EGFR-TKI Combined with Pemetrexed versus EGFR-TKI Monotherapy in Advanced EGFR-Mutated NSCLC: A Prospective, Randomized, Exploratory Study

Weiguang Gu,Hua Zhang,Yiyu Lu,Minjing Li,Shuang Yang,Jianmiao Liang,Zhijian Ye,Zhihua Li,Minhong He,Xiaoliang Shi,Fei Wang,Dong You,Weiquan Gu,Weineng Feng 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

Purpose We aimed to evaluate whether the addition of pemetrexed is effective in improving progression-free survival (PFS) in epidermal growth factor receptor (EGFR)–mutated patients with or without concomitant alterations. Materials and Methods This multicenter clinical trial was conducted in China from June 15, 2018, to May 31, 2019. A total of 92 non–small cell lung cancer (NSCLC) patients harboring EGFR-sensitive mutations were included and divided into concomitant and non-concomitant groups. Patients in each group were randomly treated with EGFR–tyrosine kinase inhibitor (TKI) monotherapy or EGFR-TKI combined with pemetrexed in a ratio of 1:1. PFS was recorded as the primary endpoint. Results The overall median PFS of this cohort was 10.1 months. There were no significant differences in PFS between patients with and without concomitant and between patients received TKI monotherapy and TKI combined with pemetrexed (p=0.210 and p=0.085, respectively). Stratification analysis indicated that patients received TKI monotherapy had a significantly longer PFS in non-concomitant group than that in concomitant group (p=0.002). In concomitant group, patients received TKI combined with pemetrexed had a significantly longer PFS than patients received TKI monotherapy (p=0.013). Molecular dynamic analysis showed rapidly emerging EGFR T790M in patients received TKI monotherapy. EGFR mutation abundance decreased in patients received TKI combined chemotherapy, which supports better efficacy for a TKI combined chemotherapy as compared to TKI monotherapy. A good correlation between therapeutic efficacy and a change in circulating tumor DNA (ctDNA) status was found in 66% of patients, supporting the guiding role of ctDNA minimal residual disease (MRD) in NSCLC treatment. Conclusion EGFR-TKI monotherapy is applicable to EGFR-sensitive patients without concomitant alterations, while a TKI combined chemotherapy is applicable to EGFR-sensitive patients with concomitant alterations. CtDNA MRD may be a potential biomarker for predicting therapeutic efficacy.

A study regarding anatomical variation of Gilssonean pedicles in right and left hemiliver

Weiguang Xu,In Gyu Kim,Yong Keun Park,Hee-Jung Wang 한국간담췌외과학회 2013 한국간담췌외과학회 학술대회지 Vol.2013 No.4

Anatomical Variation of the Glissonean Pedicle of the Right Liver

Weiguang Xu,Hee Jung Wang,Bong-Wan Kim,Yong-Keun Park,Guangyi Li 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.2

Purpose: Many studies have been conducted to date regarding whether the right hepatic vein is the accurate border that divides the anterior and posterior section of the right liver. It has been reported that the Glisson pedicle of the right liver may be an anatomical variation that does not have a consistent morphology. We analyzed the relationship between the true borders of the anterior and posterior sections, and the right hepatic vein, based on cadaver dissection and MD-CT image analysis of the anatomical variation of the Glisson pedicle of the right liver. Methods: Sixteen cadaver livers were available for dissection from the Department of Anatomy, and pre-operative MD-CTs of 20 donor livers who underwent living donor liver transplantation prior to December 2009, were obtained. We analyzed the 3D-relationship between the branches of the Glisson pedicles and the right hepatic vein of the right liver. They were divided into 3 groups according to the sliding pattern of the branches of the Glisson pedicle origin. When all segmental branches of the anterior pedicle arise from the main trunk of the anterior pedicle and all branches of posterior pedicle arise from the main trunk of posterior pedicle, it was designated as Group A (Normal Group). When a portion of the segmental branches of the anterior pedicle arises from the main trunk of the posterior pedicle, it was designated as Group B (Posterior dominant group). When a portion of the branches of the posterior pedicle arises from the main trunk of the anterior pedicle, it was designated as Group C (Anterior dominant group). Results: Among the 16 cadaver liver dissections, 6 cases were in Group A, 5 in Group B, and 3 in Group C. Two cases were excluded from the study because the inferior right hepatic vein was the main draining vein of the right liver. The analysis of preoperative MD-CT of the 20 donor livers showed that there were 13, 4, and 3 patients in Groups A, B, and C, respectively. Conclusion: According to Couinaud"s theory of anatomy, the right hepatic vein serves as the border between the anterior and posterior sections of the right liver. But, due to the frequent anatomical variations, an adequate understanding of the anatomical variations of the right Glisson pedicle should be necessary for liver surgery.

