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ung-Hoon Kang,June-Ho Byun,Su-Jin Sung,Bong-Wook Park 대한구강악안면외과학회 2017 대한구강악안면외과학회지 Vol.43 No.3
A surgical approach involving the retromolar trigone, posterolateral maxilla, and pterygoid region is the most challenging in the field of maxillofacial surgery. The upper cheek flap (Weber-Ferguson incision) with subciliary extension and the maxillary swing approach have been considered as alternatives; however, neither approach provides sufficient exposure of the pterygoid region and the anterior portion of the mandibular ramus. In this report, we describe two cases in which a lower cheek flap approach was used for complete tumor resection in the retromolar trigone and the anterior mandibular ramus. This approach allows full exposure of the posterolateral maxilla and the pterygoid region as well as the retromolar trigone without causing major sensory disturbances to the lower lip. A mental nerve anastomosis after tumor resection was performed in one patient and resulted in approximately 90% sensory recovery in the lower lip. The lower cheek flap approach provides adequate exposure of the posterolateral maxilla, including the pterygoid, retromolar trigone, and mandibular ramus areas. If the mental nerve can be anastomosed during flap approximation, postoperative sensory disturbances to the lower lip can be minimized.
Targeting Multiple Myeloma Cell Death with Polyphenol EGCG
Tae‐Hoon Lee,Hee‐Young Yang,Hoon‐In Choi,Ung Yang,Kyoung‐Jin Chung,Lina Ren 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1
(‐)‐Epigallocatechin 3‐gallate (EGCG) is a potent antioxidant polyphenol in green tea that acts as an anticancer agent via both direct and indirect pathways. Although the relationship between EGCG’s anticancer effects and its antioxidant activity is not fully understood, it is known that EGCG stimulates production of reactive oxygen species (ROS), which induce oxidative stress leading to cell death. In IM9 multiple myeloma cells, EGCG acted in a dose‐ and time‐dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin (Prdx) V were selectively and significantly reduced by EGCG. Moreover, the ROS scavenger NAC completely inhibited EGCG‐induced apoptosis and PrdxV reduction, while overexpression of PrdxV, but not a PrdxVC48S mutant, protected IM9 cells from EGCG‐induced apoptosis. EGCG‐induced reductions in cell viability and PrdxV levels were also observed in primary CD138+ multiple myeloma cells from patients. These results suggest that PrdxV is a key target via which EGCG mediates its anticancer effects.
Peroxiredoxin V Regulates Aco2, Acadm, and Acox1 Activity in Hypoxic Kidney
Tae‐Hoon Lee,Hee‐Young Yang,Joseph Kwon,Hoon‐In Choi,Lina Ren,Ung Yang,Byung‐Ju Park,Zae Young Ryoo 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1
Peroxiredoxin V, an atypical thioredoxin peroxidase, is widely expressed in mammalian tissues. In addition, Prdx V is localized in mitochondria, peroxisome, cytosol, and nucleus. Prdx V has been reported to protect a wide range of cellular environments as antioxidant enzyme, and its dysfunctions may be implicated in several diseases, such as cancer, inflammation, and neurodegenerative disease. Identification and relative quantification of proteins affected by Prdx V may help identify novel signaling mechanisms that are important for oxidative stress response. However, the role of Prdx V in the modulation of hypoxia‐related cellular response is not studied yet. In order to examine the function of endogenous Prdx V in hypoxic condition in vivo, we generated a transgenic mouse model with Prdx V siRNA expression controlled by U6 promoter. Of many tissues, the knockdown of Prdx V expression was displayed in kidney, lung, and liver, but not spleen and skin. We conducted on the basis of nano‐UPLC‐MSE proteomic study to identify the Prdx V‐affected protein networks in hypoxic kidneys. In this study, we identified protein networks associated with oxidative stress, fatty acid metabolism, and mitochondrial dysfunction. Our results indicated that Prdx V affected to regulation of kidney homeostasis under hypoxia stress.
부산-거제간 연결도로 침매터널공사의 준설작업에 따른 안전통항방안
김정훈(]ung-Hoon Kim),국승기(Seung-Gi Gug) 한국항해항만학회 2006 한국항해항만학회 학술대회논문집 Vol.3 No.1
본 연구는 준설선을 이용하여 가덕수도를 횡단하며 준설공사를 하는 동안의 선박들의 안전한 통항방안을 제시하는 것을 목적으로 한다. 부산~거제간 연결도로 건설공사 중 가덕수도의 해저로 횡단하는 침매터널을 건설하기 위해서는 준설작업이 필요하다. 이에 따라 불가피하게 준설선이 가덕수도 항로를 횡단하며 준설을 해야 한다. 이는 상대적으로 가덕수도를 통항하는 선박들의 잠재적인 위험상황으로 충돌 등의 해난사고가 발생할 가능성이 있다. 따라서 이에 대한 선박의 안전통항방안을 모색하고 대책을 제시하였다. This research does by purpose that present safe navigation plan for ships during doing dredging construction with dredger crossing waterway of Gadeok. Dredging operations need to build sunken tunnel that cross the bottom of the sea under waterway of Gadeok for access road construction between Busan-Geoje. Accordingly, dredger must cross and dredge waterway of Gadeok fatally. There is possibility of marine accident of collision for latent danger situation of ships to navigate waterway of Gadeok relatively. Therefore, safe navigation plan of ship is groped in reply and its countermeasure is presented.
