Identification and Functional Characterization of Porcine XBP-1 in PEF Cells

Jin-Yu Zhan9,Kyu-Sun Lee,Ji-Su Kim,Kyung-Kwang Lee,Kweon Yu,Deog-Bon Koo 한국동물번식학회 2008 Reproductive & Developmental Biology(Supplement) Vol.32 No.2s

Identification and Functional Characterization of Porcine XBP-1 in PEF Cells

Jin-Yu Zhan9,Kyu-Sun Lee,Ji-Su Kim,Kyung-Kwang Lee,Kweon Yu,Deog-Bon Koo 한국동물생명공학회(구 한국동물번식학회) 2008 Reproductive & developmental biology Vol.32 No.2

Some Reflections of Jain Ahimsa thought on the Current COVID-19 Pandemic

Zhan Yifang(Yifang Zhan) 아시아사회과학학회 2022 Jornal of Asia Social Science Vol.9 No.2

The teaching of Non-violence (अहिंसा, Ahimsa) refers to not harming all sentient beings. It is the core idea of Hinduism, Buddhism, Jainism, and the other religions originated in India. Especially in Jainism, the teaching and practicing on “Ahimsa” were heavily emphasized. In modern times, Mahatma Gandhi's philosophy of non-violence and non-cooperative thoughts were deeply influenced by the creed of Jainism, which served as a banner to win the national independence and liberation of India from the British. The Nonviolence thinking possesses respect for one's own life, all life forms as well as restraining and balancing on three levels of one’s physical body, speech, and mindset. In order to achieve “harmlessness” in behavior, speech, and thinking. When the COVID-19 Pandemic was raging around the world since early 2020, and countries from all over the world are facing a massive crisis, the teaching of non-violence (अहिंसा, Ahimsa) in Jainism thus becoming very precious. Under the circumstances of the overwhelming consumerism addition to the deterioration of human morality. In consequence, the natural environment is seriously damaged at the global scale. Today, what will we learn from the teachings of Jain Thirthankaras, such as Mahavira, the ancient Indian philosopher and founder of Jainism? The question is becoming quite reflective.

Effects of alfalfa flavonoids extract on the microbial flora of dairy cow rumen

Zhan, Jinshun,Liu, Mingmei,Wu, Caixia,Su, Xiaoshuang,Zhan, Kang,Zhao, Guo qi Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.9

Objective: The effect of flavonoids from alfalfa on the microbial flora was determined using molecular techniques of 16S ribosome deoxyribonucleic acid (rDNA) analysis. Methods: Four primiparous Holstein heifers fitted with ruminal cannulas were used in a $4{\times}4$ Latin square design and fed a total mixed ration to which alfalfa flavonoids extract (AFE) was added at the rates of 0 (A, control), 20 (B), 60 (C), or 100 (D) mg per kg of heifer BW. Results: The number of operational taxonomic units in heifers given higher levels of flavonoid extract (C and D) was higher than for the two other treatments. The Shannon, Ace, and Chao indices for treatment C were significantly higher than for the other treatments (p<0.05). The number of phyla and genera increased linearly with increasing dietary supplementation of AFE (p<0.05). The principal co-ordinates analysis plot showed substantial differences in the microbial flora for the four treatments. The microbial flora in treatment A was similar to that in B, C, and D were similar by the weighted analysis. The richness of Tenericutes at the phylum level tended to increase with increasing AFE (p = 0.10). The proportion of Euryarchaeota at the phylum level increased linearly, whereas the proportion of Fusobacteria decreased linearly with increasing AFE supplementation (p = 0.04). The percentage of Mogibacterium, Pyramidobacter, and Asteroleplasma at the genus level decreased linearly with increasing AFE (p<0.05). The abundance of Spirochaeta, Succinivibrio, and Suttonella at the genus level tended to decrease linearly with increasing AFE (0.05<p<0.10). Conclusion: Including AFE in the diet of dairy cows may alter the microbial composition of the rumen; however its effect on nutrient digestibility remains to be determined.

