대장암환자에서 자연살해세포의 변화

김광호,심강섭,박응범,강은숙,홍기숙 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

On the Locus of the EPP

Kwang-sup Kim 한국생성문법학회 2017 생성문법연구 Vol.27 No.3

Kim, Kwang-sup. 2017. On the Locus of the EPP. Studies in Generative Grammar, 27-3, 697-712. In English T’ must be merged with a pronouncible constituent in accordance with the Extended Projection Principle (EPP). Since T consists of Tense and Agr, it can be said that either Tense or Agr has the EPP. Unlike finite T, non-finite T has no Agr, but it is known to display an EPP effect. If so, it appears to be logically plausible that Tense, but not Agr, has the EPP feature. However, this paper claims that it is Agr that has the EPP. I propose that the EPP effect of a non-finite T originates from the fact that Tense has an uninterpretable person feature, which is fundamentally different from the EPP of Agr in that it can be deleted even by a covert constituent. This claim is shown to elucidate various types of non-DP subject constructions and to resolve a potential problem with Chomsky’s (2013) C-to-T feature inheritance approach.

Suppressive effects of three diketopiperzines from marine-derived bacteria on TGFBIp-mediated septic responese in human endothelial cells and mice

( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.

격체계 기술의 흐름

김광섭,김정민 청주대학교 인문과학연구소 2000 人文科學論集 Vol.20 No.-

흰쥐 경동맥 풍선손상 모델에서 리포좀 전달체를 이용한 에스트로겐의 국소전달 효과

윤영섭,장양수,정광회,박요석,김형관,강웅철,권진욱,정보영,조상호,김성순 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

高校佛語敎授法의 改善에 관한 考察(Ⅱ)

李光燮 誠信女子大學校 1976 硏究論文集 Vol.9 No.-

열공성 망막박리의 임상적 고찰

김광수,오준섭 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

Authors clincially analysed 50 patients(52 eyes) operated on for rhegmatogenous detachment of the retina at the Dong San Medical Center between May 1986 and August 1988. The results of study were as follows 1. Most of patients were between 10 and 39 years of age (62%) and men were affected more than women(2:1). 2. Involvement of the right eye was predominant(68%) and the incidence of bilaterality was 4%. 3. Myopia of -2D or more was found in 36.6% and of -6D or more in 21.2% and aphakia was seen in 11.5%. 4. Round holes were the most frequent(57.7%) and horse-shoe tears were 33%. One hole or tear was found in 57.7% of all cases. In site of breaks, round holes were mostly located in the temporal half of the retina and horse-shoe tears in the superior half and both types of breaks occured mostly near the equator. 5. The most frequent etiological factor was myopia and lattice degeneration(51.9%) and trauma was associated in 19.2%. 6. The overall success rate of reattachment was 88.5% and the main cause of failure was PVR. 7. A favorable surgical outcome was related to round hole in shape, short duration within 2 months, good pre-operative visual acuity and under 50 years of age. An unfavorable outcome was related to giant retinal dialysis, totally detached retina, ocular trauma and multiple operations. 8. The visual acuity was improved in 71.7% of cases of successful reattachment and the most frequent post-operative complication was PVR.

아스팔트 콘크리트의 고온변형저항 특성 측정방법 개발

김광우,이문섭,김중렬,이순제 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

본 연구는 정하중하에서 아스팔트 혼합물의 소성변형 저항특성을 측정할 수 있는 새로운 시험방법을 개발하기 위하여 수행되었다. 2가지 골재(편마암, 화강암)와 6가지 아스팔트(일반아스팔트, 5가지 개질 아스팔트)를 사용하여 총 12개의 밀입도 혼합물을 제작하였다. 마샬 배합설계를 통해 최적아스팔트 함량을 구하고, 결정된 최적아스팔트 함량으로 마샬공시체(S=10 cm)와 자이레토리 공시체(S=15cm)를 제작하여 마샬안정도시험, 휠 트랙킹 시험, 개발된 김테스트(Kim -test)를 수행하였다. 김테스트는 공시체와 하중봉을 지지할 수 있는 김시험장치(Kim tester)를 이용하여 하단이 반경(r) 0.5 또는 1.0cm로 원형절삭한 직경(D) 3cm, 4cm의 하중봉을 사용한다. 또한 재하는 마샬 하중재하 장치를 사용하여 공시체를 60℃ 수조에 30분동안 수침시킨 후 실시되었다. 정하중은 공시체의 직경방향이 아닌 축 방향으로 50 mm/min가 가해졌고, 최대하중(P_max)과 수직변형(y)이 측정되었다. 마샬안정도시험과 간접인장강도시험에서 얻어지는 것과 유사한 곡선이 각각의 시험에서 얻어졌다. 강도값은 P_max, r, y 및 H(=D-2r)을 이용한 K_D=4P_max/π(H+2√(2ry-y^2))^2식을 통하여 계산하였고, 이를 변형강도(kgf/㎠)로 정의하였다. 실험결과, 공시체 직경이나 골재종류보다는 하중봉과 하중봉 하단의 원형처리 여부가 K_D와 P_max 값에 영향을 미치는 것으로 나타났다. 통계분석결과에서 K_D가 소성변형 깊이와 동적 안정도에 높은 상관성을 보였다. 향후 연구를 통해 K_D의 유효성이 검증된다면, Kim-test는 아스팔트 혼합물의 소성변형 저항성을 판단할 수 있는 시험방법으로 사용될 수 있을 것이다. This study dealt with developing a new approach for finding properties which might represent rut resistance characteristics of asphalt mixture under static loading. Two aggregates, a normal asphalt (pen 60-70) and 5 PMAs were used in preparation of 12 dense-grade mixtures. Marshall mix design was used in determination of the optimum asphalt content (OAC) and each mixture at the OAC was prepared for a newly-developed Kim test on Marshall specimen (S=10 cm) and gyratory specimen (S=15cm), and for wheel tracking test. Kim test used Marshall loading frame and the specimen was conditioned for 30min at 60℃ before loading through Kim tester, and apparatus consisting of a loading column and a specimen and column holder. Diameter (D) of column was 3cm and 4cm with each column having different radius (r) of round cut at the bottom. The static load was applied at 50mm/min in axial direction of the specimen, not in diameteral direction, and the maximum load (P_max) and vertical deformation (y) at the maximum load point were measured. A curve, similar to the one from a Marshall test or static indirect tensile strength test was obtained from each test. A strength value was calculated based on the P_max, H(=D-2r). r and y by using the equation K_D=4P_max/π(H+2√(2ry-y^2))^2 and is defined as deformation strength (kgf/㎠). The values of P_max/y and K_I=K-D/y were also calculated to see if these have any correlation with rutting. In general, D and r were significant factors affecting K_D, while specimen size was not. The statistical analyses results showed the K_D had the best correlation with rut depth and dynamic stability. The next best correlation was found from P_max which was followed by P_max/y and K_I in order. Therefore, K_D can be used for selecting the highly resistable asphalt mixture against permanent deformation.

