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      • KCI등재

        “Advocate Goodness of Human Nature to Anyone Coming across”: Analysis on “Good Nature Theory” of Mencius

        ( Zeng Zhen-yu ) 성균관대학교 유교문화연구소 2013 儒敎文化硏究(中文版) Vol.0 No.19

        孟子人性論的基本觀點爲"人性善"或"性善",業已成爲"國民常識"。在這一常識的背後,隱伏著深度的誤讀與曲解。孟子從個體生命體驗和形式邏輯層面反複證明的一個觀點爲――人性有善端。仁義禮智"四端"源自天,存諸人心爲"立命"。人性之善是與善惡相對之善,善不是絶對之善。但是,孟子從未否定"性"有惡端。人性有惡端是眞理,惡具有實質義。硏究孟子人性學說,在方法論上應當遵循"以孟釋孟"原則,在文本釋讀與思想詮釋上,應當區別"君子所性"與"性"兩個槪念。在"君子所性"層面,孟子刻意强調君子與禽獸的"幾希"之別,君子在應然意義上當以"四端"爲性,而不可以"食色"爲性;但在"性"或"人性"層面,孟子幷沒有否定"性"或"人性"有惡端, "大體"與"小體"同在於人心。盡管君子在功夫論層面不將"味"、"色"、"聲"、"臭"稱之爲性,但芸芸衆生之"性"還是蘊含"味"、"色"、"聲"、"臭"。秦漢以降,曆代學人之所以對孟子人性學說理解不一,大多在於未厘淸"君子所性"與"性"兩個槪念的區別。 Mencius’ view on human nature can be summarized as “goodness of human nature” or “goodness of nature”; however, it is seriously misread and distorted when it becomes a “common sense of all the people.” Human nature can be a good starting point - Since Mencius, it has been proven time after time from the aspects of life-experience and of formal logic. The starting points of “humanity, righteousness, propriety and wisdom” come from Heaven (tian 天),1 and are internalized in human heart. The goodness of human nature is, however, not an absolute concept but a relative one, opposite to badness. Mencius, nevertheless, had never denied bad starting points of human nature; for him, bad starting points also truly and substantially lie within human nature. When studying and analyzing Mencius’s theory of human nature, “interpreting Mencius by Mencius” should be adopted as a methodological principle. In interpreting text and thought of Mencius, the distinction between “nature” and “nature for the exemplary person” must also be stressed. On the level of the exemplary person, Mencius deliberately emphasizes “little difference” between nature of the exemplary person and that of animals. As a matter of course, the exemplary person should take “four starting points” as his nature instead of “food and sex.” On the other side, since Mencius does not deny the bad starting points from the aspect of nature or human nature, he also maintains that “the excellent parts 大体” and “the common parts 小体” co-exist within one human heart. From a view of Gongfulun 功夫论 (accomplishment of cognizing things), the exemplary person excludes “taste,” “sex,” “sounds,” and “smell” from one’s nature, but for common people, on the contrary, such bodily functions and desires are still included in their nature. Since Qin and Han dynasties, scholars presented various interpretations on Mencius’ notion of human nature, but most of them had neglected the distinction between “nature” and “nature for the exemplary person.” [Article in Chinese]

      • SCIESCOPUS

        Comparative field tests on uplift behavior of straight-sided and belled shafts in loess under an arid environment

        Qian, Zeng-zhen,Lu, Xian-long,Yang, Wen-zhi,Cui, Qiang Techno-Press 2016 Geomechanics & engineering Vol.11 No.1

        This study elucidates the uplift behaviors of the straight-sided and belled shafts. The field uplift load tests were carried out on 18 straight-sided and 15 belled shafts at the three collapsible loess sites under an arid environment on the Loess Plateau in Northwest China. Both the site conditions and the load tests were documented comprehensively. In general, the uplift load-displacement curves of the straight-sided and belled shafts approximately exhibited an initial linear, a curvilinear transition, and a final linear region, but did not provide a well defined peak or asymptotic value of the load, and therefore their uplift resistances should be interpreted from the load test results using an appropriate criterion. Nine representative uplift resistance interpretation criteria were used to define the "interpreted failure load" for each of the load tests, and all of these interpreted uplift resistances were normalized by the failure threshold, $T_{L2}$, obtained using the $L_1-L_2$ method. These load test data were compared statistically and graphically. For the straight-sided and belled shafts, the normalized uplift load-displacement curves were respectively established by the plots that related the mean interpreted uplift resistance ratio against the mean displacement at the corresponding interpreted criteria, and the comparisons of the normalized load-displacement curves were made. Specific recommendations for the designs of uplift belled and straight-sided shafts in the loess were given, in terms of both capacity and displacement.

