미세유화약물송달시스템을 이용한 로바스타틴의 생체이용률 향상

윤복영,강복기,정상영,이영원,이시범,황성주,육순홍,강길선,이해방,조선행 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was the mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). The efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet (Mevacor^? , 20 mg/tab) by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The area under the serum concentration-time curve from time zero to the last measured time in serum, AUC_0→24h, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.

다공질 규소와 전해질 계면에서 표면물질이 EL되는 특성에 미치는 영향

陸根鐵,沈淑伊,金英猷 公州大學校 基礎科學硏究所 1998 自然科學硏究 Vol.7 No.-

Porous silicon was prepared on the p-type(l00) silicon wafers by electrochemical anodization in 10% HF-ethanol solution. Bokh EL and in situ FT-IR measurenients were carried out in 0.2M Na2SO4 during constant current anodic oxidation. Raman spectroscopy was used to probe porous silicon in order to estimate the surface Si-O species. The time dependence of the EL intensity had a good correlation with that of the amount of surface Si-Hn species, which was determined by in situ reflection FT-IR. The surface Si-Hn species seems to be consumed with the progress of EL, suggesting that the surface Si-Hn species act as electron injector during EL process for p-type porous silicon.

경연대회를 통한 초·중고생의 창의력 현황에 관한 연구

육근철,이희복,류해일,김현섭,김희수,박달원,심규철,박종석,신영숙,박상태,변두원,김태균 공주대학교 과학교육연구소 2002 과학교육연구 Vol.33 No.-

21세기의 정보화 산업사회와 지식기반 사회에서 우리의 아이들이 자신의 목소리로 세계 속에서 살아가게 하기 위해서는 다른 사람과 다른 아이디어를 낼 수 있도록 교육의 틀을 바꾸지 않으면 안된다. 다라서 21세기의 미래 사회를 살아갈 학생들을 가르치는 교육의 현장 역시 창의적인 인간을 길러낼 수 있도록 변해야 한다. 즉, 미래 사회를 대비하기 위해서는 각 개인의 개성을 존중하는 분위기에서 창의적인 능력을 지닌 인간을 양성해야 한다는 것을 의미한다. 따라서, 학교 안에서의 교육뿐만이 아니라 학교 밖에서도 다양한 학습 경험을 통해서 교육 과정이 추구하는 인간상을 구현할 수 있도록 활동할 수 있는 기회가 학생들에게 제공되어야 한다. 창의력을 발휘하여 문제를 해결하는 능력을 기르기 위해서는 개별적이 아닌 여러 명의 동료가 주어진 과제를 해결할 수 있는 기회를 갖고 짧은 시간이 아닌 장시간 동안 고민하고 그 해결책을 찾는 활동을 가질 기회가 필요하다. In order to educate our students with their special talents for the informational and knowledge based age expected in the 21st century, we must improve our educational programs such that students are able to create their own fresh ideas. Hence the present educational environment should be changed such that they are willing to respect others' characters and personality with their own original ideas. Therefore, we must make them have the opportunity that they can acquire many experiences through the school education and the social education program, so that they may grow up to the person with the humanity and creativity. In this study we have suggested new educational program where students engage themselves in long term research projects with collaboration of the team and creativity of individuals.

性別差異의 社會體育活動이 社會化에 미치는 영향

육조영,이영하 한국체육대학교 부속체육연구소 1991 체육연구소논문집 Vol.9 No.-

The purpose of this study is to find the sexual difference in socialization on sports for all participation. The conclusions from the study are as follows. (1) Men's actual participation spirit is more high them that of Woman. (2) Woman conceptual participations spirit is more high them that of man. (3) The sexual diffence is increased as the age is increased. (4) There are mary factors which make the sexual difference in sports perticipation for example. Physiological, psychological and sociological factors Among socilogical factors "equal sexual model" made great wntribution. (5) Man is inclinde to overevaluate his ability in sports actirities. (6) Woman is made to be indefferent to sports as the age is increased.

Observation of dinegative oxygen cluster : (O₂)_x^2-

金容福,李凞福,陸根鐵 公州大學校 基礎科學硏究所 1995 自然科學硏究 Vol.4 No.-

2價 陰이온 酸素集團에 관하여 주의깊게 측정 연구하였다. (O2)x2-와 더 큰 同族의 상태가 측정되었으며 이들은 분사장치를 통하여 中性 O2 集團에 약한 전자에너지를 부착시킴으로써 발생하였다. A careful search has been made for dinegatively charged cluster ions. (O2)32- and larger homologs have been observed for the first time. they were produced via electron attachment with near zero energy electrons to neutral O2 clusters formed by nozzle expansion.

사방격자에 의해서 만들어진 주기적인 무아레 무늬를 이용한 물체의 형상측정

조선미,김영유,류지욱,육근철 公州大學校 基礎科學硏究所 1997 自然科學硏究 Vol.6 No.-

사방격자를 이용해서 물체의 형상을 측정할 수 있는 방법을 제안하였다. 카메라와 광원의 위치좌표는 변화시키지 않고 사방격자의 피치 간격을 일정한 비율로 변화시키는 방법과, 사방격자의 피치간격은 변화시키지 않고 광원과 카메라 사이의 평면 위치좌표를 변화시켜서 주기적인 무아레 무늬를 얻었으며 이를 이용하여 무아레 무늬의 절대차수를 결정할 수 있는 새로운 방법을 제안하였다. We present a simple method of determining the absolute order using periodic moire fringe structures formed by criss-crossed gratings. We selected two experimental methods that one is fixed the position coordinates of light sources and camera, and than change the pitch distance of criss-crossed gratings. Another method are fixed the pitch distance of criss-crossed gratings and than change the position coordinates of light sources and camera. As a results. We could determined the absolute order only once a photographing the objects.

