A phase I dose-finding trial of hyperthermic intraperitoneal docetaxel combined with cisplatin in patients with advanced-stage ovarian cancer

Zhi-yao You,Hui Li,Miao-fang Wu,Yanfang Ye,Li-juan Wang,Zhongqiu Lin,Jing Li 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1

Objective: To identif y the maximum tolerated dose (MTD) of docetaxel combined with afixed dose of cisplatin (75 mg/m2) delivered as hyperthermic intraperitoneal chemotherapy(HIPEC) in patients with ovarian cancer. Methods: In this phase I trial, a time-to-event Bayesian optimal inter val design was used. Docetaxel was given at a starting dose of 60 mg/m2 and was increased in 5 mg/m2 incrementsuntil the MTD was determined or the maximum dose level of 75 mg/m2 was reached. The dose-limiting toxicity (DLT) rate was set at 25%, with a total sample size of 30 patients. HIPEC wasdelivered immediately following debulking surger y at a target temperature of 43°C for 90 minutes. Results: From August 2022 to November 2022, 30 patients were enrolled. Among thepatients who received a dose of docetaxel ≤65 mg/m2, no DLT was reported. DLTs wereobser ved in one patient who received 70 mg/m2 docetaxel (grade 3 anaemia) and in threepatients who received 75 mg/m2 docetaxel (one case of grade 3 anaemia, one case of grade3 hepatic impairment and one case of grade 4 thrombocytopenia). Patients treated withdocetaxel 75 mg/m2 in combination with cisplatin 75 mg/m2 had an estimated DLT rate of25%, which was the closest to the target DLT rate and was therefore chosen as the MTD. Conclusion: Docetaxel, in combination with a fixed dose of cisplatin (75 mg/m2), can be usedsafely at intraperitoneal doses of 75 mg/m2 in ovarian cancer patients who received HIPEC(43°C, 90 minutes) following debulking surger y. Trial Registration: ClinicalTrials.gov Identifier: NCT05410483

Electrical Measurements of an AlGaN/GaN High-electron-mobility Transistor Structure Grown on Si

Zhi-Yao Zhang,Shun-Tsung Lo,Li-Hung Lin,Kuang Yao Chen,J. Z. Huang,Zhi-Hao Sun,C.-T. Liang,N. C. Chen,Chin-An Chang,P. H. Chang 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.9

We report on magnetotransport results for an Al_0.15Ga_0.85N/GaN high-electron-mobility-transistor structure grown on a p-type Si (111) substrate. Our results show that there exists an approximately temperature (<i>T</i>)-independent point, which could be ascribed to a direct transition from a weak insulator to a high Landau level filling factor quantum Hall state, exists in the longitudinal resistivity ρ_xx. The Hall resistivity decreases with increasing <i>T</i>, compelling experimental evidence for electron-electron interaction effects in a weakly-disordered two-dimensional (2D) system. We find that electron-electron interaction effects can be estimated and eliminated, giving rise to a corrected nominally temperature-independent Hall slope. By fitting the low-field magnetotransport data to conventional 2D weak localization theory, we find that the dephasing rate 1/τ_φ is proportional to <i>T</i>. Moreover, 1/τ_φ is finite as <i>T</i> → 0, evidence for zero-temperature dephasing in our system.

Feasibility, accuracy and acceptability of self-sampled human papillomavirus testing using careHPV in Cambodia: a cross-sectional study

Zhi-yao You,Jing Li,Miao-fang Wu,Hui Li,Yanfang Ye,Li-juan Wang,Zhongqiu Lin 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1

Objective: Self-sampled human papillomavirus (HPV) testing is a potential option forcer vical cancer screening, but research is scarce in Cambodia. We evaluated the feasibility,accuracy, and acceptability of self-sampled HPV testing using careHPV. Methods: A cross-sectional study including women aged 20–49 years attending 2 nationalhospitals in the capital city was conducted. Women under went both self-sampling andclinician-sampling of specimens, and were then asked to complete an acceptabilityquestionnaire. The paired samples were analyzed for high-risk HPV by careHPV andgenotyped by polymerase chain reaction (PCR). Results: A total of 375 women were eligible for inclusion. Based on PCR, 78.9% were negativefor HPV in both self and clinician-samples, 9.9% had a complete HPV type match, and 6.1%had all HPV types in clinician-samples also detected in self-samples. In 5.1%, one or more HPVtypes identified in the clinician-samples were missed in self-samples. When using careHPV,the overall agreement between the 2 sampling methods was 95.7% (95% confidence inter val[CI]=95.8–95.6) with good concordance (κ=0.66, 95% CI=0.56–0.76). Nearly 90% of the womenpreferred clinician-sampling over self-sampling, citing greater comfort, ease, and speed. Conclusion: Self-sampled HPV testing using careHPV could be an option for cer vical cancerscreening in Cambodia; however, it requires periodic quality control of handling procedures. In addition, women’s health education regarding the accuracy of self-sampled HPV testingand the importance of follow-up in cases of positive results is needed.