The Development of the U.S.–Australia Alliance in the Context of the Indo–Pacic Strategy

Weiguang Kong 한국국방연구원 2020 The Korean Journal of Defense Analysis Vol.32 No.1

As the United States and Australia both shifted from the “Asia–Pacic region” to the “Indo–Pacic region” in their ofcial documents, this change means that the perception of national interests of the two countries in Asia has also changed. This change has an important impact on the future development of the U.S.–Australia alliance within the “Indo–Pacic region.” Given this situation, this paper attempts to analyze the reasons why the United States and Australia moved from the “Asia– Pacific” to the “Indo–Pacific” from the perspective of their national interests. It then compares the commonalities and differences between the two countries’ national interests in the context of the “Indo–Pacic region.” Finally, based on the previous discussion, this paper will analyze how this change will affect the future development of the U.S.–Australia alliance, especially their different ways in dealing with China.

Acylation of salicylamide to 5-acetylsalicylamide using ionic liquids as dual catalyst and solvent

Weiguang Chen,Yunsheng Zhang,Zhangzhun Lu,Aili Wang,Yutang Shen,Tingshun Jiang,Longbao Yu,Hengbo Yin 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.5

The Lewis acidic ionic liquids, 1-butyl-3-methylimidazolium chloroaluminate ([BMIM]Cl-nAlCl3) and Nbutylpyridinium chloroaluminate ([BPy]Cl-nAlCl3), were used as both catalyst and solvent in Friedel–Crafts acylation of salicylamide with acetyl chloride to 5-acetylsalicylamide. The Lewis acidic ionic liquids, substituting for the conventional carcinogenic nitrobenzene solvent and anhydrous AlCl3catalyst, showed excellent catalytic activity in the acylation of salicylamide to 5-acetylsalicylamide. When [BMIM]Cl-2AlCl3 was used as the catalyst, the yield of 5-acetylsalicylamide reached 81.3%. When [BPy]-2AlCl3 was used as the catalyst, the maximum yield of 5-acetylsalicylamide was 89.2%. The content of AlCl3 and the structure of the cations in the ionic liquids had synergistic effect on the acylation reaction. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

NUMERICAL STUDY ON COMPRESSIBLE VISCOUS INTERNAL FLOWS

Weiguang Huang,Naixing Chen 대한기계학회 1992 International Conference on Fluid Machinery Vol.1 No.1

The effect of back electrode on electric properties of SnS thin film using atomic layer deposition

Hu weiguang,Hyo Sik Chang 한국진공학회 2018 한국진공학회 학술발표회초록집 Vol.2018 No.2

간이식에 있어서 간동맥 재건을 위한 미세혈관수술교육의 효과

허위광(Weiguang Xu),김봉완(Bong-Wan Kim),배병구(Byong-Ku Bae),왕희정(Hee-Jung Wang),김명욱(Myung-Wook Kim) 한국간담췌외과학회 2010 한국간담췌외과학회지 Vol.14 No.1

