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      • The Context of Traditional Chinese Residence

        Fang,Xiaofeng 국민대학교 동양문화디자인연구소 2011 Journal of Oriental Culture&Design Vol.3 No.1

        “Pan-residence” or the pursuit of the universality of architecture is a tendency in the traditional Chinese architecture. With residence as sample, the article clarified several cultural characteristics of traditional Chinese architecture through organizing the information about traditional residence. Traditional Chinese residence attaches importance to the corresponding relationship between geometrical position and social rank; in terms of spatial form, the traditional Chinese residence is characteristic of outward closure and inward openness; for the architectural ornament, there is clear level restrictions besides the lucky culture. The article explained the relationship between Yin-Yang, five element theory and Feng-Shui. Based on this theory, traditional Chinese culture established an environmental system of universal connection, through which built up a unique ancient Chinese architecture system. In the end, the article briefly introduced the private garden which is co-existent with residence, explaining the value of traditional Chinese private garden on the theory of culture that complements mutually.

      • KCI등재후보

        Molecular Characterization of Ca_(∨)2.3 in Rat Trigemical Ganglion Neurons

        Zhi Fang,Kim, Joong-Soo,Oh, Seog-Bae The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

        R-type(Ca_(∨)2.3) calcium channel contributes to pain sensation in peripheral sensory neurons. Six isoforms of Ca_(∨)2.3 that result from combinations of presence or delection of three inserts(inserts Ⅰ and insert in the Ⅱ-Ⅲ loop, and insert Ⅲ in N-terminal regions) have been demonstrated to be present in different mammalian tissues. However, the molecular basis of Ca_(∨)2.3 in trigeminal ganglion(TG) neurons is not known. In the present study, we determined which isoforms of Ca_(∨)2.3 are expressed in rat TG neurons using the RT-PCR analysis. Whole tissue RT-PCR analyses revealed that only two isoforms, Ca_(∨)2.3a and Ca_(∨)2.3e, were present in TG neurons. From single-cell RT-PCR, we found that Ca_(∨)2.3e rather than Ca_(∨)2.3a was the major isoform expressed in TG neurons, and Ca_(∨)2.3e was preferentially detected in small-sized neurons that express nociceptive marker, transient receptor potential vanilloid 1(TRPV1). Our results suggest that Ca_(∨)2.3e in trigeminal neurons may be a potential target for the pain treatment.

      • KCI등재

        Social service purchasing in China: Rationale, features, and risks

        Natasha Cortis1,Qian Fang1,Zhenfang Dou2 한국사회복지학회 2018 Asian Social Work and Policy Review Vol.12 No.3

        progressing an agenda of purchasing child welfare and other social services from the nongovernment sector, primarily to expand capacity and address vast unmet need. This paper draws on current research evidence to explore the approaches to purchasing emerging in China, examining the rationale for purchasing and models of supply, competition, and regulation. While some approaches are modeled on direct service contracting, direct purchasing of social service “posts” is also used, aimed at achieving goals of professionalization alongside service expansion. Overall, the review shows purchasing is helping to rapidly expand service scale and capacity; however, regulatory strategies for managing and mitigating risks to quality and access appear lacking. This highlights the need for further scholarship aimed at developing the robust risk management strategies which are required to support high quality, sustainable provision of purchased services.

      • KCI등재

        Genome-wide identification and analysis of MIKC-type MADS-box genes expression in Chimonanthus salicifolius

        Gui Fang-Fang,Jiang Ge-Ge,Bin Dong,Zhong Shi-Wei,Xiao Zheng,Qiu Fang,Wang Yi-Guang,Yang Li-Yuan,Zhao Hongbo 한국유전학회 2023 Genes & Genomics Vol.45 No.9

