Association Between HLA-DQ Genotypes and Haplotypes vs Helicobacter pylori Infection in an Indonesian Population

Zhao, Yang,Wang, Jingwen,Tanaka, Tsutomu,Hosono, Akihiro,Ando, Ryosuke,Soeripto, Soeripto,Triningsih, F.X. Ediati,Triono, Tegu,Sumoharjo, Suwignyo,Astuti, E.Y. Wenny,Gunawan, Stephanus,Tokudome, Shink Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background: Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses to bacterial antigens. This study aimed to investigate the association between HLA-DQA1 and DQB1 genotypes and haplotypes vs H. pylori infection in an Indonesian population. Methods: We selected 294 healthy participants in Mataram, Lombok Island, Indonesia. H. pylori infection was determined by urea breath test (UBT). We analyzed HLA-DQA1 and DQB1 genotypes by PCR-RFLP and constructed haplotypes of HLA-DQA1 and DQB1 genes. Multiple comparisons were conducted according to the Bonferroni method. Results: The H. pylori infection rate was 11.2% in this Indonesian population. The DQB1*0401 genotype was noted to be associated with a high risk of H. pylori infection, compared with the DQB1*0301 genotype. None of the HLA-DQA1 or DQB1 haplotypes were related to the risk of H. pylori infection. Conclusions: The study suggests that HLADQB1 genes play important roles in H. pylori infection, but there was no statistically significant association between HLA-DQA1 or DQB1 haplotypes and H.pylori infection in our Lombok Indonesian population.

CNN 기반 익수자 탐지 모델 설계 방안에 관한 연구

ZHAO YANG,강정호,이경창 제어로봇시스템학회 2023 제어로봇시스템학회 국내학술대회 논문집 Vol.2023 No.6

Correction: Robust MAVE for single‑index varying‑coefficient models

Zhao Yang,Yue Lili,Li Gaorong 한국통계학회 2022 Journal of the Korean Statistical Society Vol.51 No.4

In this paper, a robust, efficient and easily implemented estimation procedure for single-index varying-coefficient models is proposed by combining minimum average variance estimation (MAVE) with exponential squared loss. The merit of the proposed method is robust against outliers or heavy-tailed error distributions while asymptotically efficient as the original MAVE under the normal error case. A practical minorization–maximization algorithm is proposed for implementation. Under some regularity conditions, asymptotic distributions of the resulting estimators are derived. Simulation studies and a real data example are conducted to examine the finite sample performance of the proposed method. Both theoretical and empirical findings confirm that our proposed method works very well.

Robust MAVE for single-index varying-coefficient models

Zhao Yang,Yue Lili,Li Gaorong 한국통계학회 2022 Journal of the Korean Statistical Society Vol.51 No.4

In this paper, a robust, efficient and easily implemented estimation procedure for single-index varying-coefficient models is proposed by combining minimum average variance estimation (MAVE) with exponential squared loss. The merit of the proposed method is robust against outliers or heavy-tailed error distributions while asymptotically efficient as the original MAVE under the normal error case. A practical minorization–maximization algorithm is proposed for implementation. Under some regularity conditions, asymptotic distributions of the resulting estimators are derived. Simulation studies and a real data example are conducted to examine the finite sample performance of the proposed method. Both theoretical and empirical findings confirm that our proposed method works very well.

Sagittal Pelvic Radius in Low-Grade Isthmic Lumbar Spondylolisthesis of Chinese Population

Zhao, Yang,Shen, Cai-Liang,Zhang, Ren-Jie,Cheng, Da-Wei,Dong, Fu-Long,Wang, Jun The Korean Neurosurgical Society 2016 Journal of Korean neurosurgical society Vol.59 No.3

Objective : To investigate the variation of pelvic radius and related parameters in low-grade isthmic lumbar spondylolisthesis. Methods : Seventy-four patients with isthmic lumbar spondylolisthesis and 47 controls were included in this study. There were 17 males and 57 females between 30 and 66 years of age, including 30 with grade I slippages and 44 grade II slippages; diseased levels included 34 cases on L4 and 40 cases on L5. Thoracic kyphosis (TK), the pelvic radius (PR), the pelvic angle (PA), pelvic morphology (PR-S1), and total lumbopelvic lordosis (PR-T12) were assessed from radiographs. Results : Statistically significant differences were found for the PA, PR-T12, and PR-S1 ($24.5{\pm}6.6^{\circ}$, $83.7{\pm}9.8^{\circ}$, and $25.4{\pm}11.2^{\circ}$, respectively) of the patients with spondylolisthesis and the healthy volunteers ($13.7{\pm}7.8^{\circ}$, $92.9{\pm}9.2^{\circ}$, and $40.7{\pm}8.9^{\circ}$, respectively). The TK/PR-T12 ratios were between 0.15 and 0.75. However, there were no differences in all the parameters between the L4 and L5 spondylolysis subgroups (p>0.05). The TK and PR-S1 of grade II were less than grade I, but the PA was greater. The PR-T12 of female patients were less than male patients, but the PA was greater (p<0.05). Conclusion : Pelvic morphology differed in patients with low-grade isthmic lumbar spondylolisthesis compared to controls. Gender and the grade of slippage impacted the sagittal configuration of the pelvis, but the segment of the vertebral slip did not. Overall, the spine of those with spondylolisthesis remains able to maintain sagittal balance despite abnormal pelvic morphology.