Purpose: During liver transplantation (LT), complications of the hepatic artery have been decreased because of microsurgery in reconstruction of hepatic artery has been widely adopted. However, in an early step of the LT program, hepatic artery reconstruction generally tends to be done with the help of a micro-surgeon from the the plastic surgery in most of Korean medical centers. In our center, we also have done reconstruction of the hepatic artery using a microscope and the skills of a plastic surgeon. We did this between Feb, 2005 and Jun, 2008 for liver transplantations. The increased the need for micro-surgeons in liver surgery as increased the cases of liver transplantation steadily. After training general surgeons of the surgical department who had no experience with microsurgery, we invested in the micro-surgery of hepatic artery reconstruction. Here we report the result of that investment. Methods: Liver transplant patients (n=176) were enrolled between Feb, 2005 and Jul, 2009. Between Jul, 2008 and Jul, 2009, 28 cases of reconstruction of the hepatic artery were done by a general surgeon who had micro-surgery training. Before training in hepatic artery reconstruction, the general surgeon spent 3 months being introduced to micro-surgery in the micro animal laboratory. Because the training was repeated, the surgeon became skilled in doing artery anastomosis using rat’s abdominal aorta. At the same time, we trained a plastic surgeon to do hepatic artery reconstruction during liver transplantation as the first assistant. From Jul, 2008 to the present time, the general surgeon was exclusively in charge of hepatic artery reconstruction during liver transplantation. Hepatic artery reconstruction was done using a microscope. Stitching was done using 8-0 or 9-0 nylon, and an interrupted end-to-end anastomosis was done. After hepatic artery reconstruction, artery flow was confirmed by ultrasonic doppler. For group A patients, left lobe grafts were used in 33, right lobe grafts in 73, dual grafts in 6, and whole liver grafts in 36. Results: For group B patients, left lobe grafts were used in 1 and right lobe grafts in 21, while whole liver grafts were used in 6. In Group A, hepatic artery complications occurred in 5 cases (3.3%), and in Group B such complications did not occur (0%). There was no statistical difference (p=0.312). Conclusion: For hepatic artery reconstruction, during micro-surgery under a surgical microscope, it is thought that it is best to invest in a general surgeon who has been trained in micro-surgery. We suggest that a general surgeon is suitable for hepatic artery reconstruction after only a short time of micro surgery training.

Thickness effect on the photoelectrochemical performances of SnS2 thin film deposited by atomic layer deposition

Hu weiguang,Hyo Sik Chang 한국진공학회 2019 한국진공학회 학술발표회초록집 Vol.2019 No.2

Application of thermally coupled energy levels in Er³⁺ doped CdMoO₄ phosphors: Enhanced solid-state lighting and non-contact thermometry

Ran, Weiguang,Noh, Hyeon Mi,Park, Sung Heum,Lee, Bo Ram,Kim, Jung Hwan,Jeong, Jung Hyun,Shi, Jinsheng Elsevier 2019 Materials research bulletin Vol.117 No.-

<P><B>Abstract</B></P> <P>Er<SUP>3+</SUP>-activated CdMoO<SUB>4</SUB> phosphors were prepared by a traditional high-temperature solid-state method. The crystal structure, photoluminescence (PL) characteristics and performance in non-contact thermometry of as-prepared phosphors were studied in detail. Benefiting from the 3D network structure of CdMoO<SUB>4</SUB> host, the desirable green emission of Er<SUP>3+</SUP>-based phosphors were observed. Especially, based on the thermally coupled energy levels, the obtained phosphors show enhanced emission intensity in high temperatures. When applied to the temperature sensor based on the fluorescence intensity ratio (FIR), the prepared CdMoO<SUB>4</SUB>:0.02Er<SUP>3+</SUP> phosphor show an excellent sensitivity (0.875% K<SUP>−1</SUP>) at 483 K. Therefore, it is demonstrated that the as-prepared Er<SUP>3+</SUP>-activated CdMoO<SUB>4</SUB> phosphors have a promising potential application in both solid-state lighting and non-contact thermometry.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Enhanced emission intensity in high temperatures has been achieved. </LI> <LI> Er<SUP>3+</SUP> doped CdMoO<SUB>4</SUB> phosphor has a potential application in solid-state lighting. </LI> <LI> High sensitivity indicates that CdMoO<SUB>4</SUB>: 0.02Er<SUP>3+</SUP> phosphor can be used in non-contact thermometer. </LI> <LI> Excellent water stability of Er<SUP>3+</SUP> doped CdMoO<SUB>4</SUB> can be used in a complex condition. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>