        Background MIKC type MADS-box transcription factors are one of the largest gene families and play a pivotal role in flowering time and flower development. Chimonanthus salicifolius belongs to the family Calycanthaceae and has a unique flowering time and flowering morphology compared to other Chimonanthus species, but the research on MIKC type MADS-box gene family of C. salicifolius has not been reported. Objective Identification, comprehensive bioinformatic analysis, the expression pattern of MIKC-type MADS-box gene family from different tissues of C. salicifolius. Methods Genome-wide investigation and expression pattern under different tissues of the MIKC-type MADS-box gene family in C. salicifolius, and their phylogenetic relationships, evolutionary characteristics, gene structure, motif distribution, promoter cis-acting element were performed. Results A total of 29 MIKC-type MADS-box genes were identified from the whole genome sequencing. Interspecies synteny analysis revealed more significant collinearity between C. salicifolius and the magnoliids species compared to eudicots and monocots. MIKC-type MADS-box genes from the same subfamily share similar distribution patterns, gene structure, and expression patterns. Compared with Arabidopsis thaliana, Nymphaea colorata, and Chimonanthus praecox, the FLC genes were absent in C. salicifolius, while the AGL6 subfamily was expanded in C. salicifolius. The selectively expanded promoter (AGL6) and lack of repressor (FLC) genes may explain the earlier flowering in C. salicifolius. The loss of the AP3 homologous gene in C. salicifolius is probably the primary cause of the morphological distinction between C. salicifolius and C. praecox. The csAGL6a gene is specifically expressed in the flowering process and indicates the potential function of promoting flowering. Conclusion This study offers a genome-wide identification and expression profiling of the MIKC-types MADS-box genes in the C. salicifolius, and establishes the foundation for screening flowering development genes and understanding the potential function of the MIKC-types MADS-box genes in the C. salicifolius.

      • Innovation of Development Model for Health-Preserving Tourism in Yunnan Province, China

        Fang Jie(Jie Fang) 아시아사회과학학회 2023 Jornal of Asia Social Science Vol.10 No.2

        The development of health-preserving tourism has become a new trend in the tourism industry, and it has played an important role in promoting social and economic development. Yunnan Province, located in southwestern China, has abundant tourism resources and a long history of traditional medicine and health preservation practices. In recent years, Yunnan Province has made significant efforts to develop health-preserving tourism, and it has achieved remarkable results. However, there are still challenges that need to be addressed, such as the lack of innovation in the development model and the need for better integration of traditional medicine and modern medical practices. This paper aims to explore the innovation of the development model for health-preserving tourism in Yunnan Province. The innovative development model for health-preserving tourism in Yunnan Province should focus on three key areas: product development, marketing, and supporting services. In terms of product development, Yunnan Province should focus on the integration of traditional medicine and modern medical practices to develop new health-preserving tourism products that meet the needs of different tourists. In terms of marketing, Yunnan Province should strengthen its brand image and develop targeted marketing strategies to attract different types of tourists. In terms of supporting services, Yunnan Province should improve the quality of tourism services and infrastructure, such as transportation, accommodation, and medical facilities. The innovation of the development model for health-preserving tourism in Yunnan Province has significant implications for the tourism industry and the local economy. The findings of this study provide insights for policymakers, industry practitioners, and researchers to promote the sustainable development of health-preserving tourism in Yunnan Province and other regions.

      • KCI등재

        The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer

        Fang-Ming Chen,Hsueh-Wei Chang,Sheau-Fang Yang,Ya-Fang Huang,Pei-Yung Nien,Yao-Tsung Yeh,Ming-Feng Hou 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.5

        The mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) belongs to the MAPK cascades which are central to cell proliferation and apoptosis. The carcinogenic role of MKP-1 has been reported in many types of cancer but it has rarely been investigated in breast cancer. The present study was designed to evaluate the MKP-1 mRNA expression and its possible regulation by methylation of MKP-1 promoter in the model of several breast cancer cell lines and tissues as well as controls. Our data demonstrate MKP-1mRNA expression significantly decreased in five breast cancer cell lines compared to breast controls (P <0.01). Using the methylation-specific PCR (MSP) analysis,the unmethylated reaction (U) is dominant in both normal cell lines and benign breast tumors (100% vs. 86.2%), whereas the methylated reaction (M) is dominant in both breast cancer cell lines and invasive breast tumors (100% vs. 57.2%). In terms of methylation ratio (M/M+U), methylation level in MKP-1 promoter is significantly higher in the invasive breast tumor tissues (n = 152) than in benign breast tumor tissues (n = 29)(P < 0.0001). Assessing the methylation ratio of the promoter of MKP-1 gene to diagnose the breast malignancy (invasive vs. benign), the area under the receiver-operating characteristic (ROC) curve was 0.809(95% CI: 0.711-0.906, P < 0.001). The best performance for this prediction has a sensitivity of 76.32% and a specificity of 82.76% at the cutoff value of 0.38. Taken together, we firstly demonstrated that the promoter methylation of MKP-1 gene is a potential breast cancer biomarker for breast malignancy.

