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RISS 인기검색어
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- 저자 : ( Ahmed M. Faried ) (검색결과 4 건)
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Faris Elbahi Joatar,Ali Ahmed Al Qarni,Muhalab E. Ali,Abdulaziz Al Masaud,Abdirashid M. Shire,Nagalla Das,Khalid Gumaa,Hayder Ahmed Giha 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.3
Background: Ghrelin (GHRL), a gastric peptide encoded by the GHRL gene, is known to be involved in energy homeostasis via its G protein receptor, encoded by the growth hormone secretagogue receptor (GHSR) gene. Some studies have shown associations between plasma GHRL levels and GHRL single-nucleotide polymorphisms (SNPs), namely the Leu72Met polymorphism (rs696217 TG), with type 2 diabetes mellitus (T2DM) and insulin resistance (IR), while others have not. The controversies in these associations raise the issue of ‘which SNPs in which populations.’ The aim of this study was to investigate whether SNPs in GHRL and/or GHSR genes were associated with T2DM, IR, or plasma GHRL levels among Arab Saudis. Methods: Blood was collected from 208 Saudi subjects with (n=107) and without (n=101) T2DM. DNA samples from these subjects were analyzed by real-time polymerase chain reaction to genotype five intronic SNPs in the GHRL (rs696217 TG, rs27647 CT, rs2075356 CT, and rs4684677 AT) and GHSR (rs509030 GC) genes. In addition, plasma GHRL levels were measured by a radioimmunoassay. Results: None of the SNPs were associated with T2DM, IR, or plasma GHRL levels. The frequencies of the alleles, genotypes, and haplotypes of the five SNPs were comparable between the T2DM patients and the non-diabetic subjects. A large number of the GHRL haplotypes indicates the molecular heterogeneity of the preproghrelin gene in this region. Conclusion: Neither the Leu72Met polymorphism nor the other intronic GHRL and GHSR SNPs were associated with T2DM, IR, or GHRL levels. Further investigations should be carried out to explain the molecular basis of the association of the GHRL peptide with T2DM and IR.
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Ali Ahmed Al Qarni,Faris Elbahi Joatar,Nagalla Das,Mohamed Awad,Mona Eltayeb,Ahmed Gasim Al-Zubair,Muhalab E. Ali,Abdulaziz Al Masaud,Abdirashid M. Shire,Khalid Gumaa,Hayder A. Giha 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.2
Background: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. Methods: Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique. Results: Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3≤ HOMA-IR <5). HOMA-IR values were not associated with age, disease duration, or gender. Importantly, T2DM itself and the co-occurrence of IR with T2DM were significantly associated with low plasma ghrelin levels. However, ghrelin levels were inversely correlated with the HOMA-IR index, body weight, and fasting plasma insulin levels, mainly in the control subjects, which was indicative of the breakdown of metabolic homeostasis in T2DM. Conclusion: The prevalence of IR was relatively low, and IR may be inversely associated with plasma ghrelin levels among Saudi patients with T2DM.
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Imran Amin,M. Yaqoob Khan,M. Waqar Ahmed,Faris Alzahrani,M. Ijaz Khan 한국자기학회 2023 Journal of Magnetics Vol.28 No.1
The entropy of electron-positron and ion plasma plays a significant role in the transportation of particles, momentum, and energy. Drift waves in these plasmas produce central mechanisms for this transport. The effects on tri-polar and quadrupolar vortexes in epi plasma have been analyzed numerically under various approximations. As plasma consists of various elements, it is important to understand the effects of entropy on systems. In this article, we have discussed how entropy affects linear and non-linear equations in the presence of temperature, equilibrium density, electrostatic potential gradients, and a magnetic field. Additionally, by investigating tri-polar and quadrupolar vortexes without regard for entropy effect we can find information about this phenomenon.
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Abdel Aziz A. Fayed,Azza M. H. El-Hadidy,Ahmed M. Faried,Asmaa O. Olwey 한국식물분류학회 2019 식물 분류학회지 Vol.49 No.1
Numerical taxonomy is employed to determine the phenetic proximity of the Egyptian taxa belong- ing to the genus Ononis L. A classical clustering analysis and a principal component analysis (PCA) were used to separate 57 macro- and micromorphological characters in order to circumscribe 11 taxa of Ononis. A clus- tering analysis using the unweighted pair-group method with the arithmetic means (UPGMA) method gives the highest co-phenetic correlation. Results from clustering and PCA revealed the segregation of five groups. Our results are in line, to some certain degree, with the traditional sub-sectional concept, as can be seen in the group- ing of the representative members of the subsections Diffusae and Mittisimae together and the representative members of the subsections Viscosae and Natrix. The phenetic uniqueness of Ononis variegata and O. reclinata subsp. mollis was formally established. However, our findings contradict the classic sectional concept; this opin- ion was suggested earlier in previous phylogenetic circumscriptions of the genus. The most useful characters that provide taxonomic clarity were discussed.
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