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Hao Tang,Nian-Guang Li,Zhi-Hao Shi,Yu-Ping Tang,Qian-Ping Shi,Ze-Xi Dong,Peng-Xuan Zhang,Jin-ao Duan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
The binding abilities of scutellarin (Scu) andscutellarein (Scue) with bovine serum albumin (BSA) wereinvestigated using equilibrium dialysis, high performanceliquid chromatography, fluorescence spectroscopy, competitivesite marker and molecular docking. The resultsshowed that the average protein binding ratios of Scu andScue with BSA were (79.85 ± 1.83) and (85.49 ± 1.21) %respectively. Under simulated physiological conditions, thefluorescence data indicated that Scu and Scue bound withBSA through a static mechanism. The thermodynamicparameters indicated that the interactions of Scu-BSA andScue-BSA mainly occurred by van der Waals forces andhydrogen bonds and it was easier for Scue to bind withBSA than Scu, indicating that the glucuronic acid moleculein Scu decreased the binding affinity. Site competitivemarker experiments showed that the binding sites of Scuand Scue mainly located within the sub-domain IIA ofBSA. Furthermore, molecular docking studies indicatedthat one BSA could bind three Scue, while one BSA couldcarry only two Scu. All these results clearly indicated theinteractions of Scu and Scue with BSA, which will lay thefoundation for further research to determine the pharmacologyand pharmacodynamics of Scu and Scue for treatingischemic cerebrovascular disease.
Manufacture and Performance of Textile-ramie Fiber Reinforced Anionic Polyamide 6 Composites
Hao Shi,Lijian Xia,Zonglei Guo,Abin Sun,Hui Wang,Ze Kan 한국섬유공학회 2019 Fibers and polymers Vol.20 No.8
A vacuum assistant resin infusion moulding (VARIM) was adopted to prepare a new-style and environmentalfriendly thermoplastic composite consisting of anionic polyamide-6 (APA-6) and textile-ramie fiber. However, the intensivepolymerization-inhibition and fiber-discoloration phenomena were found in the reactive processing. In order to overcomethese problems, two methods were used to suppress the reaction between the ramie fiber and APA-6, which are the surfacemodification of ramie fiber and a new initiator with a low activity. Finally, the inhibition and discoloration phenomena weresuppressed significantly, which overcame the major challenge during the preparation of ramie fiber reinforced APA-6composites by reactive processing. The composites showed a good polymerization during VARIM process. The tensilestrength and flexural modulus of the obtained composites were increased by 21 % and 26 % respectively compared with thatof pure APA-6. It is important to find that there were some interactions between APA-6 and ramie fiber, which produced agood interface characters. This work not only opens new avenues for the development of renewable composites, but alsofurther broadens the applications of the natural fibers.
Du, Ze-Peng,Wu, Bing-Li,Wang, Shao-Hong,Shen, Jin-Hui,Lin, Xuan-Hao,Zheng, Chun-Peng,Wu, Zhi-Yong,Qiu, Xiao-Yang,Zhan, Xiao-Fen,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
NGAL (neutrophil gelatinase-associated lipocalin) is a novel cancer-related protein involves multiple functions in many cancers and other diseases. We previously overexpressed NGAL to analyze its role in esophageal squamous cell carcinoma (ESCC). In this study, a protein-protein interaction (PPI) was constructed and the shortest paths from NGAL to transcription factors in the network were analyzed. We found 28 shortest paths from NGAL to RELA, most of them obeying the principle of extracellular to cytoplasm, then nucleus. These shortest paths were also prioritized according to their normalized intensity from the microarray by the order of interaction cascades. A systems approach was developed in this study by linking differentially expressed genes with publicly available PPI data, Gene Ontology and subcellular localizaton for the integrated analyses. These shortest paths from NGAL to DEG transcription factors or other transcription factors in the PPI network provide important clues for future experimental identification of new pathways.
Du, Ze-Peng,Wu, Bing-Li,Xie, Jian-Jun,Lin, Xuan-Hao,Qiu, Xiao-Yang,Zhan, Xiao-Fen,Wang, Shao-Hong,Shen, Jin-Hui,Li, En-Min,Xu, Li-Yan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13
Fascin-1 (FSCN1) is an actin-bundling protein that induces cell membrane protrusions, increases cell motility, and is overexpressed in various human epithelial cancers, including esophageal squamous cell carcinoma (ESCC). We analyzed various protein-protein interactions (PPI) of differentially-expressed genes (DEGs), in fascin knockdown ESCC cells, to explore the role of fascin overexpression. The node-degree distributions indicated these PPI sub-networks to be characterized as scale-free. Subcellular localization analysis revealed DEGs to interact with other proteins directly or indirectly, distributed in multiple layers of extracellular membrane-cytoskeleton/ cytoplasm-nucleus. The functional annotation map revealed hundreds of significant gene ontology (GO) terms, especially those associated with cytoskeleton organization of FSCN1. The Random Walk with Restart algorithm was applied to identify the prioritizations of these DEGs when considering their relationship with FSCN1. These analyses based on PPI network have greatly expanded our comprehension of the mRNA expression profile following fascin knockdown to future examine the roles and mechanisms of fascin action.