      • SCIESCOPUS

        Behaviour of micropiles in collapsible loess under tension or compression load

        Qian, Zeng-Zhen,Lu, Xian-Long,Yang, Wen-Zhi,Cui, Qiang Techno-Press 2014 Geomechanics & engineering Vol.7 No.5

        This study examines the behaviour of single micropiles subjected to axial tension or compression load in collapsible loess under in-situ moisture content and saturated condition. Five tension loading tests and five compression loading tests on single micropiles were carried out at a typical loess site of the Loess Plateau in Northwest China. A series of laboratory tests, including grain size distribution, specific gravity, moisture content, Atterberg limits, density, granular components, shear strength, and collapse index, were carried out during the micropile loading tests to determine the values of soil parameters. The loess at the test site poses a severe collapse risk upon wetting. The tension or compression load-displacement curves of the micropiles in loess, under in-situ moisture content or saturated condition, can generally be simplified into three distinct regions: an initial linear, a curvilinear transition, and a final linear region, and the bearing capacity or failure load can be interpreted by the L1-L2 method as done in other studies. Micropiles in loess should be considered as frictional pile foundations though the tip resistances are about 10%-15% of the applied loads. Both the tension and compression capacities increase linearly with the ratio of the pile length to the shaft diameter, L/d. For micropiles in loess under in-situ moisture content, the interpreted failure loads or capacities under tension are 66%-87% of those under compression. However, the prewetting of the loess can lead to the reductions of 50% in the tensile bearing capacity and 70% in the compressive bearing capacity.

      • KCI등재

        Obesity parameters in relation to lung function levels in a large Chinese rural adult population

        Zeng Xiang,Liu Dongling,An Zhen,Li Huijun,Song Jie,Wu Weidong 한국역학회 2021 Epidemiology and Health Vol.43 No.-

        OBJECTIVES: The association between obesity parameters and lung function indicators in the general Chinese rural adult population remains unclear. METHODS: In total, 8,284 Chinese adults aged 20 years to 80 years old from Xinxiang were recruited. Obesity-related parameters, including body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), waistto-height ratio (WHtR), body fat percentage (BFP), basal metabolism, and visceral fat index, and lung function parameters such as forced vital capacity and forced expiratory volume in first second were measured. RESULTS: The total prevalence of obesity defined by BMI, WC, WHR, WHtR, and BFP was 23.2%, 58.2%, 66.7%, 69.2%, and 56.5%, respectively. Spearman correlation analyses showed significant correlations between all obesity-related parameters and lung function. Linear regression analyses further demonstrated that BMI, WHtR, BFP, and general obesity defined using those indicators were negatively associated with lung function, while WC, WHR, and central obesity defined accordingly were positively associated with lung function. The relationship between general obesity and lung function was more evident in women than in men, while the link between central obesity and lung function was more obvious in men than in women. CONCLUSIONS: Obesity is closely related to lung function in the general Chinese adult population. Weight control and loss are important strategies to improve lung function and respiratory health.

      • KCI등재

        Proteome alterations of reverse photoperiod-sensitive genic male sterile rice (Oryza sativa L.) at fertility transformation stage

        Zhen Chen,Han-lai Zeng,Haixia Li,Xueli Ma,Hongxia Dong,Dong Ma 한국유전학회 2014 Genes & Genomics Vol.36 No.6

        The two-line system has been widely used inhybrid rice seed production, and the reverse photoperiodsensitivegenic male sterile line is a new germplasm withan opposite phenotype compared with normal photoperiodsensitivegenic male sterile rice. To better understand themolecular mechanisms of fertility regulation in reversephotoperiod-sensitive genic male sterile rice, a comparativeproteomic approach was used to analyze the proteinprofiles of three different tissues (young panicles, flagleaves and leaf sheaths) of D52S during the sensitive periodof pollen fertility transformation under sterile and fertileconditions. By quantitative analysis, 66 protein spotswere identified to be significantly changed in the threetissues. Bioinformatics analyses revealed that in sterilerice, a number of proteins involved in lignin-flavonoidbiosynthesis pathway were down-accumulated in panicles. The majority of proteins associated with energy metabolismwere down-accumulated in leaf sheaths while theproteins up-accumulated in leaves and leaf sheaths wereexclusively photosynthesis and defense related. Based onthe proteomics data, a short-day induced male sterilityprotein network was proposed. In addition, the genes ofselected protein spots were further analyzed by qPCR. These findings provide data for better understanding theregulation of pollen fertility in reverse photoperiodsensitivegenic male sterile rice, which could assist in thedevelopment of practical reverse photoperiod-sensitivegenic male sterile rice for large-scale crop breedingprograms.