桔梗의 內部構造規格設定에 관한 硏究

金鍾旭,金弘寯,朱榮丞,陸相元,韓京植 대한본초학회 2000 大韓本草學會誌 Vol.15 No.2

In order to strengthen objectivity and availability of oriental herb medicine, the standard formula for herbs has been attempted to set up by experimenting and documentary testing original herbs which were recorded in authorized document. The object herb medicines are Platycodi Radix. The internal morphological standard in this study is expected to supply the search for several physiochemical reaction, biological reaction, determination of indicator material and identification of gene with basic sources in the future. The result of study is as follows; In the shape of real herbs, I compared current herbs in market with original herbs which were just collected or were on the course of drying. It was possible that the internal shape could be identified by using microscope after butanol series. In powder herbs, it was possible to purify the shape by microscope through maceration of natural and powder herbs. Despite such a useful character, it was difficult to deal with powder herbs because it was uncertain to make a standard for them on account of the crush of these tissue. Since powders shape of herbs in a few documents were regard not as the powder shapes of natural herbs but as the maceration state of them. It is suggested that we should inspect the original herbs which are not crushed yet with a microscope in order to identify crushed shape of powder herbs from now on. An Additional standard establishment including physiochemical reaction and gene research is required in order to supplement the fault of this search.

Metabolomic Profiling, Antioxidant and Anti-inflammatory Activities of Hypericum Species Growing in South Korea

Yuk, Heung Joo,Oh, Kyeong Yeol,Kim, Doo-Young,Song, Hyuk-Hwan,Kim, Jun Young,Oh, Sei-Ryang,Ryu, Hyung Won NATURAL PRODUCT COMMUNICATIONS 2017 Natural product communications Vol.12 No.7

<P>Although Hypericum species are best known as plants that produce hypericin and are used in folk medicine, their other chemical constituents are poorly understood. Polyphenolic secondary metabolites from whole plants of representative Korean Hypericum species (H. laxum Koidz., H. erectum Thunb., and H. ascyron L.) were analyzed using a ultra performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UPLC-Q-TOF/MS)-based approach combined with unsupervised principal component analysis (PCA) multivariate analysis. On the loading scatter plot, significant changes in metabolites were found between species, and three flavonol glycosides (8: quercetin-3-O-galactoside, 12: kaempferol-3-O-glucoside, and 13: quercetin-3-O-rhamnoside) were evaluated as key markers among 17 isolated metabolites. The extracts of H. laxum Koidz. exhibited significant quenching effects on DPPH and ABTS radicals, with IC50 values of 10-20 mu g/mL, and were slightly higher in total phenol (TP) and total flavonoid (TF) contents than other species. Additionally, anti-inflammatory activity was observed by reduced nitric oxide (NO) and interleukin-6 (IL-6) production from lipopolysaccharide (LPS)-stimulated macrophages (RAW 264.7 cells). This is the first study to report the presence of bioactive metabolites and their correlating biological activities in H. laxum Koidz.</P>

Antibacterial Effect of Eucalyptus Oil, Tea Tree Oil, Grapefruit Seed Extract, Potassium Sorbate, and Lactic Acid for the development of Feminine Cleansers

Yuk, Young Sam The Institute of Internet 2021 International Journal of Internet, Broadcasting an Vol.13 No.2

Purpose: It has been reported that the diversity and abundance of microbes in the vagina decrease due to the use of antimicrobial agents, and the high recurrence rate of female vaginitis due to this suggests that a new treatment is needed. Methods: In the experiment, we detected that 10% potassium sorbate solution, 1% eucalyptus oil solution, 1% tea tree oil solution, 400 µL/10 mL grapefruit seed extract solution, 100% lactic acid, 10% acetic acid solution, and 10% lactic acid solution were prepared and used. After adjusting the pH to 4, 5, and 6 with lactic acid and acetic acid in the mixed culture medium, each bacterium was inoculated into the medium and incubated for 72 h at 35℃. Incubate and 0 h each. 24 h. 48 h. The number of bacteria was measured after 72 h. Results: In the mixed culture test between lactic acid bacteria and pathogenic microorganisms, lactic acid bacteria showed good results at pH 5-5.5. Potassium sorbate, which has varying antibacterial activity based on the pH, killed pathogenic bacteria and allowed lactic acid bacteria to survive at pH 5.5. Conclusion: The formulation ratio obtained through this study could be used for the development of a feminine cleanser that can be used as a substitute for antibacterial agents. Further, the findings of this study may be able to solve the problem of antimicrobial resistance in the future.

Poster Session : Effects of the 8-week Intervention Combined New Sport and Yoga Physical Activity on Self-esteem, Resilience, and Psychological Well-being in Children

( Young Sook Yuk ),( In Kyoung Park ),( Young Ho Kim ) 한국체육학회 2013 In Pursuit of Evidence-Based Sport and Exercise Sc Vol.0 No.-