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Impact of pigmented contact dermatitis on quality of life in Korean patients
( Yu Ri Woo ),( Yu Jin Jung ),( Jong Sic Kim ),( Ji Hong Lim ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Acquired facial hyperpigmentory disorders may lead to psychological and social distress to the patients. However, little is known about the psychosocial burden of pigmented contact dermatitis (PCD) in Korean patients. Objectives: This study was aimed to examine the level of psychosocial impacts of pigmented contact dermatitis on quality of life (QoL) in Korean patients. Methods: A prospective study recruited the 25 patients with pigmented contact dermatitis and 32 patients with melasma as well as 30 healthy controls. Participants were asked to complete questionnaires regarding demographic characteristics, Dermatology Life Quality Index (DLQI) and Melasma Quality of Life Scale (MELASQOL). Results: The mean score of DLQI was increased in patients with pigmented contact dermatitis (13.76±3.81) than that of patients with melasma (6.63±0.83; P<0.001) and healthy controls (1.83±1.16; P<0.001). In addition, the mean score of the MELASQOL was also increased in patients with pigmented contact dermatitis (54.36±9.26) than that of patients with melasma (36.40±5.65; P=0.01) and healthy controls (17.33±8.91; P<0.001). Conclusion: Among various acquired facial hyperpigmentory disorders, pigmented contact dermatitis poses the serious negative impacts on QOL of patients. Therefore, careful attention associated with psychosocial factors should be considered when managing patients with pigmented contact dermatitis.
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Woo, Yu Ri,Jung, Yu Jin,Kim, Jong Sic,Kim, Miri,Park, Young Min,Min, Chang-Ki,Kim, Dong-Wook,Park, Hyun Jeong Williams & Wilkins Co 2018 Medicine Vol.97 No.43
<P><B>Abstract</B></P><P>Multiple myeloma (MM) is a common hematologic malignancy characterized by the presence of the clonal proliferation of tumor cells. Studies on cutaneous comorbidities in Asian patients with MM have yet to be conducted.</P><P>This study aimed to analyze the prevalences, characteristics, overall survivals, and risk factors of various cutaneous comorbidities in patients with MM.</P><P>A retrospective cohort study using medical records from January 1, 2008, to December 31, 2017, in patients with MM was conducted.</P><P>Of 1438 patients with MM, 354 patients (24.61%) had one or more cutaneous comorbidities. Among them, herpes zoster infection was found to be the most common cutaneous comorbidity. The development of herpes zoster was found to be a possible candidate for good prognostic factor for overall survival [hazard ratio, 0.62; 95% confidence interval (95% CI), 0.44–0.86], while the occurrence of cutaneous malignant tumor was found to be a possible candidate for poor prognostic factor for overall survival (hazard ratio, 3.13; 95% CI, 1.76–5.56).</P><P>The development of some cutaneous comorbidities heralds the prognostic importance in patients with MM. A better understanding of the prevalences, clinical characteristics, and risk factors of various cutaneous comorbidities in patients with MM may help clinicians identify the clinical course and prognosis of the disease.</P>
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Cutaneous extramedullary plasmacytomas in Korean patients with multiple myeloma
( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sewon Hwang ),( Miri Kim ),( Jung Min Bae ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of a clonal proliferation of tumor cells. Cutaneous extramedullary plasmacytomas in patients with MM is very rare and remains poorly understood. Objectives: The aim of this study was to examine the clinical and histopathological characteristics of cutaneous extramedullary plasmacytomas in patients with MM and identify factors associated with overall survival of MM with cutaneous involvement. Methods: Medical records of 1,228 patients with MM were retrieved and analyzed. Among them, 14 patients (1.14%) with cutaneous extramedullary plasmacytomas were further evaluated for their clinical and histopathological findings. Results: Patients with cutaneous extramedullary plasmacytomas showed significantly reduced overall survival compared with those without cutaneous involvement (median: 28 months vs. 57 months; hazard ratio: 1.929; 95% confidence interval: 1.030-3.613). In subgroup analyses of patients with MM with cutaneous extramedullary plasmacytomas, erythematous nodules (P = 0.004), multiple cutaneous lesions (P = 0.002), and absence of a grenz zone (P = 0.004) were clinicopathologic features associated with reduced overall survival after Bonferroni correction. Conclusion: Cutaneous extramedullary plasmacytomas accounted for about 1.14% of patients with MM and was associated with reduced overall survival.