Radio-Sensitization by Piper longumine of Human Breast Adenoma MDA-MB-231 Cells in Vitro

Yao, Jian-Xin,Yao, Zhi-Feng,Li, Zhan-Feng,Liu, Yong-Biao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: The current study investigated the effects of Piper longumine on radio-sensitization of human breast cancer MDA-MB-231 cells and underlying mechanisms. Materials and Methods: Human breast cancer MDA-MB-231 cells were cultured in vitro and those in logarithmic growth phase were selected for experiments divided into four groups: control, X-ray exposed, Piper longumine, and Piper longumine combined with X-rays. Conogenic assays were performed to determine the radio-sensitizing effects. Cell survival curves were fitted by single-hit multi-target model and then the survival fraction (SF), average lethal dose ($D_0$), quasi-threshold dose ($D_q$) and sensitive enhancement ratio (SER) were calculated. Cell apoptosis was analyzed by flow cytometry (FCM). Western blot assays were employed for expression of apoptosis-related proteins (Bc1-2 and Bax) after treatment with Piper longumine and/or X-ray radiation. The intracellular reactive oxygen species (ROS) level was detected by FCM with a DCFH-DA probe. Results: The cloning formation capacity was decreased in the group of piperlongumine plus radiation, which displayed the values of SF2, D0, Dq significantly lower than those of radiation alone group and the sensitive enhancement ratio (SER) of D0 was1.22 and 1.29, respectively. The cell apoptosis rate was increased by the combination treatment of Piper longumine and radiation. Piper longumine increased the radiation-induced intracellular levels of ROS. Compared with the control group and individual group, the combination group demonstrated significantly decreased expression of Bcl-2 with increased Bax. Conclusions: Piper longumine at a non-cytotoxic concentration can enhance the radio-sensitivity of MDA-MB-231cells, which may be related to its regulation of apoptosis-related protein expression and the increase of intracellular ROS level, thus increasing radiation-induced apoptosis.

Bayesian forecasting approach for structure response prediction and load effect separation of a revolving auditorium

Zhi Ma,Chung-Bang Yun,Yan-Bin Shen,Feng Yu,Hua-Ping Wan,Yao-Zhi Luo 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.4

A Bayesian dynamic linear model (BDLM) is presented for a data-driven analysis for response prediction and load effect separation of a revolving auditorium structure, where the main loads are self-weight and dead loads, temperature load, and audience load. Analyses are carried out based on the long-term monitoring data for static strains on several key members of the structure. Three improvements are introduced to the ordinary regression BDLM, which are a classificatory regression term to address the temporary audience load effect, improved inference for the variance of observation noise to be updated continuously, and component discount factors for effective load effect separation. The effects of those improvements are evaluated regarding the root mean square errors, standard deviations, and 95% confidence intervals of the predictions. Bayes factors are used for evaluating the probability distributions of the predictions, which are essential to structural condition assessments, such as outlier identification and reliability analysis. The performance of the present BDLM has been successfully verified based on the simulated data and the real data obtained from the structural health monitoring system installed on the revolving structure.

Association of preoperative body mass index with surgical textbook outcomes following hepatectomy for hepatocellular carcinoma: A multicenter study of 1,206 patients

Zhi-Peng LIU,Lan-Qing YAO,Yong-Kang DIAO,Zi-Xiang CHEN,Zi-Han FENG,Timothy M. PAWLIK,Wan Yee LAU,Feng SHEN,Zhi-Yu CHEN,Tian YANG 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Characteristics Comparison before and after Lyophilization of Transferrin Modified Procationic-Liposome-Protamine-DNA Complexes (Tf-PLPD)

Zhi-Rong Zhong,Zhi-rong Zhang,Ji Liu,Yong Deng,Hong-wei Zhang,Yao Fu,Qing-guo Song,Qin He 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1

A novel non-viral gene delivery system, Procationic-Liposome-Protamine-DNA complexes (PLPD) which could further adsorb transferrin on the surface as a targeting ligand to form Tf- PLPD, was prepared and characterized before and after lyophilization. The size distribution of Tf-PLPD was in the range of 240 ± 12 nm and the zeta potential was -24.10 ± 2.5 mV. The transfection efficiencies of PLPD and Tf-PLPD were 12.18 ± 3.8 and 24.26 ± 2.6 mU β-galactosidase/ mg protein respectively. The lyophilization and the presence of serum didn’t affect the tansfectivities of PLPD or Tf-PLPD. Compared to LipofectamineTM 2000 (Invitrogen, U.S.A.), the procationic liposomes had less cytotoxicity to cells. In summary the procationic lipoplex described here, combining the condensing effect of protamine and the targeting capability of Tf, was a perspective non-viral vector for gene delivery system.

