Genetic Variants of CYP2D6 Gene and Cancer Risk: A HuGE Systematic Review and Meta-analysis

Zhou, Li-Ping,Luan, Hong,Dong, Xi-Hua,Jin, Guo-Jiang,Man, Dong-Liang,Shang, Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Objective: Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. A large number of single nucleotide polymorphisms (SNPs) in the CYP2D6 gene have been reported to associate with cancer susceptibility. However, the results are controversial. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to summarize the evidence for associations. Methods: Studies focusing on the relationship between CYP2D6 gene polymorphisms and susceptibility to cancer were selected from the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI and CBM databases. Data were extracted by two independent reviewers and the meta-analysis was performed with Review Manager Version 5.1.6 and STATA Version 12.0 software. Odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated. Results: According to the inclusion criteria, forty-three studies with a total of 7,009 cancer cases and 9,646 healthy controls, were included in the meta-analysis. The results showed that there was a positive association between heterozygote (GC) of rs1135840 and cancer risk (OR=1.92, 95%CI: 1.14-3.21, P=0.01). In addition, we found that homozygote (CC) of rs1135840 might be a protective factor for cancer (OR=0.58, 95%CI: 0.34-0.97, P=0.04). Similarly, the G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 had negative associations with cancer risk (OR=0.69, 95%CI: 0.48-0.99, P=0.04; OR=0.60, 95%CI: 0.38-0.94, P=0.03; OR=0.50, 95%CI: 0.26-0.95, P=0.03; respectively). Conclusion: This meta-analysis suggests that CYP2D6 gene polymorphisms are involved in the pathogenesis of various cancers. The heterozygote (GC) of rs1135840 in CYP2D6 gene might increase the risk while the homozygote (CC) of rs1135840, G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 might be protective factors.

Decoupling Analysis of Interaction between Tunnel Surrounding Rock and Support in Xigeda Formation Strata

Ping Zhou,Feicong Zhou,Jiayong Lin,Jinyi Li,Yifan Jiang,Bao Yang,Zhijie Wang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.12

The Xigeda Formation has the characteristics of poor cementation, variable structure, and softening in water. It is prone to lead to failure of the initial support structures, arch collapse, and even roof fall. The key to the problem lies in the exploration of the interaction between surrounding rock and support. Therefore, based on the constraint loss theory of the tunnel face space effect, this paper constructively introduces multiple dependent variables, including the intermediate principal stress, the dilatancy of the surrounding rock, the timeliness of the shotcrete support stiffness, and the water content of the Xigeda formation, to decouple the whole process of the interaction between the surrounding rock and support, and discusses the influence of each variable. The research results show that: i) there is a critical support point in the tunnel under the influence of the unified strength theoretical parameter b and water content, and when the unified strength theoretical parameter b is constant, the critical distance of the support will decrease with the increase of the water content; ii) from the perspective of deformation control, the stress of support structure will increase with the increase of dilatancy angle of Xigeda surrounding rock; iii) considering the hardening characteristics of shotcrete, the initial support stiffness of Xigeda tunnel increases nonlinearly, and the whole process of stress and deformation can be divided into four stages; iv) the combined support structure of section steel and grille has little difference in the deformation control effect of the surrounding rock and the stress of the support structure, but the combined support structure of the grille steel frame is more sensitive to the hardening parameters.

The study of theoretical method for improving the spatial resolution of satellite images with CCD cameras

Zhou, Chun Ping,Yao, Huai Jun,Ma, Jia,Chen, Xiu Wan 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1

By the integrating satellite hardware's design with ground software's processing, the article presents a new theoretical method fox improving the spatial resolution of satellite image. Computer simulations under different resolution levels are carried out on simulated target images, common scenery images and Remote Sensing images separately. The success results of experimental simulations show clearly the method for improving resolution we present is valid in theory, which also proved the theoretic feasibility to enhance the spatial resolution of satellite images up to twice, even N times. Obviously, practical applications of the research will enhance the spatial resolution of satellite images. In addition, it can also help shorten optical instruments' focus, decrease satellite camera's size and mass while remaining the same spatial resolution of satellite images.

Cinobufacin Suppresses Cell Proliferation via miR-494 in BGC-823 Gastric Cancer Cells

Zhou, Rong-Ping,Chen, Gang,Shen, Zhi-Li,Pan, Li-Qun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Cinobufacin is used clinically to treat patients with many solid malignant tumors. However, the mechanisms underlying action remain to be detailed. Our study focused on miRNAs involved in cinobufacin inhibition of GC cell proliferation. miRNA microarray analysis and real time PCR identified miR-494 as a significant cinobufacin-associated miRNA. In vivo, ectopic expression of miR-494 inhibited the proliferation and induced apoptosis of BGC-823 cells on CCK-8 and flow cytometry analysis. Further study verified BAG-1 (anti-apoptosis gene) to bea target of miR-494 by luciferase reporter assay and Western blotting. In summary, our study demonstrated that cinobufacin may inhibit the proliferation and promote the apoptosis of BGC-823 cells. Cinobufacin-associated miR-494 may indirectly be involved in cell proliferation and apoptosis by targeting BAG-1, pointing to use as a potential molecular target of cinobufacin in gastric cancer therapy.

Model Approximation of Multiple Delay Transfer Function Models Using Multiple-Point Step Response Fitting

Ping Zhou,Bo Xiang,Jun Fu,Tian-You Chai 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.1

Compared with model approximation for general SISO transfer function models with or without a single constant delay, the approximation problem for SISO transfer function models with multiple delays has received much less attention. In this paper, we attack this problem and thus present a multiple-point step response fitting based approximation method to derive the reduced models. A simple frequency-domain weighted recursive least squares (RLS) algorithm is proposed to determine a set of parameters so that the reduced models can approximate the original models by minimizing the defined frequency-domain squared-error between the step responses of the original and the reduced model. Numerical examples have demonstrated that the proposed approximation approach can not only introduce less dynamic approximation error, but also yield zero steady-state error.

