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Relationship between Stress Gene Polymorphisms and Litter Size by AI in Pigs
H. J. Jin,I. C. Kim,M. S. Wee,S. H. Yeon,C. D. Kim,S. S. Lee,C. Y. Cho,S. R. Cho,D. S. Son,C. K. Park,Z. D. Li 사단법인 한국동물생명공학회 2007 한국동물생명공학회지 Vol.22 No.4
This study was performed to investigate the relationship between PSS-HSP70 gene polymorphism and artificial insemination (AI) reproductivity in the pigs. The RFLP polymorphism of PSS and the SSCP polymorphisms of HSP70 K1, K3 and K4 PCR product were detected different patterns. In the experiment for AI of fresh semen, spring and fall season showed higher litter size born of 10.89 head than 10.47 head of summer season. Landrace was showed higher litter size of 9.96 head than that of Duroc and Yorkshire(p<0.05). Stress relating PSS and HSP70 polymorphism of PSS-Normal, HSP70 K1-BB, K3-AB, K4-AA showd a highest litter size born of 10.97 head and litter size born alive of 10.69 head than that of the other polymorphisms(p<0.05). In the experiment for AI of frozen semen, effects of season and pig breeds were not showed for litter size born. The stress relating polymorphism of PSS-Carrier, HSP70 K1-BB, K3-BB, K4-AB showed highest litter size born of 11.29 head and litter size born alive of 10.82 head and PSS-Normal, HSP70 K1-BB, K3-AB, K4-AA showed the lowest litter size born of 8.48 head and litter size born alive of 7.33 head than that of the other polymorphisms(p<0.05). These results suggest that AI litter size born for the stress of forzen thawed semen may be affected by PSS and HSP70 polymorphism in pigs.
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer
Lee, K-S,Lee, Y-S,Lee, J-M,Ito, K,Cinghu, S,Kim, J-H,Jang, J-W,Li, Y-H,Goh, Y-M,Chi, X-Z,Wee, H,Lee, H-W,Hosoya, A,Chung, J-H,Jang, J-J,Kundu, J K,Surh, Y-J,Kim, W-J,Ito, Y,Jung, H-S,Bae, S-C Macmillan Publishers Limited 2010 Oncogene Vol.29 No.23
Human lung adenocarcinoma, the most prevalent form of lung cancer, is characterized by many molecular abnormalities. K-ras mutations are associated with the initiation of lung adenocarcinomas, but K-ras-independent mechanisms may also initiate lung tumors. Here, we find that the runt-related transcription factor Runx3 is essential for normal murine lung development and is a tumor suppressor that prevents lung adenocarcinoma. Runx3−/− mice, which die soon after birth, exhibit alveolar hyperplasia. Importantly, Runx3−/− bronchioli exhibit impaired differentiation, as evidenced by the accumulation of epithelial cells containing specific markers for both alveolar (that is SP-B) and bronchiolar (that is CC10) lineages. Runx3−/− epithelial cells also express Bmi1, which supports self-renewal of stem cells. Lung adenomas spontaneously develop in aging Runx3+/− mice (∼18 months after birth) and invariably exhibit reduced levels of Runx3. As K-ras mutations are very rare in these adenomas, Runx3+/− mice provide an animal model for lung tumorigenesis that recapitulates the preneoplastic stage of human lung adenocarcinoma development, which is independent of K-Ras mutation. We conclude that Runx3 is essential for lung epithelial cell differentiation, and that downregulation of Runx3 is causally linked to the preneoplastic stage of lung adenocarcinoma.
Yu, Z,Ye, Z,Ma, K-F. A. 한국지능정보시스템학회 2022 한국지능정보시스템학회 학술대회논문집 Vol.2022 No.6
Research has shown that social commerce influences consumer purchase intentions, but little attention has been paid to the perspectives of Generation Z and its growing purchasing power. This study aimed to provide insights into the mechanisms influencing Generation Z’s intentions to continue using social commerce platforms, focusing on China’s RED as a representative platform. Though the lens of the stimulus-organism-response model, we investigated the effects of RED’s technological environments on consumers’ intrinsic values, extrinsic values and online purchase intentions. The results showed that the mediating effects of intrinsic and extrinsic values were significant. The suggests that social commerce features positively influence consumers’ intrinsic and extrinsic values, which enhances their continuance intentions. The results of this study provide similar social commerce platforms with ideas on how to improve the design of their platforms to increase consumer continuance intentions in the post-COVID-19 era.
