매스티지 브랜드 광고모델 국적의 조절효과에 대한 연구: 해석수준이론을 중심으로

진진곤(Zhenkun Chen),방정혜(Jounghae Bang),김민선(Min Sun Kim) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.2

본 연구는 방한 중국관광객에 대해 브랜드 인지도와 지각된 가격공정성이 매스티지 구매의도에 미치는 영향을 확인하고, 한 · 중 양국의 유명 광고모델이 이 관계에 어떻게 영향을 미치는 지 연구하였다. 명품의 이미지와 합리적인 가격대라는 매스티지의 특성에 따라 매스티지 원산지와 일치하는 국적(한국)모델과 중국관광객의 자국(중국)모델의 영향을 해석수준이론을 통하여 살펴보고자 하였다. 가설검증을 위해 2(브랜드인지도 고 · 저)X2(가격공정성)X2(광고모델 국적) 집단 간 실험설계를 실시하였다. 연구결과, 브랜드 인지도와 지각된 가격공정성은 각각 매스티지 구매의도에 정의 영향을 미쳤으며, 광고모델 국적의 조절효과도 유의미하였다. 광고모델이 한국 국적일 경우 브랜드인지도와 지각된 가격공정성의 구매의도에 대한 영향이 중국 국적의 광고모델의 경우보다 더 크게 나타났다. 본 논문은 매스티지 브랜드는 중국 관광객에게 심리적 거리감이 있더라도 브랜드이미지에 맞는 한류 모델의 영향이 중국 모델보다 더 크다는 것을 보여준 연구로서 시사점이 있다고 하겠다. This study investigated the effects of brand awareness and perceived price fairness on the purchase intention of masstige brands and the moderating effect of country of advertising (Korea or China) for the Chinese tourists visiting Korea. Along with the luxury image and the reasonable price range of masstige brands, the effect of Korean models matching with the country of masstige brand and Chinese models for Chinese visitors was examined based on the construal level theory. To test the hypotheses, a 2 (brand awareness H/L)×2 (perceived price fairness)×2 (country of model) factorial design was employed. As a result, brand awareness and price fairness perception were found to have positive effects on the purchase intention of masstige brands, and the moderating effect of the country of advertising models was also significant. With Korean models, the effects of brand awareness and price fairness perception on the purchase intention of masstige brands were higher than with Chinese models. This study sheds light on the fact that for Chinese tourists, Korean advertising models are more effective even with the specific signal like price when they perceive psychological distance.

miR-215 Enhances HCV Replication by Targeting TRIM22 and Inactivating NF-κB Signaling

Hui Tian,Zhenkun He 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.4

Purpose: Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associatedwith HCV infection. This study aimed to investigate the functional roles and possible molecular mechanisms of miR-215 in HCVreplication. Materials and Methods: The expression levels of miR-215 and TRIM22 were detected by quantitative real-time PCR (qRT-PCR)and western blot analysis in Con1b subgenomic genotype 1b HCV replicon cells (Con1b cells) and JFH1 full genome infectingHuh7.5.1 cells (Huh7.5.1 cells). HCV RNA levels were measured by qRT-PCR. The protein levels of NS3, NS5A, p65 subunit of NF-κB (p65), and phosphorylated p65 (p-p65) were determined by western blot analysis. The relationship between miR-215 andTRIM22 were explored by target prediction and luciferase reporter analysis. Results: miR-215 overexpression enhanced HCV replication in Con1b cells, while miR-215 knockdown suppressed HCV replicationin Huh7.5.1 cells. TRIM22 was confirmed to be a direct target of miR-215. TRIM22 upregulation resulted in a decline in HCVreplication, while TRIM22 inhibition led to enhancement of HCV replication. Additionally, exogenous expression of TRIM22 reversedthe facilitating effect of miR-215 on HCV replication, while TRIM22 downregulation counteracted the inhibitory effect ofmiR-215 knockdown on HCV replication. Furthermore, miR-215 targeted TRIM22 to block the NF-κB pathway, and exerted apositively regulatory role on HCV replication. Conclusion: miR-215 facilitated HCV replication via inactivation of the NF-κB pathway by inhibiting TRIM22, providing a novelpotential target for HCV infection.

Study of Discontinuous FeCoSi/ Native-oxide Multilayer Films Operating in Gigahertz Frequency Range

Huaping Zuo,Shihui Ge,Zhenkun Wang,Yuhua Xiao,Dongsheng Yao 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Effects of different working fluids on the performance of a radial turbine in an organic Rankine cycle power system

Ze-min Bo,Zhenkun Sang,Xiaojing Lv,Yi-wu Weng 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.9

Organic Rankine cycle (ORC) power systems are widely used for low-temperature heat recovery. The radial turbine is the most important component in the ORC system and its performance is significantly dependent on the working fluid. Therefore, the effect of different working fluid on the performance of radial turbine in ORC system for the low-temperature heat source (120~180 °C) was investigated. First, the feasibilities of different working fluids for 150 kW radial turbine using R600a as designed working fluid were investigated. The thermal aerodynamic calculation of R600a at design condition was conducted with evaporation temperature 95 °C and condensation temperature 38 °C. The operation parameters of 5 non-designed working fluids (R600, R245fa, R245ca, R123 and R601a) were selected in the same temperature variation range as R600a. Then, the performance of a radial turbine for six working fluids at design condition was analyzed, and their three-dimensional flow field performances were also obtained by CFD numerical simulation. Finally, to broaden the operation range of the radial turbine and investigate the matching relationship between operation parameters and different working fluids, the off-design performances of radial turbine using six working fluids were analyzed and the effect of rotation speed, inlet pressure and inlet temperature on the performance of radial turbine was obtained. Results show that the performance of the radial turbine using the designed working fluid R600a is the best with efficiency of 82.7 % and output power of 150.5 kW. For the non-designed working fluids, the comprehensive performance of R600 was also judged to be good owing to the highest efficiency (85.1 %) and a relatively high power output (115.8 kW) among the fluids tested. For other working fluids, the output power of the radial turbine decreased obviously. There exists an optimum rotation speed for different working fluids to ensure that the radial turbine has the highest efficiency. The inlet pressure has a larger effect on the performance of the radial turbine than that of the inlet temperature. The results can provide basic data for the optimization design and operation of radial turbines in the ORC system.

Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells.

Kim, Ja-Eun,Lou, Zhenkun,Chen, Junjie Landes Bioscience 2009 Cell cycle Vol.8 No.22

Experimental and analytical performance evaluation of steel beam to concrete-encased composite column with unsymmetrical steel section joints

Yunfeng Xiao,Lei Zeng,Zhenkun Cui,Siqian Jin,Yiguang Chen 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.1

The seismic performance of steel beam to concrete-encased composite column with unsymmetrical steel section joints is investigated and reported within this paper. Experimental and analytical evaluation were conducted on a total of 8 specimens with T-shaped and L-shaped steel section under lateral cyclic loading and axial compression. The test parameters included concrete strength, stirrup ratio and axial compression ratio. The response of the specimens was presented in terms of their hysterisis loop behavior, stress distribution, joint shear strength, and performance degradation. The experiment indicated good structural behavior and good seismic performance. In addition, a three-dimensional nonlinear finite-element analysis simulating was conducted to simulate their seismic behaviors. The finite-element analysis incorporated both bond-slip relationship and crack interface interaction between steel and concrete. The results were also compared with the test data, and the analytical prediction of joint shear strength was satisfactory for both joints with T-shaped and L-shaped steel section columns. The steel beam to concrete-encased composite column with unsymmetrical steel section joints can develop stable hysteretic response and large energy absorption capacity by providing enough stirrups and decreased spacing of transverse ties in column.

Fabrication of Si3N4/SiC nanocomposites by spark plasma sintering of amorphous SiCN powders derived from a polymeric precursor

Zhipeng Xie,Weiyou Yang,Zhenkun Fan,Huatao Wang,Hezhuo Miao,Linan An 한양대학교 세라믹연구소 2006 Journal of Ceramic Processing Research Vol.7 No.4

Si3N4/SiC nanocomposites were fabricated by spark plasma sintering (SPS) of amorphous SiCN ceramic powders derived from a polymeric precursor with 3 wt% yttria as an additive. It was found that the SPS parameters, such as sintering temperature, dwell time, pressure and heating rate, remarkably affected the density and grain size of the nanocomposites obtained. This provided a new method to fabricate Si3N4/SiC nanocomposites without applying the high pressure and high sintering temperature used by the conventional process. Si3N4/SiC nanocomposites were fabricated by spark plasma sintering (SPS) of amorphous SiCN ceramic powders derived from a polymeric precursor with 3 wt% yttria as an additive. It was found that the SPS parameters, such as sintering temperature, dwell time, pressure and heating rate, remarkably affected the density and grain size of the nanocomposites obtained. This provided a new method to fabricate Si3N4/SiC nanocomposites without applying the high pressure and high sintering temperature used by the conventional process.

Research on the rheological properties of a silicone oil-based ferrofluid

Zhang Jiajia,Cui Hongchao,Han Shida,Li Zhenkun,Lu Jingjing 한국유변학회 2023 Korea-Australia rheology journal Vol.35 No.3

To study the overall rheological characteristics of the silicone oil-based ferrofluid, a chemical co-precipitation method was adopted for preparation, and transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) were used for characterization. The average size of Fe3O4 magnetic particles was 10.4 nm and the saturation magnetization of the ferrofluid was 5.98 emu/g. Then, the fluidity, magnetoviscous effect and viscoelasticity of the ferrofluid were studied using a rotational rheometer. The results showed obvious shear thinning of the silicone oil-based ferrofluid under an external magnetic field, and the yield stress of the ferrofluid could not be accurately obtained by fitting the flow curve with an H–B model at a continuous shear rate. A strong magnetoviscous effect could be observed at different shear rates and temperatures. The magnetoviscous parameter R increased with the increase of temperature and its variation decreased with the increase of shear rate. Moreover, based on the magnetic particle chain model and the viscosity–temperature characteristics of the base carrier liquid, different mechanisms of temperature influence on the magnetoviscous effect were analyzed. Finally, a discussion of the microstructure evolution mechanism of the ferrofluid in the modulus changing with frequency was presented through the viscoelastic analysis of the silicone oil-based ferrofluid.

p30 DBC is a potential regulator of tumorigenesis.

Kim, Ja-Eun,Chen, Junjie,Lou, Zhenkun Landes Bioscience 2009 Cell Cycle Vol.8 No.18

<P>Tumorigenesis is a multistep process controlled by a number of proteins involved in diverse pathways. Traditionally, proteins are either considered as oncogenes, which promote tumorigenesis or as tumor suppressors, which prevent tumorigenesis. However, recent studies revealed quite a few proteins that could function as oncogene as well as tumor suppressor. A new member of such proteins is p30 DBC (deleted in breast cancer 1, also called DBC1). p30 DBC is one of the proteins involved in tumorigenesis that does not clearly adhere to either descriptions. Several studies show that p30 DBC is involved in cell proliferation, apoptosis and histone modification, all processes important for regulating tumorigenesis. However, there are other conflicting results regarding how p30 DBC contributes to tumorigenesis. The most interesting aspect of this is that p30 DBC is a strong inhibitor of SIRT1 protein deacetylase, whose exact role in tumorigenesis is currently under debate. This review summarizes the current understandings on p30 DBC functions, with a focus on the proposed roles of p30 DBC in tumorigenesis.</P>

DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells

Zhao Fei,김우태,Kloeber Jake A.,Lou Zhenkun 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

DNA end resection has a key role in double-strand break repair and DNA replication. Defective DNA end resection can cause malfunctions in DNA repair and replication, leading to greater genomic instability. DNA end resection is initiated by MRN-CtIP generating short, 3′-single-stranded DNA (ssDNA). This newly generated ssDNA is further elongated by multiple nucleases and DNA helicases, such as EXO1, DNA2, and BLM. Effective DNA end resection is essential for error-free homologous recombination DNA repair, the degradation of incorrectly replicated DNA and double-strand break repair choice. Because of its importance in DNA repair, DNA end resection is strictly regulated. Numerous mechanisms have been reported to regulate the initiation, extension, and termination of DNA end resection. Here, we review the general process of DNA end resection and its role in DNA replication and repair pathway choice.