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Correlation between events with different safety significance in nuclear power plants
Šimić Zdenko,Peinador Veira Miguel,Banov Reni 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7
The main purpose of collecting and analyzing operating experience events is to look for insights to improve safety. The underlying assumption is the correlation and causality between events with different safety significances. The analysis of this assumption could be valuable to optimize operating experience feedback programs and to enhance safety. This paper analyses the correlation between events with different safety significances. Groups of events from six nuclear energy related databases are considered. The findings are that a correlation exists but with various levels and not as large or consistent as might be expected across different databases. These results might be the basis for further work to analysis causality, to find out how a similarity in causes influences the correlation, and finally to improve the operating experience program.
Lee, Ho-Sun,Barraza-Villarreal, Albino,Biessy, Carine,Duarte-Salles, Talita,Sly, Peter D.,Ramakrishnan, Usha,Rivera, Juan,Herceg, Zdenko,Romieu, Isabelle American Physiological Society 2014 PHYSIOLOGICAL GENOMICS Vol.46 No.23
<P>Epigenetic regulation of imprinted genes is regarded as a highly plausible explanation for linking dietary exposures in early life with the onset of diseases during childhood and adulthood. We sought to test whether prenatal dietary supplementation with docosahexaenoic acid (DHA) during pregnancy may modulate epigenetic states at birth. This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg of DHA or a placebo from gestation <I>week 18–22</I> to parturition. We applied quantitative profiling of DNA methylation states at <I>IGF2</I> promoter 3 (<I>IGF2</I> P3), <I>IGF2</I> differentially methylated region (DMR), and <I>H19</I> DMR in cord blood mononuclear cells of the DHA-supplemented group (<I>n</I> = 131) and the control group (<I>n</I> = 130). In stratified analyses, DNA methylation levels in <I>IGF2</I> P3 were significantly higher in the DHA group than the control group in preterm infants (<I>P</I> = 0.04). We also observed a positive association between DNA methylation levels and maternal body mass index; <I>IGF2</I> DMR methylation was higher in the DHA group than the control group in infants of overweight mothers (<I>P</I> = 0.03). In addition, at <I>H19</I> DMR, methylation levels were significantly lower in the DHA group than the control group in infants of normal weight mothers (<I>P</I> = 0.01). Finally, methylation levels at <I>IGF2/H19</I> imprinted regions were associated with maternal BMI. These findings suggest that epigenetic mechanisms may be modulated by DHA, with potential impacts on child growth and development.</P>