      • SCOPUSKCI등재

        은(I)화합물:비스(디프로필디싸이오포스페이토)비스(1,10-펜안트로린)이온(I);Ag<sub>2</sub>[Phen]<sub>2</sub>[S<sub>2</sub>P(OPr)<sub>2</sub>]<sub>2</sub>

        Fang Fang Jian,Hai Lian Xiao,Huan Xiang Wang,Kui Jiao Korean Chemical Society 2003 대한화학회지 Vol.47 No.1

        이핵 화합물, $Ag_2$[Phen]_2[S_2P(OPr)_2]_2$(Phen=1,10-phenanthroline; Pr=propyl)은 비스(디프로필디싸이오포스페이토) 은(|)화합물과 1,10 펜안트로린 리간드 반응에 의하여 합성되었고, 그 화합물 구조는 X-ray에 의하여 규명되었다. 두 디프로필디싸이오포스페이토 리간드는 두 개의 은 원자를 연결하여 팔각형 $Ag_2S_4P_2$ 고리를 형성하였고, 1,10-펜안트로린 리간드는 은 이온과 결합하여 사면체구조를 이루었다. Ag-S 결합거리는 2.471(1)와 2.567(1) ${\AA}$이었고, Ag-N 결합 거리는 2.3666(3)와 2.471(3) ${\AA}$이었다. The dinuclear $Ag_2[Phen]_2[S_2P(OPr)_2]_2$(phen=1,10-phenanthroline; Pr=propyl), was prepared by the reaction of bis(dipropyldithiophosphato) silver(I) complex with 1,10-phenanthroline ligand, and its structure was determined by X-ray crystallography. The two dipropyldithiophosphato ligands each bridge two silver atoms to form an eight-membered $Ag_2S_4P_2$ ring, while the 1,10-phenanthroline molecule coordinates to a silver atom to complete the local tetrahedral geometry for the metal ion. The Ag-S bond distances are 2.559(1) and 2.567(1)${\AA}$, and the Ag-N bond distances are 2.366(3) and 2.471(3)${\AA}$.

      • KCI등재

        Effects of Different Medium Composition and Exogenous Hormones on Browning of Tree Peony (Paeonia suffruticosa Andr.) Callus in Tissue Cultu

        Fang Fang Zhou,Zheng Wang,Li Yun Shi,Jia Jia Niu,Wen Qian Shang,Dan He,Song Lin He 한국화훼학회 2016 화훼연구 Vol.24 No.2

        Browning is one of the key factors that influenced the callus subculture of tree peony (Paeonia suffruticosa Andr.). Effects of medium composition and exogenous hormones: macro elements of Murashige and Skoog (MS salts) and iron salt (Fe2+), pH, agar and 6-benzylaminopurine (6-BA), 1-naphthaleneacetic acid (NAA) and kinetin (KT) on the callus browning of P. suffruticosa ‘Shan Hu Tai’ in vitro were studied in this paper. Results showed that the browning of P. suffruticosa callus were more sensitive to KT than 6-BA in different concentrations of 6-BA and KT separately with different concentrations of NAA, and reduced to the lowest (13.3%) under 0.5 mg·L-1 NAA plus 0.3 mg·L-1 KT. 1/4 × MS plus 1/4 × Fe2+ was the best basic medium in which the browning rate was only 18.2%. The browning rate of the callus was the lowest of 4.0% under pH 6.5 and the callus grew better in 7.0 g·L-1 agar than others. This study indicated that the best medium preventing P. suffruticosa callus in vitro from browning was: 1/4 × MS medium supplemented with 6.95 mg·L-1Fe2+, 0.3 mg·L-1 KT, 0.5 mg·L-1 NAA, 6.0 g·L-1 agar and 30 g·L-1 sucrose in pH 6.5.

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