Performance assessment model for robot-based automated construction systems
Lee, Ung-Kyun,Yoo, Wi Sung,An, Sung-Hoon,Doh, Nakju,Cho, Hunhee,Jun, Changhyun,Kim, Taehoon,Lee, Young Hoon The Korean Institute of Building Construction 2013 한국건축시공학회지 Vol.13 No.4
An adjusted assessment model based on benefit-cost analysis (BCA) is proposed for evaluating the economic efficiency of automated construction technologies. In contrast to conventional BCA, the model does not compare monetary values, but the differences in benefits and costs between traditional and automated construction methods. To verify the usefulness of the model, it was applied to a real-scale building construction project that used a fully automated building construction system, and the face validity of the model was confirmed. The results indicate that the model can support decision makers in identifying valuable benefit factors and in assessing the cost effectiveness of the system.
A Study on the Generation of Critical Scenario Dataset Based on Game Engine
Ji-Ung Im,Sang-Hoon Ahn,Jin-Gyu Ahn,Jong-Hoon Won 한국차세대컴퓨팅학회 2022 한국차세대컴퓨팅학회 학술대회 Vol.2022 No.10
Autonomous driving algorithm aims to safely control the vehicle through recognition of the surrounding environment and relevant decision and control based on deep learning algorithms. However, the deep learning algorithms require appropriate datasets but many difficulties exist in generating proper datasets for critical scenarios, e.g. accident avoidance. This paper presents a method for generating datasets for critical scenarios via a game engine. The video game engine used in this paper offers an open world environment, providing realistic graphics. A variety of non-player characters in the game equipped with a high level of Artificial Intelligence (AI) are ideally suited for the reproduction of various unexpected situations in reality by the interaction between the AIs. Using this, this paper creates a high-level critical scenario dataset and presents an augmentation method for the generated dataset.
Identification of Redox Sensitive Proteins in Prdx II Deficient Red Blood Cells
Tae‐Hoon Lee,Hee‐Young Yang,Hoon‐In Choi,Gia‐Buu Tran,Ung Yang 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1
Red blood cells (RBCs) have been studied as models for infectious diseases, various symptoms of anemia, hemolysis, and erythrocyte aging. Although do not directly affect RBCs, other diseases may cause RBC physiological alterations that could be advanced for diagnostic aim or to convince better understanding of a certain pathological pattern. In this study, comparative RBC proteomics between healthy and abnormal conditions involve to promote aging related‐biomarker discovery. Peroxiredoxin II (Prdx II; a typical 2‐Cys Prdx) has been originally isolated from erythrocytes, and its structure and peroxidase activity have been adequately studied. Mice absent to Prdx II proteins had heinz bodies in their peripheral blood, and morphologically aged cells were detected in the dense RBC fractions, which contained markedly higher levels of reactive oxygen species (ROS). In addition, a labeling experiment with the thiol‐modifying reagent biotinylated iodoacetamide (BIAM) in Prdx II‒/‒ mice revealed that a variety of RBC proteins were highly oxidized. To identify oxidation‐sensitive proteins in Prdx II‒/‒ mice, we performed RBC comparative proteome analysis by nano‐UPLC‐MSE shotgun proteomics with relative protein quantitative analysis. We found oxidation‐sensitive 18 membrane and 41 cytosol proteins from 32 and 85 peptides containing cysteine oxidation, and analyzed comparative expression pattern in healthy RBCs of Prdx II+/+ mice (W1), healthy RBCs of Prdx II‒/‒ mice (K1), and abnormal RBCs of Prdx II‒/‒ mice (K2). These proteins belonged to cellular functions related with RBC lifespan maintain, such as cytoskeleton, stress‐induced proteins, amino acid/nucleic acid metabolic enzymes, signal transduction, and molecular transporters. Furthermore, protein networks among identified oxidation sensitive proteins were analyzed to associate with aging consequence. Consequently, we expected that RBC proteome may provide clues to understand redox‐imbalanced diseases.