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Yunsuk Choi(Yunsuk Choi),Hyunseok Jee(Hyunseok Jee) 대한운동학회 2023 아시아 운동학 학술지 Vol.25 No.1
BACKGROUND Various factors-based properties of the skeletal muscle are determined by mechanical stress, chemical stimuli, neuromuscular stimuli, different protein isoforms etc. The properties of the muscle are formed in the process of the balance between anabolism and catabolism. Especially, the anabolism on the way of the cell proliferation to its differentiation is accompanied by various controlling signal pathways. OBJECTIVE The purpose of this study focused on the mTOR/S6K system, Myosin, and Myocilin among these signaling pathways, especially on previously reported studies on the contribution of Myocilin to the skeletal muscle fiber type transformation. METHODS To identify the molecular pathways related to muscle development, the KEGG Mapper was used to present the mTOR-related signaling system that has not been identified so far. RESULTS Consequently, it suggests that it affects the myogenic process, through the path of PI3K->AKT- >MEF2->MyoC->mTOR->p70S6K->S6. CONCLUSIONS It also suggests that Myocilin serves as a potential effector to control skeletal muscle cell type. Furthermore, more detailed study on the potential target-oriented (to the fast or slow fiber type change) role of Myocilin for enhancing the health state by adjusted exercise programs developed by its optimal type, intensity, frequency, and time is awaited.
The Relationship between Perceived Occupational Well-Being and Innovative Behavior in the Workplace
Yunsuk Cha(차윤석) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.2
주요 경영관련 저널에서는 매년 ‘일하고 싶은 회사(100 best companies to work for)’를 발표해 오고 있다. 여기에 선정된 회사들은 높은 기업성과 뿐만 아니라 다양한 형태의 복지프로그램 제공과 구성원들의 높은 직무만족, 조직몰입, 일-가정 균형 인식, 및 긍정적 정서를 높일 수 있는 프로그램을 제공하는 특징을 갖고 있다. 이는 조직 구성원들은 이러한 프로그램을 통해 직무만족, 조직몰입, 일-가정 균형에서 오는 안정감과 행복감을 느끼며, 이는 삶에 대한 전반적 만족 및 긍정적 정서로 나타나기 때문이다. 최근 기업들은 조직 구성원들의 심리적 안정과 긍정적 사고가 개인 및 조직의 성과를 향상시킨다는 믿음으로 많은 노력을 해오고 있다. 본 연구에서는 구성원이 지각하는 행복감과 혁신행동 간의 관계에서 일-가정 촉진의 조절효과를 검증하였다. 이를 위해 IT, 서비스, 제조업 등 총 11 개 기업의 직원들을 대상으로 설문조사를 실시하여 실증 분석하였다. 분석결과는 다음과 같다. 첫째, 직장 행복감이 혁신행동에 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 직장 행복감과 혁신행동 간의 관계에 있어 일-가정 촉진 및 가정-일 촉진의 조절효과가 통계적으로 유의한 결과가 나타났다. 결론 부분에 이 연구의 시사점과 한계점, 그리고 향후 연구 방향을 제시하였다. Major business journals have been annually announced ‘100 best companies to work for’. These companies have some characteristics having not only high organization performance but also various benefit programs such as job satisfaction, organization commitment, work-family balance and positive psychology. When people have job satisfaction, organization commitment, and happiness, it will increase the positive psychology of people. Therefore, in this study, we examined the moderating effect of work-family facilitation between occupational well-being and innovative behavior. For the empirical analysis, the survey was executed on employees of 11 companies in IT, Service, and Manufacturing business field. The analysis result is as follows. First, occupational well-being gives positive(+) influence on innovative behavior. Second, the control effect of work-family facilitation in the relationship between occupational well-being and innovative behavior was significant according to statistics. The conclusion states the implications and limitations of this study, and suggests directions on future studies.
Yunsuk Choi,Sang Bong Chung,Myoung Soo Kim 대한뇌혈관외과학회 2018 Journal of Cerebrovascular and Endovascular Neuros Vol.20 No.4
A persistent proatlantal artery (PA) is rare. We report a type 1 persistent PA originating from the right external carotid artery (ECA). A 78-year-old woman presented with dizziness. Computed tomographic (CT) angiography showed a persistent PA originating from the right ECA. This persistent PA did not pass through the atlas transverse foramen. The extracranial segment of this artery in the atlas transverse process level had a more lateral position than a normal left vertebral artery. CT angiography well demonstrated the relationship with bony structures and the course of this persistent PA. This anomalous artery in our patient presented as an incidental finding. Surgeon should recognize a persistent PA when performing carotid endarterectomy or ligation of the ECA for avoidance of complication.