Effects of alfalfa flavonoids on the production performance, immune system, and ruminal fermentation of dairy cows

Zhan, Jinshun,Liu, Mingmei,Su, Xiaoshuang,Zhan, Kang,Zhang, Chungang,Zhao, Guoqi Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.10

Objective: The objective of this study was to examine the effects of alfalfa flavonoids on the production performance, immunity, and ruminal fermentation of dairy cows. Methods: The experiments employed four primiparous Holstein cows fitted with ruminal cannulas, and used a $4{\times}4$ Latin square design. Cattle were fed total mixed ration supplemented with 0 (control group, Con), 20, 60, or 100 mg of alfalfa flavonoids extract (AFE) per kg of dairy cow body weight (BW). Results: The feed intake of the group receiving 60 mg/kg BW of AFE were significantly higher (p<0.05) than that of the group receiving 100 mg/kg BW. Milk yields and the fat, protein and lactose of milk were unaffected by AFE, while the total solids content of milk reduced (p = 0.05) linearly as AFE supplementation was increased. The somatic cell count of milk in group receiving 60 mg/kg BW of AFE was significantly lower (p<0.05) than that of the control group. Apparent total-tract digestibility of neutral detergent fiber and crude protein showed a tendency to increase (0.05<$p{\leq}0.10$) with ingestion of AFE. Methane dicarboxylic aldehyde concentration decreased (p = 0.03) linearly, whereas superoxide dismutase activity showed a tendency to increase (p = 0.10) quadratically, with increasing levels of AFE supplementation. The lymphocyte count and the proportion of lymphocytes decreased (p = 0.03) linearly, whereas the proportion of neutrophil granulocytes increased (p = 0.01) linearly with increasing levels of dietary AFE supplementation. The valeric acid/total volatile fatty acid (TVFA) ratio was increased (p = 0.01) linearly with increasing of the level of AFE supplementation, the other ruminal fermentation parameters were not affected by AFE supplementation. Relative levels of the rumen microbe Ruminococcus flavefaciens tended to decrease (p = 0.09) quadratically, whereas those of Butyrivibrio fibrisolvens showed a tendency to increase (p = 0.07) quadratically in response to AFE supplementation. Conclusion: The results of this study demonstrate that AFE supplementation can alter composition of milk, and may also have an increase tendency of nutrient digestion by regulating populations of microbes in the rumen, improve antioxidant properties by increasing antioxidant enzyme activities, and affect immunity by altering the proportions of lymphocyte and neutrophil granulocytes in dairy cows. The addition of 60 mg/kg BW of AFE to the diet of dairy cows was shown to be beneficial in this study.

Effect of abdominal acupuncture combined with routine rehabilitation training on shoulder-hand syndrome after stroke: A randomized controlled trial

Zhan Jie,Ai Yirang,Zhan Lechang,Pan Ruihuan,Wang Yiqiao,Dong Cong,Wang Qiuchun,Chen Hongxia,Lu Liming,Li Mei 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.2

Background: Post-stroke shoulder-hand syndrome (SHS) is a common complication after stroke. To date, there is still a lack of consistently effective and good patient compliance methods for SHS. Methods: Fifty patients with SHS were included in this study. Patients in the control group received rehabilitation training (RT) for 2 weeks; each session was 30 min, 1 time per day, and 5 times per week. Patients in the observation group were additionally given Bo’s abdominal acupuncture (BAA) with the same frequency and duration. The primary outcome was the change value in the VAS score from baseline to 2 weeks. The secondary outcomes measured were motor function of the upper limb, shoulder range of motion, ADL, and swelling volume. Results: Compared with baseline values, the mean VAS score at 2 weeks was reduced by 3.68 in the observation group and by 1.92 in the control group, with a difference between the two groups of 1.84 (P < 0.001); the mean MBI score at 2 weeks increased by 10.44 in the observation group and by 4.79 in the control group, with a difference between the two groups of 5.84 (P = 0.032); the mean swelling volume at 2 weeks decreased by 9.64 in the observation group and by 3.29 in the control group, with a difference between the two groups of 6.48 (P < 0.001). BAA-related adverse events were not found during the study. Conclusions: BAA combined with RT is superior to RT alone in improving shoulder pain, swelling, and ADL in post-stroke SHS patients. Trial Registration: ChiCTR2100045464 (www.chictr.org.cn).

