http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Zeniya (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
<sup>123</sup>I-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice
Nakano, Atushi,Kawashima, Hidekazu,Miyake, Yoshinori,Zeniya, Tsutomu,Yamamoto, Akihide,Koshino, Kazuhiro,Temma, Takashi,Fukuda, Tetsuya,Fujita, Yoshiko,Kakino, Akemi,Kanaya, Shigehiko,Sawamura, Tatsuy 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.2
Purpose Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods We synthesized $^{123}I-oxLDL$ by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the $^{123}I-oxLDL$ autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver. Whole-body dynamic planar images were acquired 10 min post injection of $^{123}I-oxLDL$ to generate regional time-activity curves (TACs) of the liver, heart, lungs, kidney, head, and abdomen. Regional radioactivity for those excised tissues as well as the bladder, stomach, gut, and thyroid were assessed using a gamma counter, yielding percent injected dose (%ID) and dose uptake ratio (DUR). The presence of $^{123}I-oxLDL$ in serum was assessed by radio-HPLC. Results The cellular uptakes of $^{123}I-oxLDL$ were identical to those of DiI-oxLDL, and autoradiograms and fluorescence images also exhibited consistent distributions. TACs after injection of $^{123}I-oxLDL$ demonstrated extremely fast kinetics. The radioactivity uptake at 10 min post-injection was highest in the liver ($40.8{\pm}2.4%$ ID). Notably, radioactivity uptake was equivalent throughout the rest of the body ($39.4{\pm}2.7%$ ID). HPLC analysis revealed no remaining $^{123}I-oxLDL$ or its metabolites in the blood. Conclusion $^{123}I-oxLDL$ was widely distributed not only in the liver, but also throughout the whole body, providing insight into the pathophysiological effects of oxLDL.
-
Sasaya, Tenta,Sunaguchi, Naoki,Seo, Seung-Jum,Hyodo, Kazuyuki,Zeniya, Tsutomu,Kim, Jong-Ki,Yuasa, Tetsuya Elsevier 2018 Nuclear Instruments & Methods in Physics Research. Vol.886 No.-
<P><B>Abstract</B></P> <P>Gold nanoparticles (GNPs) have recently attracted attention in nanomedicine as novel contrast agents for cancer imaging. A decisive tomographic imaging technique has not yet been established to depict the 3-D distribution of GNPs in an object. An imaging technique known as pinhole-based X-ray fluorescence computed tomography (XFCT) is a promising method that can be used to reconstruct the distribution of GNPs from the X-ray fluorescence emitted by GNPs. We address the acceleration of data acquisition in pinhole-based XFCT for preclinical use using a multiple pinhole scheme. In this scheme, multiple projections are simultaneously acquired through a multi-pinhole collimator with a 2-D detector and full-field volumetric beam to enhance the signal-to-noise ratio of the projections; this enables fast data acquisition. To demonstrate the efficacy of this method, we performed an imaging experiment using a physical phantom with an actual multi-pinhole XFCT system that was constructed using the beamline AR-NE7A at KEK. The preliminary study showed that the multi-pinhole XFCT achieved a data acquisition time of 20 min at a theoretical detection limit of approximately 0.1 Au mg/ml and at a spatial resolution of 0.4 mm.</P>
-
( Toshiaki Suzuki ),( Reina Ohba ),( Ei Kataoka ),( Yui Kudo ),( Akira Zeniya ),( Daisuke Segawa ),( Keisuke Oikawa ),( Masaru Odashima ),( Taiji Saga ),( Tomoyuki Kuramitsu ),( Hideaki Sasahara ),( K 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1
Background/Aims Gastric acid secretion is suspected to be a pivotal contributor to the pathogenesis of functional dyspepsia. The present study investigates the potential association of the gastric acid secretion estimated by measuring serum pepsinogen with therapeutic responsiveness to the prokinetic drug acotiamide. Methods Dyspeptic patients consulting participating clinics from October 2017 to March 2019 were prospectively enrolled in the study. The dyspeptic symptoms were classified into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Gastric acid secretion levels were estimated by the Helicobacter pylori infection status and serum pepsinogen using established criteria and classified into hypo-, normo-, and hyper-secretion. Each patient was then administered 100 mg acotiamide thrice daily for 4 weeks, and the response rate to the treatment was evaluated using the overall treatment efficacy scale. Results Of the 86 enrolled patients, 56 (65.1%) and 26 (30.2%) were classified into PDS and EPS, respectively. The estimated gastric acid secretion was not significantly different between PDS and EPS. The response rates were 66.0% for PDS and 73.1% for EPS, showing no significant difference. While the response rates were stable, ranging from 61.0% to 75.0% regardless of the estimated gastric acid secretion level among subjects with PDF, the rates were significantly lower in hyper-secretors than in non-hyper-secretors among subjects with EPS (42.0% vs 83.0%, P = 0.046). Conclusion Although acotiamide is effective for treating EPS as well as PDS overall, the efficacy is somewhat limited in EPS with gastric acid hypersecretion, with gastric acid suppressants, such as proton pump inhibitors, being more suitable. (J Neurogastroenterol Motil 2022;28:53-61)
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