Cui, H.Z.,Wen, J.F.,Choi, H.R.,Li, X.,Cho, K.W.,Kang, D.G.,Lee, H.S. North-Holland ; Elsevier Science Ltd 2011 european journal of pharmacology Vol.653 No.1
Ursolic acid is reported to have beneficial effects on the regulation of cardiovascular homeostasis. However, the effects of ursolic acid on cardiac hormone secretion are yet to be defined. The present study was designed to test the effects of ursolic acid on the secretory and contractile functions of the atria. Experiments were conducted in isolated perfused beating rabbit atria. We measured the changes in atrial dynamics, pulse pressure, stroke volume, cAMP efflux, as well as the secretion of atrial natriuretic peptide (ANP). Ursolic acid increased ANP secretion and mechanical dynamics in a concentration-dependent manner. The inhibition of L-type Ca<SUP>2+</SUP> channels with nifedipine attenuated the ursolic acid-induced increase in ANP secretion but not mechanical dynamics. The inhibition of K<SUP>+</SUP><SUB>ATP</SUB> channels with glibenclamide attenuated the ursolic acid-induced increase in ANP secretion-but not atrial dynamics-in a concentration-dependent manner. The selective Na<SUP>+</SUP>-K<SUP>+</SUP>-ATPase inhibitor ouabain blocked the ursolic acid-induced increase in atrial dynamics but not ANP secretion. These findings show that ursolic acid increases ANP secretion via its activation of K<SUP>+</SUP><SUB>ATP</SUB> channels and subsequent inhibition of Ca<SUP>2+</SUP> entry through L-type Ca<SUP>2+</SUP> channels in rabbit atria. These data also suggest that ursolic acid increases atrial dynamics via its inhibition of Na<SUP>+</SUP>-K<SUP>+</SUP>-ATPase activity.
Strange meson production in Al+Al collisions at 1.9 A GeV
Gasik, P.,Piasecki, K.,Herrmann, N.,Leifels, Y.,Matulewicz, T.,Andronic, A.,Averbeck, R.,Barret, V.,Basrak, Z.,Bastid, N.,Benabderrahmane, M. L.,Berger, M.,Buehler, P.,Cargnelli, M.,Č,aplar, R.,C Springer 2016 European Physical Journal A Vol.52 No.6
<P>The production of K+, K- and phi(1020) mesons is studied in Al+Al collisions at a beam energy of 1.9 A GeV which is close to or below the production threshold in NN reactions. Inverse slopes, anisotropy parameters, and total emission yields of K-+/- mesons are obtained. A comparison of the ratio of kinetic energy distributions of K- and K+ mesons to the HSD transport model calculations suggests that the inclusion of the in-medium modifications of kaon properties is necessary to reproduce the ratio. The inverse slope and total yield of phi mesons are deduced. The contribution to K- production from phi meson decays is found to be [17 +/- 3(stat)(-7)(+2) (syst)]%. The results are in line with the previous K-+/- and phi data obtained for different colliding systems at similar incident beam energies.</P>
Photoproduction ofΛand<sup>Σ0</sup>hyperons using linearly polarized photons
Paterson, C. A.,Ireland, D. G.,Livingston, K.,McKinnon, B.,Adhikari, K. P.,Adikaram, D.,Akbar, Z.,Amaryan, M.,Anefalos Pereira, S.,Badui, R. A.,Ball, J.,Baltzell, N. A.,Battaglieri, M.,Bedlinskiy, I. American Physical Society 2016 Physical review. C Vol.93 No.6
<P>Background: Measurements of polarization observables for the reactions (gamma) over right arrowp -> K+ Lambda and (gamma) over right arrowp -> K+ Sigma(0) have been performed. This is part of a program of measurements designed to study the spectrum of baryon resonances in particular, and nonperturbative QCD in general. Purpose: The accurate measurement of several polarization observables provides tight constraints for phenomenological fits, which allow the study of strangeness in nucleon and nuclear systems. Beam-recoil observables for the (gamma) over right arrowp -> K+ Sigma(0) reaction have not been reported before now. Method: Themeasurements were carried out using linearly polarized photon beams incident on a liquid hydrogen target, and the CLAS detector at the Thomas Jefferson National Accelerator Facility. The energy range of the results is 1.71 < W < 2.19 GeV, with an angular range -0.75 < cos theta(K)* < +0.85. Results: The observables extracted for both reactions are beam asymmetry Sigma, target asymmetry T, and the beam-recoil double polarization observables O-x and O-z. Conclusions: Comparison with theoretical fits indicates that, in the regions where no previous data existed, the new data contain significant new information, and strengthen the evidence for the set of resonances used in the latest Bonn-Gatchina fit.</P>