      • Coevolution between Human's Anticancer Activities and Functional Foods from Crop Origin Center in the World

        Zeng, Ya-Wen,Du, Juan,Pu, Xiao-Ying,Yang, Jia-Zhen,Yang, Tao,Yang, Shu-Ming,Yang, Xiao-Meng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

        Cancer is the leading cause of death around the world. Anticancer activities from many functional food sources have been reported in years, but correlation between cancer prevalence and types of food with anticancer activities from crop origin center in the world as well as food source with human migration are unclear. Hunger from food shortage is the cause of early human evolution from Africa to Asia and later into Eurasia. The richest functional foods are found in crop origin centers, housing about 70% in the world populations. Crop origin centers have lower cancer incidence and mortality in the world, especially Central Asia, Middle East, Southwest China, India and Ethiopia. Asia and Africa with the richest anticancer crops is not only the most important evolution base of humans and origin center of anticancer functional crop, but also is the lowest mortality and incidence of cancers in the world. Cancer prevention of early human migrations was associated with functional foods from crop origin centers, especially Asia with four centers and one subcenter of crop origin, accounting for 58% of the world population. These results reveal that coevolution between human's anticancer activities associated with functional foods for crop origin centers, especially in Asia and Africa.

      • Mortality Characteristic and Prediction of Nasopharyngeal Carcinoma in China from 1991 to 2013

        Xu, Zhen-Xi,Lin, Zhi-Xiong,Fang, Jia-Ying,Wu, Ku-Sheng,Du, Pei-Ling,Zeng, Yang,Tang, Wen-Rui,Xu, Xiao-Ling,Lin, Kun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

        Background: To analyze the mortality distribution of nasopharyngeal carcinoma in China from 1991 to 2013, to predict the mortality in the ensuing five years, and to provide evidence for prevention and treatment of nasopharyngeal carcinoma. Materials and Methods: Mortality data for Nasopharyngeal Carcinoma in China from 1991 to 2013 were used to describe its epidemiological characteristics, such as the change of the standardized mortality rate, sex and age differences, urban-rural differences. Trend-surface analysis was used to study the geographical distribution of the mortality. Curve estimation, time series, gray modeling, and joinpoint regression were used to predict the mortality for the ensuing five years in the future. Results: In China, the standardized mortality rate of Nasopharyngeal Carcinoma increased with time from 1996, reaching the peak values of $1.45/10^5$ at the year of 2002, and decreased gradually afterwards. With males being 1.51 times higher than females, and the city had a higher rate than the rural during the past two decades. The mortality rate increased from age 40. Geographical analysis showed the mortality rate increased from middle to southern China. Conclusions: The standardized mortality rate of Nasopharyngeal Carcinoma is falling. The regional disease control for Nasopharyngeal Carcinoma should be focused on Guangdong province of China, and the key targets for prevention and treatment are rural men, especially after the age of 40. The mortality of Nasopharyngeal Carcinoma will decrease in the next five years.

      • KCI등재

        VDR mediated HSD3B1 to regulate lipid metabolism and promoted testosterone synthesis in mouse Leydig cells

        Xue Zhen,Zhuang Jianan,Bai Hao,Wang Ling,Lu Hongzhao,Wang Shanshan,Zeng Wenxian,Zhang Tao 한국유전학회 2022 Genes & Genomics Vol.44 No.5

        Background: The vitamin D receptor (VDR) mediates the pleiotropic biological actions that include osteoporosis, immune responses and androgen synthesis wherein the VDR transcriptionally regulates expression of the genes involved in this complex process. 3β-Hydroxysteroid dehydrogenase-1 (HSD3B1) is an absolutely necessary enzyme for androgen synthesis. Objective: The purpose of the present study was to explore the molecular mechanism of VDR mediated HSD3B1 regulation of lipid metabolism and testosterone synthesis. Methods: The levels of VDR, HSD3B1 and lipid metabolism associated protein were determined by quantitative real-time polymerase chain reaction (RT-qPCR) or western blot. The levels of testosterone concentrations in cell culture media serum by enzyme-linked immunosorbent assay (ELISA). Targeted relationship between VDR and Hsd3b1 was evaluated by dual-luciferase reporter assay. Results: Based on the data analysis of mouse testicular proteome, we found that the expression of HSD3B1 was significantly reduced after VDR deletion. Here, we identified that Hsd3b1 was widely expressed in different tissues of mice by RT-qPCR, and was highly expressed in testis, and mainly located in testicular Leydig cells. Dual-luciferase assay confirmed that VDR could bind candidate vitamin D responsive elements (VDREs) in upstream region of Hsd3b1, and enhance gene expression. Furthermore, over-expression VDR and HSD3B1 significantly increased testosterone synthesis in mice Leydig cells. Meanwhile, Lpl expression was significantly down-regulated and Angptl4 expression was significantly up-regulated in the present of HSD3B1 overexpression. Both LPL and ANGPTL4 play important roles in regulating lipid metabolism. Conclusions: The present study unveiled VDR mediated HSD3B1 to regulate lipid metabolism and promoted testosterone synthesis in mouse Leydig cells. These findings will greatly help us to understand the roles of VDR and HSD3B1 in testosterone synthesis and lipid metabolism.

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