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Yueyue Hao,Nan Zhang,Jing Luo,Xiaoya Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.1
In this work, a facile, environmental-friendly and cost-effective method was developed to prepare silver nanoparticles (Ag NPs) in aqueous solution at room temperature. In our approach, tannic acid was employed as the reducing agent and stabilizer simultaneously, avoiding the usage of any toxic agent. The tannic acid derived silver nanoparticles (TA-Ag NPs) were fully characterized by UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and thermogravimetric analyzer (TGA). The particle size of the synthesized TA-Ag NPs is tunable from 6.5 nm to 19.2nm with narrow distribution by varying the molar ratio of TA to silver precursor. Efficient reduction of methylene blue (MB) catalyzed by TA-Ag NPs was observed, which was dependent upon the particle size of TA-Ag NPs or the TA concentration used for synthesis. By optimizing the TA concentration, complete reduction of MB was accomplished by TA-Ag NPs within 8 min. The high catalytic activity of TA-Ag NPs was attributed to their nanosize and good dispersity as well as the electrostatic interaction between TA and MB which induces rapid enrichment of MB towards TA-Ag NPs, creating a locally concentrated layer of MB. Considering the facile and environmental-friendly preparation procedure and excellent catalytic activity, TA-Ag NPs are green, efficient and highly economical candidates for the catalysis of organic dyes and extendable of other reducible contaminants as well.
Yueyue Guan,Guohua Tang,Lei Li,Jianzhong Shu,Yuhua Zhao,Li Huang,Jun Tang 대한약학회 2024 Archives of Pharmacal Research Vol.47 No.2
The gut microbiota that exists in the human gastrointestinal tract is incredibly important for the maintenance of general healthas it contributes to multiple aspects of host physiology. Recent research has revealed a dynamic connection between the gutmicrobiota and the central nervous system, that can infl uence neurodegenerative diseases (NDs). Indeed, imbalances in thegut microbiota, or dysbiosis, play a vital role in the pathogenesis and progression of human diseases, particularly NDs. Herbalmedicine has been used for centuries to treat human diseases, including NDs. These compounds help to relieve symptomsand delay the progression of NDs by improving intestinal barrier function, reducing neuroinfl ammation, and modulatingneurotransmitter production. Notably, herbal medicine can mitigate the progression of NDs by regulating the gut microbiota. Therefore, an in-depth understanding of the potential mechanisms by which herbal medicine regulates the gut microbiotain the treatment of NDs can help explain the pathogenesis of NDs from a novel perspective and propose novel therapeuticstrategies for NDs. In this review, we investigate the potential neuroprotective eff ects of herbal medicine, focusing on itsability to regulate the gut microbiota and restore homeostasis. We also highlight the challenges and future research prioritiesof the integration of herbal medicine and modern medicine. As the global population ages, access to this information isbecoming increasingly important for developing eff ective treatments for these diseases.
沈月月(Yueyue Shen),罗雪燕(Xueyan Luo),袁泉(Quan Yuan) 아시아사회과학학회 2022 International Science Research Vol.2 No.2
目的:分析带量采购对中选与非中选抗高血压类药品的使用影响,为政策制定及医院合理用药提供参考。方法:以抗高血压药为例,采用实证研究对某院带量采购实施前后一年的数量、金额、用药频度(DDDs)、日均费用(DDC)、仿制药替代率及费用节省等情况进行比较分析。结果:实施带量采购后,抗高血压类药品总体使用量上升 18.60%,销售额下降 7.71%,仿制药对原研药的替代率为 65.07%,潜在节省费用 489.44万元,较带量前实际节省费用 545.78 万元。结论:带量采购实施后,仿制药中选品种呈价减量增的趋势,对原研药的替代率有显著提升,极大缓解了高血压类疾病患者用药负担。 Objective: To analyze the influence of the volume-based procurement policy on the use of antihypertensive and to provide reference for policy formulation and rational drug use in hospital. Methods: Take antihypertensive for examples, empirical approach was used to analyze sales amount, sales volume, generics substitution rate etc., comparing the policy before and after implementation. Results: After the implementation of the volume-based procurement policy, the overall use of antihypertensive drugs increased by 18.60%, and sales fell by 7.71%. Under the effect of the same curative efficacy, the substitution rate of generic drugs for the original drugs was 65.07%, and the potential cost saving was 4.89 million yuan, which is 5 457 800 yuan in actual cost savings compared with before the implementation of the volume-based procurement policy. Conclusion: After the implementation of volume-based procurement policy, the selected varieties of generic drugs showed a trend of decreasing prices and increasing volume, significantly increasing the replacement rate of original research drugs, which effectively alleviated the burden of medication for patients with hypertensive diseases.