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( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sewon Hwang ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Acanthosis nigricans (AN) is a cutaneous eruption characterized by hyperpigmention and velvety skin texture, and primarily involves the intertriginous areas such as axillae, posterior neck and inframammary folds. Unilateral linear AN is a rare form of AN, characterized by localized linear lesions or a solitary lesion following Blaschko`s line. A 15-year-old male presented with an asymptomatic, linear, localized velvety brownish plaque on his neck that had been present for 5 months. He obtained a linear scratch mark on the anterior neck 6 months prior after climbing over a fence. In addition, symmetrically distributed, velvety, gray-brown, hyperpigmented patches on both axilla were observed. Skin biopsies were performed of the anterior neck and axillae, respectively. Histopathological examination of both lesions revealed papillomatosis, hyperkeratosis, and mild acanthosis of the epidermis. In this case, the patient already had hyperpigmented patches on the axillae before the appearance of the linear AN on the neck, implying that in patients with benign AN, the linear form of AN can occur in association with the Koebner phenomenon. We hypothesize that trauma might act as a trigger of AN, resulting in abnormal growth factor signaling pathways. Therefore, we suggest that in patients with AN, careful examination and regular follow-up are needed and the patient should avoid further trauma because this could trigger the development of AN
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P145 Erythroid differentiation regulator 1 expression in various types of alopecias
( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sae Won Hwang ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Erythroid differentiation regulator 1 (Erdr1) is known to involved in the inflammatory process via regulating immune system in various cutaneous disorders, psoriasis, rosacea. However, the role of Erdr1 in alopecia has not been studied. Objectives: The aim of this study is to investigate the expression patterns of Erdr1 in various types of alopecias. Methods: In all, twenty patients with alopecia were included. Skin samples from nine patients with alopecia areata, eight patients with scarring alopecia, three patients with traumatic alopecia, and five control subjects were retrieved for evaluation of Erdr1 expression. Results: Downregulation of Erdr1 was observed in alopecia than control groups. The expression density of Erdr1 was weaker in hair follicle than epidermis. In particular, a significant decrease in expression density of Erdr1 was observed in 44% of patients with alopecia areata, who were recalcitrant to the treatment. Conclusion: The expression of Erdr1 was downregulated in alopecia, which suggest that Erdr1 may be involved in the pathogenesis. Especially for alopecia areata, the expression of Erdr1 could be used as a prognostic factor for disease progression and treatment outcome.
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( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sae Won Hwang ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Actinic keratosis (AK) is a most common premalignant lesion that may progress into the invasive squamous cell carcinoma (SCC). Ingenol mebutate gel has been shown to be effective and safe for treatment of AK. Erythroid differentiation regulator 1 (Erdr1), which functions as stress-related factor, was recently reported to play a crucial role in malignant skin cancers like malignant melanoma. Objectives: The purpose of this study is to investigate whether expression of Erdr1, p53, and bcl-2 was affected by treatment of ingenol mebutate gel in actinic keratosis. Methods: Nine patients with AK received the skin biopsy at baseline and 2 months after the treatment with ingenol mebutate gel for histological and immunological evaluation. In addition, skin samples from five control subjects were retrieved. Immunohistochemical staining with Erdr1, p53, and bcl-2 was performed. Results: Upregulation of Erdr1 was observed after treatment with ingenol mebutate gel. In addition, a significant decrease in p53 and bcl-2 expression was observed after the treatment. Conclusion: The expression of Erdr1 was upregulated after treatment with ingenol mebutate gel, suggesting that Erdr1 may be involved in the pathogenesis of AK. Furthermore, p53 and bcl-2 can be used as a biomarker for evaluating the treatment outcome in AK after treatment with ingenol mebutate gel.
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[P296] Bullous scabies: a case report and review of the literature
( Jong Sic Kim ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Scabies is a common parasitic infection caused by the miteSarcoptes Scabiei. It is characterized by an erythematous excoriated papulovesicular rash, burrows, nodules and hyperkeratotic lesions in specific body areas. However, bullous scabies is a rare subtype that can mimic clinically and histologically bullous pemphigoid. Herein, we report a rare case of bullous scabies. A 78-year-old patient with diabetes mellitus presented with a 3-day of intensely pruritic, multiple, tense, 1-3 cm sized bullae on trunk and both extremities including both palms. He had been treated for chronic urticaria for several years with antihistamines. The symptoms have been recently aggravated with newly developed bullae and poor response to antihistamines and steroid. The skin biopsy revealed a subepidermal blister, superficial perivascular infiltrate with abundant eosinophils. Although histopathologic findings failed to show a scabies mite, and mite scraping was negative, the patient was clinically diagnosed with bullous scabies and treated with gamma benzene hexachloride cream. After 1 week, the bullae started to disappear with significant improvement of pruritus. The pathogenesis of bullae formation in scabies is not entirely understood. Several mechanisms have been suggested such as Staphylococcus Aureus superinfection and autoantibody. The diagnosis of scabies should be considered in the patients who present with tense bullae with severe pruritus, especially when the skin lesions do not resolve with conventional therapy.
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[P209] Dermojet induced myositis
( Jong Sic Kim ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
The Dermojet<sup>TM</sup> has been widely used to treat various skin disorders in dermatological practice because of its convenience and safety. Reported DermojetTM induced complications include mild pain, erythema, secondary infection, cutaneous atrophy and traumatic tattoo at the injection site. We report herein a rare case of myositis induced by a jet injector. A 41-year-old woman presented with a pruritic eczematous lesion of the right shoulder and both arms. The lesions were treated twice at 4-week intervals with an intralesional injection of 0.1 mL triamcinolone (40 mg/mL) using a jet injector. One day after the second injection, the patient complained of painful swelling on the right shoulder at the injection site. The pain came on gradually with fever and progressive right shoulder weakness. At the injection site, there was a localized, ill-defined, tender, erythematous, indurated plaque. Using laboratory test and T1-weighted MRI, the patient was diagnosed with myositis of the deltoid. Skin biopsy revealed a moderate lymphohistiocytic infiltration involving the dermis. The patient was treated with systemic antibiotics. Three weeks later, the lesion had completely resolved. Several factors may contribute to the development of myositis. We suggest that physicianstreating patients with steroids using a jet injector near damaged skin or bony prominences should be aware of the risk of deep infection and should be cautious when using DermojetTM
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