Failure analysis for hoisting wire ropes with local accumulated broken wire damage on the surface

Ping Zhou,Gongbo Zhou,Lianfeng Han,Xiaodong Yan,Hanyu Wang,Zhenzhi He 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7

Surface broken wire (BW) damage to hoisting steel wire ropes (SWR) is unavoidable during the service process, and it continues to accumulate locally during the evolution process. The specific influence analysis of the surface damage with local cumulative BWs on the performance of the hoisting SWR is insufficient at present, which seriously affects the safety of the rope system. In this paper, a failure analysis method for the state of surface cumulative BW rope based on the integration of finite element (FE) and mechanical tension is proposed. First, a method for creating an FE model of surface BW damage is presented, and the stress-strain distribution features of damaged section under tensile load are revealed. Then, the residual mechanical strength of SWR under local cumulative BW damage is determined by performing a tensile test. Finally, based on the analysis of FE and breaking behavior, combined with the regulations, the state of the damaged SWR is comprehensively evaluated. The results show that the breaking position of the SWR under mechanical tension is the maximum stress distribution in the simulation analysis, which verifies the consistency between the simulation and the experiment; and the accumulation degree and distribution of local BW affect the residual mechanical strength of the SWR. This method explores the influence of different degrees of local BW damage on the mechanical properties of the SWR, which provides a direct basis for the non-destructive evaluation of the SWR state.

A combined spline chirplet transform and local maximum synchrosqueezing technique for structural instantaneous frequency identification

Ping-Ping Yuan,Zhou-Jie Zhao,Ya Liu,Zhong-Xiang Shen 국제구조공학회 2024 Smart Structures and Systems, An International Jou Vol.33 No.3

Spline chirplet transform and local maximum synchrosqueezing are introduced to present a novel structural instantaneous frequency (IF) identification method named local maximum synchrosqueezing spline chirplet transform (LMSSSCT). Namely spline chirplet transform (SCT), a transform is firstly introduced based on classic chirplet transform and spline interpolated kernel function. Applying SCT in association with local maximum synchrosqueezing, the LMSSSCT is then proposed. The index of accuracy and Rényi entropy show that LMSSSCT outperforms the other time-frequency analysis (TFA) methods in processing analytical signals, especially in the presence of noise. Numerical examples of a Duffing nonlinear system with single degree of freedom and a two-layer shear frame structure with time-varying stiffness are used to verify the effectiveness of structural IF identification. Moreover, a nonlinear supported beam structure test is conducted and the LMSSSCT is utilized for structural IF identification. Numerical simulation and experimental results demonstrate that the presented LMSSSCT can effectively identify the IFs of nonlinear structures and time-varying structures with good accuracy and stability.

Association Between XRCC5, 6 and 7 Gene Polymorphisms and the Risk of Breast Cancer: A HuGE Review and Meta-analysis

Zhou, Li-Ping,Luan, Hong,Dong, Xi-Hua,Jin, Guo-Jiang,Man, Dong-Liang,Shang, Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Objective: Non-homologous end joining (NHEJ) is a pathway for repairing DNA double-strand breaks. Recent publications indicated that XRCC5, XRCC6 and XRCC7 genes may participate in the pathogenesis of breast cancer. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to investigate associations between XRCC5, XRCC6 and XRCC7 genetic polymorphisms in the NHEJ pathway and breast cancer risk. Methods: Studies focusing on the relationship between genetic polymorphisms in XRCC5, XRCC6 and XRCC7 genes and susceptibility to breast cancer were selected from the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI and CBM databases. Data were extracted by two independent reviewers. The meta-analysis was performed with Review Manager Version 5.1.6 and STATA Version 12.0 software. The odds ratio (OR) with 95% confidence interval (95%CI) was calculated based on the extracted data. Results: According to the inclusion criteria, we final included seven studies with a total of 2,864 breast cancer cases and 3,060 healthy controls. Meta-analysis results showed that rs3835 (G>A) and rs828907 (G>T) in XRCC5 gene, and rs132793 (G>A) in XRCC6 gene might increase the risk of breast cancer, while rs132788 G>T and rs6002421 (A>G) might be protective factors. However, there was no relationship between XRCC7 genetic polymorphisms and the risk of breast cancer. Conclusion: This meta-analysis suggests that the rs3835 G>A and rs828907 G>T in XRCC5 gene, rs6002421 (A>G), rs132788 (G>T) and rs132793 (G>A) in XRCC6 gene might be risk factors for breast cancer, while the rs132788 (G>T) and rs6002421 (A>G) in XRCC6 gene might be protective.

Influence of synthetic polymers on the mechanical properties of hardened b-calcium sulfate hemihydrate plasters

Ping-ping Zhou,Hua-chun Wu,Yong-Mei Xia 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.33 No.-

Polymers have been used to modulate mechanical strengths and water absorption of construction ormodeling materials as like gypsum. To understand the structure–performance relationship of polymersin hydration and properties of gypsum plaster, several designed carboxyl polyether sulfonates wereinvestigated with comparison of some commercial polymers. It is found that bending strength of thehardened b-hemihydrate plaster is inversely proportional to number of carboxyl groups in the polymerthat retards hydration. The mechanical strengths enhancement is coincident with acceleration of initialhydration, while decrease of mechanical strengths happened with retard of the hydration.

The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

Zhou, Ping,Huang, Wei,Chu, Xing,Du, Liang-Feng,Li, Jian-Ping,Zhang, Chun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC). Methods: Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified. Results: This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations. Conclusion: Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.