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Zhen-Hua Chen,Liang-Peng Sun,Wei Zhang,Qiang Shen,Li-Xin Gao,Jia Li,Hu-Ri Piao 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.5
Protein tyrosine phosphatase 1B (PTP1B) is a key factor in negative regulation of the insulin pathway, and is a promising target for the treatment of type-II diabetes, obesity and cancer. Herein, compound (4) was first observed to have moderate inhibitory activity against PTP1B with an IC50 value of 13.72 ± 1.53 μM. To obtain more potent PTP1B inhibitors, we synthesized a series of chalcone derivatives using compound (4) as the lead compound. Compound 4l (IC50 = 3.12 ± 0.18 μM) was 4.4-fold more potent than the lead compound 4 (IC50 = 13.72 ± 1.53 μM), and more potent than the positive control, ursolic acid (IC50 = 3.40 ± 0.21 μM). These results may help to provide suitable drug-like lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
Zhen hua He,Jae yeon Sim 한국융합학회 2020 한국융합학회논문지 Vol.11 No.12
중국 국민의 경제 수준이 점진적으로 향상되고, 명절과 공휴일제도가 지속적으로 개선되면서, 마음을 안정시키 는 생활체험이 주요 목적으로 부각되면서 농촌 관광이 급속도로 발전하였다. 농업인의 기업가정신, 농가소득 증대, 농 촌 번영 및 관광경영학과, 관광기업의 경영 및 운영목표 달성을 위하여, 본 연구는 관련 문헌 검토와 참고자료에 기초 하여 연구 가설을 제시하였다. 본 논문은 앞선 연구결과를 바탕으로 주민의 농촌관광 행동 의도에 대한 설문조사를 하였고, SPSS23.0을 이용하여 표본 데이터에 대한 상관분석과 가설검증을 통하여 다음과 같은 결론을 도출하였다. (1) 시골 관광 태도, 주관적인 규범과 지각 행위 통제가 농촌 관광 행위의 방향에 긍정적인 영향을 미친다는 것이다. (2)정 책 시스템과 자원 조건은 농촌 관광 행동 의도에 상당히 긍정적인 영향을 미친다는 것이다. (3)정책 시스템은 주관적 규범과 인식된 행동 통제에 상당히 긍정적인 영향을 미치고, 자원 조건은 농촌 관광 태도, 주관적 규범, 인식된 행동 통제에 모두 상당히 긍정적인 영향을 미친 것으로 나타났다. With the gradual improvement of China's residents' economic level, the continuous improvement of the holiday system, and the main purpose of relaxing mood and experiencing life, rural tourism has developed rapidly. In order to further achieve the goals of farmers' entrepreneurship, agricultural income increase, rural prosperity, and tourism management departments and tourism enterprises' management and operation objectives, this paper puts forward research hypotheses on the basis of relevant literature review and references. Based on the previous research results, this paper designs a questionnaire on Residents' rural tourism behavior intention, and uses SPSS23.0 to conduct correlation analysis and hypothesis test on the sample data, and draws the following conclusions: (1) rural tourism attitude, subjective norms, and perceived behavior control have a significant positive impact on rural tourism behavior intention; (2) policy system and resource conditions have a significant positive impact on rural tourism behavior intention; (3) policy system has a significant positive impact on subjective norms and perceived behavior control, and resource conditions have a significant positive impact on rural tourism attitude, subjective norms, and perceived behavior control.
Asymptotic distribution of the discounted proper deficit in the discrete time delayed renewal model
Zhen-hua Bao,Jing Wang 대한수학회 2011 대한수학회보 Vol.48 No.2
In this paper we consider the discrete time delayed renewal risk model. We investigate what will happen when the distribution function of the discounted proper deficit is asymptotic in the initial surplus. In doing this we establish several lemmas regarding some related ruin quantities in the discrete time delayed renewal risk model, which are of significance on their own right.
Factors affecting the properties of recycled concrete by using neural networks
Zhen-Hua Duan,Chi-Sun Poon 사단법인 한국계산역학회 2014 Computers and Concrete, An International Journal Vol.14 No.5
Artificial neural networks (ANN) has been proven to be able to predict the compressive strength and elastic modulus of recycled aggregate concrete (RAC) made with recycled aggregates (RAs) from different sources. However, ANN is itself like a black box and the output from the model cannot generate an exact mathematical model that can be used for detailed analysis. So in this study, sensitivity analysis is conducted to further examine the influence of each selected factor on the output value of the models. This is not only conducive to the determination and selection of the more important factors affecting the results, but also can provide guidance for researchers in adjusting mix proportions appropriately when designing RAC based on the variation of these factors.
Exposing Image Sharpen Forgeries Based on Dyadic Contrast Contourlet
Hua Zhen,Li Jinjiang 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.7
In order to distinguish the sharpening operation in a manipulated image, a sharpen forgeries detection algorithm is proposed. Combined with efficient image signal processing method, a new non-subsampled dyadic contourlet transform based on contrast à trous wavelet is designed. In contourlet domain, sharpening characteristics are analyzed by multi-scale and multi-directional methods. A classifier is trained by artificial intelligence methods to complete sharpening tampered image detection. Experimental results show that the algorithm in this paper can detect possible sharpening and locate the tampering boundary accurately.
A Study on the Performance and Flow Distribution of Fresh Water Generator with Plate Heat Exchanger
Zhen-Hua Jin,Pil-Hwan Kim,Gyeong-Hwan Lee,Soon-Ho Choi,Han-Shik Chung,Hyo-Min Jeong 대한설비공학회 2008 대한설비공학회 학술발표대회논문집 Vol.2008 No.2
Nowadays Plate Heat Exchanger (PHE) is widely used in different industries such as chemical, food and pharmaceutical process and refrigeration due to the efficient heat transfer performance, extreme compact design and efficient use of the construction material. In present study, discussed main conception of plate heat exchanger and applied in vacuum. PHE and aimed apply in the fresh water generator which installed in ship to desalinate seawater to fresh water use heat from engines. The experiment is proceeded to investigate the heat transfer between cold and hot fluid stream at different flow rate and supply temperature of hot fluid. Generated fresh water as outcome of the system. PHE is an important part of a condensing or evaporating system. One of common assumptions in basic heat exchanger design theory is that fluid is to be distributed uniformly at the inlet of each fluid side and throughout the core. However, in practice, flow mal-distribution is more common and can significantly reduce the heat exchanger performance. The flow and heat transfer are simulated by the k-ε standard turbulence model. Moreover, the simulation contacted flow maldistribution in a PHE with 6 channels.
The deficit at ruin in the Sparre Andersen model with interest
ZHEN-HUA BAO,ZHONG-XING YE 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1
In this paper, we consider the Sparre Andersen risk model modified by the inclusion of interest on the surplus. By using the techniques of Cai and Dickson [Ins.: Math. Econ. 32(2003)], we give the functional and also the exponential type upper bounds for the tail probability of the deficit at ruin. Some special cases are also discussed.