청국장 타블렛의 제조와 품질 특성

윤광섭 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.5

This study was carried out to develop a new product using Cheonggukjang (fermented soybean product) and sub-ingredients(lactic acid bacillus powder, chlorella, lactose, green tea). Fresh Cheonggukjang was dried by a infrared drying (50℃, 36hr) and powdered by a roll mill. The powder was mixed with sub- ingredients and then moulded as tablet type by a press moulder. The pH of tablet was low with the addition of lactobacillus and total sugar content was high with the addition of lactose. Disintegration, absorption capacity and textural properties of tablet were not affected by the addition of any sub-ingredient. Color of non-added tablet was yellow to red, but changed to green when chlorella was added. Sensory properties(color, taste, flavor, chewiness, hardness, acceptability) were not affected by the addition of sub-ingredients. The results indicate that functional healthy tablet could be made from Cheonggukjang powder and various sub-ingredients.

대장암조직에서 아포토시스 검출 방법에 관한 연구

김광호,심강섭,김성숙,구혜수,박응범 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.2

1989년 1월부터 1992년 12월 사이에 대장암으로 근치적 절제술을 시행받은후 추적조사가 가능한 45명의 환자를 대상 대장암조직의 Hematoxylin-Eosin염색을 통하여 apoptotic body를 광학 현미경하에서 400배율 하에서 관찰하여 암세포 100개당 평균개수를 세었으며 TUNEL 방법을 이용하여 면화학적염색을 통하여 염색정도를 판정을하여 대장암에서 아포토시스의 정도를 판정하여 다음과 같은 결과를 얻었다. Dukes병기 A 일 때 apoptotic body가 평균 1.93개, B 일 때 2.66개, C 인 경우 2.76개 였으며 분화도에 따라서는 고분화암인 경우 2.51개, 중등도분화암인 경우는 3.01개, 저분화암인 경우는 2.15개였다. 5년내 사망한 환자에서는 3.55개 였으며 5년이상 생존한 환자에서는 2.8개였다. 형태학적으로 apoptotic body의 수를 세어 아포토시스를 측정하여 예후예측인자로 사용할 수 있으리라 사료되며 아포토시스와 p53의 발현과의 관계를 보았을 때 특별한 상관관계를 발견 할 수 없어 bcl-2의 발현과 더불어 아토토시스와의 관게에 대하여 좀더 연구가 되어야 하겠다. Objectives : Apoptosis is a specific mode of cell death recognized by a characteristic pattern of morphological, biochemical, and molecular changes, There are several methods of detection of apoptosis. Morphological changes involve a characteristic pattern of chromation and cytoplasm. The landmark of apoptosis is endonucleolysis, with nuclear DNA initially degraded at the linker sections to fragments equivalent to single and multiple nucleosomes. Detection of DNA fragments is situ using the terminal deoxyribonucleotidyl transferase(TDT)-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay is increasingly applied to investigate apoptosis. We studied the detection method of apoptosis morphologically and by using TUNEL assay and examined the correlation of p53 expression and apoptosis. Methods : Forty-five cases of colorectal cancer were selected. The number of apoptotic bodies was expressed as a number per 100 cancer cells. The TUNEL assay was performed with in situ Apoptag kit®. Results : The mean number of the apoptotic bodies was 2.28 in the patients who survived over 5 years after curative resection and 3.55 in the patients who died within 5 years(p=0.001). There was a relationship between the number of apoptotic bodies which were measured by morphologic study and the results which were measured by TUNEL assay. There was no relationship between p53 expression and apoptosis. Conclusion : These results suggest that the frequency of apoptotic bodies may be a prognostic factor for colorectal cancer and apoptosis could be measured by morphological study without special study.