Yunfei Chen,Qian Shen,Yueyue Wang,Tao Wang,Shaoyan Wu,Ling Zhang,Xu Lu,Fangyuan Zhang,Weimin Jiang,Bo Qiu,Erdi Gao,Xiaofen Sun,Kexuan Tang 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.3
Artemisinin is an endoperoxide sesquiterpenelactone isolated from the aerial parts of Artemisia annua L.,and is presently the most potent anti-malarial drug. Owingto the low yield of artemisinin from A. annua as well as thewidespread application of artemisinin-based combinationtherapy recommended by the World Health Organization,the global demand for artemisinin is substantially increasingand is therefore rendering artemisinin in short supply. An economical way to increase artemisinin production is toincrease the content of artemisinin in A. annua. In thisstudy, three key genes in the artemisinin biosynthesispathway, encoding farnesyl diphosphate synthase, amorpha-4, 11-diene C-12 oxidase and its redox partner cytochromeP450 reductase, were over-expressed in A. annuathrough Agrobacterium-mediated transformation. Thetransgenic lines were confirmed by Southern blotting andthe over-expressions of the genes were demonstrated byreal-time PCR assays. The HPLC analysis showed that theartemisinin contents in transgenic lines were increasedsignificantly, with the highest one found to be 3.6-foldhigher (2.9 mg/g FW) than that of the control. Theseresults demonstrate that multigene engineering is aneffective way to enhance artemisinin content in A. annua.
Miao-miao Cheng,Zhiguo Liu,Yueyue Bao,Zhongjie Zhang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5
Continuous conduction mode (CCM) boost converters are commonly used in home appliances and various industries because of their simple topology and low input current ripples. However, these converters suffer from several disadvantages, such as hard switching of the active switch and reverse recovery problems of the output diode. These disadvantages increase voltage stresses across the switch and output diode and thus contribute to switching losses and electromagnetic interference. A new topology is presented in this work to improve the switching characteristics of CCM boost converters. Zero-current turn-on and zero-voltage turn-off are achieved for the active switches. The reverse-recovery current is reduced by soft turning-off the output diode. In addition, an input current sensorless control is applied to the proposed topology by pre-calculating the duty cycles of the active switches. Power factor correction is thus achieved with less effort than that required in the traditional method. Simulation and experimental results verify the soft-switching characteristics of the proposed topology and the effectiveness of the proposed input current sensorless control.
Chang Tian,Hui Zhang,Pei Chen,Yueyue Song,Jinyuan Zhang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.10
To efficiently remove pollutants such as dyes, antibiotics and heavy metal ions from wastewater without causingsecond polluting, it is imperative and challenging to prepare the omnipotence photocatalysis materials. In this study, wool/Fe3O4@TiO2/UiO-66 composite was prepared by a facile one-step solvothermal method. The morphology, composition,structure, chemical bonding states, magnetism, specific surface area, and optical properties of the resultant composite weresystematically examined. Experiment results suggested that the specific surface area of the wool/Fe3O4@TiO2/UiO-66increased from 370.48 to 465.06 m2/g when wool particles were incorporated into Fe3O4@TiO2/UiO-66. Both the compositesexhibited the superior photocatalytic degradation and reduction capabilities toward cationic methylene blue (MB) and anionicCongo red (CR) dyes, tetracycline hydrochloride (TC-HCl) and Cr(VI) ions under visible lights. For organic dyes and heavymetal ions, the wool/Fe3O4@TiO2/UiO-66 composite behaved much better than the Fe3O4@TiO2/UiO-66 one, however, itwas contrary for TC-HCl. The magnetic wool/Fe3O4 core imparted the composite with the easily recyclable ability because ofthe ferromagnetic and superparamagnetism behaviors of Fe3O4. The TiO2/UiO-66 hybrid shell endowed the photocatalyticproperty of the composite. The wools had a strong adsorption ability toward MB and CR dyes and Cr(VI) ions. The wool/Fe3O4@TiO2/UiO-66 composite possessed good stability and repeatability to MB photodegradation and Cr(VI)photoreduction. The holes and singlet oxygen radicals were the main reactive species, while the superoxide and hydroxylradicals were also involved.