산소 연소 기반 복합발전 시스템에 대한 공정해석을 수행하였다. 대상 공정은 가압 순산소 연소로 생성된 고온 연소가스 일부를 가스화제로, 가스화기에서 발생되는 미반응 촤를 연소기 연료로 사용하는 복합공정으로, 두 반응기 사이의 열 및 물질 전달이 매우 중요한 시스템이다. 연소기에서 발생된 배가스 내 고온의 CO₂와 H₂O는 가스화기로 공급되어 각각 Boudouard 반응, 스팀 가스화 반응을 통해 CO와 H₂의 수율에 영향을 준다. 이때 연소 가스는 가스화에 필요한 열원을 공급하는 동시에 가스화제로 이용되므로 가스화기 온도 및 반응물 제어에 큰 영향을 미치며 결과적으로 합성가스의 품질을 좌우한다. 본 연구에서는 상용 공정해석 툴을 활용해 운전인자에 따른 합성가스 생성특성을 파악하고 최적 운전조건 도출을 위한 민감도 분석을 수행하였다. 가스화 운전 제어를 위해 연소가스와 함께 산소를 가스화제로 사용하여 합성가스의 조성 및 발열량을 분석하였으며 연소기로 공급되는 미반응 촤의 순환량에 따른 결과를 분석하여 최적 운전조건을 파악하였다.
교량상판 슬래브의 동적응답을 이용한 영향선 추출 및 통행차량 축 하중의 인식
김병화 ( Kim Byeong Hwa ),김수진 ( Kim Soo Jin ),여금수 ( Yeo Keum Soo ),박민석 ( Park Min Seok ),박희구 ( Park Heui Gu ) 한국구조물진단유지관리공학회 2009 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.13 No.2
Introducing a new algorithm to extract moment influence sequence from field data, a new identification algorithm for the axle loads of moving vehicles has been proposed. The proposed approach is based on an optimal linear filter design theory. The proposed algorithm makes use of the strain time histories of a bridge deck plate. The accuracy and practicability of the algorithm have been examined experimentally for a folded deck plate on Yongjong Grand suspension bridge. It turns out that the algorithms are feasible and economical while some further works for the accuracy improvement are expected.
프리스트레스 콘크리트 보의 긴장력과 종진동특성 사이의 관계
김병화(Kim, Byeong Hwa),김수진(Kim, Soo Jin),여금수(Yeo, Keum Soo),장정범,이홍표,Park, Min Seok,Park, Heui Gu 한국구조물진단유지관리학회 2009 한국구조물진단학회 학술발표회논문집 Vol.2009 No.2
This study investigates the experimental relationship between applied prestress force level and dynamic property of a bonded prestressed concrete beam. Total six prestressed concrete beams with different stress levels have been constructed for this investigation. The various axial vibration tests have been conducted to extract dynamic characteristics of the prestressed concrete beams. It turns out that the axial frequency, elastic wave velocity and elastic modulus nonlinearly increase as the prestress force level increases.