Intensity modulation-based fibre optic vibration sensor using an aperture within a proof mass
Zuo, Ze-Wei,Hao, Yi,Choi, Sang-Jin,Song, Minho,Kim, Young-Chon,Pan, Jae-Kyung IET 2017 IET science, measurement & technology Vol.11 No.1
<P>The authors propose an intensity modulation-based fibre optic vibration sensor (FOVS) using an aperture within a proof mass. It consists of an optical collimator, a mass-spring structure, a mirror, and a rectangular aperture. They verify its feasibility via experimental demonstration. For the feasibility test, they implement three lab-based prototype FOVSs with different natural frequencies and measure each FOVS's frequency response according to the base vibration and sensitivity. The experimental results for three lab-based prototype FOVSs show the sensitivities of 163, 183, and 206 mV/g, the minimum detectable accelerations of 0.082, 0.086, and 0.082 mg, and the dynamic ranges of 18-45, 26-52, and 20-120 Hz, respectively. They also experimentally demonstrate its remote sensing and multipoint sensing characteristics. The proposed FOVS has the virtues of easy controllable sensitivity and dynamic range, simple structure, and remote sensing and multipoint sensing characteristics.</P>
Finite-Time Cluster Synchronization of Lur’e Networks: A Nonsmooth Approach
Tang, Ze,Park, Ju H.,Shen, Hao IEEE 2018 IEEE transactions on systems, man, and cybernetics Vol.48 No.8
<P>This paper is devoted to the finite-time cluster synchronization issue of nonlinearly coupled complex networks which consist of discontinuous Lur’e systems. On the basis of the definition of Filippov regularization process and the measurable selection theorem, the discontinuously nonlinear function is mapped into a function-valued set, then a measurable function is accordingly selected from the Filippov set to ensure the existence of the solution for the discontinuous system. By designing the finite-time pinning controller, some sufficient conditions are obtained for cluster synchronization of the identical and nonidentical Lur’e networks, respectively. In addition, the settling time for achieving the cluster synchronization is estimated by applying the finite-time stability theory. And finally, a numerical example is presented to illustrate the validity of theoretical analysis.</P>
Drug-induced hyperglycaemia and diabetes: pharmacogenomics perspectives
Mou-Ze Liu,Hai-Yan He,Jian-Quan Luo,Fa-Zhong He,Zhang-Ren Chen,Yi-Ping Liu,Da-Xiong Xiang,Hong-Hao Zhou,Wei Zhang 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.7
Drug-induced diabetes is widely reported inclinical conditions, and it is becoming a global issuebecause of its potential to increase the risk of severe cardiovascularcomplications. However, which drug mechanismsexert their diabetogenic effects and why the effectspresent significant inter-individual differences remain largelyunknown. Pharmacogenomics, which is the study ofhow genomic variation influences drug responses, providesan explanation for individual differences in drug-induceddiabetes. We highlight that pharmacogenomics can beinvolved in regulating the expression of genes in signalingpathways related to the pharmacokinetics or pharmacodynamicsof drugs or the pathogenesis of diabetes, contributingto the differences in drug-induced glucoseimpairment. The pharmacogenomics studies of the majordiabetogenic drugs are reviewed, including calcineurininhibitors, antipsychotics, hormones, and antihypertensivedrugs. We intend to elucidate the genetic basis of druginduceddiabetes and pave the way for the precise use ofthese drugs in the clinic.
Finite-time Secondary Frequency Modulation of Microgrid Based on Event Triggering Mechanism
Chenglong Zhou,Ze Li,Guozeng Cui,Yifan Chen,Wangjun Hao 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.4
This paper designs a ratio consistency algorithm based on event triggering mechanism aiming at the frequency recovery deviation caused by traditional droop control in microgrid. It achieves secondary frequency modulation in microgrid by adjusting the active power setting value. The max-min consistency algorithm is proposed to realize asymptotic consistency of distributed power supply in a finite time. Communication delay is added to ensure the accuracy of frequency update and verifies the robustness of the algorithm against itself. Meanwhile, the validity of event triggering conditions is verified. Finally, the simulation examples are carried out to prove the correctness and superiority of the proposed finite-time control strategy.