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Two New Acorane Sesquiterpenes from Illicium henryi
Tai-Fa Song,Wei-Dong Zhang,Xin-Hua Xia,Yun-Heng Shen,Chun-Mei Liu,Sheng Lin,Hui-zi Jin,Hui-Liang Li 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9
Two new acorane sesquiterpenes, 10-hydroxyacoronene (1) and 1β-isopropyl-4β-methyl-9β-hydroxy spiro[4.5]dec-6-en-8-one (2), one new natural product, 4-hydroxy-4, 6-dimethyl-1-tetralone (3), and one known acorane sesquiterpene, acoradiepoxide (4) were isolated from the twigs and leaves of Illicium henryi. The structures of the new compounds were elucidated primarily on the basis of analysis of spectroscopic data. In addition, the inhibitory effect on NO production of these compounds were tested. Compounds 1 and 4 exhibited slight inhibitory effects on NO production with IC50 values of 82.4 μg/mL and 76.5 μg/mL, respectively.
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Ye, Qi-Fa,Zhang, Yi-Chuan,Peng, Xiao-Qing,Long, Zhi,Ming, Ying-Zi,He, Le-Ye Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Purpose: Notch is an important signaling pathway that regulates cell fate, stem cell maintenance and the initiation of differentiation in many tissues. It has been reported that activation of Notch-1 contributes to tumorigenesis. However, whether Notch signaling might have a role in chemoresistance of prostate cancer is unclear. This study aimed to investigate the effects of Notch-1 silencing on the sensitivity of prostate cancer cells to docetaxel treatment. Methods: siRNA against Notch-1 was transfected into PC-3 prostate cancer cells. Proliferation, apoptosis and cell cycle distribution were examined in the presence or absence of docetaxel by MTT and flow cytometry. Expression of $p21^{waf1/cip1}$ and Akt as well as activation of Akt in PC-3 cells were detected by Western blot and Real-time PCR. Results: Silencing of Notch-1 promoted docetaxel induced cell growth inhibition, apoptosis and cell cycle arrest in PC-3 cells. In addition, these effects were associated with increased $p21^{waf1/cip1}$ expression and decreased Akt expression and activation in PC-3 cells. Conclusion: Notch-1 promotes chemoresistance of prostate cancer and could be a potential therapeutic target.
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An Intelligent Nano-positioning Control System Driven by an Ultrasonic Motor
Fan, Kuang-Chao,Lai, Zi-Fa Korean Society for Precision Engineering 2008 International Journal of Precision Engineering and Vol.9 No.3
This paper presents a linear positioning system and its control algorithm design with nano accuracy/resolution. The basic linear stage structure is driven by an ultrasonic motor and its displacement feedback is detected by a LDGI (Laser Diffraction Grating Interferometer), which can achieve nanometer resolution. Due to the friction driving property of the ultrasonic motor, the driving situation differs in various ranges along the travel. Experiments have been carried out in order to observe and realize the phenomena of the three main driving modes: AC mode (for mm motion), Gate mode (for ${\mu}m$ motion), and DC mode (for nm motion). A proposed FCMAC (Fuzzy Cerebella Model Articulation Controller) control algorithm is implemented for manipulating and predicting the velocity variation during the motion of each mode respectively. The PCbased integral positioning system is built up with a NI DAQ Device by a BCB (Borland $C^{++}$ Builder) program to accomplish the purpose of an intelligent nanopositioning control.
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An Intelligent Nano-positioning Control System Driven by an Ultrasonic Motor
Kuang-Chao Fan,Zi-Fa Lai 한국정밀공학회 2008 International Journal of Precision Engineering and Vol.9 No.3
This paper presents a linear positioning system and its control algorithm design with nano accuracy/resolution. The basic linear stage structure is driven by an ultrasonic motor and its displacement feedback is detected by a LDGI(Laser Diffraction Grating Interferometer), which can achieve nanometer resolution. Due to the friction driving property of the ultrasonic motor, the driving situation differs in various ranges along the travel. Experiments have been carried out in order to observe and realize the phenomena of the three main driving modes: AC mode (for ㎜ motion), Gate mode (for ㎛ motion), and DC mode (for ㎚ motion). A proposed FCMAC(Fuzzy Cerebella Model Articulation Controller) control algorithm is implemented for manipulating and predicting the velocity variation during the motion of each mode respectively. The PCbased integral positioning system is built up with a NI DAQ Device by a BCB (Borland C?? Builder) program to accomplish the purpose of an intelligent nano-positioning control.
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Aerosol Observation with Raman LIDAR in Beijing, China
Chen-Bo Xie,Jun Zhou,Nobuo Sugimoto,Zi-Fa Wang 한국광학회 2010 Current Optics and Photonics Vol.14 No.3
Aerosol observation with Raman LIDAR in NIES (National Institute for Environmental Studies, Japan) LIDAR network was conducted from 17 April to 12 June 2008 over Beijing, China. The aerosol optical properties derived from Raman LIDAR were compared with the retrieved data from sun photometer and sky radiometer observations in the Aerosol Robotic Network (AERONET). The comparison provided the complete knowledge of aerosol optical and physical properties in Beijing, especially in pollution and Asian dust events. The averaged aerosol optical depth (AOD) at 675 nm was 0.81 and the Angstrom exponent between 440 nm and 675 nm was 0.99 during experiment. The LIDAR derived AOD at 532 nm in the planetary boundary layer (PBL) was 0.48, which implied that half of the total AOD was contributed by the aerosol in PBL. The corresponding averaged LIDAR ratio and total depolarization ratio (TDR) were 48.5sr and 8.1%. The negative correlation between LIDAR ratio and TDR indicated the LIDAR ratio decreased with aerosol size because of the high TDR associated with nonspherical and large aerosols. The typical volume size distribution of the aerosol clearly demonstrated that the coarse mode radius located near 3 μm in dust case, a bi-mode with fine particle centered at 0.2 μm and coarse particle at 2 μm was the characteristic size distribution in the pollution and clean cases. The different size distributions of aerosol resulted in its different optical properties. The retrieved LIDAR ratio and TDR were 41.1sr and 19.5% for a dust event, 53.8sr and 6.6% for a pollution event as well as 57.3sr and 7.2% for a clean event. In conjunction with the observed surface wind field near the LIDAR site, most of the pollution aerosols were produced locally or transported from the southeast of Beijing, whereas the dust aerosols associated with the clean air mass were transported by the northwesterly or southwesterly winds.
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