Photoproduction of the<sub>f1</sub>(1285)meson
Dickson, R.,Schumacher, R. A.,Adhikari, K. P.,Akbar, Z.,Amaryan, M. J.,Anefalos Pereira, S.,Badui, R. A.,Ball, J.,Battaglieri, M.,Batourine, V.,Bedlinskiy, I.,Biselli, A.,Boiarinov, S.,Briscoe, W. J. American Physical Society 2016 Physical Review C Vol.93 No.6
<P>The f(1)(1285) meson withmass 1281.0 +/- 0.8MeV/c(2) and width 18.4 +/- 1.4MeV (full width at half maximum) was measured for the first time in photoproduction from a proton target using CLAS at Jefferson Lab. Differential cross sections were obtained via the eta pi(+)pi(-), K+(K) over bar (0) pi(-), and (K-K0)pi(+) decay channels from threshold up to a center-of-mass energy of 2.8 GeV. The mass, width, and an amplitude analysis of the eta pi(+)pi(-) final-state Dalitz distribution are consistent with the axial-vector J(P) = 1(+) f(1)(1285) identity, rather than the pseudoscalar 0(-) eta(1295). The production mechanism is more consistent with s-channel decay of a high-mass N* state and not with t-channel meson exchange. Decays to eta pi pi go dominantly via the intermediate a(0)(+/-) (980)pi(-/+) states, with the branching ratio Gamma [a(0)pi (no (K) over barK)]/Gamma[eta pi pi (all)] = 0.74 +/- 0.09. The branching ratios Gamma (K (K) over bar pi)/Gamma(eta pi pi) = 0.216 +/- 0.033 and Gamma (gamma rho(0))/Gamma(eta pi pi) = 0.047 +/- 0.018 were also obtained. The first is in agreement with previous data for the f(1)(1285), while the latter is lower than the world average.</P>
The Effects of Stress Related Genes on Carcass Traits and Meat Quality in Pigs
H. J. Jin,B. Y. Park,J. C. Park,I. H. Hwang,S. S. Lee,S. H. Yeon,C. D. Kim,C. Y. Cho,Y. K. Kim,K. S. Min,S. T. Feng,Z. D. Li,C. K. Park,C. I. Kim 아세아·태평양축산학회 2006 Animal Bioscience Vol.19 No.2
The current study was conducted to investigate the relationship between stress related gene and meat quality in pigs. A total number of 212 three-way cross bred (Landrace-Yorkshire횞Duroc) and 38 Duroc were sampled from the Korean pig industry to determine genotype requency of porcine stress syndrome (PSS) and heat shock protein 70 kDa (HSP70) genes and their relationship with carcass traits and longissimus meat quality. Screen of HSP70 was performed by the single strand conformation polymorphism (SSCP) technique. Based on the analysis of restriction fragment length polymorphism (RFLP) in ryanodine receptor 1 (RYR1) gene, genetic disorder of PSS was related to a mutation at 18,168th (C to T) of exon 17. There was no significant difference in ultimate meat pH and backfat thickness between HSP70 K1-AA type and -BB type in pure Duroc breed. In Landrace-Yorkshire횞Duroc (L-YxD) cross bred pig, our results indicated that HSP70 derivate type in Duroc had a limited effect on backfat thickness, but L-YxD type had a noticeable linkage with HSP70 K1-AA and K3-AB. This tendency was also observed in hot carcass weight where HSP70 K1-AA and K3-AB resulted in heavier weight with 86.3 kg compared to HSP70 K1-AB and K3-BB of 74.3 kg. Results imply that stress related HSP70 genotype has a potential association with backfat thickness and carcass weight.
Centrality dependence of subthresholdϕmeson production in Ni + Ni collisions at1.9AGeV
Piasecki, K.,Tymiń,ski, Z.,Herrmann, N.,Averbeck, R.,Andronic, A.,Barret, V.,Basrak, Z.,Bastid, N.,Benabderrahmane, M. L.,Berger, M.,Buehler, P.,Cargnelli, M.,Č,aplar, R.,Cordier, E.,Crochet American Physical Society 2016 Physical Review C Vol.94 No.1
<P>We analyzed the phi meson production in central Ni + Ni collisions at a beam kinetic energy of 1.93A GeV with the FOPI spectrometer and found a production probability per event of [8.6 +/- 1.6(stat) +/- 1.5(syst)] x 10(-4). This new data point allows us for the first time to inspect the centrality dependence of subthreshold phi meson production in heavy-ion collisions. The rise of phi meson multiplicity per event with mean number of participants can be parametrized by a power function with exponent alpha = 1.8 +/- 0.6. The ratio of phi to K- production yields seems not to depend, within the experimental uncertainties, on the collision centrality, and the average of measured values was found to be 0.36 +/- 0.05.</P>