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崔志鹰 韓國外國語大學校 外國學綜合硏究센터 中國硏究所 2005 中國硏究 Vol.36 No.-
On the Korean Peninsula, Sino-American have some common interests, but also have some difference. This paper discuss some Sino-American Cooperation-Idea on the Korean Peninsula.
Ying Zhi Gao,Shi Ping Wang,You Neng Yang,De Li Wang,Jie Zhang 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
Grazing restoration succession of the degraded grassland is an important aspect in community ecology. Field experiment was carried out to examine how major species restore in first four years restoration following 11 consecutive grazing under different stocking rates in Inner Mongolian steppe. A. frigida and P. acaulis are the most important two species in the all treatments (NG, LG, MG and HG) after four years restoration, although they had high fluctuation. The biomasses of these two species account for 40-90% of total biomass. Especially in no grazing area, which was exclosured since 1990, A. frigida and P. acaulis are still the most important two species in the community. These results suggested A. frigida and P. acaulis conununity are quite stable, and will keep long-time if no special measurements were taken during the restoration of the degraded grassland.
Ying-Jie Chen,Jia-Ying Wu,Yu-Yi Deng,Ying Wu,Xiao-Qi Wang,Amy Sze-man Li,Lut Yi Wong,Xiuqiong Fu,Zhi-Ling Yu,Chun Liang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3
Sorafenib is effective in treating hepatoma, but most patients develop resistance to it. STAT3signaling has been implicated in sorafenib resistance. Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3)have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells. This study aimed to evaluatethe effects of Rg3 in combination with ART (Rg3-plus-ART) in overcoming sorafenib resistance, and toexamine the involvement of STAT3 signaling in these effects. Methods: Sorafenib-resistant HepG2 cells (HepG2-SR) were used to evaluate the in vitro anti-hepatomaeffects of Rg3-plus-ART. A HepG2-SR hepatoma-bearing BALB/c-nu/nu mouse model was used to assessthe in vivo anti-hepatoma effects of Rg3-plus-ART. CCK-8 assays and Annexin V-FITC/PI double stainingwere used to examine cell proliferation and apoptosis, respectively. Immunoblotting was employed toexamine protein levels. ROS generation was examined by measuring DCF-DA fluorescence. Results: Rg3-plus-ART synergistically reduced viability of, and evoked apoptosis in HepG2-SR cells, andsuppressed HepG2-SR tumor growth in mice. Mechanistic studies revealed that Rg3-plus-ART inhibitedactivation/phosphorylation of Src and STAT3 in HepG2-SR cultures and tumors. The combination alsodecreased the STAT3 nuclear level and induced ROS production in HepG2-SR cultures. Furthermore, overactivation of STAT3 or removal of ROS diminished the anti-proliferative effects of Rg3-plus-ART, andremoval of ROS diminished Rg3-plus-ART's inhibitory effects on STAT3 activation in HepG2-SR cells. Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms. Thisstudy provides a pharmacological basis for developing Rg3-plus-ART into a novel modality for treatingsorafenib-resistant hepatoma.
( Zhi-ying Cai ),( Yi-xian Liu ),( Yu-ping Shi ),( Li-ming Dai ),( Lan-lan Li ),( Hong-jun Mu ),( Mei-lin Lv ),( Xiao-yong Liu ) 한국균학회 2019 Mycobiology Vol.47 No.1
A new species of Alternaria causing leaf spots on the rubber tree (Hevea brasiliensis) in Yunnan, China, was isolated, examined, and illustrated. Morphologically, it belongs to the section Porri of Alternaria, which produces relatively large conidia and a simple or branched, filamentous long beak. It is, however, characterized by conidiophores gradually enlarging near the apex into a clavate conidiogenous cell and long ellipsoid to obclavate, smoothwalled conidia with a long filamentous beak. Molecular phylogenetic analyses based on ITS rDNA, GAPDH, and TEF1-alpha sequences demonstrate that the phytopathogen falls in the clade of the section Porri, being most closely related to A. sidae, A. sennae, A. deseriticola, A. cyamopsidis, A. rostellata, A. nitrimali, A. crassa, and A. thunbergiae.
Ying Zhi Gao,Shi Ping Wang,De Li Wang,Jie Zhang,Huai Yu Wan 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
To explore the relationship of species diversity and aboveground productivity in grazing ecosystem is very important to manage grassland. We used the four years' data to check this relationship and to look how abiotic factor affect species diversity and aboveground productivity. We found a good linear relationship between species diversity and aboveground productivity in all previous grazing sites, while no any relationship was found in the no grazing site. From our results, we concluded that drought affects aboveground productivity more than grazing, while heavy grazing affects species diversity more than drought in Inner Mongolian steppe.
