http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A New Direction of Cancer Classification: Positive Effect of Low-Ranking MicroRNAs
Feifei Li,Minghao Piao,Yongjun Piao,Meijing Li,류근호 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.5
Objectives: Many studies based on microRNA (miRNA) expression profiles showed a new aspect of cancer classification. Because one characteristic of miRNA expression data is the high dimensionality, feature selection methods have been used to facilitate dimensionality reduction. The feature selection methods have one shortcoming thus far: they just consider the problem of where feature to class is 1:1 or n:1. However, because one miRNA may influence more than one type of cancer, human miRNA is considered to be ranked low in traditional feature selection methods and are removed most of the time. In view of the limitation of the miRNA number, low-ranking miRNAs are also important to cancer classification. Methods: We considered both high- and low-ranking features to cover all problems (1:1, n:1, 1:n, and m:n) in cancer classification. First, we used the correlation-based feature selection method to select the high-ranking miRNAs, and chose the support vector machine, Bayes network, decision tree, k-nearestneighbor, and logistic classifier to construct cancer classification. Then, we chose Chi-square test, information gain, gain ratio, and Pearson’s correlation feature selection methods to build the m:n feature subset, and used the selected miRNAs to determine cancer classification. Results: The low-ranking miRNA expression profiles achieved higher classification accuracy compared with just using high-ranking miRNAs in traditional feature selection methods. Conclusion: Our results demonstrate that the m:n feature subset made a positive impression of low-ranking miRNAs in cancer classification.
Identification of QTLs for agronomic traits in indica rice using an RIL population
Feifei Xu,Yan Huang,Jinsong Bao 한국유전학회 2015 Genes & Genomics Vol.37 No.10
Increasing grain weight and breeding for ideal plant architecture are two means to improve the productivity of rice. Quantitative trait locus (QTL) mapping was conducted on ten yield component traits using a recombinant inbred line population derived from an indica 9 indica cross (M201 9 JY293). Correlation analysis revealed that plant height, panicle length and flag leaf length, classified as plant morphology traits, were positively correlated with grain shape traits such as thousandgrain weight, grain length and grain width. Two tillering traits, total and effective tiller numbers, showed negative correlations with nearly all the other traits tested. A total of 37 QTLs were detected over the 2-year study period, and 14 of them were identified in both years. Four clustered QTLs corresponding to known genes/QTLs (GW2, GS3, qGL3 and qTGW3.3) were revealed on chromosomes 2 and 3, which had pleiotropic effects on grain weight and plant architecture traits. QTL mapping demonstrated that qGL3 was a major QTL controlling grain length and weight, as well as plant height, panicle length and flag leaf length in rice. Three new QTLs, qTGW3.0, qGL2.2 and qETN4, were detected in both years and worth attention in breeding for high-yield rice varieties.
( Feifei Song ),( Yunfeng Lin ),( Chen Chen ),( Ensi Shao ),( Xiong Guan ),( Zhipeng Huang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.10
Vegetative insecticidal proteins (Vips) are insecticidal proteins synthesized by Bacillus thuringiensis during the vegetative stage of growth. In this study, Vip3Aa protein, obtained by in vitro expression of the vip3Aa gene from B. thuringiensis WB5, displayed high insecticidal activity against Spodoptera litura aside from Spodoptera exigua and Helicoverpa armigera. Bioassay results showed that the toxicity of Vip3Aa protein against S. litura larvae statistically decreased along with the increase of the age of the larvae, with LC<sub>50</sub> = 2.609 ng/cm² for neonatal larvae, LC<sub>50</sub> = 28.778 ng/cm² for first instar larvae, LC<sub>50</sub> = 70.460 ng/cm² for second instar larvae, and LC<sub>50</sub> = 200.627 ng/cm² for third instar larvae. The accumulative mortality of 100% larvae appeared at 72 h for all instars of S. litura larvae, when feeding respectively with 83.22, 213.04, 341.40, and 613.20 ng/cm² of Vip3Aa toxin to the neonatal and first to third instar larvae. The histopathological effects of Vip3Aa toxin on the midgut epithelial cells of S. litura larvae was also investigated. The TEM observations showed wide damage of the epithelial cell in the midgut of S. litura larvae fed with Vip3Aa toxin.
