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Zhuo, Wen-Lei,Zhang, Liang,Xie, Qi-Chao,Zhu, Bo,Chen, Zheng-Tang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Background: Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth factor receptor (EGFR) and HER2/neu pathways, has been indicated to have significant efficacy in treating HER2-positive breast cancer. However, acquired drug resistance has become a very serious clinical problem that hampers the use of this agent. In this study, we aimed to screen small molecule drugs that might reverse lapatinib-resistance of breast cancer by exploring differentially expressed genes (DEGs) via a bioinformatics method. Materials and Methods: We downloaded the gene expression profile of BT474-J4 (acquired lapatinib-resistant) and BT474 (lapatinib-sensitive) cell lines from the Gene Expression Omnibus (GEO) database and selected differentially expressed genes (DEGs) using dChip software. Then, gene ontology and pathway enrichment analyses were performed with the DAVID database. Finally, a connectivity map was utilized for predicting potential chemicals that reverse lapatinib-resistance. Results: A total of 1, 657 DEGs were obtained. These DEGs were enriched in 10 pathways, including cell cycling, regulation of actin cytoskeleton and focal adhesion associate examples. In addition, several small molecules were screened as the potential therapeutic agents capable of overcoming lapatinib-resistance. Conclusions: The results of our analysis provided a novel strategy for investigating the mechanism of lapatinib-resistance and identifying potential small molecule drugs for breast cancer treatment.
Prognostic Model Built on Blood-based Biomarkers in Patients with Metastatic Colorectal Cancer
He, Wen-Zhuo,Jiang, Chang,Yin, Chen-Xi,Guo, Gui-Fang,Rong, Ru-Ming,Qiu, Hui-Juan,Chen, Xu-Xian,Zhang, Bei,Xia, Liang-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: We had previously showed that the neutrophil lymphocyte ratio (NLR), ${\gamma}$-glutamyl transpeptidase (GGT) and carcinoembryonic antigen (CEA) are prognostic factors for metastatic colorectal cancer (mCRC) patients. In this study we developed a prognostic model based on these three indices. Materials and Methods: A total of 243 patients who were initially diagnosed as mCRC between 2005 and 2010 in the Sun Yat-sen University Cancer Center were studied. The endpoint was overall survival (OS). Results: NLR>3, elevated GGT and elevated CEA were confirmed as independent risk factors which could predict poor prognosis. Patients could be divided into three groups according to the number of risk factors they had. Those with two or three were defined as the high risk group, individuals with one risk factor as the modest risk group and patients without risk factor as the low risk group. The OS values for these three groups were 16.2 months (2.80~68.8), 24.2 months (4.07~79.0), and 37.2 months (12.6~87.8), respectively (p<0.001). Conclusions: We developed a simple but useful model based on NLR, GGT and CEA to provide prognostic information to clinical practice in highly selected mCRC patients. Further prospective and multi-center studies are warranted to test our model.
Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients
Zhang, Wen-Hua,Wu, Xiao-Jing,Niu, Jing-Xiu,Yan, Hao,Wang, Xin-Zhuo,Yin, Xiao-Dong,Pang, Yan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
The role of Helicobacter pylori status and serum zinc value in gastric disease patients and healthy controls were investigated. Cases used in this work were 45 gastric cancer patients, 44 with peptic ulcers, 52 suffering gastritis and 64 healthy controls, all diagnosed histologically with the controls undergoing medical checkups. Helicobacter pylori status and serum levels of Zn were determined by 13C-urea breath test and flame atomic absorption spectrophotometer, respectively. Our study showed that Helicobacter pylori infection has no change in gastritis, peptic ulcer and gastric cancer group, on the contrast, serum levels of Zn were significantly reduced in gastritis, peptic ulcer and gastric cancer group, compared with healthy controls, and the higher the Zn levels are, the more increased risk of gastric cancer. Helicobacter pylori infection is a cause of gastritis, peptic ulcers and even gastric cancer, while serum zinc level is an indicator of protection of gastric membranes against damage.
( Shi Zhuo Yang ),( Wen Rui Yang ) 한국통역번역학회 2010 FORUM Vol.8 No.2
La traduction a pour objectif de transmettre tous les renseignements de la langue source au texte de la langue cible, cependant dans la plupart des cas, les elements ideologiques de la langue cible reagissent sur la traduction. En prenant comme exemple les deux versions de The Gadfly, ce present article a fait des recherches sur l`influence de l`ideologie de la langue cible sur le processus et le produit de traduction, et essentiellement sur les cinq aspects: selection du texte de la langue de depart; choix des strategies du traducteur; redaction et publication des traductions; critique du texte traduit et reaction des lecteurs, ainsi que canonisation de la traduction avec les efforts conjugues des traducteurs, des editeurs, des critiques et des lecteurs.
( Shi Zhuo Yang ),( Wen Rui Yang ) 한국통역번역학회 2009 FORUM Vol.7 No.2
La Foire aux Vanites(Vanity Fair) de William Thackeray depeint la vie diverse de la haute societe anglaise de la premiere moitie du 19eme siecle et critique l`ordre social du monde bourgeois en caricaturant les individus des differentes couches sociales. Depuis que ce roman a ete introduit en Chine au 20eme siecle, de diverses versions chinoises ont fait successivement leur apparition, dont les versions de Yang Bi des annees cinquante et de Peng Changjiang des annees quatre-vingt dix les meilleures. Fonde sur la theorie ? recriture ? d`Andre Lefevre, a savoir ? ideologie, poetique, patronage et professionnel ?, ce present article recherche l`influence de ces quatre elements sur les choix des strategies traductrices de ces deux traducteurs a leur epoque. Nous etudions egalement la subjectivite du traducteur en examinant le choix de la poetique de traduction des deux traducteurs et en soulignant l`importance pour les traducteurs de devenir mediateur competent dans les echanges culturels, au lieu d`etre seulement ? marionnette ? manipulee par les elements exterieurs.