Ying-Hua Li,Yin-Yin Wang,Shan Zhong,Zhi-Li Rong,Yong-Ming Ren,Zhi-Yong Li,Shu-Ping Zhang,Zhi-Jie Chang,Li Liu 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.1
Ligand-dependent or independent oligomerization of receptor protein tyrosine kinase (RPTK) is often an essential step for receptor activation and intracellular signaling. The novel oncogene with kinase-domain (NOK) is a unique RPTK that almost completely lacks an ectodomain, expresses intracellularly and activates constitutively. However, it is unknown whether NOK can form oligomer or what function oligomerization would have. In this study, two NOK deletion mutants were generated by either removing the ectodomain (NOKECD) or including the endodomain (NOK-ICD). Co-immunoprecipitation demonstrated that the transmembrane (TM) domain of NOK was essential for its intermolecular interaction. The results further showed that NOK aggregated more closely as lower order oligomers (the dimer- and trimer-sized) than either deletion mutant did since NOK could be cross-linked by both Sulfo-EGS and formaldehyde, whereas either deletion mutant was only sensitive to Sulfo-EGS. Removing the NOK TM domain (NOK-ICD) not only markedly promoted higher order oligomerization, but also altered the subcellular localization of NOK and dramatically elevated the NOK-mediated constitutive activation of extracellular signal-regulated kinase (ERK). Moreover, NOK-ICD but not NOK or NOKECD was co-localized with the upstream signaling molecule RAS on cell membrane. Thus, TM-mediated intermolecular contacting may be mainly responsible for the constitutive activation of NOK and contribute to the autoinhibitory effect on RAS/MAPK signaling.
Ying-Zhi Yin,Guo-Qiang Li,Ming-Fei Li 국제구조공학회 2002 Steel and Composite Structures, An International J Vol.2 No.4
The high-temperature material properties of steel are very important to the fire resistance analysis of high-strength bolt connections. This paper reports on the results of the experimental studies on the high-temperature properties of 20 MnTiB steel which is widely used in high-strength bolts, and the friction coefficient of 16Mn steel plates at elevated temperature which is a necessary parameter for bolted frictional connection analysis. The test data includes yield strength, limit strength, modulus of elasticity, elongation and expansion coefficient of 20MnTiB steel at elevated temperature, and the friction coefficients between two 16Mn steel plates under elevated temperatures and after cooling. Based on the data from the tests, the mathematical models for predicting the mechanical properties of 20MnTiB steel and friction coefficients of 16Mn steel plates have been established.
Ying-ying Xu,Hai-ru Yu,Jia-yi Sun,Zhao Zhao,Shuang Li,Xin-feng Zhang,Zhi-xuan Liao,Ming-ke Cui,Juan Li,Chan Li,Qiang Zhang 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Although the interferon (IFN) signaling and the paired-like homeodomain transcription factor 2 (PITX2) have both been implicated in the progression of breast cancer (BCa), it remains obscure whether these two pathways act in a coordinated manner. We therefore aimed to elucidate the expression and function of PITX2 during the pathogenesis of endocrine resistance in BCa. Materials and Methods PITX2 expression was assessed in BCa tissues using quantitative reverse transcription polymerase chain reaction (RT-qPCR) and immunohistochemistry and in experimentally induced letrozole-resistant BCa cells using RT-qPCR and immunoblotting. Effects of PITX2 deregulation on BCa progression was determined by assessing MTT, apoptosis and xenograft model. Finally, using multiple assays, the transcriptional regulation of interferon-inducible transmembrane protein 1 (IFITM1) by PITX2 was studied at both molecular and functional levels. Results PITX2 expression was induced in letrozole-resistant BCa tissues and cells, and PITX2 induction by IFN signaling powerfully protected BCa cells against letrozole insult and potentiated letrozole-resistance. Mechanistically, PITX2 enhanced IFN-induced AKT activation by transactivating the transcription of IFITM1, thus rendering BCa cells unresponsive to letrozoleelicited cell death. Additionally, ablation of IFITM1 expression using siRNA substantially abolished IFN-elicited AKT phosphorylation, even in the presence of PITX2 overexpression, thus sensitizing BCa cells to letrozole treatment. Conclusion These results demonstrate that constitutive upregulation of PITX2/IFITM1 cascade is an intrinsic adaptive mechanism during the pathogenesis of letrozole-resistance, and modulation of PITX2/IFITM1 level using different genetic and pharmacological means would thus have a novel therapeutic potential against letrozole resistance in BCa.
The resilience of farmer’s livelihood to climate change and influencing factors: a case in China
Han Zhi-Ying(한지영),Youn Yeochang(윤여창),Hyeyeong Choe(최혜영) 한국환경정책학회 2022 한국환경정책학회 학술대회논문집 Vol.2022 No.2
The socio-economic development and livelihoods in most developing countries are severely affected by climate change, especially, agricultural systems, which are the main source of livelihood for rural households in developing countries. Resilience theory provides a new tool for the study of ecological environment, natural resource management, and socio-economic sustainable development by analyzing the ability of systems to adapt to climate change. Based on the theory of resilience, an index system for measuring farmer’s livelihood resilience under the impact of climate change was constructed. Based on a survey of 596 farmer households in Aohan Banner, Inner Mongolia, China, a comprehensive index method was used to evaluate the resilience of farmer’s livelihoods after climate change disturbance. A multiple linear regression model was used to analyze the key factors that affect farmer’s livelihood resilience. This paper contributes to providing a reference basis for government decision-makers to formulate scientific and effective climate change adaptation strategies and guide farmers to adopt effective livelihood strategies to cope with climate change, thus providing a theoretical basis for improving farmer’s resilience to climate change and promoting sustainable development of farmer’s livelihoods.