A Novel Brain Tumor Segmentation Method for Multi-Modality Human Brain MRIs

Tianming Zhan,Shenghua Gu,Lei Jiang,Yongzhao Zhan 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.11

Delineating brain tumor boundaries from multi-modality magnetic resonance images (MRIs) is a crucial step in brain cancer surgical and treatment planning. In this paper, we propose a fully automatic technique for brain tumor segmentation from multi-modality human brain MRIs. We first use the intensities of different modalities in MRIs to represent the features of both normal and abnormal tissues. Then, the multiple classifier system (MCS) is applied to calculate the probabilities of brain tumor and normal brain tissue in the whole image. At last, the spatial-contextual information is proposed by constraining the classified neighbors to improve the classification accuracy. Our method was evaluated on 20 multi-modality patient datasets with competitive segmentation results.

Brain Tumor Segmentation from Multispectral MRIs Using Sparse Representation Classification and Markov Random Field Regularization

Tianming Zhan,Shenghua Gu,Can Feng,Yongzhao Zhan,Jin Wang 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.9

Automatic brain tumor segmentation from multispectral magnetic resonance imaging (MRI) data is an important but a challenging task because of the high diversity in the appearance of tumor tissues among different patients and in many cases similarity with the normal tissues. In this paper, we propose a fully automatic technique for brain tumor segmentation from multispectral human brain MRIs. We first use the intensities of different patches in multispectral MRIs to represent the features of both normal and abnormal tissues and generate a dictionary for following tissue classification. Then, the sparse representation classification (SRC) is applied to classify the brain tumor and normal brain tissue in the whole image. At last, the Markov random field (MRF) regularization introduces spatial constraints to the SRC to take into account the pair-wise homogeneity in terms of classification labels and multispectral voxel intensities. Our method was evaluated on 20 multi-modality patient datasets with competitive segmentation results.

Growth Inhibition and Apoptosis Induction of Human Umbilical Vein Endothelial Cells by Apogossypolone

Zhan, Yong-Hua,Huang, Xiao-Feng,Hu, Xing-Bin,An, Qun-Xing,Liu, Zhi-Xin,Zhang, Xian-Qing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Aims and Background: Prostate cancer is one of the most common malignant tumors in the male reproductive system, which causes the second most cancer deaths of males, and control of angiogenesis in prostate lesions is of obvious importance. This study assessed the effect of apogossypolone (ApoG2) on proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs). Subjects and Methods: HUVECs were treated with different concentrations of ApoG2. The survival rate of HUVECs were determined by MTT assay. Utrastructural changes of HUVECs were assessed with transmission electron microscopy. Apoptosis in HUVECs was analyzed by flow cytometry and cell migration by Boyden chamber assay. Matrigel assays were used to quantify the development of tube-like networks. Results: ApoG2 significantly inhibited HUVEC growth even at 24 h (P<0.05). The inhibitory effect of ApoG2 is more obvious as the concentration and the culture time increased (P<0.05). These results indicate that ApoG2 inhibits the proliferation of HUVECs in a time- and concentration-dependent manner with increase of the apoptosis rate. Besides, ApoG2 reduced the formation of total pseudotubule length and network branches of HUVECs. Conclusions: The results suggest that ApoG2 inhibits angiogenesis of HUVECs by growth inhibition and apoptosis induction.

Static Shear Strength Calculation of Plastic Helical Gears Mating with Steel Worm

Zhan Jiaxing,Katherine Ilie 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

The mesh mechanism shows the different characteristics of worm and helical gear compared to other kind of gear pairs. A new calculation method is proposed in this paper. With two sorts of design parameters of worms and gears, and two kinds of plastic material, the shear torque of gears were experimentally obtained with a fixture. Compared with the actual test results, the proposed theoretical calculation results only have less than 4% deviation, which were more accurate than the number calculated with DuPont's method.