Brace-type shear fuses for seismic control of long-span three-tower self-anchored suspension bridge
Feifei Shao,Liangjiu Jia,Hanbin Ge 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.81 No.2
The Brace-Type Shear Fuse (BSF) device is a newly proposed steel damper with excellent cumulative ductility and stable energy dissipation. In consideration of the current situation where there are not many alternatives for transversal seismic devices used in long-span three-tower self-anchored bridges (TSSBs), this paper implements improved BSFs into the world’s longest TSSB, named Jinan Fenghuang Yellow River Bridge. The new details of the BSF are developed for the TSSB, and the force-displacement hysteretic curves of the BSFs are obtained using finite element (FE) simulations. A three-dimensional refined finite element model for the research TSSB was established in SAP2000, and the effects of BSFs on dynamic characteristics and seismic response of the TSSB under different site conditions were investigated by the numerical simulation method. The results show that remarkable controlling effects of BSFs on seismic response of TSSBs under different site conditions were obtained. Compared with the case without BSFs, the TSSB installed with BSFs has mitigation ratios of the tower top displacement, lateral girder displacement, tower bending moment and tower shear force exceeding 95%, 78%, 330% and 346%, respectively. Meanwhile, BSFs have a sufficient restoring force mechanism with a minor post-earthquake residual displacement. The proposed BSFs exhibit good application prospects in long-span TSSBs.
Feifei Zhao,Yanan Li,Li-juan Chen,Lisha Zhu,Han Ren,Honghui Lin,Dehui Xi 한국식물학회 2016 Journal of Plant Biology Vol.59 No.3
Temperature is an important environmental factor controlling plant growth, development, and immune response. However, the role of temperature in plant disease resistance is still elusive. In the present study, the potential effects of temperature on the interaction between Nicotiana tabacum and Cucumber mosaic virus (CMV) were investigated. Our results indicated that N. tabacum plants displayed severe symptoms at early stage of post inoculation at high temperature (HT, 28°C), associated with higher viral replication level, more serious stress damages. By contrast, low temperature (LT, 18°C) effectively delayed the replication of CMV compared with elevated temperatures. Additionally, quantitative real-time PCR analyses revealed that lower temperatures (≤ 24°C) promote salicylic acid (SA) dependent responses, whereas higher temperatures (> 24°C) activate the genes expression of jasmonic acid (JA) pathway. Interestingly, the dark green islands (DGIs) appeared much earlier in CMV-inoculated plants grown at HT compared with those at LT and the accumulation of virus small interfering RNAs in plants were significantly up-regulated under elevated temperatures at early stage of post inoculation. Taken together, these results indicated that temperature changes had important effects on plant defence response, and different temperatures could induce different immune pathways of N. tabacum against CMV infection.
Bio-inspired Micro Pump Model Based on the Movement Pattern of Sperm
Feifei Liu,Xiaofei Ren,Shoushui Wei,Zhiping Liu 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11
Micro pumps play important roles in microfluidic system. Biologically inspired actuation mechanisms have great advantages in the micro pump design. This work aims to develop a numerical model for bio-inspired micro pump based on the specific and genuine movement pattern of the sperm. The model also employs a modified immersed boundary-lattice Boltzmann method. In the model, an elastic film is used to mimic a sperm moving with its head fixed. The fluctuation vibration of the film could then drive the static fluid to move. The modified immersed boundary-lattice Boltzmann method directly introduces the velocity information of the film into the traditional lattice Boltzmann equation, which improve the computational efficiency. Pressure distribution, streamlines and the flow rate curves are used to analyze the flow field dynamic process of the model. The effects of the model parameters (e.g. frequency, kinematic viscosity, amplitude and wavelength) on the stable flow rate are also studied comprehensively.
Feifei Shen,Meihong Wang,Lingxiang Huang,Feng Qian 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
In chemical industry, most processes face the challenge of high energy consumption. The approachpresented in this study can reduce the energy footprint and increase efficiency. The energy system of aseparation process in ethylene manufacturing is used to demonstrate the effectiveness of the approach. The chilling train system of the separation process in a typical ethylene plant consumes most cooling andprovides appropriate feed for distillation columns. The steady state simulation of system was presentedand the simulation results were proved accurate. The conventional exergy analysis identifies thatDephlegmator No.1 (a heat exchange and mass transfer device) has the highest exergy destruction(1401.28 kW). Based on advanced exergy analysis, Dephlegmator No.1 has the highest rate of avoidableexergy destruction (89.04 %). Finally, a multi-objective optimisation aiming to maximise system exergyefficiency and to minimise operational cost was performed and the Pareto frontier was obtained. Themulti-objective optimized exergy efficiency is 79.53 % (improved by 0.61 %) and the operational cost is0.02031 yuan/kg (saved by 11.19 %). This study will guide future research to reduce energy consumptionin process manufacturing.