Research on the axial velocity of the raw coal particles in vertical screw conveyor by using the discrete element method

Zhao Yang,Sun Xiaoxia,Meng Wenjun 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.6

An incorrect formula of the average axial speed can lead to the incorrect derivation of the conveying volume formula, which in turn can produce an incorrect design of the vertical screw conveyor. In this study, the conveying model of the vertical screw conveyor and the raw coal particle model are established. Using the discrete element method, the influence of various parameters, such as the spiral speed, filling rate, pipe diameter, and pitch, on the axial velocity of the raw coal particles is calculated, simulated, and analyzed. Corresponding to the average axial velocity distribution histogram and the derivation of the particle average axial velocity formula, a theoretical basis for the optimization design of the vertical screw conveyor is provided.

Robust Predictive Control of Input Constraints and Interference Suppression for Semi-Trailer System

Zhao, Yang 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.7

Spatial–Temporal Clustering and Optimization of Aircraft Descent and Approach Trajectories

Zhao Yang,Rong Tang,Yixin Chen,Bing Wang 한국항공우주학회 2021 International Journal of Aeronautical and Space Sc Vol.22 No.6

This study presents a procedure for the spatial–temporal clustering and optimization of aircraft descent and approach trajectories. First, the spatial–temporal similarity between two trajectories is defined. Clustering analysis are conducted to identify the prevailing trajectories. The clustering centers obtained based on spatial–temporal distance are compared with those obtained based on the traditional Euclidean distance. Second, a multi-objective optimization model is established to minimize fuel consumption, aircraft emission and noise impact considering flight constraints. The Pareto solution that has the highest similarity with the prevailing trajectories is selected as the final optimized trajectory. The performance indicators of the optimized trajectory are compared with the average values of historic trajectories. It is found that travel time, fuel consumption and noise impact for the optimized trajectory are reduced by 5.34%, 0.96% and 11.86%, respectively. The percentages are 0.96%, 1.32%, 9.18%, 3.54% and 4.00% for CO2, SOx, NOx, CO and HC, respectively. Also, the performance indicators for the two clustering centers based on spatial–temporal distance are generally closer to average performance of original trajectories, as well as those of the optimized trajectories, as compared with the two clustering centers based on Euclidean distance. The spatial–temporal clustering methods may help to discover the valuable information that lies in those indicators associated with features reflected in time dimension.

Investigation on large turbo-generator stator end winding dynamic characteristics based on response surface method

Zhao, Yang,Xiao, Yang,Lu, Sheng,Sun, Hao,Huo, Wenhao,Liao, Yong The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.10

The natural frequencies corresponding to the particular mode shapes of a large turbo-generator must not be in the resonance region before delivery. Different parameters may clearly affect these dynamic characteristics. Different from other studies, this paper introduces a method for obtaining the inherent characteristics of end winding in a short period of time under multiple simultaneously changing parameters. The proposed process is based on the response surface method (RSM). In this method, the main concerned natural frequencies were taken as the critical index to describe the dynamic behaviors of the end winding, with which the mathematical relationship between the dynamic characteristics and design variables was analyzed. First, the stiffness of the rings, stiffness of the radial braces and number of pins bonded to the radial braces were used as samples for orthogonal experimental design. Then, the natural modes and frequencies of 25 different samples were acquired by conducting modal analysis with ABAQUS software. Utilizing these dynamic results, a second-order polynomial response surface model was established to describe the relationships between natural frequencies and these three different parameters. Then, the quality of this model was verified by calculating the valuating indexes for comparison with support vector regression (SVR). With the response surface model, the variation regularities of the natural frequencies and modes due to the above parameters were discussed. The method proposed in this paper can enable natural frequencies in the whole design space to be quickly determined without finite-element analysis, greatly improving the development efficiency and laying a foundation for dynamic response prediction during normal operation with different parameters and additional large turbo-generator stator end winding optimization.

Sensitivity analysis and chemical reaction mechanism simplification of blast furnace gas in gas turbine combustor environment

Zhao Yang,Xiangsheng Li,Zhenping Feng,Lian Lu 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.4

To solve the lack of reduced Blast furnace gas (BFG) mechanism under elevated pressure environment in numerical simulation, the present paper analyzes the sensitivity of every elementary reaction to combustion rate by using one dimensional laminar premixed reactor model. The steps with sensitivities larger than 0.1 are selected and the chemical kinetic parameters are revised by the method of weighted least squares fitting. The reduced 18-step mechanism which is specified to 0.1-3 Mpa is validated for laminar flame speeds, ignition delay times with available experiment data and GRI3.0 mechanism. Moreover, both the reduced and DRM-22 mechanisms are introduced into an experimental burner and an industrial gas turbine combustor simulation. The results of temperature and main species distribution illustrate that the 18-step mechanism is able to give a reasonable prediction combustion simulation. The 18-step mechanism lays the foundation of further studying the combustion of the low calorific value fuels at high pressure conditions.