Jing, Chang-Wen,Wang, Zhuo,Cao, Hai-Xia,Ma, Rong,Wu, Jian-Zhong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background:The aim of the research was to explore a cost effective, fast, easy to perform, and sensitive method for epidermal growth factor receptor (EGFR) mutation testing. Methods: High resolution melting analysis (HRM) was introduced to evaluate the efficacy of the analysis for dectecting EGFR mutations in exons 18 to 21 using formalin-fixed paraffin-embedded (FFPE) tissues and plasma free DNA from 120 patients. Results: The total EGFR mutation rate was 37.5% (45/120) detected by direct sequencing. There were 48 mutations in 120 FFPE tissues assessed by HRM. For plasma free DNA, the EGFR mutation rate was 25.8% (31/120). The sensitivity of HRM assays in FFPE samples was 100% by HRM. There was a low false-positive mutation rate but a high false-negative rate in plasma free DNA detected by HRM. Conclusions: Our results show that HRM analysis has the advantage of small tumor sample need. HRM applied with plasma free DNA showed a high false-negative rate but a low false-positive rate. Further research into appropriate methods and analysis needs to be performed before HRM for plasma free DNA could be accepted as an option in diagnostic or screening settings.
Modified beluga whale optimization with multi-strategies for solving engineering problems
Jia Heming,Wen Qixian,Wu Di,Wang Zhuo,WANG YUHAO,Wen Changsheng,Abualigah Laith 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.6
The beluga whale optimization (BWO) algorithm is a recently proposed metaheuristic optimization algorithm that simulates three behaviors: beluga whales interacting in pairs to perform mirror swimming, population sharing information to cooperate in predation, and whale fall. However, the optimization performance of the BWO algorithm still needs to be improved to enhance its practicality. This paper proposes a modified beluga whale optimization (MBWO) with a multi-strategy. It was inspired by beluga whales’ two behaviors: group gathering for foraging and searching for new habitats in long-distance migration. This paper proposes a group aggregation strategy (GAs) and a migration strategy (Ms). The GAs can improve the local development ability of the algorithm and accelerate the overall rate of convergence through the group aggregation fine search; the Ms randomly moves towards the periphery of the population, enhancing the ability to jump out of local optima. In order to verify the optimization ability of MBWO, this article conducted comprehensive testing on MBWO using 23 benchmark functions, IEEE CEC2014, and IEEE CEC2021. The experimental results indicate that MBWO has a strong optimization ability. This paper also tests MBWO’s ability to solve practical engineering optimization problems through five practical engineering problems. The final results prove the effectiveness of MBWO in solving practical engineering optimization problems.
Endothelial Aquaporin-1 (AQP1) Expression Is Regulated by Transcription Factor Mef2c
Yong Jiang,He Liu,Wen-jing Liu,Hai-bin Tong,Chang-jun Chen,Fu-gui Lin,Yan-hang Zhuo,Xiao-zhen Qian,Zeng-bin Wang,Yu Wang,Peng Zhang,Hong-liang Jia 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.4
Aquaporin 1 (AQP1) is expressed in most microvascula-ture endothelial cells and forms water channels that play major roles in a variety of physiologic processes. This study aimed to delineate the transcriptional regulation of AQP1 by Mef2c in endothelial cells. Mef2c cooperated with Sp1 to activate human AQP1 transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells (HUVEC). Over-expression of Mef2c, Sp1, or Mef2c/Sp1 increased HUVEC migration and tube-forming ability, which can be abolished AQP1 knockdown. These data indicate that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells.
Pan Li,Zuan-hao Liang,Zhuo Jiang,Ziyou Qiu,Bing Du,Yu-bing Liu,Wen-zhi Li,Li-hao Tan 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.6
Phthalate plasticizers residue in food is a serious threat to public health. Spores of Ganoderma lucidum are easy to be contaminated with phthalates during collection and processing. In this study, supercritical fluid extraction (SFE) was performed to remove phthalates in spores of G. lucidum, and the effects on acid and peroxide values of spores’ oil were also evaluated. The results showed SFE removed 100% of the residual di-iso-butyl phthalate, di-nbutyl phthalate and di-2-ethylhexyl phthalate in the spores of G. lucidum. No significant differences in polysaccharides content and fatty acid composition were observed between SFE and control spores. However, the triterpenoid extracts of SFE spores had a 7.45% increase, significantly higher than that in control spores. Accelerated oxidation tests further implied that SFE could improve the stability of spores’ oil. Our results suggested SFE is a potential approach to remove phthalate from food related products.
Endothelial Aquaporin-1 (AQP1) Expression Is Regulated by Transcription Factor Mef2c
Jiang, Yong,Liu, He,Liu, Wen-jing,Tong, Hai-bin,Chen, Chang-jun,Lin, Fu-gui,Zhuo, Yan-hang,Qian, Xiao-zhen,Wang, Zeng-bin,Wang, Yu,Zhang, Peng,Jia, Hong-liang Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.4
Aquaporin 1 (AQP1) is expressed in most microvasculature endothelial cells and forms water channels that play major roles in a variety of physiologic processes. This study aimed to delineate the transcriptional regulation of AQP1 by Mef2c in endothelial cells. Mef2c cooperated with Sp1 to activate human AQP1 transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells (HUVEC). Over-expression of Mef2c, Sp1, or Mef2c/Sp1 increased HUVEC migration and tube-forming ability, which can be abolished AQP1 knockdown. These data indicate that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells.