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Jun-Hui Zheng,Jian-Fen Liu 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.3
In this paper, a robust kalman filter is designed for the uncertainty time-varying discrete systems with state delay in process and output matrices combined with the possibility of missing measurements. The uncertainties are expected in the process, output and white noise covariance matrices. A formula for a candidate upper bound on the actual state estimation error variances for all admissible parameter uncertainties and possible missing measurements is obtained. The filter parameters are optimized to give a minimal upper bound on the state estimation error covariance for all admissible uncertainties and missing measurements.
Jun Guan,Yu Xue,Rong-yu Zang,Ji-hong Liu,Jian-qing Zhu,Ying Zheng,Bo Wang,Hua-ying Wang,Xiao-jun Chen 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.4
Background: Sentinel lymph node (SLN) mapping has been recommended as an alternative staging approach to lymphadenectomy for apparent uterine-confined endometrial cancer (EC). However, the prognostic value of SLN mapping alone instead of systematic lymphadenectomy on EC patients remains unclear. Methods: A multi-center, open label, non-inferiority randomized controlled trial has been designed to identify if SLN mapping alone is not inferior to pelvic lymphadenectomy on prognosis of patients with intermediate-high-risk EC clinically confined to uterus. Eligible patients will be 1:1 randomly assigned to accept SLN mapping or pelvic lymphadenectomy. The primary endpoint is the 2-year progression-free survival (PFS). The second points are the 5-year PFS, 5-year overall survival, surgery-related adverse events and life quality. A total of 780 patients will be enrolled from 6 hospitals in China within 3-year period and followed up for 5 years. Trial Registration: ClinicalTrials.gov Identifier: NCT04276532
Jun-Cheng Guo,Yi-Jun Yang,Jin-Fang Zheng,Jian-Quan Zhang,Min Guo,Xiang Yang,Xiang-Ling Jiang,Li Xiang,You Li,Huang Ping,Liu Zhuo 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that of HCC. However, the role of homeobox A11 antisense (HOXA11-AS) in determining HCC stem cell characteristics remains to be explained; hence, this study aimed to investigate the effects of HOXA11-AS on HCC stem cell characteristics. Initially, the expression patterns of HOXA11-AS and HOXA11 in HCC tissues, cells, and stem cells were determined. HCC stem cells, successfully sorted from Hep3B and Huh7 cells, were transfected with short hairpin or overexpression plasmids for HOXA11-AS or HOXA11 overexpression and depletion, with an aim to study the influences of these mediators on the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo. Additionally, the potential relationship and the regulatory mechanisms that link HOXA11-AS, HOXA11, and the Wnt signaling pathway were explored through treatment with Dickkopf-1 (a Wnt signaling pathway inhibitor). HCC stem cells showed high expression of HOXA11-AS and low expression of HOXA11. Both HOXA11-AS silencing and HOXA11 overexpression suppressed the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo, as evidenced by the decreased expression of cancer stem cell surface markers (CD133 and CD44) and stemness-related transcription factors (Nanog, Sox2, and Oct4). Moreover, silencing HOXA11-AS inactivated the Wnt signaling pathway by decreasing the methylation level of the HOXA11 promoter, thereby inhibiting HCC stem cell characteristics. Collectively, this study suggested that HOXA11-AS silencing exerts an antitumor effect, suppressing HCC development via Wnt signaling pathway inactivation by decreasing the methylation level of the HOXA11 promoter.
Jun Zheng,Sai Krishna Chigurupati 한국통신학회 2019 ICT Express Vol.5 No.3
Smudge attacks are a threat specifically targeting Android pattern unlock. Current solutions improve the security of pattern unlock by significantly reducing its usability. In this paper, we propose a novel scheme called M-Pattern to improve the security of pattern unlock against smudge attacks without significantly compromising the usability. A security analysis was performed to demonstrate that M-Pattern can have significantly stronger security than normal pattern unlock by just using two simple patterns. A pilot user study was also carried out to investigate the usability of M-Pattern.
Jun Zheng,Xuwei Lai,Xingjian Zhou,Ankai Chen,Wang Zheng 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.5
The scientific and reasonable prediction of energy consumption in WEDM process is the key for energy-saving optimization of wire-cutting process in the design stage. The existing research about WEDM energy-saving studies mainly focus on the pulsed power control strategies. And, the research on non-pulsed energy consumption of WEDM is deficient. The non-pulsed energy consumption takes up a larger proportion in the whole WEDM process through theoretical analysis and case verification, and the energy consumption characteristics are equally representative. Therefore, the paper analyzes the energy characteristics based on non-pulsed energy consumption subunits of WEDM. A non-pulsed auxiliary energy consumption and feeding energy prediction model is established, and a WEDM machine tool is used for the experiment. The accuracy of the prediction model proposed in this paper can reach more than 96%. The raise and establishment of the model provides the basis for energy saving optimization of the subsequent wire cutting process.
Zheng, Liang Jun,Kang, Dong Hee,Kim, Na Kyong,Youn, Young Jik,Kang, Hyun Wook Elsevier 2019 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.143 No.-
<P><B>Abstract</B></P> <P>Theoretical model of thermoelectric generator (TEG) cooled by direct evaporative cooling technology is developed. In the theoretical model, thermoelectric material properties depending on temperature change and effects of heat loss by radiation, conduction, and Thomson phenomenon are considered. To investigate the effect of evaporative cooling to the efficiency of TEG, the simulation conditions are set as hot-side temperature of 40–120 °C and 1 mm thickness of thin water film covering for cold-side. The ambient temperature is 25 °C and the relative humidity of the air is set from 25% to 75%. Based on the developed theoretical model, the output power of TEG is increased as increasing hot side temperature under fixed relative humidity or as decreasing relative humidity under fixed hot-side temperature. Consequently, the maximum output power of 130.69 W m<SUP>−2</SUP> and an efficiency of 1.63% are obtained with 25% relative humidity and 120 °C for the hot-side temperature condition. The results show that the output power and efficiency are increased 100.53 and 10.53 times higher than without evaporative cooling (natural convection case, output power of 1.30 W m<SUP>−2</SUP> and efficiency of 0.1548%), respectively.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Theoretical model of TEG cooled by direct evaporative cooling technology. </LI> <LI> Thermophysical relations in TEG system and cooling process at theoretical model. </LI> <LI> Analyzing thermal resistance network for quantifying heat flow rates and heat dissipation rates. </LI> <LI> Increasing TEG performance by applying evaporative cooling technology. </LI> <LI> TEG performance evaluation based on hot-side temperature and relative humidity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>