( Yunsuk Choi ),( Jung-hee Lee ),( Chul Won Jung ),( Jae-cheol Jo ),( Jin Seok Kim ),( Inho Kim ),( Silvia Park ),( June-won Cheong ),( Sang-hyuk Park ),( Sung-yong Kim ),( Hong-ghi Lee ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1
Background/Aims: Compared with Western countries, chronic lymphocytic leukemia (CLL) rarely occurs in Asia and has different clinical characteristics. Thus, we aimed to evaluate the clinical characteristics, treatment outcomes, and prognostic significance of Korean patients with CLL. Methods: We retrospectively analyzed 90 patients with CLL who had received chemotherapy at 6 centers in Korea between 2000 and 2012. Results: Compared with Western patients with CLL, Korean patients with CLL express lambda (42.0%) and atypical markers such as CD22 and FMC7 (76.7% and 40.0%, respectively) more frequently. First-line chemotherapy regimens included chlorambucil (n = 43), fludarabine and cyclophosphamide (FC) (n = 20), fludarabine (n = 13), rituximab-FC (n = 4). The remaining patients were treated with other various regimens (n = 10). The 5-year overall survival (OS) and progression-free survival (PFS) rates were 79.3% and 28.1%, respectively. Multivariate analyses showed that hyperleukocytosis (≥ 100 × 10<sup>3</sup>/μL), extranodal involvement, and the Binet C stage were significant negative prognostic factors for OS (hazard ratio [HR] 4.75, p = 0.039; HR 21.6, p = 0.002; and HR 4.35, p = 0.034, respectively). Cytogenetic abnormalities including complex karyotypes (≥ 3), del(11q), and del(17) had a significantly adverse impact on both OS and PFS (p < 0.001 and p = 0.010, respectively). Conclusions: Initial hyperleukocytosis, extranodal involvement, complex karyotype, del(17) and del(11q) need to be considered in the risk stratification system for CLL.
Yunsuk Choi,Moon Jong Un,Cheolsu Jwa 대한말초신경학회 2018 The Nerve Vol.4 No.1
A 51-year-old woman presented with visual disturbances that had persisted for approximately one year. She had been taking psychiatric medication for schizophrenia. Brain magnetic resonance imaging showed engorged vessels in both hemispheres, and a delay in the mean transit time and time to peak was observed on perfusion images. The initial transfemoral cerebral angiography showed multiple dural arteriovenous fistulas (AVFs) with cortical venous reflux and venous ectasia. Both middle meningeal arteries (MMAs), superficial temporal arteries (STAs), and occipital arteries (OAs) were feeding the fistulas, and the superior sagittal sinus was the draining vein. Owing to the presence of multiple lesions and feeder arteries, a staged treatment was planned. We first performed the Onyx embolization of the left MMA, followed by the surgical ligation of the left STA, with subsequent embolization of the left OA. Finally, the venous ectasia was clipped. Importantly, after treatment, the patient’s schizophrenia-like symptoms improved. The patient could be originally misdiagnosed with schizophrenia. This case shows that staged and active treatment should be considered in case of multiple dural AVFs for improvement of symptoms.
( Yunsuk Choi ),( Eun-hye Hur ),( Ju Hyun Moon ),( Bon-kwan Goo ),( Dae Ro Choi ),( Je-hwan Lee ) 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.2
Background/Aims: Various alterations of microRNA (miRNA) expression have been reported in myelodysplastic syndrome (MDS). We aimed to investigate the unique patterns and prognostic significance of miRNA expression in Korean patients with MDS. Methods: Bone marrow mononuclear cells were collected from eight healthy controls and 26 patients with MDS, and miRNAs were isolated and assessed via quantitative real-time polymerase chain reaction for selected miRNAs, including miR-21, miR-124a, miR-126, miR-146b-5p, miR-155, miR-182, miR-200c, miR-342- 5p, miR-708, and Let-7a. Results: MiR-124a, miR-155, miR-182, miR-200c, miR-342-5p, and Let-7a were significantly underexpressed in patients with MDS, compared to healthy controls. MiR-21, miR-126, 146b-5p, and miR-155 transcript levels were significantly lower in international prognostic scoring system lower (low and intermediate-1) risk MDS than in higher (intermediate-2 and high) risk MDS. Higher expression levels of miR-126 and miR-155 correlated with significantly shorter overall survival and leukemia-free survival. Higher miR-124a expression also tended to be related to shorter survivals. Conclusions: Although our study was limited by the relatively small number of patients included, we identified several miRNAs associated with pathogenesis, leukemic transformation, and prognosis in MDS.
Choi, Yunsuk,Chung, Sang Bong,Kim, Myoung Soo The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.2
Objective : Aberrant right subclavian artery (ARSA) is a rare anatomical variant of the origin of the right subclavian artery. ARSA is defined as the right subclavian artery originating as the final branch of the aortic arch. The purpose of this study is to determine the prevalence and the anatomy of ARSA evaluated with computed tomography (CT) angiography. Methods : CT angiography was performed in 3460 patients between March 1, 2014 and November 30, 2015 and the results were analyzed. The origin of the ARSA, course of the vessel, possible inadvertent ARSA puncture site during subclavian vein catheterization, Kommerell diverticula, and associated vascular anomalies were evaluated. We used the literature to review the clinical importance of ARSA. Results : Seventeen in 3460 patients had ARSA. All ARSAs in 17 patients originated from the posterior aspect of the aortic arch and traveled along a retroesophageal course to the right thoracic outlet. All 17 ARSAs were located in the anterior portion from first to fourth thoracic vertebral bodies and were located near the right subclavian vein at the medial third of the clavicle. Only one of 17 patients presented with dysphagia. Conclusion : It is important to be aware ARSA before surgical approaches to upper thoracic vertebrae in order to avoid complications and effect proper treatment. In patients with a known ARSA, a right transradial approach for aortography or cerebral angiography should be changed to a left radial artery or transfemoral approach.