중국 배달 앱의 온라인리뷰가 행동의도에 미치는 영향에 관한 연구 -가격민감도와 멤버십의 매개적 조절효과-

지로요 ( Zhi Lu Yao ),하홍열 ( Ha Hong Youl ) 한중사회과학학회 2022 한중사회과학연구 Vol.20 No.1

본 연구는 배달 앱을 이용하는 중국 소비자를 대상으로, 온라인리뷰가 어떻게 소비자의 행동의도에 영향을 미치는가를 고찰한다. 이를 위해 온라인 고객이 상품을 구매할 때 고려하는 가격민감도와 특정 앱을 이용할 때 사용되는 고객정보인 멤버십의 조절 및 매개적 조절효과를 함께 고찰한다. 총 881명의 유효한 표본을 가지고, 본 연구에서 제시한 가설을 회귀분석 Process Macro를 이용하여 분석하였다. 연구결과를 살펴보면, 첫째, 온라인리뷰 수준이 높아지면, 소비자의 지각된 가치에 긍정적인 영향을 준다는 결과를 보여주고 있다. 둘째, 온라인리뷰와 행동의도의 관계는 가격민감도 수준에 의해 영향을 받고 있으며, 특히, 가격민감도가 낮은 집단에서는 온라인리뷰가 긍정적일 때, 행동의도가 높아진다. 다만, 가격민감도가 높은 집단에서 온라인리뷰가 긍정적일 때, 행동의도는 상대적으로 높아진다. 마지막으로, 가격민감도가 높고 비회원인 고객인 경우, 온라인리뷰가 긍정적일 때, 지각된 가치가 상대적으로 낮게 나타나는 결과를 보여주고 있다. This study examines how online reviews influence behavioral intentions in the context of the Chinese food delivery applications. In so doing, we test the impacts of price sensitivity and the type of customer membership using the mediated moderation approach which plays an important role in bridging the relationship between the two constructs. We collected a total of 881 usable samples, and then, test our proposed hypotheses using Process Macro. First, our findings show that positive online reviews significantly influence customers’ perceived value. Second, the relationship between online reviews and behavioral intentions is affected by the level of price sensitivity. In particular, for the group of low price sensitivity, when online reviews are positive, behavioral intentions are high. However, for the group of high price sensitivity, when online reviews are positive, behavioral intentions are relatively high. Finally, in the case of high price sensitivity and non-membership customers, when online reviews are positive, perceived value is relatively low.

Membrane surface charge and morphological and mechanical properties of young and old erythrocytes

Xing-Yao Chen,Yao-Xiong Huang,Wen-jing Liu,Zhi-jian Yuan 한국물리학회 2007 Current Applied Physics Vol.7 No.s1

ditions were studied as a function of cell age. The young and old cells were separated from fresh rabbit blood by using Percoll densitygradients. A novel multi-dimensional microscope was employed to perform real-time, non-invasivein situmeasurements on the mem-brane bending elastic modulus and the cell shape and size. A phase-analysis micro-electrophoresis laser scattering technique was usedto measure the surface charge density. The results show that the membrane Zeta potential of red blood cells is reduced when they become.

Ginseng berry polysaccharides on infl ammation-associated colon cancer: inhibiting T-cell differentiation, promoting apoptosis, and enhancing the effects of 5-fl uorouracil

Chong-Zhi Wang,Lifei Hou,Jin-Yi Wan,Haiqiang Yao,Jinbin Yuan,Jinxiang Zeng,Chan Woong Park,Su Hwan Kim,Dae Bang Seo,Kwang-Soon Shin,Chun-Feng Zhang,Lina Chen,Qi-Hui Zhang,Zhi Liu,Clara Sava-Segal,Chun 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2

Background: Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In thisproject, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC andrelated immune regulation mechanisms. Methods: Ginseng berry polysaccharide extract (GBPE) and purified ginseng berry polysaccharideportion (GBPP) were used to evaluate their activities on human HCT-116 and HT-29 CRC cell proliferation. Interleukin-8 secretion analysis was performed on HT-29 cells. Naive CD4 cell isolation and T-helper celldifferentiation were performed and determined using flow cytometry for Th1 and Treg in addition to cellcycle and apoptotic investigation. Results: GBPE and GBPP significantly inhibited interleukin-8 secretion and cancer cell proliferation,inhibited CD4þIFN-gþ cell (Th1) differentiation, and decreased CD4þFoxP3þ cell (Treg) differentiation. Compared to the GBPE, GBPP showed more potent antiinflammatory activities on the malignant cells. This is consistent with the observation that GBPP can also inhibit Th1-cell differentiation better, suggestingthat it has an important role in antiinflammation, whereas Treg cells hinder the body’s immuneresponse against malignancies. Supported by cell cycle and apoptosis data, GBPE and GBPP, at variousdegrees, remarkably enhanced the anticancer activities of 5-fluorouracil. Conclusion: Data from this project suggested that Asian ginseng berry potentially has clinical utility inmanaging enteric inflammation and suppressing CRC through immunomodulation mechanisms.